SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4aii'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2X_E_TMQE202_1
(DIHYDROFOLATE
REDUCTASE)		 4aii GTP-BINDING PROTEIN
REM 2
(Rattus
norvegicus) 		5 / 12 ILE A 278
ILE A 157
ARG A 155
LEU A 270
LEU A 193
 None
 1.07A 4m2xE-4aiiA:
undetectable		 4m2xE-4aiiA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z90_E_4LEE401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 4aii GTP-BINDING PROTEIN
REM 2
(Rattus
norvegicus) 		5 / 7 THR A 259
THR A 267
LEU A 270
THR A 134
THR A 130
 None
None
None
None
GDP  A1284 (-3.4A)
 1.18A 4z90A-4aiiA:
undetectable
4z90B-4aiiA:
undetectable
4z90C-4aiiA:
undetectable
4z90D-4aiiA:
undetectable
4z90E-4aiiA:
undetectable		 4z90A-4aiiA:
18.27
4z90B-4aiiA:
18.27
4z90C-4aiiA:
18.27
4z90D-4aiiA:
18.27
4z90E-4aiiA:
18.27