SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ag9'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JGS_A_SALA256_1
(MULTIPLE ANTIBIOTIC
RESISTANCE PROTEIN
MARR)		 4ag9 GLUCOSAMINE-6-PHOSPH
ATE
N-ACETYLTRANSFERASE
(Caenorhabditis
elegans) 		4 / 7 VAL A  81
LEU A  39
LEU A 117
VAL A  24
 None
None
COA  A1166 (-4.9A)
None
 0.93A 1jgsA-4ag9A:
undetectable		 1jgsA-4ag9A:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JTV_A_TESA500_1
(17
BETA-HYDROXYSTEROID
DEHYDROGENASE TYPE 1)		 4ag9 GLUCOSAMINE-6-PHOSPH
ATE
N-ACETYLTRANSFERASE
(Caenorhabditis
elegans) 		4 / 8 VAL A  24
LEU A  10
PRO A  15
SER A 127
 None
 0.87A 1jtvA-4ag9A:
undetectable		 1jtvA-4ag9A:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZ7_A_CA4A1_1
(ANDROGEN RECEPTOR)		 4ag9 GLUCOSAMINE-6-PHOSPH
ATE
N-ACETYLTRANSFERASE
(Caenorhabditis
elegans) 		5 / 12 LEU A 125
LEU A 128
GLY A 129
LEU A 139
PHE A 154
 None
None
None
16G  A1168 ( 4.0A)
None
 1.16A 2oz7A-4ag9A:
undetectable		 2oz7A-4ag9A:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CL9_A_MTXA602_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE (DHFR-TS))		 4ag9 GLUCOSAMINE-6-PHOSPH
ATE
N-ACETYLTRANSFERASE
(Caenorhabditis
elegans) 		5 / 12 ALA A   7
THR A 124
PHE A  22
LEU A  18
PRO A  19
 None
 1.29A 3cl9A-4ag9A:
undetectable		 3cl9A-4ag9A:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LTW_A_HLZA300_1
(ARYLAMINE
N-ACETYLTRANSFERASE
NAT)		 4ag9 GLUCOSAMINE-6-PHOSPH
ATE
N-ACETYLTRANSFERASE
(Caenorhabditis
elegans) 		4 / 6 PHE A 152
TYR A 149
VAL A 108
PHE A 148
 None
None
COA  A1166 ( 4.8A)
COA  A1166 (-4.0A)
 1.38A 3ltwA-4ag9A:
undetectable		 3ltwA-4ag9A:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_C_6ZPC902_1
(GLUTAMATE RECEPTOR 2)		 4ag9 GLUCOSAMINE-6-PHOSPH
ATE
N-ACETYLTRANSFERASE
(Caenorhabditis
elegans) 		4 / 7 ASP A  20
PRO A  19
SER A  78
ASN A  77
 None
 1.13A 5l1fC-4ag9A:
undetectable		 5l1fC-4ag9A:
12.17