SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ak9'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CQP_A_803A311_1
(ANTIGEN CD11A (P180))		 4ak9 CPFTSY
(Physcomitrella
patens) 		5 / 10 LEU A 306
VAL A 307
LEU A 282
GLU A 285
LEU A 286
 None
 0.95A 1cqpA-4ak9A:
2.8
1cqpB-4ak9A:
2.4		 1cqpA-4ak9A:
21.38
1cqpB-4ak9A:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBM_B_RTLB951_2
(PROTEIN (CARTILAGE
OLIGOMERIC MATRIX
PROTEIN))		 4ak9 CPFTSY
(Physcomitrella
patens) 		4 / 4 THR A  91
LEU A  95
VAL A  97
LEU A 101
 None
 0.85A 1fbmD-4ak9A:
undetectable		 1fbmD-4ak9A:
10.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICU_B_NIOB219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 4ak9 CPFTSY
(Physcomitrella
patens) 		4 / 6 PHE A 377
GLY A 343
SER A 348
PHE A 126
 None
 1.06A 1icuA-4ak9A:
undetectable
1icuB-4ak9A:
undetectable		 1icuA-4ak9A:
19.75
1icuB-4ak9A:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICU_C_NIOC225_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 4ak9 CPFTSY
(Physcomitrella
patens) 		4 / 6 SER A 348
PHE A 126
PHE A 377
GLY A 343
 None
 1.09A 1icuC-4ak9A:
undetectable
1icuD-4ak9A:
undetectable		 1icuC-4ak9A:
19.75
1icuD-4ak9A:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICV_B_NIOB702_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 4ak9 CPFTSY
(Physcomitrella
patens) 		4 / 5 PHE A 377
GLY A 343
SER A 348
PHE A 126
 None
 0.94A 1icvA-4ak9A:
undetectable
1icvB-4ak9A:
undetectable		 1icvA-4ak9A:
19.75
1icvB-4ak9A:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SA1_B_PODB700_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 4ak9 CPFTSY
(Physcomitrella
patens) 		5 / 12 LEU A 213
ALA A 260
ALA A 296
VAL A 293
ALA A 300
 None
 1.08A 1sa1A-4ak9A:
3.3
1sa1B-4ak9A:
3.4		 1sa1A-4ak9A:
22.06
1sa1B-4ak9A:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SA1_D_PODD701_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 4ak9 CPFTSY
(Physcomitrella
patens) 		5 / 12 LEU A 213
ALA A 260
ALA A 296
VAL A 293
ALA A 300
 None
 1.08A 1sa1C-4ak9A:
3.6
1sa1D-4ak9A:
3.5		 1sa1C-4ak9A:
22.06
1sa1D-4ak9A:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_D_SAMD301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 4ak9 CPFTSY
(Physcomitrella
patens) 		3 / 3 LYS A 207
ASP A 338
ASP A 367
 None
 0.87A 2br4D-4ak9A:
undetectable		 2br4D-4ak9A:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEU_A_ACTA141_0
(PUTATIVE
CARBOXYMUCONOLACTONE
DECARBOXYLASE)		 4ak9 CPFTSY
(Physcomitrella
patens) 		3 / 3 VAL A 135
ASP A 136
GLU A 118
 None
 0.69A 2qeuA-4ak9A:
undetectable		 2qeuA-4ak9A:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEU_C_ACTC141_0
(PUTATIVE
CARBOXYMUCONOLACTONE
DECARBOXYLASE)		 4ak9 CPFTSY
(Physcomitrella
patens) 		3 / 3 VAL A 135
ASP A 136
GLU A 118
 None
 0.67A 2qeuC-4ak9A:
undetectable		 2qeuC-4ak9A:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_B_ASDB1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 4ak9 CPFTSY
(Physcomitrella
patens) 		4 / 6 LEU A 213
PRO A 181
LEU A 297
ALA A 296
 None
 0.94A 2vcvB-4ak9A:
undetectable		 2vcvB-4ak9A:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN3_A_ID8A1356_1
(THYROXINE-BINDING
GLOBULIN)		 4ak9 CPFTSY
(Physcomitrella
patens) 		4 / 8 LEU A 114
LEU A 147
LYS A 148
LEU A 102
 None
 0.85A 2xn3A-4ak9A:
undetectable
2xn3B-4ak9A:
undetectable		 2xn3A-4ak9A:
23.76
2xn3B-4ak9A:
9.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_B_SAMB301_0
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 4ak9 CPFTSY
(Physcomitrella
patens) 		5 / 12 GLY A 199
THR A 235
ILE A 186
LEU A 201
ARG A 204
 None
 1.29A 3iv6B-4ak9A:
undetectable		 3iv6B-4ak9A:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_B_LYAB514_2
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 4ak9 CPFTSY
(Physcomitrella
patens) 		3 / 3 ARG A 275
THR A 196
THR A 312
 None
 0.70A 3k2hB-4ak9A:
3.2		 3k2hB-4ak9A:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZT_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 2)		 4ak9 CPFTSY
(Physcomitrella
patens) 		3 / 3 PHE A 382
THR A 137
LEU A 121
 None
 0.76A 4qztA-4ak9A:
undetectable		 4qztA-4ak9A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5INZ_D_DVAD2_0
(THETA DEFENSIN-2,
D-PEPTIDE
THETA DEFENSIN-2,
L-PEPTIDE)		 4ak9 CPFTSY
(Physcomitrella
patens) 		4 / 4 GLY A 313
CYH A 345
ARG A 342
GLY A 310
 None
 1.40A 5inzA-4ak9A:
undetectable
5inzC-4ak9A:
undetectable
5inzD-4ak9A:
undetectable		 5inzA-4ak9A:
4.35
5inzC-4ak9A:
4.35
5inzD-4ak9A:
4.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OY0_2_PQN2843_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 4ak9 CPFTSY
(Physcomitrella
patens) 		5 / 12 ILE A 355
PHE A 377
ILE A 134
LEU A 165
ALA A 374
 None
 1.00A 5oy02-4ak9A:
undetectable		 5oy02-4ak9A:
11.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QH8_A_ACTA302_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 4ak9 CPFTSY
(Physcomitrella
patens) 		3 / 3 CYH A 345
MET A 316
ASN A 315
 None
 0.98A 5qh8A-4ak9A:
undetectable		 5qh8A-4ak9A:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VC0_A_RITA602_2
(CYTOCHROME P450 3A4)		 4ak9 CPFTSY
(Physcomitrella
patens) 		4 / 7 ILE A 134
LEU A 165
PHE A 377
ARG A  92
 None
 1.04A 5vc0A-4ak9A:
undetectable		 5vc0A-4ak9A:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VEU_H_RITH602_1
(CYTOCHROME P450 3A5)		 4ak9 CPFTSY
(Physcomitrella
patens) 		5 / 12 LEU A 165
GLY A 310
PHE A 377
ILE A 161
GLY A 313
 None
 1.07A 5veuH-4ak9A:
undetectable		 5veuH-4ak9A:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_D_CVID301_1
(REGULATORY PROTEIN
TETR)		 4ak9 CPFTSY
(Physcomitrella
patens) 		4 / 8 GLY A 361
GLU A 364
GLN A 319
ASP A 309
 None
 1.09A 5vlmD-4ak9A:
2.8		 5vlmD-4ak9A:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H7L_A_Y00A406_1
(BETA-1 ADRENERGIC
RECEPTOR)		 4ak9 CPFTSY
(Physcomitrella
patens) 		4 / 6 GLY A 313
LEU A 314
VAL A 360
PHE A 377
 None
 1.03A 6h7lA-4ak9A:
undetectable		 6h7lA-4ak9A:
13.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H7L_B_Y00B405_1
(BETA-1 ADRENERGIC
RECEPTOR)		 4ak9 CPFTSY
(Physcomitrella
patens) 		4 / 6 GLY A 313
LEU A 314
VAL A 360
PHE A 377
 None
 1.03A 6h7lB-4ak9A:
undetectable		 6h7lB-4ak9A:
13.21