SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4af5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E9X_A_NIMA1_1
(LACTOTRANSFERRIN')		 4af5 HTH-TYPE
TRANSCRIPTIONAL
REPRESSOR ACNR
COMPND 2
(Corynebacterium
glutamicum) 		4 / 4 GLU A  38
GLY A  42
THR A  41
GLU A  15
 None
 1.07A 3e9xA-4af5A:
undetectable		 3e9xA-4af5A:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHX_B_PXLB313_1
(PYRIDOXAL KINASE)		 4af5 HTH-TYPE
TRANSCRIPTIONAL
REPRESSOR ACNR
COMPND 2
(Corynebacterium
glutamicum) 		4 / 8 VAL A 180
PHE A 152
HIS A 150
VAL A 127
 None
 1.16A 3fhxB-4af5A:
undetectable		 3fhxB-4af5A:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_B_SUEB1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 4af5 HTH-TYPE
TRANSCRIPTIONAL
REPRESSOR ACNR
COMPND 2
(Corynebacterium
glutamicum) 		3 / 3 TYR A  93
LEU A  17
ARG A  99
 None
 0.79A 3sufB-4af5A:
undetectable		 3sufB-4af5A:
24.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_C_ZMRC1470_2
(NEURAMINIDASE)		 4af5 HTH-TYPE
TRANSCRIPTIONAL
REPRESSOR ACNR
COMPND 2
(Corynebacterium
glutamicum) 		3 / 3 ARG A  99
ARG A  92
TRP A  95
 None
 1.16A 4cpzC-4af5A:
undetectable		 4cpzC-4af5A:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_E_ZMRE1471_2
(NEURAMINIDASE)		 4af5 HTH-TYPE
TRANSCRIPTIONAL
REPRESSOR ACNR
COMPND 2
(Corynebacterium
glutamicum) 		3 / 3 ARG A  99
ARG A  92
TRP A  95
 None
 1.13A 4cpzE-4af5A:
undetectable		 4cpzE-4af5A:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_F_ZMRF1470_2
(NEURAMINIDASE)		 4af5 HTH-TYPE
TRANSCRIPTIONAL
REPRESSOR ACNR
COMPND 2
(Corynebacterium
glutamicum) 		3 / 3 ARG A  99
ARG A  92
TRP A  95
 None
 1.12A 4cpzF-4af5A:
undetectable		 4cpzF-4af5A:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_G_ZMRG1471_2
(NEURAMINIDASE)		 4af5 HTH-TYPE
TRANSCRIPTIONAL
REPRESSOR ACNR
COMPND 2
(Corynebacterium
glutamicum) 		3 / 3 ARG A  99
ARG A  92
TRP A  95
 None
 1.13A 4cpzG-4af5A:
undetectable		 4cpzG-4af5A:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_H_ZMRH1470_2
(NEURAMINIDASE)		 4af5 HTH-TYPE
TRANSCRIPTIONAL
REPRESSOR ACNR
COMPND 2
(Corynebacterium
glutamicum) 		3 / 3 ARG A  99
ARG A  92
TRP A  95
 None
 1.14A 4cpzH-4af5A:
undetectable		 4cpzH-4af5A:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X61_A_SAMA701_0
(PROTEIN ARGININE
N-METHYLTRANSFERASE
5)		 4af5 HTH-TYPE
TRANSCRIPTIONAL
REPRESSOR ACNR
COMPND 2
(Corynebacterium
glutamicum) 		5 / 12 LEU A 177
ASN A  77
MET A  86
GLU A 154
LEU A 157
 None
MG  A1187 ( 4.4A)
None
None
None
 1.31A 4x61A-4af5A:
undetectable		 4x61A-4af5A:
15.13