SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4afr'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_A_THAA1_1
(LIVER
CARBOXYLESTERASE I)		 4afr METACASPASE
(Trypanosoma
brucei) 		5 / 11 LEU A 336
PHE A 152
GLY A 107
LEU A 292
MET A 293
 None
 1.16A 1mx1A-4afrA:
undetectable		 1mx1A-4afrA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_1
(DNA TOPOISOMERASE II)		 4afr METACASPASE
(Trypanosoma
brucei) 		4 / 7 HIS A  60
ASN A 133
TYR A 137
LEU A  76
 None
 1.07A 1qzrA-4afrA:
undetectable		 1qzrA-4afrA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VQ1_A_SAMA301_1
(N5-GLUTAMINE
METHYLTRANSFERASE,
HEMK)		 4afr METACASPASE
(Trypanosoma
brucei) 		3 / 3 GLY A  19
ASP A  16
ASN A  24
 None
 0.59A 1vq1A-4afrA:
undetectable		 1vq1A-4afrA:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E7F_A_C2FA3000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 4afr METACASPASE
(Trypanosoma
brucei) 		5 / 12 MET A 254
ILE A  80
GLY A 159
SER A 215
ILE A 176
 None
 1.23A 2e7fA-4afrA:
undetectable		 2e7fA-4afrA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E7F_B_C2FB4000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 4afr METACASPASE
(Trypanosoma
brucei) 		5 / 12 MET A 254
ILE A  80
GLY A 159
SER A 215
ILE A 176
 None
 1.27A 2e7fB-4afrA:
undetectable		 2e7fB-4afrA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OGY_A_C2FA3000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 4afr METACASPASE
(Trypanosoma
brucei) 		5 / 12 MET A 254
ILE A  80
GLY A 159
SER A 215
ILE A 176
 None
 1.20A 2ogyA-4afrA:
undetectable		 2ogyA-4afrA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OGY_B_C2FB4000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 4afr METACASPASE
(Trypanosoma
brucei) 		5 / 12 MET A 254
ILE A  80
GLY A 159
SER A 215
ILE A 176
 None
 1.23A 2ogyB-4afrA:
undetectable		 2ogyB-4afrA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YCJ_A_C2FA3000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 4afr METACASPASE
(Trypanosoma
brucei) 		5 / 12 MET A 254
ILE A  80
GLY A 159
SER A 215
ILE A 176
 None
 1.18A 2ycjA-4afrA:
undetectable		 2ycjA-4afrA:
24.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGN_A_PCFA1179_0
(WNT INHIBITORY
FACTOR 1)		 4afr METACASPASE
(Trypanosoma
brucei) 		5 / 12 LEU A 100
ILE A 255
LEU A 322
ILE A 328
MET A 253
 None
 0.97A 2ygnA-4afrA:
undetectable		 2ygnA-4afrA:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z0A_A_GLYA73_0
(NONSTRUCTURAL
PROTEIN 1)		 4afr METACASPASE
(Trypanosoma
brucei) 		4 / 5 ALA A 233
GLN A 232
ILE A 305
ARG A 308
 None
 1.35A 2z0aA-4afrA:
undetectable		 2z0aA-4afrA:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DJF_A_C2FA300_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 4afr METACASPASE
(Trypanosoma
brucei) 		5 / 12 MET A 254
ILE A  80
GLY A 159
SER A 215
ILE A 176
 None
 1.22A 4djfA-4afrA:
undetectable		 4djfA-4afrA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNV_B_QI9B602_0
(CYTOCHROME P450 2D6)		 4afr METACASPASE
(Trypanosoma
brucei) 		5 / 9 LEU A  68
LEU A 292
SER A 335
THR A 207
VAL A  73
 None
 1.42A 4wnvB-4afrA:
undetectable		 4wnvB-4afrA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CK2_C_IPHC101_0
(INSULIN A CHAIN
INSULIN B CHAIN)		 4afr METACASPASE
(Trypanosoma
brucei) 		4 / 4 ILE A 134
LEU A 196
HIS A 154
ALA A 208
 None
 0.95A 6ck2C-4afrA:
undetectable
6ck2D-4afrA:
undetectable		 6ck2C-4afrA:
11.76
6ck2D-4afrA:
7.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CP4_A_CAMA422_0
(CYTOCHROME P450CAM)		 4afr METACASPASE
(Trypanosoma
brucei) 		4 / 8 LEU A 292
THR A 337
VAL A  73
VAL A 150
 None
 0.96A 6cp4A-4afrA:
undetectable		 6cp4A-4afrA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DEB_B_MTXB303_1
(BIFUNCTIONAL PROTEIN
FOLD)		 4afr METACASPASE
(Trypanosoma
brucei) 		4 / 5 TYR A  17
GLN A 104
GLY A  59
ILE A 115
 None
 1.23A 6debB-4afrA:
2.5		 6debB-4afrA:
12.15