SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ak1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_C_ADNC603_2
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 4ak1 BT_4661
(Bacteroides
thetaiotaomicron) 		4 / 5 GLU A 240
THR A 249
HIS A 294
LEU A 325
 None
 1.24A 1d4fC-4ak1A:
undetectable		 1d4fC-4ak1A:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H4O_A_BEZA1162_0
(PEROXIREDOXIN 5)		 4ak1 BT_4661
(Bacteroides
thetaiotaomicron) 		5 / 10 GLY A  81
LEU A  72
PHE A  61
THR A  78
GLY A  24
 None
 0.92A 1h4oA-4ak1A:
undetectable
1h4oB-4ak1A:
undetectable		 1h4oA-4ak1A:
12.70
1h4oB-4ak1A:
12.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNH_A_9CRA501_1
(CYTOCHROME P450 2C8)		 4ak1 BT_4661
(Bacteroides
thetaiotaomicron) 		5 / 11 GLY A  24
SER A  26
SER A 198
VAL A 110
PRO A 109
 None
 1.04A 2nnhA-4ak1A:
undetectable		 2nnhA-4ak1A:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNH_A_9CRA501_1
(CYTOCHROME P450 2C8)		 4ak1 BT_4661
(Bacteroides
thetaiotaomicron) 		5 / 11 GLY A  24
SER A  26
THR A 144
VAL A 110
PRO A 109
 None
 1.14A 2nnhA-4ak1A:
undetectable		 2nnhA-4ak1A:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNH_B_9CRB501_1
(CYTOCHROME P450 2C8)		 4ak1 BT_4661
(Bacteroides
thetaiotaomicron) 		5 / 9 GLY A  24
SER A  26
THR A 144
VAL A 110
PRO A 109
 None
 1.10A 2nnhB-4ak1A:
undetectable		 2nnhB-4ak1A:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QWX_A_ML1A233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4ak1 BT_4661
(Bacteroides
thetaiotaomicron) 		4 / 8 ILE A  23
PHE A  61
PHE A  56
GLY A  81
 None
 0.99A 2qwxA-4ak1A:
undetectable
2qwxB-4ak1A:
undetectable		 2qwxA-4ak1A:
16.22
2qwxB-4ak1A:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VL2_B_BEZB1162_0
(PEROXIREDOXIN-5)		 4ak1 BT_4661
(Bacteroides
thetaiotaomicron) 		4 / 7 GLY A  81
LEU A  72
PHE A  61
THR A  78
 None
 0.81A 2vl2B-4ak1A:
undetectable		 2vl2B-4ak1A:
13.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A99_D_MIYD393_1
(TETX2 PROTEIN)		 4ak1 BT_4661
(Bacteroides
thetaiotaomicron) 		4 / 5 ILE A 190
ILE A 221
TYR A 195
GLU A 220
 None
 1.24A 4a99D-4ak1A:
undetectable		 4a99D-4ak1A:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JX1_F_CAMF502_0
(CAMPHOR
5-MONOOXYGENASE)		 4ak1 BT_4661
(Bacteroides
thetaiotaomicron) 		4 / 4 TYR A  17
THR A  67
VAL A  30
ILE A  63
 None
 1.31A 4jx1F-4ak1A:
undetectable		 4jx1F-4ak1A:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOG_A_ML1A302_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4ak1 BT_4661
(Bacteroides
thetaiotaomicron) 		4 / 8 ILE A  23
PHE A  61
PHE A  56
GLY A  81
 None
 0.98A 4qogA-4ak1A:
undetectable
4qogB-4ak1A:
undetectable		 4qogA-4ak1A:
16.22
4qogB-4ak1A:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXD_A_RBVA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 4ak1 BT_4661
(Bacteroides
thetaiotaomicron) 		3 / 3 THR A 464
HIS A 534
LEU A 436
 None
 0.77A 5axdA-4ak1A:
undetectable		 5axdA-4ak1A:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BMV_C_VLBC507_1
(TUBULIN BETA CHAIN
TUBULIN ALPHA-1B
CHAIN)		 4ak1 BT_4661
(Bacteroides
thetaiotaomicron) 		4 / 6 ASP A 341
TYR A 399
PRO A 371
LEU A 378
 None
 1.37A 5bmvB-4ak1A:
undetectable		 5bmvB-4ak1A:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TWJ_C_SAMC201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)		 4ak1 BT_4661
(Bacteroides
thetaiotaomicron) 		5 / 12 LEU A 567
ILE A 571
GLY A 570
LEU A 545
VAL A 543
 None
 1.15A 5twjC-4ak1A:
undetectable		 5twjC-4ak1A:
11.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6J_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 4ak1 BT_4661
(Bacteroides
thetaiotaomicron) 		3 / 3 MET A 537
ASP A 540
ARG A 582
 None
 1.21A 5z6jA-4ak1A:
undetectable		 5z6jA-4ak1A:
13.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DH0_A_017A101_1
(PROTEASE)		 4ak1 BT_4661
(Bacteroides
thetaiotaomicron) 		5 / 12 ASP A 540
GLY A 686
ALA A 687
GLY A 507
LEU A 578
 None
 1.09A 6dh0B-4ak1A:
undetectable		 6dh0B-4ak1A:
8.75