SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ajv'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XP0_A_VDNA201_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 4ajv TRANSFORMING GROWTH
FACTOR BETA RECEPTOR
TYPE 3
(Mus
musculus) 		5 / 10 LEU A 702
ILE A 640
VAL A 612
ALA A 613
PHE A 689
 None
 1.04A 1xp0A-4ajvA:
undetectable		 1xp0A-4ajvA:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TVT_A_ASCA302_0
(THAUMATIN-1)		 4ajv TRANSFORMING GROWTH
FACTOR BETA RECEPTOR
TYPE 3
(Mus
musculus) 		3 / 3 ARG A 711
GLN A 629
GLU A 681
 None
 0.83A 4tvtA-4ajvA:
undetectable		 4tvtA-4ajvA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4ajv TRANSFORMING GROWTH
FACTOR BETA RECEPTOR
TYPE 3
(Mus
musculus) 		3 / 3 VAL A 673
LEU A 750
MET A 594
 None
 0.88A 5ikrA-4ajvA:
undetectable		 5ikrA-4ajvA:
14.29