SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ajt'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDS_A_ESTA350_1
(17-BETA-HYDROXYSTERO
ID-DEHYDROGENASE)		 4ajt PROTEIN Z-DEPENDENT
PROTEASE INHIBITOR
(Mus
musculus) 		5 / 12 LEU A 334
GLY A  66
HIS A  77
SER A  74
PHE A  83
 None
 1.44A 1fdsA-4ajtA:
undetectable		 1fdsA-4ajtA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_A_SAMA293_1
(GLYCINE
N-METHYLTRANSFERASE)		 4ajt PROTEIN Z-DEPENDENT
PROTEASE INHIBITOR
(Mus
musculus) 		3 / 3 ARG A  71
ASP A 263
ASN A 310
 None
 0.94A 1nbhA-4ajtA:
undetectable		 1nbhA-4ajtA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_D_SAMD3293_1
(GLYCINE
N-METHYLTRANSFERASE)		 4ajt PROTEIN Z-DEPENDENT
PROTEASE INHIBITOR
(Mus
musculus) 		3 / 3 ARG A  71
ASP A 263
ASN A 310
 None
 0.94A 1nbhD-4ajtA:
undetectable		 1nbhD-4ajtA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X8V_A_ESLA472_1
(CYTOCHROME P450 51)		 4ajt PROTEIN Z-DEPENDENT
PROTEASE INHIBITOR
(Mus
musculus) 		4 / 6 MET A  92
LEU A  88
PHE A  83
MET A 331
 None
 1.03A 1x8vA-4ajtA:
undetectable		 1x8vA-4ajtA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO5_B_CHDB501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4ajt PROTEIN Z-DEPENDENT
PROTEASE INHIBITOR
(Mus
musculus) 		5 / 11 LEU A 418
LEU A  70
SER A  74
LEU A 293
VAL A 284
 None
 1.37A 2po5B-4ajtA:
undetectable		 2po5B-4ajtA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I5U_A_SAMA401_1
(O-METHYLTRANSFERASE)		 4ajt PROTEIN Z-DEPENDENT
PROTEASE INHIBITOR
(Mus
musculus) 		4 / 4 ASP A 217
SER A  89
PHE A  86
SER A 144
 None
 1.24A 3i5uA-4ajtA:
0.0		 3i5uA-4ajtA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O1X_A_ADNA1450_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 1)		 4ajt PROTEIN Z-DEPENDENT
PROTEASE INHIBITOR
(Mus
musculus) 		5 / 10 ILE A 207
PHE A 204
ILE A 188
SER A 363
LEU A 366
 None
 1.32A 3o1xA-4ajtA:
undetectable		 3o1xA-4ajtA:
14.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_B_SUEB1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 4ajt PROTEIN Z-DEPENDENT
PROTEASE INHIBITOR
(Mus
musculus) 		3 / 3 PHE A  67
TYR A 408
LEU A 111
 None
 0.75A 3sueB-4ajtA:
undetectable		 3sueB-4ajtA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JO9_A_SORA302_0
(RIBITOL
2-DEHYDROGENASE)		 4ajt PROTEIN Z-DEPENDENT
PROTEASE INHIBITOR
(Mus
musculus) 		5 / 12 SER A  89
LEU A  88
PRO A  85
PHE A  83
LEU A  69
 None
 1.42A 5jo9A-4ajtA:
undetectable		 5jo9A-4ajtA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_A_6ZPA902_1
(GLUTAMATE RECEPTOR 2)		 4ajt PROTEIN Z-DEPENDENT
PROTEASE INHIBITOR
(Mus
musculus) 		4 / 8 SER A 147
ASP A 217
PHE A  86
SER A  84
 None
 1.04A 5l1fA-4ajtA:
undetectable
5l1fB-4ajtA:
undetectable		 5l1fA-4ajtA:
21.22
5l1fB-4ajtA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUG_A_VIVA301_1
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 4ajt PROTEIN Z-DEPENDENT
PROTEASE INHIBITOR
(Mus
musculus) 		3 / 3 SER A  59
SER A  63
PHE A 135
 None
 0.63A 5mugA-4ajtA:
undetectable		 5mugA-4ajtA:
20.30