SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4age'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CQP_A_803A311_1
(ANTIGEN CD11A (P180))		 4age SMALL-CONDUCTANCE
MECHANOSENSITIVE
CHANNEL
(Escherichia
coli) 		5 / 10 LEU A 138
VAL A 136
ILE A 175
LEU A 124
VAL A 148
 None
 0.97A 1cqpA-4ageA:
undetectable
1cqpB-4ageA:
undetectable		 1cqpA-4ageA:
20.96
1cqpB-4ageA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RF4_B_FUNB202_1
(MACROPHAGE MIGRATION
INHIBITORY FACTOR)		 4age SMALL-CONDUCTANCE
MECHANOSENSITIVE
CHANNEL
(Escherichia
coli) 		5 / 11 ILE A 190
ILE A 209
VAL A 237
PHE A 235
VAL A 223
 None
 1.08A 3rf4A-4ageA:
3.6
3rf4B-4ageA:
3.6		 3rf4A-4ageA:
16.08
3rf4B-4ageA:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOP_C_HQEC503_1
(CATALASE)		 4age SMALL-CONDUCTANCE
MECHANOSENSITIVE
CHANNEL
(Escherichia
coli) 		4 / 8 ILE A 165
PHE A 130
LEU A 138
LEU A 124
 None
 0.70A 4qopC-4ageA:
undetectable		 4qopC-4ageA:
20.62