SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ak5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_A_ACTA1869_0
(FPRA)		 4ak5 ANHYDRO-ALPHA-L-GALA
CTOSIDASE
(Bacteroides
plebeius) 		4 / 4 ASP A 320
HIS A 302
ARG A 273
GLU A 262
 None
 1.33A 1lqtA-4ak5A:
undetectable		 1lqtA-4ak5A:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXC_A_P1ZA2001_1
(SERUM ALBUMIN)		 4ak5 ANHYDRO-ALPHA-L-GALA
CTOSIDASE
(Bacteroides
plebeius) 		5 / 12 SER A 340
LEU A 351
ILE A 249
ILE A 313
ALA A 314
 None
 1.09A 2bxcA-4ak5A:
undetectable		 2bxcA-4ak5A:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA2_A_SCKA901_1
(ACETYLCHOLINESTERASE)		 4ak5 ANHYDRO-ALPHA-L-GALA
CTOSIDASE
(Bacteroides
plebeius) 		4 / 8 TYR A 251
ASP A 332
TYR A 256
TYR A 294
 None
 1.44A 2ha2A-4ak5A:
undetectable		 2ha2A-4ak5A:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA2_B_SCKB951_1
(ACETYLCHOLINESTERASE)		 4ak5 ANHYDRO-ALPHA-L-GALA
CTOSIDASE
(Bacteroides
plebeius) 		4 / 8 TYR A 251
ASP A 332
TYR A 256
TYR A 294
 None
 1.42A 2ha2B-4ak5A:
undetectable		 2ha2B-4ak5A:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRC_A_CHDA702_0
(FERROCHELATASE)		 4ak5 ANHYDRO-ALPHA-L-GALA
CTOSIDASE
(Bacteroides
plebeius) 		4 / 7 ARG A 383
LEU A  76
PRO A 166
VAL A 103
 None
 1.12A 2hrcA-4ak5A:
undetectable		 2hrcA-4ak5A:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO5_A_CHDA502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4ak5 ANHYDRO-ALPHA-L-GALA
CTOSIDASE
(Bacteroides
plebeius) 		4 / 8 ARG A 383
LEU A  76
PRO A 166
VAL A 103
 None
 1.00A 2po5A-4ak5A:
undetectable		 2po5A-4ak5A:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO5_B_CHDB502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4ak5 ANHYDRO-ALPHA-L-GALA
CTOSIDASE
(Bacteroides
plebeius) 		4 / 8 ARG A 383
LEU A  76
PRO A 166
VAL A 103
 None
 0.90A 2po5B-4ak5A:
undetectable		 2po5B-4ak5A:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YS6_A_GLYA431_0
(PHOSPHORIBOSYLGLYCIN
AMIDE SYNTHETASE)		 4ak5 ANHYDRO-ALPHA-L-GALA
CTOSIDASE
(Bacteroides
plebeius) 		4 / 8 ASP A 332
TYR A 251
GLY A 312
PRO A 331
 None
 0.96A 2ys6A-4ak5A:
undetectable		 2ys6A-4ak5A:
25.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HGX_A_SALA102_1
(SALICYLATE
BIOSYNTHESIS PROTEIN
PCHB)		 4ak5 ANHYDRO-ALPHA-L-GALA
CTOSIDASE
(Bacteroides
plebeius) 		4 / 7 VAL A 279
ILE A 249
TYR A 256
ILE A 248
 None
 0.95A 3hgxA-4ak5A:
undetectable		 3hgxA-4ak5A:
13.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VM4_A_IZPA1_1
(FATTY ACID
ALPHA-HYDROXYLASE)		 4ak5 ANHYDRO-ALPHA-L-GALA
CTOSIDASE
(Bacteroides
plebeius) 		4 / 5 LEU A 351
ARG A 353
PRO A 308
ALA A 357
 None
 1.40A 3vm4A-4ak5A:
undetectable		 3vm4A-4ak5A:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOD_A_HQEA1173_1
(FMN-BINDING PROTEIN)		 4ak5 ANHYDRO-ALPHA-L-GALA
CTOSIDASE
(Bacteroides
plebeius) 		4 / 7 HIS A 302
ASP A  90
HIS A 244
HIS A 371
 None
EDO  A1404 ( 4.3A)
EDO  A1404 ( 3.5A)
None
 1.22A 3zodA-4ak5A:
undetectable		 3zodA-4ak5A:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M0O_A_EPAA502_1
(TERMINAL
OLEFIN-FORMING FATTY
ACID DECARBOXYLASE)		 4ak5 ANHYDRO-ALPHA-L-GALA
CTOSIDASE
(Bacteroides
plebeius) 		5 / 10 PRO A  91
LEU A 351
PRO A 308
ALA A 314
VAL A 304
 None
 1.29A 5m0oA-4ak5A:
undetectable		 5m0oA-4ak5A:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1B_B_CHDB302_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 4ak5 ANHYDRO-ALPHA-L-GALA
CTOSIDASE
(Bacteroides
plebeius) 		5 / 10 MET A 264
GLY A 265
GLU A 266
THR A 269
PHE A 238
 None
 1.39A 5x1bA-4ak5A:
undetectable
5x1bB-4ak5A:
undetectable
5x1bT-4ak5A:
undetectable		 5x1bA-4ak5A:
19.51
5x1bB-4ak5A:
18.43
5x1bT-4ak5A:
13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AZ3_1_PAR11802_1
(RRNA ALPHA
RIBOSOMAL PROTEIN
UL4
RIBOSOMAL PROTEIN
UL15
RIBOSOMAL PROTEIN
EL15)		 4ak5 ANHYDRO-ALPHA-L-GALA
CTOSIDASE
(Bacteroides
plebeius) 		3 / 3 ARG A 152
LYS A 208
ARG A 129
 None
 1.46A 6az3C-4ak5A:
undetectable
6az3L-4ak5A:
undetectable
6az3M-4ak5A:
undetectable		 6az3C-4ak5A:
13.44
6az3L-4ak5A:
10.64
6az3M-4ak5A:
10.86