SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4akk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AV2_A_DVAA6_0
(GRAMICIDIN A)		 4akk NITRATE REGULATORY
PROTEIN
(Klebsiella
oxytoca) 		3 / 3 ALA A 124
VAL A 118
TRP A  56
 None
 0.93A 1av2A-4akkA:
undetectable
1av2B-4akkA:
undetectable		 1av2A-4akkA:
3.24
1av2B-4akkA:
3.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AV2_A_DVAA6_0
(GRAMICIDIN A)		 4akk NITRATE REGULATORY
PROTEIN
(Klebsiella
oxytoca) 		3 / 3 ALA A 125
VAL A 118
TRP A  56
 None
 0.86A 1av2A-4akkA:
undetectable
1av2B-4akkA:
undetectable		 1av2A-4akkA:
3.24
1av2B-4akkA:
3.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AV2_D_DVAD6_0
(GRAMICIDIN A)		 4akk NITRATE REGULATORY
PROTEIN
(Klebsiella
oxytoca) 		3 / 3 TRP A  56
ALA A 125
VAL A 118
 None
 0.97A 1av2C-4akkA:
undetectable
1av2D-4akkA:
undetectable		 1av2C-4akkA:
3.24
1av2D-4akkA:
3.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D1G_A_MTXA171_1
(DIHYDROFOLATE
REDUCTASE)		 4akk NITRATE REGULATORY
PROTEIN
(Klebsiella
oxytoca) 		5 / 12 ALA A  96
ASP A 148
ILE A  39
LEU A  35
ILE A 101
 None
 1.20A 1d1gA-4akkA:
undetectable		 1d1gA-4akkA:
16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D1G_B_MTXB171_1
(DIHYDROFOLATE
REDUCTASE)		 4akk NITRATE REGULATORY
PROTEIN
(Klebsiella
oxytoca) 		5 / 12 VAL A 377
ALA A 369
ASP A 201
ARG A 340
ILE A 343
 None
 1.13A 1d1gB-4akkA:
undetectable		 1d1gB-4akkA:
16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W5U_A_DVAA6_0
(GRAMICIDIN D)		 4akk NITRATE REGULATORY
PROTEIN
(Klebsiella
oxytoca) 		3 / 3 ALA A 124
VAL A 118
TRP A  56
 None
 0.96A 1w5uA-4akkA:
undetectable
1w5uB-4akkA:
undetectable		 1w5uA-4akkA:
3.24
1w5uB-4akkA:
3.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W5U_A_DVAA6_0
(GRAMICIDIN D)		 4akk NITRATE REGULATORY
PROTEIN
(Klebsiella
oxytoca) 		3 / 3 ALA A 125
VAL A 118
TRP A  56
 None
 0.82A 1w5uA-4akkA:
undetectable
1w5uB-4akkA:
undetectable		 1w5uA-4akkA:
3.24
1w5uB-4akkA:
3.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W5U_B_DVAB6_0
(GRAMICIDIN D)		 4akk NITRATE REGULATORY
PROTEIN
(Klebsiella
oxytoca) 		3 / 3 TRP A  56
ALA A 124
VAL A 118
 None
 0.95A 1w5uA-4akkA:
undetectable
1w5uB-4akkA:
undetectable		 1w5uA-4akkA:
3.24
1w5uB-4akkA:
3.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W5U_B_DVAB6_0
(GRAMICIDIN D)		 4akk NITRATE REGULATORY
PROTEIN
(Klebsiella
oxytoca) 		3 / 3 TRP A  56
ALA A 125
VAL A 118
 None
 0.86A 1w5uA-4akkA:
undetectable
1w5uB-4akkA:
undetectable		 1w5uA-4akkA:
3.24
1w5uB-4akkA:
3.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_C_SAMC301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 4akk NITRATE REGULATORY
PROTEIN
(Klebsiella
oxytoca) 		5 / 12 GLY A 328
ARG A 199
ARG A 375
SER A 133
ALA A 331
 None
 1.08A 2br4C-4akkA:
undetectable		 2br4C-4akkA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_B_1FLB2003_1
(SERUM ALBUMIN)		 4akk NITRATE REGULATORY
PROTEIN
(Klebsiella
oxytoca) 		5 / 10 LEU A  86
PHE A  82
LEU A  97
ILE A 142
ALA A 102
 None
 1.01A 2bxeB-4akkA:
undetectable		 2bxeB-4akkA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXQ_A_P1ZA2002_1
(SERUM ALBUMIN)		 4akk NITRATE REGULATORY
PROTEIN
(Klebsiella
oxytoca) 		5 / 12 LEU A  86
PHE A  82
LEU A  97
ILE A 142
ALA A 102
 None
 0.92A 2bxqA-4akkA:
3.1		 2bxqA-4akkA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IZQ_D_DVAD6_0
(GRAMICIDIN D)		 4akk NITRATE REGULATORY
PROTEIN
(Klebsiella
oxytoca) 		3 / 3 TRP A  56
ALA A 124
VAL A 118
 None
 0.97A 2izqC-4akkA:
undetectable
2izqD-4akkA:
undetectable		 2izqC-4akkA:
3.24
2izqD-4akkA:
3.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IZQ_D_DVAD6_0
(GRAMICIDIN D)		 4akk NITRATE REGULATORY
PROTEIN
(Klebsiella
oxytoca) 		3 / 3 TRP A  56
ALA A 125
VAL A 118
 None
 0.79A 2izqC-4akkA:
undetectable
2izqD-4akkA:
undetectable		 2izqC-4akkA:
3.24
2izqD-4akkA:
3.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q72_A_IXXA802_1
(TRANSPORTER)		 4akk NITRATE REGULATORY
PROTEIN
(Klebsiella
oxytoca) 		4 / 6 ILE A 135
ARG A 137
ILE A 142
PHE A  82
 None
 1.09A 2q72A-4akkA:
0.7		 2q72A-4akkA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEU_A_ACTA141_0
(PUTATIVE
CARBOXYMUCONOLACTONE
DECARBOXYLASE)		 4akk NITRATE REGULATORY
PROTEIN
(Klebsiella
oxytoca) 		3 / 3 VAL A  75
ASP A  76
GLU A  49
 None
EDO  A1394 (-3.3A)
None
 0.40A 2qeuA-4akkA:
2.4		 2qeuA-4akkA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEU_C_ACTC141_0
(PUTATIVE
CARBOXYMUCONOLACTONE
DECARBOXYLASE)		 4akk NITRATE REGULATORY
PROTEIN
(Klebsiella
oxytoca) 		3 / 3 VAL A  75
ASP A  76
GLU A  49
 None
EDO  A1394 (-3.3A)
None
 0.41A 2qeuC-4akkA:
undetectable		 2qeuC-4akkA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QWX_B_ML1B233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4akk NITRATE REGULATORY
PROTEIN
(Klebsiella
oxytoca) 		4 / 7 GLY A 173
GLN A 203
PHE A 207
PHE A 222
 EDO  A1392 (-4.4A)
None
None
None
 0.93A 2qwxA-4akkA:
undetectable
2qwxB-4akkA:
undetectable		 2qwxA-4akkA:
18.40
2qwxB-4akkA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QX4_B_ML1B233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4akk NITRATE REGULATORY
PROTEIN
(Klebsiella
oxytoca) 		4 / 7 GLY A 173
GLN A 203
PHE A 207
PHE A 222
 EDO  A1392 (-4.4A)
None
None
None
 0.94A 2qx4A-4akkA:
undetectable
2qx4B-4akkA:
undetectable		 2qx4A-4akkA:
18.16
2qx4B-4akkA:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_2
(THYROXINE-BINDING
GLOBULIN)		 4akk NITRATE REGULATORY
PROTEIN
(Klebsiella
oxytoca) 		3 / 3 LEU A 235
ARG A 254
ILE A 232
 None
 0.66A 2xn5B-4akkA:
undetectable		 2xn5B-4akkA:
7.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_B_REMB350_1
(RENIN)		 4akk NITRATE REGULATORY
PROTEIN
(Klebsiella
oxytoca) 		5 / 12 GLN A 234
GLY A 179
THR A 251
LEU A 192
ALA A 239
 None
 1.22A 3d91B-4akkA:
undetectable		 3d91B-4akkA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DZU_A_9CRA7223_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4akk NITRATE REGULATORY
PROTEIN
(Klebsiella
oxytoca) 		6 / 12 ILE A 142
ALA A  36
GLN A  38
PHE A  82
LEU A  35
HIS A 138
 None
 1.50A 3dzuA-4akkA:
undetectable		 3dzuA-4akkA:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K9F_F_LFXF0_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B)		 4akk NITRATE REGULATORY
PROTEIN
(Klebsiella
oxytoca) 		4 / 5 SER A  40
ARG A 262
GLY A 173
GLU A 175
 None
None
EDO  A1392 (-4.4A)
None
 1.29A 3k9fA-4akkA:
undetectable
3k9fB-4akkA:
undetectable
3k9fC-4akkA:
undetectable		 3k9fA-4akkA:
23.02
3k9fB-4akkA:
23.02
3k9fC-4akkA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_D_DVAD6_0
(GRAMICIDIN D)		 4akk NITRATE REGULATORY
PROTEIN
(Klebsiella
oxytoca) 		3 / 3 TRP A  56
ALA A 124
VAL A 118
 None
 0.89A 3l8lC-4akkA:
undetectable
3l8lD-4akkA:
undetectable		 3l8lC-4akkA:
3.24
3l8lD-4akkA:
3.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_D_DVAD6_0
(GRAMICIDIN D)		 4akk NITRATE REGULATORY
PROTEIN
(Klebsiella
oxytoca) 		3 / 3 TRP A  56
ALA A 125
VAL A 118
 None
 0.76A 3l8lC-4akkA:
undetectable
3l8lD-4akkA:
undetectable		 3l8lC-4akkA:
3.24
3l8lD-4akkA:
3.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGH_B_FLPB701_1
(CYCLOOXYGENASE-2)		 4akk NITRATE REGULATORY
PROTEIN
(Klebsiella
oxytoca) 		5 / 11 ARG A 115
MET A  45
VAL A  75
GLY A  71
ALA A  72
 EDO  A1394 (-4.0A)
None
None
None
None
 1.24A 3pghB-4akkA:
undetectable		 3pghB-4akkA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3S_F_9PLF1_1
(CYTOCHROME P450 2A13)		 4akk NITRATE REGULATORY
PROTEIN
(Klebsiella
oxytoca) 		4 / 8 PHE A 256
ALA A 184
ALA A 125
THR A 129
 None
 0.99A 3t3sF-4akkA:
0.0		 3t3sF-4akkA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E7B_C_ACTC513_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 4akk NITRATE REGULATORY
PROTEIN
(Klebsiella
oxytoca) 		3 / 3 TYR A 107
HIS A 138
ARG A 134
 None
 1.16A 4e7bC-4akkA:
undetectable		 4e7bC-4akkA:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERS_A_ACTA803_0
(GEPHYRIN)		 4akk NITRATE REGULATORY
PROTEIN
(Klebsiella
oxytoca) 		3 / 3 THR A 129
ALA A 177
ASN A  54
 None
EDO  A1392 (-3.3A)
EDO  A1392 (-4.2A)
 0.59A 5ersA-4akkA:
undetectable		 5ersA-4akkA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4akk NITRATE REGULATORY
PROTEIN
(Klebsiella
oxytoca) 		5 / 12 ARG A 115
MET A  45
VAL A  75
GLY A  71
ALA A  72
 EDO  A1394 (-4.0A)
None
None
None
None
 1.12A 5iktA-4akkA:
undetectable		 5iktA-4akkA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4akk NITRATE REGULATORY
PROTEIN
(Klebsiella
oxytoca) 		5 / 12 ARG A 115
MET A  45
VAL A  75
GLY A  71
ALA A  72
 EDO  A1394 (-4.0A)
None
None
None
None
 1.14A 5iktB-4akkA:
undetectable		 5iktB-4akkA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A7P_B_9SCB601_1
(SERUM ALBUMIN)		 4akk NITRATE REGULATORY
PROTEIN
(Klebsiella
oxytoca) 		4 / 6 CYH A 226
PHE A 207
LEU A 273
SER A  40
 None
 1.23A 6a7pB-4akkA:
undetectable		 6a7pB-4akkA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MA6_A_MYTA603_0
(CYTOCHROME P450 3A4)		 4akk NITRATE REGULATORY
PROTEIN
(Klebsiella
oxytoca) 		4 / 6 SER A 133
ARG A 176
ALA A 177
ALA A  52
 None
EDO  A1392 (-3.7A)
EDO  A1392 (-3.3A)
None
 1.11A 6ma6A-4akkA:
1.6		 6ma6A-4akkA:
10.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NM4_A_SAMA402_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
PRDM9)		 4akk NITRATE REGULATORY
PROTEIN
(Klebsiella
oxytoca) 		4 / 7 ALA A 156
GLY A 157
GLY A  33
ASN A 147
 None
 0.71A 6nm4A-4akkA:
undetectable		 6nm4A-4akkA:
16.90