SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ag6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P7L_C_SAMC885_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 4ag6 TYPE IV SECRETORY
PATHWAY VIRB4
COMPONENTS-LIKE
PROTEIN
(Thermoanaerobact
er
pseudethanolicus) 		4 / 8 PRO A 307
THR A 481
PHE A 448
ASP A 490
 None
 1.21A 1p7lD-4ag6A:
undetectable		 1p7lD-4ag6A:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_A_SAMA385_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 4ag6 TYPE IV SECRETORY
PATHWAY VIRB4
COMPONENTS-LIKE
PROTEIN
(Thermoanaerobact
er
pseudethanolicus) 		4 / 8 PRO A 307
THR A 481
PHE A 448
ASP A 490
 None
 1.21A 1rg9A-4ag6A:
undetectable		 1rg9A-4ag6A:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_B_SAMB485_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 4ag6 TYPE IV SECRETORY
PATHWAY VIRB4
COMPONENTS-LIKE
PROTEIN
(Thermoanaerobact
er
pseudethanolicus) 		4 / 8 PRO A 307
THR A 481
PHE A 448
ASP A 490
 None
 1.21A 1rg9B-4ag6A:
undetectable		 1rg9B-4ag6A:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_C_SAMC585_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 4ag6 TYPE IV SECRETORY
PATHWAY VIRB4
COMPONENTS-LIKE
PROTEIN
(Thermoanaerobact
er
pseudethanolicus) 		4 / 8 PRO A 307
THR A 481
PHE A 448
ASP A 490
 None
 1.22A 1rg9C-4ag6A:
undetectable		 1rg9C-4ag6A:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_C_SAMC685_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 4ag6 TYPE IV SECRETORY
PATHWAY VIRB4
COMPONENTS-LIKE
PROTEIN
(Thermoanaerobact
er
pseudethanolicus) 		4 / 8 PRO A 307
THR A 481
PHE A 448
ASP A 490
 None
 1.20A 1rg9D-4ag6A:
undetectable		 1rg9D-4ag6A:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z2B_C_VLBC800_1
(TUBULIN BETA CHAIN
TUBULIN ALPHA CHAIN)		 4ag6 TYPE IV SECRETORY
PATHWAY VIRB4
COMPONENTS-LIKE
PROTEIN
(Thermoanaerobact
er
pseudethanolicus) 		4 / 8 ASP A 511
TYR A 447
PRO A 273
LEU A 435
 None
 0.93A 1z2bB-4ag6A:
undetectable		 1z2bB-4ag6A:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z2B_C_VLBC800_2
(TUBULIN ALPHA CHAIN)		 4ag6 TYPE IV SECRETORY
PATHWAY VIRB4
COMPONENTS-LIKE
PROTEIN
(Thermoanaerobact
er
pseudethanolicus) 		4 / 5 VAL A 450
ASN A 449
VAL A 432
ILE A 289
 None
 1.05A 1z2bC-4ag6A:
undetectable		 1z2bC-4ag6A:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BL9_A_CP6A1240_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4ag6 TYPE IV SECRETORY
PATHWAY VIRB4
COMPONENTS-LIKE
PROTEIN
(Thermoanaerobact
er
pseudethanolicus) 		5 / 12 ILE A 505
ALA A 473
LEU A 488
ILE A 495
ILE A 503
 None
 1.11A 2bl9A-4ag6A:
undetectable		 2bl9A-4ag6A:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RIW_A_T44A1395_1
(THYROXINE-BINDING
GLOBULIN)		 4ag6 TYPE IV SECRETORY
PATHWAY VIRB4
COMPONENTS-LIKE
PROTEIN
(Thermoanaerobact
er
pseudethanolicus) 		5 / 10 ALA A 406
LEU A 340
LEU A 348
LEU A 403
LEU A 337
 None
 1.20A 2riwA-4ag6A:
undetectable
2riwB-4ag6A:
undetectable		 2riwA-4ag6A:
23.06
2riwB-4ag6A:
8.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGO_A_PCFA1213_0
(WNT INHIBITORY
FACTOR 1)		 4ag6 TYPE IV SECRETORY
PATHWAY VIRB4
COMPONENTS-LIKE
PROTEIN
(Thermoanaerobact
er
pseudethanolicus) 		5 / 12 ILE A 242
ILE A 505
ILE A 503
ILE A 579
VAL A 226
 None
 0.92A 2ygoA-4ag6A:
undetectable		 2ygoA-4ag6A:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UWL_D_FOZD316_0
(THYMIDYLATE SYNTHASE)		 4ag6 TYPE IV SECRETORY
PATHWAY VIRB4
COMPONENTS-LIKE
PROTEIN
(Thermoanaerobact
er
pseudethanolicus) 		5 / 12 LEU A 534
LEU A 541
GLY A 537
ILE A 544
ALA A 543
 None
 1.07A 3uwlD-4ag6A:
undetectable		 3uwlD-4ag6A:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_B_W9TB513_1
(HEMOLYTIC LECTIN
CEL-III)		 4ag6 TYPE IV SECRETORY
PATHWAY VIRB4
COMPONENTS-LIKE
PROTEIN
(Thermoanaerobact
er
pseudethanolicus) 		4 / 6 CYH A 291
THR A 292
ASN A 290
ILE A 271
 None
None
SO4  A1590 (-3.3A)
None
 1.27A 3w9tB-4ag6A:
undetectable		 3w9tB-4ag6A:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q1X_A_017A101_2
(ASPARTYL PROTEASE)		 4ag6 TYPE IV SECRETORY
PATHWAY VIRB4
COMPONENTS-LIKE
PROTEIN
(Thermoanaerobact
er
pseudethanolicus) 		5 / 12 LEU A 451
ALA A 484
ASP A 478
GLY A 521
VAL A 470
 None
 0.91A 4q1xB-4ag6A:
undetectable		 4q1xB-4ag6A:
14.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4H_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 4ag6 TYPE IV SECRETORY
PATHWAY VIRB4
COMPONENTS-LIKE
PROTEIN
(Thermoanaerobact
er
pseudethanolicus) 		4 / 5 ARG A 465
GLN A 264
ILE A 228
ASP A 227
 None
 1.30A 4z4hA-4ag6A:
2.5		 4z4hA-4ag6A:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZOW_A_CLMA500_0
(MULTIDRUG
TRANSPORTER MDFA)		 4ag6 TYPE IV SECRETORY
PATHWAY VIRB4
COMPONENTS-LIKE
PROTEIN
(Thermoanaerobact
er
pseudethanolicus) 		5 / 11 TYR A 336
LEU A 340
LEU A 352
LEU A 348
LEU A 301
 None
 0.94A 4zowA-4ag6A:
undetectable		 4zowA-4ag6A:
23.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BMV_C_VLBC507_1
(TUBULIN BETA CHAIN
TUBULIN ALPHA-1B
CHAIN)		 4ag6 TYPE IV SECRETORY
PATHWAY VIRB4
COMPONENTS-LIKE
PROTEIN
(Thermoanaerobact
er
pseudethanolicus) 		4 / 6 ASP A 511
TYR A 447
PRO A 273
LEU A 435
 None
 1.15A 5bmvB-4ag6A:
undetectable		 5bmvB-4ag6A:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KVA_A_SAMA301_1
(CAFFEOYL-COA
O-METHYLTRANSFERASE)		 4ag6 TYPE IV SECRETORY
PATHWAY VIRB4
COMPONENTS-LIKE
PROTEIN
(Thermoanaerobact
er
pseudethanolicus) 		3 / 3 THR A 481
SER A 334
ASP A 342
 None
 0.51A 5kvaA-4ag6A:
3.5		 5kvaA-4ag6A:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KVA_B_SAMB301_1
(CAFFEOYL-COA
O-METHYLTRANSFERASE)		 4ag6 TYPE IV SECRETORY
PATHWAY VIRB4
COMPONENTS-LIKE
PROTEIN
(Thermoanaerobact
er
pseudethanolicus) 		3 / 3 THR A 481
SER A 334
ASP A 342
 None
 0.50A 5kvaB-4ag6A:
3.6		 5kvaB-4ag6A:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T8S_B_SAMB402_1
(S-ADENOSYLMETHIONINE
SYNTHASE)		 4ag6 TYPE IV SECRETORY
PATHWAY VIRB4
COMPONENTS-LIKE
PROTEIN
(Thermoanaerobact
er
pseudethanolicus) 		4 / 8 PRO A 307
THR A 481
PHE A 448
ASP A 490
 None
 1.22A 5t8sB-4ag6A:
undetectable		 5t8sB-4ag6A:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_B_ACTB308_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 4ag6 TYPE IV SECRETORY
PATHWAY VIRB4
COMPONENTS-LIKE
PROTEIN
(Thermoanaerobact
er
pseudethanolicus) 		3 / 3 LEU A 524
ILE A 485
TYR A 447
 None
 0.64A 5uunB-4ag6A:
undetectable		 5uunB-4ag6A:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGC_A_ACTA811_0
(GEPHYRIN)		 4ag6 TYPE IV SECRETORY
PATHWAY VIRB4
COMPONENTS-LIKE
PROTEIN
(Thermoanaerobact
er
pseudethanolicus) 		3 / 3 LEU A 533
LEU A 550
ARG A 574
 None
 0.70A 6fgcA-4ag6A:
2.2		 6fgcA-4ag6A:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JNH_A_ASCA202_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 4ag6 TYPE IV SECRETORY
PATHWAY VIRB4
COMPONENTS-LIKE
PROTEIN
(Thermoanaerobact
er
pseudethanolicus) 		3 / 3 ASN A 449
PRO A 300
GLN A 302
 None
 0.91A 6jnhA-4ag6A:
undetectable		 6jnhA-4ag6A:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JOG_A_ASCA202_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 4ag6 TYPE IV SECRETORY
PATHWAY VIRB4
COMPONENTS-LIKE
PROTEIN
(Thermoanaerobact
er
pseudethanolicus) 		3 / 3 ASN A 449
PRO A 300
GLN A 302
 None
 0.88A 6jogA-4ag6A:
undetectable		 6jogA-4ag6A:
18.88