SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ag4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AXW_B_MTXB733_1
(THYMIDYLATE SYNTHASE)		 4ag4 EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1
(Homo
sapiens) 		5 / 11 ASP A 216
LEU A 228
GLY A 229
TYR A 122
VAL A 160
 None
 1.46A 1axwB-4ag4A:
undetectable		 1axwB-4ag4A:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I00_A_D16A315_1
(THYMIDYLATE SYNTHASE)		 4ag4 EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1
(Homo
sapiens) 		5 / 9 PHE A 272
ASP A 216
LEU A 228
GLY A 227
TYR A 122
 None
 1.49A 1i00A-4ag4A:
undetectable		 1i00A-4ag4A:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I00_B_D16B409_1
(THYMIDYLATE SYNTHASE)		 4ag4 EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1
(Homo
sapiens) 		5 / 9 PHE A 272
ASP A 216
LEU A 228
GLY A 227
TYR A 122
 None
 1.48A 1i00B-4ag4A:
undetectable		 1i00B-4ag4A:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ISM_B_NCAB305_0
(BONE MARROW STROMAL
CELL ANTIGEN 1)		 4ag4 EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1
(Homo
sapiens) 		4 / 7 TRP A 356
LEU A 357
TRP A 258
PHE A 263
 None
 1.21A 1ismB-4ag4A:
undetectable		 1ismB-4ag4A:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JLF_A_NVPA999_1
(HIV-1 RT A-CHAIN
HIV-1 RT B-CHAIN)		 4ag4 EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1
(Homo
sapiens) 		4 / 8 LEU A 231
TYR A 255
GLY A 199
TYR A 194
 None
 1.06A 1jlfA-4ag4A:
undetectable
1jlfB-4ag4A:
undetectable		 1jlfA-4ag4A:
17.95
1jlfB-4ag4A:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KF6_B_ACTB704_0
(FUMARATE REDUCTASE
FLAVOPROTEIN
FUMARATE REDUCTASE
IRON-SULFUR PROTEIN)		 4ag4 EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1
(Homo
sapiens) 		3 / 3 ARG A 124
GLY A 217
ASP A 216
 None
 0.54A 1kf6A-4ag4A:
undetectable
1kf6B-4ag4A:
undetectable		 1kf6A-4ag4A:
22.11
1kf6B-4ag4A:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG1_A_SPMA999_1
(TYROSYL-DNA
PHOSPHODIESTERASE 1)		 4ag4 EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1
(Homo
sapiens) 		3 / 3 TRP A 258
VAL A 198
PRO A 197
 None
 0.69A 1rg1A-4ag4A:
undetectable		 1rg1A-4ag4A:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RH0_A_SPMA999_1
(TYROSYL-DNA
PHOSPHODIESTERASE 1)		 4ag4 EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1
(Homo
sapiens) 		3 / 3 TRP A 258
VAL A 198
PRO A 197
 None
 0.70A 1rh0A-4ag4A:
undetectable		 1rh0A-4ag4A:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_1
(CES1 PROTEIN)		 4ag4 EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1
(Homo
sapiens) 		5 / 12 GLY A 226
GLY A 227
LEU A 223
MET A 270
LEU A 231
 None
 1.22A 1ya4B-4ag4A:
undetectable		 1ya4B-4ag4A:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C8A_B_NCAB1246_0
(MONO-ADP-RIBOSYLTRAN
SFERASE C3)		 4ag4 EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1
MONOCLONAL ANTIBODY
3E3 HEAVY CHAIN
(Homo
sapiens;
Mus
musculus) 		4 / 7 ARG A 341
GLY A 315
SER H  32
SER H  30
 None
 1.09A 2c8aB-4ag4A:
undetectable		 2c8aB-4ag4A:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C8A_D_NCAD1247_0
(MONO-ADP-RIBOSYLTRAN
SFERASE C3)		 4ag4 EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1
MONOCLONAL ANTIBODY
3E3 HEAVY CHAIN
(Homo
sapiens;
Mus
musculus) 		4 / 7 ARG A 341
GLY A 315
SER H  32
SER H  30
 None
 1.06A 2c8aD-4ag4A:
undetectable		 2c8aD-4ag4A:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IEO_A_017A402_2
(PROTEASE)		 4ag4 MONOCLONAL ANTIBODY
3E3 HEAVY CHAIN
(Mus
musculus) 		5 / 12 LEU H 138
VAL H 163
GLY H 157
VAL H 183
VAL H 181
 None
 0.90A 2ieoB-4ag4H:
undetectable		 2ieoB-4ag4H:
14.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y03_A_5FWA601_1
(BETA-1 ADRENERGIC
RECEPTOR)		 4ag4 MONOCLONAL ANTIBODY
3E3 HEAVY CHAIN
(Mus
musculus) 		5 / 12 VAL H 163
VAL H 181
SER H 179
ASN H 196
ASN H 155
 None
 1.44A 2y03A-4ag4H:
undetectable		 2y03A-4ag4H:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y03_B_5FWB601_1
(BETA-1 ADRENERGIC
RECEPTOR)		 4ag4 MONOCLONAL ANTIBODY
3E3 HEAVY CHAIN
(Mus
musculus) 		5 / 12 VAL H 163
VAL H 181
SER H 179
ASN H 196
ASN H 155
 None
 1.48A 2y03B-4ag4H:
undetectable		 2y03B-4ag4H:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZTH_A_SAMA305_1
(CATECHOL
O-METHYLTRANSFERASE)		 4ag4 EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1
(Homo
sapiens) 		3 / 3 SER A  54
GLU A 113
ASP A  70
 None
 0.67A 2zthA-4ag4A:
undetectable		 2zthA-4ag4A:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWM_A_SAMA301_1
(CATECHOL
O-METHYLTRANSFERASE)		 4ag4 EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1
(Homo
sapiens) 		3 / 3 SER A  54
GLU A 113
ASP A  70
 None
 0.82A 3bwmA-4ag4A:
undetectable		 3bwmA-4ag4A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWY_A_SAMA301_1
(COMT PROTEIN)		 4ag4 EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1
(Homo
sapiens) 		3 / 3 SER A  54
GLU A 113
ASP A  70
 None
 0.83A 3bwyA-4ag4A:
undetectable		 3bwyA-4ag4A:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D9L_A_ACTA501_0
(CTD-PEPTIDE
RNA-BINDING PROTEIN
16)		 4ag4 MONOCLONAL ANTIBODY
3E3 HEAVY CHAIN
(Mus
musculus) 		4 / 5 ILE H  51
PRO H  52
TYR H  52
TYR H  56
 None
 1.30A 3d9lA-4ag4H:
undetectable
3d9lY-4ag4H:
undetectable		 3d9lA-4ag4H:
19.16
3d9lY-4ag4H:
6.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NYA_A_JTZA1203_1
(BETA-2 ADRENERGIC
RECEPTOR, LYSOZYME)		 4ag4 MONOCLONAL ANTIBODY
3E3 HEAVY CHAIN
(Mus
musculus) 		5 / 12 VAL H 163
VAL H 181
SER H 179
ASN H 196
ASN H 155
 None
 1.40A 3nyaA-4ag4H:
undetectable		 3nyaA-4ag4H:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EB4_D_D16D402_1
(THYMIDYLATE SYNTHASE)		 4ag4 EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1
(Homo
sapiens) 		5 / 10 PHE A 272
ASP A 216
LEU A 228
GLY A 227
TYR A 122
 None
 1.44A 4eb4D-4ag4A:
undetectable		 4eb4D-4ag4A:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L6V_1_PQN12001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
FUSION PROTEIN OF
PHOTOSYSTEM I
SUBUNIT III AND
SUBUNIT IX)		 4ag4 EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1
MONOCLONAL ANTIBODY
3E3 HEAVY CHAIN
(Homo
sapiens;
Mus
musculus) 		5 / 11 TRP H 103
GLY A 339
LEU H  99
GLY H  97
ALA H  88
 None
 1.12A 4l6v1-4ag4H:
undetectable
4l6v6-4ag4H:
undetectable		 4l6v1-4ag4H:
13.96
4l6v6-4ag4H:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L6V_1_PQN12001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
FUSION PROTEIN OF
PHOTOSYSTEM I
SUBUNIT III AND
SUBUNIT IX)		 4ag4 EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1
MONOCLONAL ANTIBODY
3E3 HEAVY CHAIN
(Homo
sapiens;
Mus
musculus) 		5 / 11 TRP H 103
GLY A 340
TRP H  33
GLY H  97
ALA H  88
 None
 1.04A 4l6v1-4ag4H:
undetectable
4l6v6-4ag4H:
undetectable		 4l6v1-4ag4H:
13.96
4l6v6-4ag4H:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LDO_A_ALEA1402_1
(LYSOZYME, BETA-2
ADRENERGIC RECEPTOR)		 4ag4 MONOCLONAL ANTIBODY
3E3 HEAVY CHAIN
(Mus
musculus) 		5 / 10 VAL H 163
VAL H 181
SER H 179
ASN H 196
ASN H 155
 None
 1.49A 4ldoA-4ag4H:
undetectable		 4ldoA-4ag4H:
18.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4M7K_H_ACTH302_0
(10H10 HEAVY CHAIN)		 4ag4 MONOCLONAL ANTIBODY
3E3 HEAVY CHAIN
(Mus
musculus) 		4 / 5 VAL H   2
TYR H  27
ARG H  94
TYR H 102
 None
 0.29A 4m7kH-4ag4H:
26.9		 4m7kH-4ag4H:
69.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q56_A_ACTA201_0
(HELIX ASPERSA
AGGLUTININ (HAA))		 4ag4 EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1
(Homo
sapiens) 		4 / 4 ASN A 325
ARG A 296
HIS A 291
ASN A 289
 None
 1.34A 4q56A-4ag4A:
0.0		 4q56A-4ag4A:
13.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5I_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 4ag4 EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1
(Homo
sapiens) 		3 / 3 ASP A 212
ARG A 128
ARG A 124
 None
 0.98A 4x5iA-4ag4A:
undetectable		 4x5iA-4ag4A:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XQE_A_AG2A505_1
(HOMOSPERMIDINE
SYNTHASE)		 4ag4 MONOCLONAL ANTIBODY
3E3 HEAVY CHAIN
(Mus
musculus) 		5 / 12 ALA H 201
PRO H 200
TYR H 145
TYR H 175
THR H 110
 None
 1.40A 4xqeA-4ag4H:
undetectable		 4xqeA-4ag4H:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XQE_B_AG2B504_1
(HOMOSPERMIDINE
SYNTHASE)		 4ag4 MONOCLONAL ANTIBODY
3E3 HEAVY CHAIN
(Mus
musculus) 		5 / 12 ALA H 201
PRO H 200
TYR H 145
TYR H 175
THR H 110
 None
 1.40A 4xqeB-4ag4H:
undetectable		 4xqeB-4ag4H:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XRG_B_AG2B502_1
(HOMOSPERMIDINE
SYNTHASE)		 4ag4 MONOCLONAL ANTIBODY
3E3 HEAVY CHAIN
(Mus
musculus) 		5 / 12 ALA H 201
PRO H 200
TYR H 145
TYR H 175
THR H 110
 None
 1.40A 4xrgB-4ag4H:
0.0		 4xrgB-4ag4H:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUD_A_SAMA303_1
(CATECHOL
O-METHYLTRANSFERASE)		 4ag4 EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1
(Homo
sapiens) 		3 / 3 SER A  54
GLU A 113
ASP A  70
 None
 0.79A 4xudA-4ag4A:
undetectable		 4xudA-4ag4A:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_O_EVPO2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 4ag4 EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1
(Homo
sapiens) 		4 / 6 SER A 259
ASP A 240
ARG A 242
GLY A 252
 None
 0.94A 5cdnC-4ag4A:
undetectable
5cdnD-4ag4A:
undetectable		 5cdnC-4ag4A:
21.07
5cdnD-4ag4A:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EAJ_B_FOLB201_1
(DIHYDROFOLATE
REDUCTASE)		 4ag4 EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1
(Homo
sapiens) 		3 / 3 ASP A 212
ARG A 128
ARG A 124
 None
 0.86A 5eajB-4ag4A:
undetectable		 5eajB-4ag4A:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EYP_B_LOCB502_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 4ag4 MONOCLONAL ANTIBODY
3E3 HEAVY CHAIN
(Mus
musculus) 		3 / 3 SER H 203
ALA H 198
VAL H 197
 None
 0.57A 5eypA-4ag4H:
undetectable		 5eypA-4ag4H:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FSA_B_X2NB590_2
(CYP51 VARIANT1)		 4ag4 MONOCLONAL ANTIBODY
3E3 HEAVY CHAIN
(Mus
musculus) 		3 / 3 PRO H  82
LEU H  11
SER H  17
 None
 0.75A 5fsaB-4ag4H:
undetectable		 5fsaB-4ag4H:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JLC_A_1YNA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4ag4 MONOCLONAL ANTIBODY
3E3 HEAVY CHAIN
(Mus
musculus) 		4 / 5 TYR H  91
GLY H 106
THR H 107
GLY H 162
 None
 0.88A 5jlcA-4ag4H:
undetectable		 5jlcA-4ag4H:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJC_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 1)		 4ag4 EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1
(Homo
sapiens) 		4 / 7 LEU A  91
ILE A 141
TRP A 132
MET A 159
 None
 1.45A 5ljcA-4ag4A:
undetectable		 5ljcA-4ag4A:
15.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5MTH_A_ACTA302_0
(ANTIBODY FAB HEAVY
CHAIN)		 4ag4 MONOCLONAL ANTIBODY
3E3 HEAVY CHAIN
(Mus
musculus) 		4 / 5 SER H 112
ALA H 114
PHE H 146
LEU H 170
 None
 0.40A 5mthA-4ag4H:
28.7		 5mthA-4ag4H:
82.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X5Q_E_D16E402_1
(THYMIDYLATE SYNTHASE)		 4ag4 EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1
(Homo
sapiens) 		5 / 6 PHE A 272
ASP A 216
LEU A 228
GLY A 227
TYR A 122
 None
 1.43A 5x5qE-4ag4A:
undetectable		 5x5qE-4ag4A:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIW_D_LOCD503_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA CHAIN)		 4ag4 MONOCLONAL ANTIBODY
3E3 HEAVY CHAIN
(Mus
musculus) 		3 / 3 SER H 203
ALA H 198
VAL H 197
 None
 0.51A 5xiwC-4ag4H:
undetectable		 5xiwC-4ag4H:
18.00