SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4akm'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KW0_A_H4BA429_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 4akm LYSOSOME-ASSOCIATED
MEMBRANE
GLYCOPROTEIN 3
(Homo
sapiens) 		5 / 12 LEU A 360
SER A 336
PHE A 337
THR A 355
GLU A 375
 None
 1.15A 1kw0A-4akmA:
undetectable		 1kw0A-4akmA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MMT_A_H4BA1426_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 4akm LYSOSOME-ASSOCIATED
MEMBRANE
GLYCOPROTEIN 3
(Homo
sapiens) 		5 / 11 LEU A 360
SER A 336
PHE A 337
THR A 355
GLU A 375
 None
 1.20A 1mmtA-4akmA:
undetectable		 1mmtA-4akmA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UT5_D_LOCD502_1
(TUBULIN BETA CHAIN)		 4akm LYSOSOME-ASSOCIATED
MEMBRANE
GLYCOPROTEIN 3
(Homo
sapiens) 		5 / 12 LEU A 360
LEU A 292
ASN A 291
ALA A 270
ILE A 244
 None
None
NAG  A1379 (-2.0A)
None
None
 1.08A 3ut5D-4akmA:
undetectable		 3ut5D-4akmA:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DO3_A_0LAA602_1
(FATTY-ACID AMIDE
HYDROLASE 1)		 4akm LYSOSOME-ASSOCIATED
MEMBRANE
GLYCOPROTEIN 3
(Homo
sapiens) 		4 / 5 LEU A 360
LEU A 292
MET A 328
THR A 355
 None
 1.32A 4do3A-4akmA:
undetectable		 4do3A-4akmA:
15.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E0F_A_RBFA301_2
(RIBOFLAVIN SYNTHASE
SUBUNIT ALPHA)		 4akm LYSOSOME-ASSOCIATED
MEMBRANE
GLYCOPROTEIN 3
(Homo
sapiens) 		3 / 3 LYS A 278
THR A 293
ILE A 322
 NAG  A1379 ( 4.5A)
NAG  A1379 (-2.7A)
None
 0.92A 4e0fB-4akmA:
undetectable		 4e0fB-4akmA:
25.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LVC_C_ADNC501_2
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(SAHASE))		 4akm LYSOSOME-ASSOCIATED
MEMBRANE
GLYCOPROTEIN 3
(Homo
sapiens) 		4 / 5 GLN A 330
THR A 331
THR A 355
LEU A 292
 None
 1.34A 4lvcC-4akmA:
undetectable		 4lvcC-4akmA:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1I_D_LOCD502_1
(TUBULIN BETA CHAIN)		 4akm LYSOSOME-ASSOCIATED
MEMBRANE
GLYCOPROTEIN 3
(Homo
sapiens) 		5 / 12 LEU A 360
LEU A 292
ASN A 291
ALA A 270
ILE A 244
 None
None
NAG  A1379 (-2.0A)
None
None
 1.06A 4x1iD-4akmA:
undetectable		 4x1iD-4akmA:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1Y_D_LOCD502_2
(TUBULIN BETA CHAIN)		 4akm LYSOSOME-ASSOCIATED
MEMBRANE
GLYCOPROTEIN 3
(Homo
sapiens) 		5 / 12 LEU A 360
LEU A 292
ASN A 291
ALA A 270
ILE A 244
 None
None
NAG  A1379 (-2.0A)
None
None
 1.02A 4x1yD-4akmA:
undetectable		 4x1yD-4akmA:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X20_B_LOCB502_1
(TUBULIN BETA CHAIN)		 4akm LYSOSOME-ASSOCIATED
MEMBRANE
GLYCOPROTEIN 3
(Homo
sapiens) 		5 / 12 LEU A 360
LEU A 292
ASN A 291
ALA A 270
ILE A 244
 None
None
NAG  A1379 (-2.0A)
None
None
 1.00A 4x20B-4akmA:
undetectable		 4x20B-4akmA:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K7U_A_SAMA601_1
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT)		 4akm LYSOSOME-ASSOCIATED
MEMBRANE
GLYCOPROTEIN 3
(Homo
sapiens) 		3 / 3 ASP A 357
ASN A 262
GLN A 245
 None
 0.75A 5k7uA-4akmA:
undetectable		 5k7uA-4akmA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5K_A_ADNA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 4akm LYSOSOME-ASSOCIATED
MEMBRANE
GLYCOPROTEIN 3
(Homo
sapiens) 		4 / 4 GLN A 330
THR A 331
THR A 355
LEU A 292
 None
 1.35A 5m5kA-4akmA:
undetectable		 5m5kA-4akmA:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5K_C_ADNC502_2
(ADENOSYLHOMOCYSTEINA
SE)		 4akm LYSOSOME-ASSOCIATED
MEMBRANE
GLYCOPROTEIN 3
(Homo
sapiens) 		4 / 4 GLN A 330
THR A 331
THR A 355
LEU A 292
 None
 1.35A 5m5kC-4akmA:
undetectable		 5m5kC-4akmA:
15.50