SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ah6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IWI_A_CAMA418_0
(CYTOCHROME P450-CAM)		 4ah6 ASPARTATE--TRNA
LIGASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 8 PHE A 484
LEU A 325
VAL A 324
VAL A 530
 None
 0.95A 1iwiA-4ah6A:
undetectable		 1iwiA-4ah6A:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L2I_B_CCSB417_0
(ESTROGEN RECEPTOR)		 4ah6 ASPARTATE--TRNA
LIGASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 6 PRO A 126
GLN A  91
LYS A 142
VAL A 122
 None
 1.34A 1l2iB-4ah6A:
undetectable		 1l2iB-4ah6A:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RMT_D_ADND1504_1
(CLASS B ACID
PHOSPHATASE)		 4ah6 ASPARTATE--TRNA
LIGASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 8 ASP A 334
LEU A 479
THR A 330
TYR A 328
 None
 0.96A 1rmtD-4ah6A:
undetectable		 1rmtD-4ah6A:
15.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S8F_B_BEZB1503_0
(RAS-RELATED PROTEIN
RAB-9A)		 4ah6 ASPARTATE--TRNA
LIGASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 6 VAL A 122
GLU A 138
LEU A  57
ARG A  58
 None
 1.06A 1s8fB-4ah6A:
undetectable		 1s8fB-4ah6A:
16.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BYO_A_LNLA1217_1
(LIPOPROTEIN LPPX)		 4ah6 ASPARTATE--TRNA
LIGASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 4 VAL A 312
LEU A 201
ILE A 283
LEU A 583
 None
 1.05A 2byoA-4ah6A:
1.2		 2byoA-4ah6A:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JFA_B_RALB600_2
(ESTROGEN RECEPTOR)		 4ah6 ASPARTATE--TRNA
LIGASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 4 LEU A  68
THR A  67
ILE A 139
HIS A  61
 None
 1.26A 2jfaB-4ah6A:
undetectable		 2jfaB-4ah6A:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_E_SVRE510_3
(PHOSPHOLIPASE A2)		 4ah6 ASPARTATE--TRNA
LIGASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 5 VAL A 469
VAL A 468
THR A 474
THR A 465
 None
 1.21A 3bjwG-4ah6A:
undetectable		 3bjwG-4ah6A:
13.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_F_SVRF509_1
(PHOSPHOLIPASE A2)		 4ah6 ASPARTATE--TRNA
LIGASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 5 VAL A 469
VAL A 468
THR A 474
THR A 465
 None
 1.18A 3bjwC-4ah6A:
undetectable		 3bjwC-4ah6A:
13.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_Q_TRPQ1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 4ah6 ASPARTATE--TRNA
LIGASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 8 GLN A 422
VAL A 347
ILE A 342
VAL A 438
 None
 0.72A 3fi0Q-4ah6A:
undetectable		 3fi0Q-4ah6A:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FSU_A_C2FA995_0
(5,10-METHYLENETETRAH
YDROFOLATE REDUCTASE)		 4ah6 ASPARTATE--TRNA
LIGASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 GLN A 245
THR A 219
LEU A 249
GLN A 569
LEU A 567
 None
 1.33A 3fsuA-4ah6A:
undetectable		 3fsuA-4ah6A:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDT_B_VORB506_1
(CHOLESTEROL
24-HYDROXYLASE)		 4ah6 ASPARTATE--TRNA
LIGASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 11 LEU A  81
VAL A 143
ILE A  72
ALA A 146
ALA A 110
 None
 1.08A 3mdtB-4ah6A:
undetectable		 3mdtB-4ah6A:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SG9_B_KANB305_1
(APH(2'')-ID)		 4ah6 ASPARTATE--TRNA
LIGASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 8 HIS A 526
ASP A 331
GLU A 498
GLU A 491
 None
 1.02A 3sg9B-4ah6A:
undetectable		 3sg9B-4ah6A:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VW1_D_CVID301_1
(PUTATIVE REGULATORY
PROTEIN)		 4ah6 ASPARTATE--TRNA
LIGASE,
MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 TYR A 185
MET A 197
LEU A 588
 None
 1.01A 3vw1D-4ah6A:
undetectable		 3vw1D-4ah6A:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2X_A_TMQA202_1
(DIHYDROFOLATE
REDUCTASE)		 4ah6 ASPARTATE--TRNA
LIGASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 ASP A 586
ILE A 589
ARG A 190
LEU A 583
LEU A 300
 None
 1.03A 4m2xA-4ah6A:
undetectable		 4m2xA-4ah6A:
14.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2X_G_TMQG202_1
(DIHYDROFOLATE
REDUCTASE)		 4ah6 ASPARTATE--TRNA
LIGASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 ILE A 141
LEU A 107
PRO A  95
VAL A 103
THR A  51
 None
 1.06A 4m2xG-4ah6A:
undetectable		 4m2xG-4ah6A:
14.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_A_IPHA101_0
(INSULIN)		 4ah6 ASPARTATE--TRNA
LIGASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 10 LEU A 567
LEU A 249
ALA A 570
HIS A 578
LEU A 571
 None
 1.23A 4p65A-4ah6A:
undetectable
4p65B-4ah6A:
undetectable
4p65F-4ah6A:
undetectable
4p65H-4ah6A:
undetectable		 4p65A-4ah6A:
2.42
4p65B-4ah6A:
5.30
4p65F-4ah6A:
5.30
4p65H-4ah6A:
5.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_E_IPHE101_0
(INSULIN)		 4ah6 ASPARTATE--TRNA
LIGASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 11 LEU A 567
LEU A 249
ALA A 570
HIS A 578
LEU A 571
 None
 1.11A 4p65E-4ah6A:
undetectable
4p65F-4ah6A:
undetectable
4p65J-4ah6A:
undetectable
4p65L-4ah6A:
undetectable		 4p65E-4ah6A:
2.42
4p65F-4ah6A:
5.30
4p65J-4ah6A:
5.30
4p65L-4ah6A:
5.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P66_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 4ah6 ASPARTATE--TRNA
LIGASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 11 ALA A 262
LEU A 585
LEU A 300
ILE A 283
TYR A 258
 None
 1.16A 4p66A-4ah6A:
undetectable		 4p66A-4ah6A:
14.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOP_D_HQED503_1
(CATALASE)		 4ah6 ASPARTATE--TRNA
LIGASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 9 ILE A 543
LEU A 548
GLN A 549
LEU A 486
PHE A 487
 None
 0.84A 4qopD-4ah6A:
0.0		 4qopD-4ah6A:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y1D_D_DVAD5_0
(CYCLIC HEXAPEPTIDE
CYC[NDPOPPKID]
INTEGRASE)		 4ah6 ASPARTATE--TRNA
LIGASE,
MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 GLU A 158
LYS A 164
ASN A 161
 None
 1.09A 4y1dA-4ah6A:
undetectable
4y1dD-4ah6A:
undetectable		 4y1dA-4ah6A:
13.75
4y1dD-4ah6A:
2.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4C_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 4ah6 ASPARTATE--TRNA
LIGASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 6 ARG A 599
ILE A 602
GLN A 275
ASP A 273
 None
 1.09A 4z4cA-4ah6A:
1.9		 4z4cA-4ah6A:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E8Q_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 4ah6 ASPARTATE--TRNA
LIGASE,
MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 ASP A 586
LEU A 171
ARG A 174
 None
 0.89A 5e8qA-4ah6A:
undetectable		 5e8qA-4ah6A:
14.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YBB_A_SAMA601_0
(TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT)		 4ah6 ASPARTATE--TRNA
LIGASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 ALA A 448
THR A 327
GLY A 329
THR A 441
ASN A 446
 None
 1.18A 5ybbA-4ah6A:
undetectable		 5ybbA-4ah6A:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BRD_A_RFPA502_2
(RIFAMPIN
MONOOXYGENASE)		 4ah6 ASPARTATE--TRNA
LIGASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 4 GLN A  91
VAL A 143
ARG A  58
ARG A 125
 None
 1.31A 6brdA-4ah6A:
1.1		 6brdA-4ah6A:
10.27