SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4aib'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJJ_A_NCTA501_1
(CYTOCHROME P450 2A6)		 4aib ORNITHINE
DECARBOXYLASE
(Entamoeba
histolytica) 		4 / 7 PHE A 226
GLY A 223
ILE A 239
PHE A 235
 None
 0.85A 4ejjA-4aibA:
undetectable		 4ejjA-4aibA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O2B_B_LOCB503_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA-2B
CHAIN)		 4aib ORNITHINE
DECARBOXYLASE
(Entamoeba
histolytica) 		3 / 3 SER A 327
ALA A 341
VAL A 340
 None
 0.61A 4o2bA-4aibA:
undetectable		 4o2bA-4aibA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PEV_B_ADNB501_1
(MEMBRANE LIPOPROTEIN
FAMILY PROTEIN)		 4aib ORNITHINE
DECARBOXYLASE
(Entamoeba
histolytica) 		5 / 12 ASP A  32
ASN A 359
GLY A  35
PHE A  54
GLY A 361
 None
 1.31A 4pevB-4aibA:
undetectable		 4pevB-4aibA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_C_29SC601_2
(ESTROGEN RECEPTOR)		 4aib ORNITHINE
DECARBOXYLASE
(Entamoeba
histolytica) 		4 / 6 ASP A 162
GLU A 164
ILE A 120
HIS A 183
 None
 1.04A 4xi3C-4aibA:
undetectable		 4xi3C-4aibA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XYZ_A_ACTA103_0
(POLYUBIQUITIN-C)		 4aib ORNITHINE
DECARBOXYLASE
(Entamoeba
histolytica) 		4 / 4 LEU A 356
ILE A  30
HIS A 268
VAL A 270
 None
 1.10A 4xyzA-4aibA:
undetectable		 4xyzA-4aibA:
12.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M0O_A_EPAA502_1
(TERMINAL
OLEFIN-FORMING FATTY
ACID DECARBOXYLASE)		 4aib ORNITHINE
DECARBOXYLASE
(Entamoeba
histolytica) 		5 / 10 LEU A 200
ILE A 222
PHE A 196
ALA A 256
PHE A 226
 None
 1.32A 5m0oA-4aibA:
undetectable		 5m0oA-4aibA:
23.13