SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4agd'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FMO_E_ADNE351_1
(CAMP-DEPENDENT
PROTEIN KINASE)		 4agd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		7 / 12 LEU A 840
GLY A 841
VAL A 848
ALA A 866
VAL A 899
ASN A1033
LEU A1035
 B49  A2000 (-3.7A)
B49  A2000 ( 4.6A)
None
B49  A2000 (-3.5A)
B49  A2000 ( 4.6A)
None
B49  A2000 (-4.5A)
 0.54A 1fmoE-4agdA:
20.3		 1fmoE-4agdA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GMK_D_DVAD8_0
(GRAMICIDIN A)		 4agd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		3 / 3 TRP A1071
VAL A1088
TRP A1089
 None
 1.21A 1gmkC-4agdA:
undetectable
1gmkD-4agdA:
undetectable		 1gmkC-4agdA:
4.14
1gmkD-4agdA:
4.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1IEP_A_STIA201_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL)		 4agd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		8 / 12 LEU A 840
VAL A 848
ALA A 866
GLU A 885
PHE A 918
GLY A 922
LEU A1035
ASP A1046
 B49  A2000 (-3.7A)
None
B49  A2000 (-3.5A)
None
B49  A2000 (-4.4A)
B49  A2000 ( 3.7A)
B49  A2000 (-4.5A)
None
 0.90A 1iepA-4agdA:
33.2		 1iepA-4agdA:
35.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1IEP_B_STIB202_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL)		 4agd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		8 / 12 LEU A 840
VAL A 848
ALA A 866
GLU A 885
ILE A 892
PHE A 918
GLY A 922
ASP A1046
 B49  A2000 (-3.7A)
None
B49  A2000 (-3.5A)
None
None
B49  A2000 (-4.4A)
B49  A2000 ( 3.7A)
None
 0.94A 1iepB-4agdA:
32.7		 1iepB-4agdA:
35.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_A_NOVA400_1
(DNA GYRASE SUBUNIT B)		 4agd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		5 / 12 ASP A 807
ASP A1087
ARG A1027
ILE A 804
ILE A 888
 None
 1.49A 1kijA-4agdA:
undetectable		 1kijA-4agdA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OHR_A_1UNA201_2
(ASPARTYLPROTEASE)		 4agd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		5 / 9 VAL A 898
ILE A 892
ILE A1025
VAL A1012
ILE A1044
 None
 0.93A 1ohrB-4agdA:
undetectable		 1ohrB-4agdA:
12.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1OPJ_A_STIA3_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4agd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		8 / 12 LEU A 840
ALA A 866
GLU A 885
ILE A 892
VAL A 899
PHE A 918
LEU A1035
ASP A1046
 B49  A2000 (-3.7A)
B49  A2000 (-3.5A)
None
None
B49  A2000 ( 4.6A)
B49  A2000 (-4.4A)
B49  A2000 (-4.5A)
None
 0.69A 1opjA-4agdA:
32.4		 1opjA-4agdA:
35.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1OPJ_A_STIA3_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4agd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		8 / 12 LEU A 840
VAL A 848
ALA A 866
GLU A 885
ILE A 892
VAL A 899
PHE A 918
LEU A1035
 B49  A2000 (-3.7A)
None
B49  A2000 (-3.5A)
None
None
B49  A2000 ( 4.6A)
B49  A2000 (-4.4A)
B49  A2000 (-4.5A)
 0.68A 1opjA-4agdA:
32.4		 1opjA-4agdA:
35.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1OPJ_B_STIB4_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4agd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		7 / 12 ALA A 866
GLU A 885
ILE A 892
VAL A 899
PHE A 918
GLY A 922
ASP A1046
 B49  A2000 (-3.5A)
None
None
B49  A2000 ( 4.6A)
B49  A2000 (-4.4A)
B49  A2000 ( 3.7A)
None
 0.72A 1opjB-4agdA:
32.5		 1opjB-4agdA:
35.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1OPJ_B_STIB4_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4agd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		7 / 12 VAL A 848
ALA A 866
GLU A 885
ILE A 892
VAL A 899
PHE A 918
ASP A1046
 None
B49  A2000 (-3.5A)
None
None
B49  A2000 ( 4.6A)
B49  A2000 (-4.4A)
None
 0.81A 1opjB-4agdA:
32.5		 1opjB-4agdA:
35.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1OPJ_B_STIB4_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4agd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		4 / 6 LEU A 802
ILE A 892
MET A 883
ARG A 863
 None
 0.94A 1opjB-4agdA:
32.6		 1opjB-4agdA:
35.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1T46_A_STIA3_1
(HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG)		 4agd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		11 / 12 LEU A 840
VAL A 848
ALA A 866
LYS A 868
GLU A 885
LEU A 889
VAL A 899
GLY A 922
LEU A1035
ASP A1046
PHE A1047
 B49  A2000 (-3.7A)
None
B49  A2000 (-3.5A)
B49  A2000 (-3.0A)
None
None
B49  A2000 ( 4.6A)
B49  A2000 ( 3.7A)
B49  A2000 (-4.5A)
None
B49  A2000 (-4.0A)
 0.68A 1t46A-4agdA:
41.9		 1t46A-4agdA:
49.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1T46_A_STIA3_2
(HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG)		 4agd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		4 / 7 VAL A 914
CYH A 919
ARG A1027
CYH A1045
 None
B49  A2000 (-4.2A)
None
B49  A2000 ( 4.1A)
 0.95A 1t46A-4agdA:
41.9		 1t46A-4agdA:
49.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1T46_A_STIA3_2
(HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG)		 4agd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		4 / 7 VAL A 914
CYH A 919
CYH A1024
CYH A1045
 None
B49  A2000 (-4.2A)
None
B49  A2000 ( 4.1A)
 0.48A 1t46A-4agdA:
41.9		 1t46A-4agdA:
49.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWH_A_BAXA1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 4agd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		6 / 12 ALA A 866
GLU A 885
LEU A 889
CYH A 919
LEU A1019
HIS A1026
 B49  A2000 (-3.5A)
None
None
B49  A2000 (-4.2A)
None
None
 0.69A 1uwhA-4agdA:
28.8		 1uwhA-4agdA:
28.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWH_B_BAXB1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 4agd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		6 / 12 ALA A 866
GLU A 885
LEU A 889
CYH A 919
LEU A1019
HIS A1026
 B49  A2000 (-3.5A)
None
None
B49  A2000 (-4.2A)
None
None
 0.70A 1uwhB-4agdA:
28.4		 1uwhB-4agdA:
28.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWJ_A_BAXA1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 4agd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		6 / 12 VAL A 848
ALA A 866
GLU A 885
CYH A 919
LEU A1019
HIS A1026
 None
B49  A2000 (-3.5A)
None
B49  A2000 (-4.2A)
None
None
 0.66A 1uwjA-4agdA:
7.2		 1uwjA-4agdA:
29.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWJ_B_BAXB1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 4agd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		6 / 12 VAL A 848
ALA A 866
GLU A 885
CYH A 919
LEU A1019
HIS A1026
 None
B49  A2000 (-3.5A)
None
B49  A2000 (-4.2A)
None
None
 0.65A 1uwjB-4agdA:
7.2		 1uwjB-4agdA:
29.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XBB_A_STIA1_1
(TYROSINE-PROTEIN
KINASE SYK)		 4agd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		5 / 9 LEU A 840
VAL A 848
ALA A 866
GLY A 922
LEU A1035
 B49  A2000 (-3.7A)
None
B49  A2000 (-3.5A)
B49  A2000 ( 3.7A)
B49  A2000 (-4.5A)
 0.47A 1xbbA-4agdA:
31.0		 1xbbA-4agdA:
32.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2GQG_A_1N1A501_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4agd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		7 / 12 LEU A 840
ALA A 866
GLU A 885
VAL A 899
PHE A 918
GLY A 922
LEU A1035
 B49  A2000 (-3.7A)
B49  A2000 (-3.5A)
None
B49  A2000 ( 4.6A)
B49  A2000 (-4.4A)
B49  A2000 ( 3.7A)
B49  A2000 (-4.5A)
 0.69A 2gqgA-4agdA:
30.5		 2gqgA-4agdA:
35.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2GQG_B_1N1B502_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4agd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		7 / 12 LEU A 840
VAL A 848
ALA A 866
GLU A 885
VAL A 899
GLY A 922
LEU A1035
 B49  A2000 (-3.7A)
None
B49  A2000 (-3.5A)
None
B49  A2000 ( 4.6A)
B49  A2000 ( 3.7A)
B49  A2000 (-4.5A)
 0.53A 2gqgB-4agdA:
30.1		 2gqgB-4agdA:
35.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HYY_A_STIA600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4agd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		8 / 12 VAL A 848
ALA A 866
GLU A 885
ILE A 892
PHE A 918
GLY A 922
LEU A1035
ASP A1046
 None
B49  A2000 (-3.5A)
None
None
B49  A2000 (-4.4A)
B49  A2000 ( 3.7A)
B49  A2000 (-4.5A)
None
 0.93A 2hyyA-4agdA:
33.2		 2hyyA-4agdA:
35.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HYY_B_STIB600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4agd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		8 / 12 VAL A 848
ALA A 866
GLU A 885
ILE A 892
PHE A 918
GLY A 922
LEU A1035
ASP A1046
 None
B49  A2000 (-3.5A)
None
None
B49  A2000 (-4.4A)
B49  A2000 ( 3.7A)
B49  A2000 (-4.5A)
None
 0.91A 2hyyB-4agdA:
33.4		 2hyyB-4agdA:
35.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HYY_C_STIC600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4agd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		9 / 12 VAL A 848
ALA A 866
GLU A 885
ILE A 892
VAL A 899
PHE A 918
GLY A 922
LEU A1035
ASP A1046
 None
B49  A2000 (-3.5A)
None
None
B49  A2000 ( 4.6A)
B49  A2000 (-4.4A)
B49  A2000 ( 3.7A)
B49  A2000 (-4.5A)
None
 0.80A 2hyyC-4agdA:
33.0		 2hyyC-4agdA:
35.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HYY_D_STID600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4agd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		7 / 12 VAL A 848
ALA A 866
GLU A 885
ILE A 892
PHE A 918
LEU A1035
ASP A1046
 None
B49  A2000 (-3.5A)
None
None
B49  A2000 (-4.4A)
B49  A2000 (-4.5A)
None
 0.94A 2hyyD-4agdA:
33.7		 2hyyD-4agdA:
35.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ITO_A_IREA2020_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4agd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		6 / 12 LEU A 840
ALA A 866
LYS A 868
GLU A 885
GLY A 922
LEU A1035
 B49  A2000 (-3.7A)
B49  A2000 (-3.5A)
B49  A2000 (-3.0A)
None
B49  A2000 ( 3.7A)
B49  A2000 (-4.5A)
 0.74A 2itoA-4agdA:
29.9		 2itoA-4agdA:
30.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2IVU_A_ZD6A3015_0
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
PRECURSOR)		 4agd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		6 / 12 LEU A 840
GLY A 841
VAL A 848
GLU A 885
LEU A 889
VAL A 916
 B49  A2000 (-3.7A)
B49  A2000 ( 4.6A)
None
None
None
B49  A2000 (-4.8A)
 0.39A 2ivuA-4agdA:
32.0		 2ivuA-4agdA:
43.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3AOX_A_EMHA901_1
(ALK TYROSINE KINASE
RECEPTOR)		 4agd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		6 / 10 LEU A 840
ALA A 866
LYS A 868
VAL A 899
GLY A 922
LEU A1035
 B49  A2000 (-3.7A)
B49  A2000 (-3.5A)
B49  A2000 (-3.0A)
B49  A2000 ( 4.6A)
B49  A2000 ( 3.7A)
B49  A2000 (-4.5A)
 0.78A 3aoxA-4agdA:
29.6		 3aoxA-4agdA:
33.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3C7Q_A_XINA1172_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 4agd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		12 / 12 LEU A 840
GLY A 841
GLU A 850
ALA A 866
LYS A 868
VAL A 899
VAL A 916
PHE A 918
CYH A 919
GLY A 922
LEU A1035
CYH A1045
 B49  A2000 (-3.7A)
B49  A2000 ( 4.6A)
None
B49  A2000 (-3.5A)
B49  A2000 (-3.0A)
B49  A2000 ( 4.6A)
B49  A2000 (-4.8A)
B49  A2000 (-4.4A)
B49  A2000 (-4.2A)
B49  A2000 ( 3.7A)
B49  A2000 (-4.5A)
B49  A2000 ( 4.1A)
 0.62A 3c7qA-4agdA:
39.4		 3c7qA-4agdA:
89.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_A_NILA600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4agd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		5 / 10 LEU A 840
VAL A 848
VAL A 899
PHE A 918
ASP A1046
 B49  A2000 (-3.7A)
None
B49  A2000 ( 4.6A)
B49  A2000 (-4.4A)
None
 0.83A 3cs9A-4agdA:
33.3		 3cs9A-4agdA:
35.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_A_NILA600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4agd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		6 / 12 ALA A 866
GLU A 885
ILE A 892
GLY A 922
HIS A1026
LEU A1035
 B49  A2000 (-3.5A)
None
None
B49  A2000 ( 3.7A)
None
B49  A2000 (-4.5A)
 0.75A 3cs9A-4agdA:
33.2		 3cs9A-4agdA:
35.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_B_NILB600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4agd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		5 / 12 ALA A 866
GLU A 885
ILE A 892
GLY A 922
HIS A1026
 B49  A2000 (-3.5A)
None
None
B49  A2000 ( 3.7A)
None
 0.68A 3cs9B-4agdA:
31.2		 3cs9B-4agdA:
35.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_B_NILB600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4agd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		5 / 12 ALA A 866
ILE A 892
GLY A 922
HIS A1026
ASP A1046
 B49  A2000 (-3.5A)
None
B49  A2000 ( 3.7A)
None
None
 0.70A 3cs9B-4agdA:
31.2		 3cs9B-4agdA:
35.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_C_NILC600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4agd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		5 / 12 ALA A 866
GLU A 885
ILE A 892
PHE A 918
HIS A1026
 B49  A2000 (-3.5A)
None
None
B49  A2000 (-4.4A)
None
 0.64A 3cs9C-4agdA:
30.3		 3cs9C-4agdA:
35.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_C_NILC600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4agd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		5 / 12 ALA A 866
ILE A 892
PHE A 918
HIS A1026
ASP A1046
 B49  A2000 (-3.5A)
None
B49  A2000 (-4.4A)
None
None
 0.64A 3cs9C-4agdA:
30.3		 3cs9C-4agdA:
35.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_D_NILD600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4agd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		6 / 12 ALA A 866
GLU A 885
ILE A 892
PHE A 918
GLY A 922
HIS A1026
 B49  A2000 (-3.5A)
None
None
B49  A2000 (-4.4A)
B49  A2000 ( 3.7A)
None
 0.71A 3cs9D-4agdA:
31.7		 3cs9D-4agdA:
35.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKX_B_1UNB201_2
(PROTEASE)		 4agd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		5 / 11 VAL A 898
ILE A 892
ILE A1025
VAL A1012
ILE A1044
 None
 1.02A 3ekxB-4agdA:
undetectable		 3ekxB-4agdA:
13.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G0E_A_B49A9000_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR)		 4agd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		8 / 11 LEU A 840
VAL A 848
ALA A 866
VAL A 899
CYH A 919
GLY A 922
LEU A1035
ALA A1050
 B49  A2000 (-3.7A)
None
B49  A2000 (-3.5A)
B49  A2000 ( 4.6A)
B49  A2000 (-4.2A)
B49  A2000 ( 3.7A)
B49  A2000 (-4.5A)
None
 0.75A 3g0eA-4agdA:
39.8		 3g0eA-4agdA:
50.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G0E_A_B49A9000_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR)		 4agd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		8 / 11 LEU A 840
VAL A 848
ALA A 866
VAL A 899
CYH A 919
GLY A 922
LEU A1035
CYH A1045
 B49  A2000 (-3.7A)
None
B49  A2000 (-3.5A)
B49  A2000 ( 4.6A)
B49  A2000 (-4.2A)
B49  A2000 ( 3.7A)
B49  A2000 (-4.5A)
B49  A2000 ( 4.1A)
 0.68A 3g0eA-4agdA:
39.8		 3g0eA-4agdA:
50.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G0F_A_B49A9001_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR)		 4agd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		8 / 11 LEU A 840
VAL A 848
ALA A 866
CYH A 919
GLY A 922
LEU A1035
CYH A1045
PHE A1047
 B49  A2000 (-3.7A)
None
B49  A2000 (-3.5A)
B49  A2000 (-4.2A)
B49  A2000 ( 3.7A)
B49  A2000 (-4.5A)
B49  A2000 ( 4.1A)
B49  A2000 (-4.0A)
 0.75A 3g0fA-4agdA:
39.5		 3g0fA-4agdA:
50.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G0F_B_B49B9001_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR)		 4agd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		8 / 10 LEU A 840
VAL A 848
ALA A 866
CYH A 919
GLY A 922
LEU A1035
CYH A1045
PHE A1047
 B49  A2000 (-3.7A)
None
B49  A2000 (-3.5A)
B49  A2000 (-4.2A)
B49  A2000 ( 3.7A)
B49  A2000 (-4.5A)
B49  A2000 ( 4.1A)
B49  A2000 (-4.0A)
 0.63A 3g0fB-4agdA:
39.8		 3g0fB-4agdA:
50.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G5D_A_1N1A1_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4agd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		7 / 12 LEU A 840
VAL A 848
ALA A 866
GLU A 885
VAL A 899
GLY A 922
LEU A1035
 B49  A2000 (-3.7A)
None
B49  A2000 (-3.5A)
None
B49  A2000 ( 4.6A)
B49  A2000 ( 3.7A)
B49  A2000 (-4.5A)
 0.53A 3g5dA-4agdA:
29.5		 3g5dA-4agdA:
31.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GP0_A_NILA1_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 11)		 4agd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		6 / 12 VAL A 848
ALA A 866
GLU A 885
LEU A 889
HIS A1026
PHE A1047
 None
B49  A2000 (-3.5A)
None
None
None
B49  A2000 (-4.0A)
 0.86A 3gp0A-4agdA:
21.8		 3gp0A-4agdA:
24.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GP0_A_NILA1_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 11)		 4agd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		6 / 12 VAL A 848
ALA A 866
LEU A 889
HIS A1026
ASP A1046
PHE A1047
 None
B49  A2000 (-3.5A)
None
None
None
B49  A2000 (-4.0A)
 0.95A 3gp0A-4agdA:
21.8		 3gp0A-4agdA:
24.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GVU_A_STIA1001_1
(TYROSINE-PROTEIN
KINASE ABL2)		 4agd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		8 / 12 LEU A 840
VAL A 848
ALA A 866
GLU A 885
ILE A 892
VAL A 899
LEU A1035
ASP A1046
 B49  A2000 (-3.7A)
None
B49  A2000 (-3.5A)
None
None
B49  A2000 ( 4.6A)
B49  A2000 (-4.5A)
None
 0.76A 3gvuA-4agdA:
32.5		 3gvuA-4agdA:
37.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3IK3_A_0LIA1_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4agd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		4 / 7 LEU A 802
ILE A 892
MET A 883
ARG A 863
 None
 1.29A 3ik3A-4agdA:
32.3		 3ik3A-4agdA:
34.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K5V_A_STIA2_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4agd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		8 / 12 VAL A 848
ALA A 866
GLU A 885
ILE A 892
PHE A 918
GLY A 922
LEU A1035
ASP A1046
 None
B49  A2000 (-3.5A)
None
None
B49  A2000 (-4.4A)
B49  A2000 ( 3.7A)
B49  A2000 (-4.5A)
None
 0.86A 3k5vA-4agdA:
32.5		 3k5vA-4agdA:
35.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K5V_B_STIB2_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4agd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		8 / 12 VAL A 848
ALA A 866
GLU A 885
ILE A 892
PHE A 918
GLY A 922
LEU A1035
ASP A1046
 None
B49  A2000 (-3.5A)
None
None
B49  A2000 (-4.4A)
B49  A2000 ( 3.7A)
B49  A2000 (-4.5A)
None
 0.86A 3k5vB-4agdA:
26.3		 3k5vB-4agdA:
35.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MIY_A_B49A1_1
(TYROSINE-PROTEIN
KINASE ITK/TSK)		 4agd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		6 / 11 ALA A 866
LYS A 868
VAL A 899
PHE A 918
GLY A 922
LEU A1035
 B49  A2000 (-3.5A)
B49  A2000 (-3.0A)
B49  A2000 ( 4.6A)
B49  A2000 (-4.4A)
B49  A2000 ( 3.7A)
B49  A2000 (-4.5A)
 0.79A 3miyA-4agdA:
30.2		 3miyA-4agdA:
30.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MIY_B_B49B2_1
(TYROSINE-PROTEIN
KINASE ITK/TSK)		 4agd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		5 / 9 ALA A 866
LYS A 868
PHE A 918
GLY A 922
LEU A1035
 B49  A2000 (-3.5A)
B49  A2000 (-3.0A)
B49  A2000 (-4.4A)
B49  A2000 ( 3.7A)
B49  A2000 (-4.5A)
 0.71A 3miyB-4agdA:
30.1		 3miyB-4agdA:
30.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MS9_A_STIA1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4agd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		8 / 12 LEU A 840
VAL A 848
ALA A 866
GLU A 885
ILE A 892
PHE A 918
LEU A1035
ASP A1046
 B49  A2000 (-3.7A)
None
B49  A2000 (-3.5A)
None
None
B49  A2000 (-4.4A)
B49  A2000 (-4.5A)
None
 0.86A 3ms9A-4agdA:
32.4		 3ms9A-4agdA:
35.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MS9_B_STIB1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4agd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		9 / 12 LEU A 840
VAL A 848
ALA A 866
GLU A 885
ILE A 892
PHE A 918
GLY A 922
LEU A1035
ASP A1046
 B49  A2000 (-3.7A)
None
B49  A2000 (-3.5A)
None
None
B49  A2000 (-4.4A)
B49  A2000 ( 3.7A)
B49  A2000 (-4.5A)
None
 0.86A 3ms9B-4agdA:
32.8		 3ms9B-4agdA:
35.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MSS_A_STIA1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4agd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		8 / 12 LEU A 840
VAL A 848
ALA A 866
GLU A 885
ILE A 892
PHE A 918
LEU A1035
ASP A1046
 B49  A2000 (-3.7A)
None
B49  A2000 (-3.5A)
None
None
B49  A2000 (-4.4A)
B49  A2000 (-4.5A)
None
 0.88A 3mssA-4agdA:
32.7		 3mssA-4agdA:
35.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MSS_B_STIB1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4agd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		6 / 12 ALA A 866
ILE A 892
PHE A 918
GLY A 922
LEU A1035
ASP A1046
 B49  A2000 (-3.5A)
None
B49  A2000 (-4.4A)
B49  A2000 ( 3.7A)
B49  A2000 (-4.5A)
None
 0.60A 3mssB-4agdA:
32.5		 3mssB-4agdA:
35.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MSS_B_STIB1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4agd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		7 / 12 LEU A 840
VAL A 848
ALA A 866
GLU A 885
ILE A 892
PHE A 918
LEU A1035
 B49  A2000 (-3.7A)
None
B49  A2000 (-3.5A)
None
None
B49  A2000 (-4.4A)
B49  A2000 (-4.5A)
 0.81A 3mssB-4agdA:
32.5		 3mssB-4agdA:
35.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MSS_C_STIC1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4agd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		8 / 12 LEU A 840
VAL A 848
ALA A 866
GLU A 885
ILE A 892
PHE A 918
LEU A1035
ASP A1046
 B49  A2000 (-3.7A)
None
B49  A2000 (-3.5A)
None
None
B49  A2000 (-4.4A)
B49  A2000 (-4.5A)
None
 0.90A 3mssC-4agdA:
32.7		 3mssC-4agdA:
35.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MSS_D_STID1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4agd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		8 / 12 LEU A 840
ALA A 866
GLU A 885
ILE A 892
PHE A 918
GLY A 922
LEU A1035
ASP A1046
 B49  A2000 (-3.7A)
B49  A2000 (-3.5A)
None
None
B49  A2000 (-4.4A)
B49  A2000 ( 3.7A)
B49  A2000 (-4.5A)
None
 0.80A 3mssD-4agdA:
32.7		 3mssD-4agdA:
35.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OXZ_A_0LIA1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4agd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		7 / 12 ALA A 866
GLU A 885
ILE A 892
VAL A 899
GLY A 922
HIS A1026
ASP A1046
 B49  A2000 (-3.5A)
None
None
B49  A2000 ( 4.6A)
B49  A2000 ( 3.7A)
None
None
 0.78A 3oxzA-4agdA:
31.8		 3oxzA-4agdA:
34.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3PYY_A_STIA3_1
(V-ABL ABELSON MURINE
LEUKEMIA VIRAL
ONCOGENE HOMOLOG 1
ISOFORM B VARIANT)		 4agd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		6 / 12 ALA A 866
GLU A 885
ILE A 892
PHE A 918
GLY A 922
LEU A1035
 B49  A2000 (-3.5A)
None
None
B49  A2000 (-4.4A)
B49  A2000 ( 3.7A)
B49  A2000 (-4.5A)
 0.83A 3pyyA-4agdA:
33.5		 3pyyA-4agdA:
37.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3PYY_A_STIA3_1
(V-ABL ABELSON MURINE
LEUKEMIA VIRAL
ONCOGENE HOMOLOG 1
ISOFORM B VARIANT)		 4agd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		6 / 12 ALA A 866
ILE A 892
PHE A 918
GLY A 922
LEU A1035
ASP A1046
 B49  A2000 (-3.5A)
None
B49  A2000 (-4.4A)
B49  A2000 ( 3.7A)
B49  A2000 (-4.5A)
None
 0.68A 3pyyA-4agdA:
33.5		 3pyyA-4agdA:
37.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3PYY_A_STIA3_1
(V-ABL ABELSON MURINE
LEUKEMIA VIRAL
ONCOGENE HOMOLOG 1
ISOFORM B VARIANT)		 4agd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		6 / 12 LEU A 840
VAL A 848
ALA A 866
GLU A 885
ILE A 892
PHE A 918
 B49  A2000 (-3.7A)
None
B49  A2000 (-3.5A)
None
None
B49  A2000 (-4.4A)
 0.81A 3pyyA-4agdA:
33.5		 3pyyA-4agdA:
37.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3PYY_B_STIB4_1
(V-ABL ABELSON MURINE
LEUKEMIA VIRAL
ONCOGENE HOMOLOG 1
ISOFORM B VARIANT)		 4agd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		8 / 12 LEU A 840
VAL A 848
ALA A 866
GLU A 885
ILE A 892
VAL A 899
LEU A1035
ASP A1046
 B49  A2000 (-3.7A)
None
B49  A2000 (-3.5A)
None
None
B49  A2000 ( 4.6A)
B49  A2000 (-4.5A)
None
 0.78A 3pyyB-4agdA:
31.2		 3pyyB-4agdA:
37.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3SXR_B_1N1B2_1
(CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX)		 4agd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		6 / 12 LEU A 840
VAL A 848
ALA A 866
VAL A 899
GLY A 922
LEU A1035
 B49  A2000 (-3.7A)
None
B49  A2000 (-3.5A)
B49  A2000 ( 4.6A)
B49  A2000 ( 3.7A)
B49  A2000 (-4.5A)
 0.48A 3sxrB-4agdA:
28.1		 3sxrB-4agdA:
32.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UE4_B_DB8B601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4agd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		7 / 12 LEU A 840
VAL A 848
ALA A 866
VAL A 899
PHE A 918
GLY A 922
LEU A1035
 B49  A2000 (-3.7A)
None
B49  A2000 (-3.5A)
B49  A2000 ( 4.6A)
B49  A2000 (-4.4A)
B49  A2000 ( 3.7A)
B49  A2000 (-4.5A)
 0.64A 3ue4B-4agdA:
31.5		 3ue4B-4agdA:
34.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 4agd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		8 / 12 LEU A 840
GLY A 841
ALA A 866
GLU A 885
LEU A 889
VAL A 916
CYH A 919
CYH A1045
 B49  A2000 (-3.7A)
B49  A2000 ( 4.6A)
B49  A2000 (-3.5A)
None
None
B49  A2000 (-4.8A)
B49  A2000 (-4.2A)
B49  A2000 ( 4.1A)
 0.79A 3wzdA-4agdA:
37.6		 3wzdA-4agdA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 4agd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		9 / 12 LEU A 840
VAL A 848
ALA A 866
GLU A 885
LEU A 889
VAL A 916
CYH A 919
GLY A 922
CYH A1045
 B49  A2000 (-3.7A)
None
B49  A2000 (-3.5A)
None
None
B49  A2000 (-4.8A)
B49  A2000 (-4.2A)
B49  A2000 ( 3.7A)
B49  A2000 ( 4.1A)
 0.49A 3wzdA-4agdA:
37.6		 3wzdA-4agdA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3WZE_A_BAXA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 4agd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		11 / 12 LEU A 840
VAL A 848
ALA A 866
GLU A 885
LEU A 889
ILE A 892
VAL A 916
PHE A 918
GLY A 922
LEU A1019
HIS A1026
 B49  A2000 (-3.7A)
None
B49  A2000 (-3.5A)
None
None
None
B49  A2000 (-4.8A)
B49  A2000 (-4.4A)
B49  A2000 ( 3.7A)
None
None
 0.57A 3wzeA-4agdA:
44.7		 3wzeA-4agdA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3WZE_A_BAXA1201_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 4agd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		8 / 8 VAL A 898
VAL A 899
CYH A 919
LEU A1035
ILE A1044
CYH A1045
ASP A1046
PHE A1047
 None
B49  A2000 ( 4.6A)
B49  A2000 (-4.2A)
B49  A2000 (-4.5A)
None
B49  A2000 ( 4.1A)
None
B49  A2000 (-4.0A)
 0.49A 3wzeA-4agdA:
44.7		 3wzeA-4agdA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ZOS_A_0LIA1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 4agd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		9 / 12 LEU A 840
ALA A 866
LYS A 868
GLU A 885
LEU A1019
HIS A1026
LEU A1035
ASP A1046
PHE A1047
 B49  A2000 (-3.7A)
B49  A2000 (-3.5A)
B49  A2000 (-3.0A)
None
None
None
B49  A2000 (-4.5A)
None
B49  A2000 (-4.0A)
 0.85A 3zosA-4agdA:
33.1		 3zosA-4agdA:
30.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ZOS_B_0LIB1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 4agd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		8 / 12 ALA A 866
LYS A 868
GLU A 885
HIS A1026
ARG A1027
LEU A1035
ASP A1046
PHE A1047
 B49  A2000 (-3.5A)
B49  A2000 (-3.0A)
None
None
None
B49  A2000 (-4.5A)
None
B49  A2000 (-4.0A)
 1.11A 3zosB-4agdA:
33.5		 3zosB-4agdA:
30.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ZOS_B_0LIB1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 4agd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		8 / 12 ALA A 866
LYS A 868
GLU A 885
LEU A1019
HIS A1026
LEU A1035
ASP A1046
PHE A1047
 B49  A2000 (-3.5A)
B49  A2000 (-3.0A)
None
None
None
B49  A2000 (-4.5A)
None
B49  A2000 (-4.0A)
 0.89A 3zosB-4agdA:
33.5		 3zosB-4agdA:
30.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4AG8_A_AXIA2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 4agd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		12 / 12 LEU A 840
VAL A 848
ALA A 866
LYS A 868
GLU A 885
VAL A 899
VAL A 916
PHE A 918
GLY A 922
LEU A1035
CYH A1045
PHE A1047
 B49  A2000 (-3.7A)
None
B49  A2000 (-3.5A)
B49  A2000 (-3.0A)
None
B49  A2000 ( 4.6A)
B49  A2000 (-4.8A)
B49  A2000 (-4.4A)
B49  A2000 ( 3.7A)
B49  A2000 (-4.5A)
B49  A2000 ( 4.1A)
B49  A2000 (-4.0A)
 0.57A 4ag8A-4agdA:
45.2		 4ag8A-4agdA:
89.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4AGC_A_AXIA2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 4agd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		10 / 12 ILE A 804
LEU A 840
VAL A 848
ALA A 866
GLU A 885
VAL A 916
GLY A 922
LEU A1035
CYH A1045
PHE A1047
 None
B49  A2000 (-3.7A)
None
B49  A2000 (-3.5A)
None
B49  A2000 (-4.8A)
B49  A2000 ( 3.7A)
B49  A2000 (-4.5A)
B49  A2000 ( 4.1A)
B49  A2000 (-4.0A)
 0.42A 4agcA-4agdA:
48.6		 4agcA-4agdA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4AGC_A_AXIA2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 4agd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		10 / 12 ILE A 804
LEU A 840
VAL A 848
ALA A 866
LYS A 868
GLU A 885
GLY A 922
LEU A1035
CYH A1045
PHE A1047
 None
B49  A2000 (-3.7A)
None
B49  A2000 (-3.5A)
B49  A2000 (-3.0A)
None
B49  A2000 ( 3.7A)
B49  A2000 (-4.5A)
B49  A2000 ( 4.1A)
B49  A2000 (-4.0A)
 0.52A 4agcA-4agdA:
48.6		 4agcA-4agdA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4AGC_A_AXIA2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 4agd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		10 / 12 LEU A 840
VAL A 848
ALA A 866
GLU A 885
LEU A 889
VAL A 916
GLY A 922
LEU A1035
CYH A1045
PHE A1047
 B49  A2000 (-3.7A)
None
B49  A2000 (-3.5A)
None
None
B49  A2000 (-4.8A)
B49  A2000 ( 3.7A)
B49  A2000 (-4.5A)
B49  A2000 ( 4.1A)
B49  A2000 (-4.0A)
 0.45A 4agcA-4agdA:
48.6		 4agcA-4agdA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4AGC_A_AXIA2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 4agd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		10 / 12 LEU A 840
VAL A 848
ALA A 866
LYS A 868
GLU A 885
LEU A 889
GLY A 922
LEU A1035
CYH A1045
PHE A1047
 B49  A2000 (-3.7A)
None
B49  A2000 (-3.5A)
B49  A2000 (-3.0A)
None
None
B49  A2000 ( 3.7A)
B49  A2000 (-4.5A)
B49  A2000 ( 4.1A)
B49  A2000 (-4.0A)
 0.56A 4agcA-4agdA:
48.6		 4agcA-4agdA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ASD_A_BAXA1500_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 4agd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		11 / 12 LEU A 840
VAL A 848
ALA A 866
GLU A 885
LEU A 889
VAL A 916
PHE A 918
GLY A 922
LEU A1019
HIS A1026
PHE A1047
 B49  A2000 (-3.7A)
None
B49  A2000 (-3.5A)
None
None
B49  A2000 (-4.8A)
B49  A2000 (-4.4A)
B49  A2000 ( 3.7A)
None
None
B49  A2000 (-4.0A)
 0.59A 4asdA-4agdA:
34.3		 4asdA-4agdA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ASD_A_BAXA1500_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 4agd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		10 / 12 VAL A 848
ALA A 866
LYS A 868
GLU A 885
LEU A 889
VAL A 916
GLY A 922
LEU A1019
HIS A1026
PHE A1047
 None
B49  A2000 (-3.5A)
B49  A2000 (-3.0A)
None
None
B49  A2000 (-4.8A)
B49  A2000 ( 3.7A)
None
None
B49  A2000 (-4.0A)
 0.77A 4asdA-4agdA:
34.3		 4asdA-4agdA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ASD_A_BAXA1500_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 4agd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		6 / 6 ILE A 892
VAL A 899
CYH A 919
LEU A1035
ILE A1044
CYH A1045
 None
B49  A2000 ( 4.6A)
B49  A2000 (-4.2A)
B49  A2000 (-4.5A)
None
B49  A2000 ( 4.1A)
 0.36A 4asdA-4agdA:
34.3		 4asdA-4agdA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4BKJ_B_STIB1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 4agd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		6 / 12 VAL A 848
ALA A 866
GLU A 885
ILE A 888
LEU A1035
ASP A1046
 None
B49  A2000 (-3.5A)
None
None
B49  A2000 (-4.5A)
None
 0.97A 4bkjB-4agdA:
32.0		 4bkjB-4agdA:
30.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4CKJ_A_ADNA2014_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET)		 4agd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		7 / 10 LEU A 840
GLY A 841
GLY A 843
VAL A 848
ALA A 866
VAL A 916
LEU A1035
 B49  A2000 (-3.7A)
B49  A2000 ( 4.6A)
None
None
B49  A2000 (-3.5A)
B49  A2000 (-4.8A)
B49  A2000 (-4.5A)
 0.42A 4ckjA-4agdA:
32.9		 4ckjA-4agdA:
43.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4CSV_A_STIA1265_1
(SRC-ABL TYROSINE
KINASE ANCESTOR)		 4agd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		7 / 12 VAL A 848
ALA A 866
GLU A 885
ILE A 888
LEU A1035
ASP A1046
PHE A1047
 None
B49  A2000 (-3.5A)
None
None
B49  A2000 (-4.5A)
None
B49  A2000 (-4.0A)
 1.02A 4csvA-4agdA:
31.4		 4csvA-4agdA:
37.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4CSV_A_STIA1265_1
(SRC-ABL TYROSINE
KINASE ANCESTOR)		 4agd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		7 / 12 VAL A 848
ALA A 866
GLU A 885
ILE A 888
VAL A 899
LEU A1035
ASP A1046
 None
B49  A2000 (-3.5A)
None
None
B49  A2000 ( 4.6A)
B49  A2000 (-4.5A)
None
 0.89A 4csvA-4agdA:
31.4		 4csvA-4agdA:
37.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4G5J_A_0WMA1102_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4agd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		4 / 7 PHE A 921
TYR A 927
TYR A1008
HIS A1004
 None
 1.20A 4g5jA-4agdA:
23.5		 4g5jA-4agdA:
30.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KS8_A_B49A701_1
(SERINE/THREONINE-PRO
TEIN KINASE PAK 6)		 4agd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		5 / 10 ALA A 866
VAL A 899
PHE A 918
GLY A 922
LEU A1035
 B49  A2000 (-3.5A)
B49  A2000 ( 4.6A)
B49  A2000 (-4.4A)
B49  A2000 ( 3.7A)
B49  A2000 (-4.5A)
 0.43A 4ks8A-4agdA:
6.6		 4ks8A-4agdA:
27.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MKC_A_4MKA1503_1
(ALK TYROSINE KINASE
RECEPTOR)		 4agd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		6 / 12 LEU A 840
VAL A 848
ALA A 866
LYS A 868
GLY A 922
LEU A1035
 B49  A2000 (-3.7A)
None
B49  A2000 (-3.5A)
B49  A2000 (-3.0A)
B49  A2000 ( 3.7A)
B49  A2000 (-4.5A)
 0.58A 4mkcA-4agdA:
30.2		 4mkcA-4agdA:
35.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O0S_A_ADNA500_1
(AURORA KINASE A)		 4agd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		7 / 11 LEU A 840
GLY A 841
VAL A 848
ALA A 866
LYS A 868
ASN A1033
LEU A1035
 B49  A2000 (-3.7A)
B49  A2000 ( 4.6A)
None
B49  A2000 (-3.5A)
B49  A2000 (-3.0A)
None
B49  A2000 (-4.5A)
 0.60A 4o0sA-4agdA:
17.4		 4o0sA-4agdA:
25.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O0U_A_ADNA501_1
(AURORA KINASE A)		 4agd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		4 / 6 VAL A 848
ALA A 866
LYS A 868
LEU A1035
 None
B49  A2000 (-3.5A)
B49  A2000 (-3.0A)
B49  A2000 (-4.5A)
 0.34A 4o0uA-4agdA:
16.1		 4o0uA-4agdA:
25.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O0W_A_ADNA501_1
(AURORA KINASE A)		 4agd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		5 / 6 LEU A 840
GLY A 841
VAL A 848
ALA A 866
LEU A1035
 B49  A2000 (-3.7A)
B49  A2000 ( 4.6A)
None
B49  A2000 (-3.5A)
B49  A2000 (-4.5A)
 0.47A 4o0wA-4agdA:
23.0		 4o0wA-4agdA:
25.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OGR_E_ADNE401_1
(CYCLIN-DEPENDENT
KINASE 9)		 4agd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		4 / 7 GLY A 841
ALA A 866
CYH A 919
LEU A1035
 B49  A2000 ( 4.6A)
B49  A2000 (-3.5A)
B49  A2000 (-4.2A)
B49  A2000 (-4.5A)
 0.33A 4ogrE-4agdA:
21.7		 4ogrE-4agdA:
26.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTI_A_MI1A1001_1
(SERINE/THREONINE-PRO
TEIN KINASE N1)		 4agd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		7 / 12 LEU A 840
GLY A 841
GLY A 846
VAL A 848
ALA A 866
VAL A 899
LEU A1035
 B49  A2000 (-3.7A)
B49  A2000 ( 4.6A)
None
None
B49  A2000 (-3.5A)
B49  A2000 ( 4.6A)
B49  A2000 (-4.5A)
 0.37A 4otiA-4agdA:
18.5		 4otiA-4agdA:
26.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QGI_A_ROCA101_2
(PROTEASE)		 4agd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		5 / 11 VAL A 898
ILE A 892
ILE A1025
VAL A1012
ILE A1044
 None
 0.90A 4qgiB-4agdA:
undetectable		 4qgiB-4agdA:
12.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QKN_A_JMSA602_1
(ALPHA-KETOGLUTARATE-
DEPENDENT
DIOXYGENASE FTO)		 4agd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		4 / 8 LEU A1069
LEU A1119
VAL A1093
SER A1090
 None
 1.09A 4qknA-4agdA:
undetectable		 4qknA-4agdA:
20.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QRC_A_0LIA802_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 4agd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		5 / 12 ALA A 866
GLU A 885
VAL A 916
ARG A1027
LEU A 802
 B49  A2000 (-3.5A)
None
B49  A2000 (-4.8A)
None
None
 1.02A 4qrcA-4agdA:
35.2		 4qrcA-4agdA:
49.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QRC_A_0LIA802_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 4agd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		5 / 12 ALA A 866
GLU A 885
VAL A 916
LEU A1019
ARG A1027
 B49  A2000 (-3.5A)
None
B49  A2000 (-4.8A)
None
None
 0.91A 4qrcA-4agdA:
35.2		 4qrcA-4agdA:
49.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QRC_A_0LIA802_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 4agd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		5 / 12 ALA A 866
GLU A 885
VAL A 916
LEU A1019
CYH A1024
 B49  A2000 (-3.5A)
None
B49  A2000 (-4.8A)
None
None
 0.87A 4qrcA-4agdA:
35.2		 4qrcA-4agdA:
49.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4R7I_A_STIA1001_1
(MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR)		 4agd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		9 / 12 VAL A 848
ALA A 866
LYS A 868
GLU A 885
CYH A 919
CYH A1024
LEU A1035
ASP A1046
PHE A1047
 None
B49  A2000 (-3.5A)
B49  A2000 (-3.0A)
None
B49  A2000 (-4.2A)
None
B49  A2000 (-4.5A)
None
B49  A2000 (-4.0A)
 0.63A 4r7iA-4agdA:
40.8		 4r7iA-4agdA:
50.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4TYJ_A_0LIA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 4agd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		6 / 12 ALA A 866
GLU A 885
HIS A1026
LEU A1035
ASP A1046
PHE A1047
 B49  A2000 (-3.5A)
None
None
B49  A2000 (-4.5A)
None
B49  A2000 (-4.0A)
 0.96A 4tyjA-4agdA:
35.3		 4tyjA-4agdA:
47.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4TYJ_A_0LIA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 4agd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		7 / 12 ALA A 866
GLU A 885
ILE A 892
VAL A 916
CYH A1024
LEU A1035
ASP A1046
 B49  A2000 (-3.5A)
None
None
B49  A2000 (-4.8A)
None
B49  A2000 (-4.5A)
None
 0.86A 4tyjA-4agdA:
35.3		 4tyjA-4agdA:
47.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4TYJ_A_0LIA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 4agd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		7 / 12 ALA A 866
GLU A 885
ILE A 892
VAL A 916
HIS A1026
LEU A1035
ASP A1046
 B49  A2000 (-3.5A)
None
None
B49  A2000 (-4.8A)
None
B49  A2000 (-4.5A)
None
 0.81A 4tyjA-4agdA:
35.3		 4tyjA-4agdA:
47.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4U0I_A_0LIA1001_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR
KIT,MAST/STEM CELL
GROWTH FACTOR
RECEPTOR KIT)		 4agd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		6 / 10 LEU A 840
VAL A 848
GLU A 885
VAL A 899
VAL A 914
ILE A1044
 B49  A2000 (-3.7A)
None
None
B49  A2000 ( 4.6A)
None
None
 0.46A 4u0iA-4agdA:
41.5		 4u0iA-4agdA:
49.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4U0I_A_0LIA1001_2
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR
KIT,MAST/STEM CELL
GROWTH FACTOR
RECEPTOR KIT)		 4agd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		8 / 12 ALA A 866
LEU A 889
CYH A 919
GLY A 922
CYH A1024
LEU A1035
CYH A1045
ASP A1046
 B49  A2000 (-3.5A)
None
B49  A2000 (-4.2A)
B49  A2000 ( 3.7A)
None
B49  A2000 (-4.5A)
B49  A2000 ( 4.1A)
None
 0.69A 4u0iA-4agdA:
41.5		 4u0iA-4agdA:
49.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4U0I_A_0LIA1001_2
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR
KIT,MAST/STEM CELL
GROWTH FACTOR
RECEPTOR KIT)		 4agd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		9 / 12 ALA A 866
LEU A 889
CYH A 919
GLY A 922
HIS A1026
LEU A1035
CYH A1045
ASP A1046
PHE A1047
 B49  A2000 (-3.5A)
None
B49  A2000 (-4.2A)
B49  A2000 ( 3.7A)
None
B49  A2000 (-4.5A)
B49  A2000 ( 4.1A)
None
B49  A2000 (-4.0A)
 0.67A 4u0iA-4agdA:
41.5		 4u0iA-4agdA:
49.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4U0I_A_0LIA1001_2
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR
KIT,MAST/STEM CELL
GROWTH FACTOR
RECEPTOR KIT)		 4agd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		7 / 12 LYS A 868
LEU A 889
GLY A 922
CYH A1024
LEU A1035
CYH A1045
ASP A1046
 B49  A2000 (-3.0A)
None
B49  A2000 ( 3.7A)
None
B49  A2000 (-4.5A)
B49  A2000 ( 4.1A)
None
 0.89A 4u0iA-4agdA:
41.5		 4u0iA-4agdA:
49.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4U0I_A_0LIA1001_2
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR
KIT,MAST/STEM CELL
GROWTH FACTOR
RECEPTOR KIT)		 4agd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		8 / 12 LYS A 868
LEU A 889
GLY A 922
HIS A1026
LEU A1035
CYH A1045
ASP A1046
PHE A1047
 B49  A2000 (-3.0A)
None
B49  A2000 ( 3.7A)
None
B49  A2000 (-4.5A)
B49  A2000 ( 4.1A)
None
B49  A2000 (-4.0A)
 0.84A 4u0iA-4agdA:
41.5		 4u0iA-4agdA:
49.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4UXQ_A_0LIA1752_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 4agd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		6 / 12 ALA A 866
GLU A 885
ILE A 892
VAL A 916
LEU A1019
CYH A1024
 B49  A2000 (-3.5A)
None
None
B49  A2000 (-4.8A)
None
None
 1.08A 4uxqA-4agdA:
35.5		 4uxqA-4agdA:
48.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4UXQ_A_0LIA1752_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 4agd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		6 / 12 ALA A 866
GLU A 885
ILE A 892
VAL A 916
LEU A1019
HIS A1026
 B49  A2000 (-3.5A)
None
None
B49  A2000 (-4.8A)
None
None
 0.98A 4uxqA-4agdA:
35.5		 4uxqA-4agdA:
48.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4UXQ_A_0LIA1752_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 4agd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		6 / 12 LEU A 840
ALA A 866
GLU A 885
HIS A1026
LEU A1035
PHE A1047
 B49  A2000 (-3.7A)
B49  A2000 (-3.5A)
None
None
B49  A2000 (-4.5A)
B49  A2000 (-4.0A)
 0.93A 4uxqA-4agdA:
35.5		 4uxqA-4agdA:
48.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4UXQ_A_0LIA1752_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 4agd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		7 / 12 LEU A 840
ALA A 866
GLU A 885
VAL A 916
LEU A1019
CYH A1024
LEU A1035
 B49  A2000 (-3.7A)
B49  A2000 (-3.5A)
None
B49  A2000 (-4.8A)
None
None
B49  A2000 (-4.5A)
 0.89A 4uxqA-4agdA:
35.5		 4uxqA-4agdA:
48.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4UXQ_A_0LIA1752_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 4agd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		7 / 12 LEU A 840
ALA A 866
GLU A 885
VAL A 916
LEU A1019
HIS A1026
LEU A1035
 B49  A2000 (-3.7A)
B49  A2000 (-3.5A)
None
B49  A2000 (-4.8A)
None
None
B49  A2000 (-4.5A)
 0.74A 4uxqA-4agdA:
35.5		 4uxqA-4agdA:
48.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4UXQ_A_0LIA1752_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 4agd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		6 / 12 LEU A 840
ALA A 866
HIS A1026
LEU A1035
ASP A1046
PHE A1047
 B49  A2000 (-3.7A)
B49  A2000 (-3.5A)
None
B49  A2000 (-4.5A)
None
B49  A2000 (-4.0A)
 1.00A 4uxqA-4agdA:
35.5		 4uxqA-4agdA:
48.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4UXQ_A_0LIA1752_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 4agd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		6 / 12 LEU A 840
ALA A 866
LEU A1019
HIS A1026
LEU A1035
ASP A1046
 B49  A2000 (-3.7A)
B49  A2000 (-3.5A)
None
None
B49  A2000 (-4.5A)
None
 0.69A 4uxqA-4agdA:
35.5		 4uxqA-4agdA:
48.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V01_A_0LIA1776_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 4agd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		6 / 12 ALA A 866
GLU A 885
ILE A 892
VAL A 916
LEU A1019
HIS A1026
 B49  A2000 (-3.5A)
None
None
B49  A2000 (-4.8A)
None
None
 0.59A 4v01A-4agdA:
34.8		 4v01A-4agdA:
49.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V01_A_0LIA1776_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 4agd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		6 / 12 ALA A 866
ILE A 892
VAL A 916
LEU A1019
HIS A1026
ASP A1046
 B49  A2000 (-3.5A)
None
B49  A2000 (-4.8A)
None
None
None
 0.72A 4v01A-4agdA:
34.8		 4v01A-4agdA:
49.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V01_A_0LIA1776_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 4agd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		5 / 9 LEU A 840
VAL A 848
CYH A1024
LEU A1035
ILE A1044
 B49  A2000 (-3.7A)
None
None
B49  A2000 (-4.5A)
None
 0.50A 4v01A-4agdA:
34.8		 4v01A-4agdA:
49.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V01_B_0LIB1770_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 4agd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		5 / 12 ALA A 866
GLU A 885
VAL A 916
LEU A1019
HIS A1026
 B49  A2000 (-3.5A)
None
B49  A2000 (-4.8A)
None
None
 0.53A 4v01B-4agdA:
35.1		 4v01B-4agdA:
49.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V01_B_0LIB1770_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 4agd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		5 / 12 ALA A 866
VAL A 916
LEU A1019
HIS A1026
ASP A1046
 B49  A2000 (-3.5A)
B49  A2000 (-4.8A)
None
None
None
 0.74A 4v01B-4agdA:
35.1		 4v01B-4agdA:
49.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V01_B_0LIB1770_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 4agd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		6 / 9 LEU A 840
VAL A 848
LYS A 868
ILE A 892
LEU A1035
ILE A1044
 B49  A2000 (-3.7A)
None
B49  A2000 (-3.0A)
None
B49  A2000 (-4.5A)
None
 0.71A 4v01B-4agdA:
35.1		 4v01B-4agdA:
49.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V04_A_0LIA1772_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 4agd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		6 / 12 VAL A 848
ALA A 866
GLU A 885
VAL A 916
LEU A1019
CYH A1024
 None
B49  A2000 (-3.5A)
None
B49  A2000 (-4.8A)
None
None
 0.82A 4v04A-4agdA:
34.6		 4v04A-4agdA:
49.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V04_A_0LIA1772_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 4agd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		7 / 12 VAL A 848
ALA A 866
GLU A 885
VAL A 916
LEU A1019
HIS A1026
ASP A1046
 None
B49  A2000 (-3.5A)
None
B49  A2000 (-4.8A)
None
None
None
 0.71A 4v04A-4agdA:
34.6		 4v04A-4agdA:
49.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V04_B_0LIB1771_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 4agd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		5 / 12 ALA A 866
GLU A 885
VAL A 916
LEU A1019
CYH A1024
 B49  A2000 (-3.5A)
None
B49  A2000 (-4.8A)
None
None
 0.93A 4v04B-4agdA:
35.5		 4v04B-4agdA:
49.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V04_B_0LIB1771_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 4agd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		6 / 12 ALA A 866
GLU A 885
VAL A 916
LEU A1019
HIS A1026
ASP A1046
 B49  A2000 (-3.5A)
None
B49  A2000 (-4.8A)
None
None
None
 0.67A 4v04B-4agdA:
35.5		 4v04B-4agdA:
49.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XEY_A_1N1A601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4agd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		7 / 12 LEU A 840
VAL A 848
ALA A 866
LYS A 868
PHE A 918
GLY A 922
LEU A1035
 B49  A2000 (-3.7A)
None
B49  A2000 (-3.5A)
B49  A2000 (-3.0A)
B49  A2000 (-4.4A)
B49  A2000 ( 3.7A)
B49  A2000 (-4.5A)
 0.63A 4xeyA-4agdA:
31.6		 4xeyA-4agdA:
32.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XEY_A_1N1A601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4agd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		7 / 12 LEU A 840
VAL A 848
ALA A 866
VAL A 899
PHE A 918
GLY A 922
LEU A1035
 B49  A2000 (-3.7A)
None
B49  A2000 (-3.5A)
B49  A2000 ( 4.6A)
B49  A2000 (-4.4A)
B49  A2000 ( 3.7A)
B49  A2000 (-4.5A)
 0.58A 4xeyA-4agdA:
31.6		 4xeyA-4agdA:
32.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XEY_B_1N1B601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4agd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		7 / 12 LEU A 840
VAL A 848
ALA A 866
VAL A 899
PHE A 918
GLY A 922
LEU A1035
 B49  A2000 (-3.7A)
None
B49  A2000 (-3.5A)
B49  A2000 ( 4.6A)
B49  A2000 (-4.4A)
B49  A2000 ( 3.7A)
B49  A2000 (-4.5A)
 0.61A 4xeyB-4agdA:
30.9		 4xeyB-4agdA:
32.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z69_A_DIFA1006_1
(SERUM ALBUMIN)		 4agd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		4 / 7 ILE A1034
LEU A1029
GLY A1015
LYS A1014
 None
 1.04A 4z69A-4agdA:
undetectable		 4z69A-4agdA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AJQ_A_DB8A800_1
(SERINE/THREONINE-PRO
TEIN KINASE 10)		 4agd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		6 / 12 LEU A 840
ALA A 866
LYS A 868
PHE A 918
GLY A 922
LEU A1035
 B49  A2000 (-3.7A)
B49  A2000 (-3.5A)
B49  A2000 (-3.0A)
B49  A2000 (-4.4A)
B49  A2000 ( 3.7A)
B49  A2000 (-4.5A)
 0.88A 5ajqA-4agdA:
21.3		 5ajqA-4agdA:
25.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AJQ_A_DB8A800_1
(SERINE/THREONINE-PRO
TEIN KINASE 10)		 4agd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		7 / 12 LEU A 840
GLY A 841
ALA A 866
PHE A 918
CYH A 919
GLY A 922
LEU A1035
 B49  A2000 (-3.7A)
B49  A2000 ( 4.6A)
B49  A2000 (-3.5A)
B49  A2000 (-4.4A)
B49  A2000 (-4.2A)
B49  A2000 ( 3.7A)
B49  A2000 (-4.5A)
 0.76A 5ajqA-4agdA:
21.3		 5ajqA-4agdA:
25.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AJQ_A_DB8A800_1
(SERINE/THREONINE-PRO
TEIN KINASE 10)		 4agd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		7 / 12 LEU A 840
GLY A 841
PHE A 918
CYH A 919
GLY A 922
LEU A1035
ASP A1046
 B49  A2000 (-3.7A)
B49  A2000 ( 4.6A)
B49  A2000 (-4.4A)
B49  A2000 (-4.2A)
B49  A2000 ( 3.7A)
B49  A2000 (-4.5A)
None
 0.96A 5ajqA-4agdA:
21.3		 5ajqA-4agdA:
25.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSW_A_P06A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4agd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		5 / 12 VAL A 848
ALA A 866
LYS A 868
LEU A 889
CYH A 919
 None
B49  A2000 (-3.5A)
B49  A2000 (-3.0A)
None
B49  A2000 (-4.2A)
 0.74A 5cswA-4agdA:
26.0		 5cswA-4agdA:
27.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5H2U_C_1N1C501_1
(PROTEIN-TYROSINE
KINASE 6)		 4agd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		5 / 12 LEU A 840
ALA A 866
LYS A 868
GLY A 922
LEU A1035
 B49  A2000 (-3.7A)
B49  A2000 (-3.5A)
B49  A2000 (-3.0A)
B49  A2000 ( 3.7A)
B49  A2000 (-4.5A)
 0.67A 5h2uC-4agdA:
4.0		 5h2uC-4agdA:
33.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H8T_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 1)		 4agd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		5 / 12 LEU A 834
ALA A 851
ARG A 863
ILE A 856
LEU A 886
 None
 1.03A 5h8tA-4agdA:
undetectable		 5h8tA-4agdA:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HI2_A_BAXA801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4agd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		6 / 12 ALA A 866
GLU A 885
LEU A 889
CYH A 919
LEU A1019
HIS A1026
 B49  A2000 (-3.5A)
None
None
B49  A2000 (-4.2A)
None
None
 0.66A 5hi2A-4agdA:
27.7		 5hi2A-4agdA:
27.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IZJ_F_AZ1F2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAR-DAR-DAR)		 4agd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		4 / 7 GLY A 841
GLY A 843
GLY A 846
VAL A 848
 B49  A2000 ( 4.6A)
None
None
None
 0.29A 5izjB-4agdA:
21.0		 5izjB-4agdA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LVN_A_ADNA402_1
(3-PHOSPHOINOSITIDE-D
EPENDENT PROTEIN
KINASE 1)		 4agd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		6 / 11 LEU A 840
GLY A 841
VAL A 848
ALA A 866
VAL A 899
LEU A1035
 B49  A2000 (-3.7A)
B49  A2000 ( 4.6A)
None
B49  A2000 (-3.5A)
B49  A2000 ( 4.6A)
B49  A2000 (-4.5A)
 0.47A 5lvnA-4agdA:
22.2		 5lvnA-4agdA:
25.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MO4_A_NILA601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4agd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		6 / 10 LEU A 840
VAL A 848
GLU A 885
PHE A 918
GLY A 922
PHE A1047
 B49  A2000 (-3.7A)
None
None
B49  A2000 (-4.4A)
B49  A2000 ( 3.7A)
B49  A2000 (-4.0A)
 1.03A 5mo4A-4agdA:
9.2		 5mo4A-4agdA:
27.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MO4_A_NILA601_2
(TYROSINE-PROTEIN
KINASE ABL1)		 4agd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		5 / 12 ALA A 866
VAL A 899
HIS A1026
LEU A1035
ASP A1046
 B49  A2000 (-3.5A)
B49  A2000 ( 4.6A)
None
B49  A2000 (-4.5A)
None
 0.73A 5mo4A-4agdA:
9.2		 5mo4A-4agdA:
27.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N4T_B_BEZB306_0
(BETA-LACTAMASE VIM-2)		 4agd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		3 / 3 HIS A1159
ASN A1162
ALA A1166
 None
 0.41A 5n4tB-4agdA:
undetectable		 5n4tB-4agdA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OWR_A_1N1A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 10)		 4agd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		4 / 8 ALA A 866
GLU A 885
CYH A 919
LEU A1035
 B49  A2000 (-3.5A)
None
B49  A2000 (-4.2A)
B49  A2000 (-4.5A)
 0.57A 5owrA-4agdA:
19.4		 5owrA-4agdA:
25.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TE0_A_XINA401_1
(AP2-ASSOCIATED
PROTEIN KINASE 1)		 4agd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		6 / 12 ALA A 866
GLU A 885
VAL A 899
PHE A 918
GLY A 922
LEU A1035
 B49  A2000 (-3.5A)
None
B49  A2000 ( 4.6A)
B49  A2000 (-4.4A)
B49  A2000 ( 3.7A)
B49  A2000 (-4.5A)
 0.57A 5te0A-4agdA:
22.3		 5te0A-4agdA:
25.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TE0_A_XINA401_2
(AP2-ASSOCIATED
PROTEIN KINASE 1)		 4agd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		4 / 5 LEU A 840
VAL A 848
CYH A 919
CYH A1045
 B49  A2000 (-3.7A)
None
B49  A2000 (-4.2A)
B49  A2000 ( 4.1A)
 0.59A 5te0A-4agdA:
22.3		 5te0A-4agdA:
25.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W5V_A_ANWA701_0
(SERINE/THREONINE-PRO
TEIN KINASE TBK1)		 4agd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		5 / 9 LEU A 840
ALA A 866
VAL A 899
CYH A 919
GLY A 922
 B49  A2000 (-3.7A)
B49  A2000 (-3.5A)
B49  A2000 ( 4.6A)
B49  A2000 (-4.2A)
B49  A2000 ( 3.7A)
 0.40A 5w5vA-4agdA:
4.7		 5w5vA-4agdA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7Z_A_IREA401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 4agd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		7 / 12 LEU A 840
VAL A 848
ALA A 866
GLU A 885
CYH A 919
GLY A 922
LEU A1035
 B49  A2000 (-3.7A)
None
B49  A2000 (-3.5A)
None
B49  A2000 (-4.2A)
B49  A2000 ( 3.7A)
B49  A2000 (-4.5A)
 0.70A 5y7zA-4agdA:
21.9		 5y7zA-4agdA:
14.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7Z_A_IREA401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 4agd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		7 / 12 LEU A 840
VAL A 848
ALA A 866
GLU A 885
CYH A 919
GLY A 922
LEU A1035
 B49  A2000 (-3.7A)
None
B49  A2000 (-3.5A)
None
B49  A2000 (-4.2A)
B49  A2000 ( 3.7A)
B49  A2000 (-4.5A)
 0.70A 5y7zA-4agdA:
21.9		 5y7zA-4agdA:
25.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7Z_B_IREB401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 4agd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		8 / 12 LEU A 840
ALA A 866
GLU A 885
CYH A 919
GLY A 922
LEU A1035
CYH A1045
ASP A1046
 B49  A2000 (-3.7A)
B49  A2000 (-3.5A)
None
B49  A2000 (-4.2A)
B49  A2000 ( 3.7A)
B49  A2000 (-4.5A)
B49  A2000 ( 4.1A)
None
 0.99A 5y7zB-4agdA:
22.0		 5y7zB-4agdA:
14.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		 4agd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		7 / 12 LEU A 840
GLY A 841
PHE A1047
ALA A 866
GLU A 885
VAL A 916
GLY A 922
 B49  A2000 (-3.7A)
B49  A2000 ( 4.6A)
B49  A2000 (-4.0A)
B49  A2000 (-3.5A)
None
B49  A2000 (-4.8A)
B49  A2000 ( 3.7A)
 1.22A 5zv2A-4agdA:
34.0		 5zv2A-4agdA:
15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		 4agd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		7 / 12 LEU A 840
PHE A1047
VAL A 848
ALA A 866
GLU A 885
VAL A 916
GLY A 922
 B49  A2000 (-3.7A)
B49  A2000 (-4.0A)
None
B49  A2000 (-3.5A)
None
B49  A2000 (-4.8A)
B49  A2000 ( 3.7A)
 0.84A 5zv2A-4agdA:
34.0		 5zv2A-4agdA:
15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		 4agd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		7 / 12 LEU A 840
PHE A1047
VAL A 848
ALA A 866
GLU A 885
VAL A 916
GLY A 922
 B49  A2000 (-3.7A)
B49  A2000 (-4.0A)
None
B49  A2000 (-3.5A)
None
B49  A2000 (-4.8A)
B49  A2000 ( 3.7A)
 0.83A 5zv2B-4agdA:
34.0		 5zv2B-4agdA:
15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD4_A_STIA604_0
(TYROSINE-PROTEIN
KINASE ABL1)		 4agd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		7 / 12 VAL A 848
ALA A 866
GLU A 885
ILE A 892
VAL A 899
LEU A1035
ASP A1046
 None
B49  A2000 (-3.5A)
None
None
B49  A2000 ( 4.6A)
B49  A2000 (-4.5A)
None
 0.80A 6hd4A-4agdA:
32.5		 6hd4A-4agdA:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD4_B_STIB602_0
(TYROSINE-PROTEIN
KINASE ABL1)		 4agd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		7 / 12 VAL A 848
ALA A 866
GLU A 885
ILE A 892
VAL A 899
LEU A1035
ASP A1046
 None
B49  A2000 (-3.5A)
None
None
B49  A2000 ( 4.6A)
B49  A2000 (-4.5A)
None
 0.79A 6hd4B-4agdA:
26.1		 6hd4B-4agdA:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD6_A_STIA603_0
(TYROSINE-PROTEIN
KINASE ABL1)		 4agd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		7 / 12 VAL A 848
ALA A 866
GLU A 885
VAL A 899
PHE A 918
LEU A1035
ASP A1046
 None
B49  A2000 (-3.5A)
None
B49  A2000 ( 4.6A)
B49  A2000 (-4.4A)
B49  A2000 (-4.5A)
None
 0.83A 6hd6A-4agdA:
32.4		 6hd6A-4agdA:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD6_B_STIB601_0
(TYROSINE-PROTEIN
KINASE ABL1)		 4agd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		9 / 12 LEU A 840
VAL A 848
ALA A 866
GLU A 885
ILE A 892
VAL A 899
PHE A 918
LEU A1035
ASP A1046
 B49  A2000 (-3.7A)
None
B49  A2000 (-3.5A)
None
None
B49  A2000 ( 4.6A)
B49  A2000 (-4.4A)
B49  A2000 (-4.5A)
None
 0.86A 6hd6B-4agdA:
32.1		 6hd6B-4agdA:
14.49