SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4akr'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZ9_A_CAMA503_0
(CYTOCHROME P450-CAM)		 4akr F-ACTIN-CAPPING
PROTEIN SUBUNIT
ALPHA
F-ACTIN-CAPPING
PROTEIN SUBUNIT BETA
(Dictyostelium
discoideum;
Dictyostelium
discoideum) 		4 / 8 TYR A 243
LEU A 202
VAL B 189
THR A 206
 None
 1.03A 1dz9A-4akrA:
undetectable		 1dz9A-4akrA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HA2_A_SWFA3001_1
(SERUM ALBUMIN)		 4akr F-ACTIN-CAPPING
PROTEIN SUBUNIT
ALPHA
F-ACTIN-CAPPING
PROTEIN SUBUNIT BETA
(Dictyostelium
discoideum) 		5 / 11 LEU B  16
LEU B  12
LEU B  28
ILE A  10
ALA A  11
 None
 1.04A 1ha2A-4akrB:
undetectable		 1ha2A-4akrB:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1O76_B_CAMB1420_0
(CYTOCHROME P450-CAM)		 4akr F-ACTIN-CAPPING
PROTEIN SUBUNIT
ALPHA
F-ACTIN-CAPPING
PROTEIN SUBUNIT BETA
(Dictyostelium
discoideum;
Dictyostelium
discoideum) 		4 / 8 TYR A 243
LEU A 202
VAL B 189
THR A 206
 None
 0.99A 1o76B-4akrA:
undetectable		 1o76B-4akrA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RMT_D_ADND1504_1
(CLASS B ACID
PHOSPHATASE)		 4akr F-ACTIN-CAPPING
PROTEIN SUBUNIT
ALPHA
F-ACTIN-CAPPING
PROTEIN SUBUNIT BETA
(Dictyostelium
discoideum) 		4 / 8 LEU B 195
ASP A 197
THR B 238
TYR A 194
 None
 1.04A 1rmtD-4akrB:
undetectable		 1rmtD-4akrB:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UYU_A_CAMA1416_0
(CYTOCHROME P450-CAM)		 4akr F-ACTIN-CAPPING
PROTEIN SUBUNIT
ALPHA
F-ACTIN-CAPPING
PROTEIN SUBUNIT BETA
(Dictyostelium
discoideum;
Dictyostelium
discoideum) 		4 / 8 TYR A 243
LEU A 202
VAL B 189
THR A 206
 None
 1.14A 1uyuA-4akrA:
undetectable		 1uyuA-4akrA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CIZ_A_ACTA1321_0
(CHLOROPEROXIDASE)		 4akr F-ACTIN-CAPPING
PROTEIN SUBUNIT
ALPHA
(Dictyostelium
discoideum) 		4 / 5 LEU A  40
PHE A  48
VAL A  30
ALA A  11
 None
 1.14A 2cizA-4akrA:
undetectable		 2cizA-4akrA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DXR_A_SORA1002_0
(LACTOTRANSFERRIN)		 4akr F-ACTIN-CAPPING
PROTEIN SUBUNIT
ALPHA
(Dictyostelium
discoideum) 		3 / 3 THR A 220
PRO A 177
TYR A 114
 None
 0.94A 2dxrA-4akrA:
undetectable		 2dxrA-4akrA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJT_A_SAMA501_1
(N(2),N(2)-DIMETHYLGU
ANOSINE TRNA
METHYLTRANSFERASE)		 4akr F-ACTIN-CAPPING
PROTEIN SUBUNIT BETA
(Dictyostelium
discoideum) 		3 / 3 ARG B  14
ASP B  44
ASP B  63
 None
 0.81A 2ejtA-4akrB:
undetectable		 2ejtA-4akrB:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HW2_A_RFPA1200_1
(RIFAMPIN ADP-RIBOSYL
TRANSFERASE)		 4akr F-ACTIN-CAPPING
PROTEIN SUBUNIT
ALPHA
F-ACTIN-CAPPING
PROTEIN SUBUNIT BETA
(Dictyostelium
discoideum) 		5 / 12 PHE A  48
ASN A  13
THR A  47
LEU B  31
LEU B  28
 None
 1.04A 2hw2A-4akrA:
undetectable		 2hw2A-4akrA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QBL_A_CAMA517_0
(CYTOCHROME P450-CAM)		 4akr F-ACTIN-CAPPING
PROTEIN SUBUNIT
ALPHA
F-ACTIN-CAPPING
PROTEIN SUBUNIT BETA
(Dictyostelium
discoideum;
Dictyostelium
discoideum) 		4 / 7 LEU A 202
VAL B 189
THR A 204
ASP A 240
 None
 0.87A 2qblA-4akrA:
undetectable		 2qblA-4akrA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD5_B_CHDB1104_0
(FERROCHELATASE)		 4akr F-ACTIN-CAPPING
PROTEIN SUBUNIT
ALPHA
(Dictyostelium
discoideum) 		3 / 3 LEU A  34
PRO A  35
LEU A  39
 None
 0.48A 2qd5B-4akrA:
undetectable		 2qd5B-4akrA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZAW_A_CAMA422_0
(CYTOCHROME P450-CAM)		 4akr F-ACTIN-CAPPING
PROTEIN SUBUNIT
ALPHA
F-ACTIN-CAPPING
PROTEIN SUBUNIT BETA
(Dictyostelium
discoideum;
Dictyostelium
discoideum) 		4 / 6 TYR A 243
LEU A 202
VAL B 189
ASP A 240
 None
 1.19A 2zawA-4akrA:
undetectable		 2zawA-4akrA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HGG_A_CHDA211_0
(CMER)		 4akr F-ACTIN-CAPPING
PROTEIN SUBUNIT
ALPHA
(Dictyostelium
discoideum) 		4 / 7 CYH A  21
PHE A 195
SER A 164
TYR A 163
 None
 1.47A 3hggA-4akrA:
undetectable		 3hggA-4akrA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IAZ_A_AINA1202_1
(LACTOTRANSFERRIN)		 4akr F-ACTIN-CAPPING
PROTEIN SUBUNIT
ALPHA
(Dictyostelium
discoideum) 		3 / 3 GLU A  78
GLY A  99
THR A  98
 None
 0.57A 3iazA-4akrA:
undetectable		 3iazA-4akrA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OGP_B_017B200_1
(FIV PROTEASE)		 4akr F-ACTIN-CAPPING
PROTEIN SUBUNIT
ALPHA
F-ACTIN-CAPPING
PROTEIN SUBUNIT BETA
(Dictyostelium
discoideum) 		5 / 10 ILE B  21
GLY B  27
ILE A  10
VAL A  26
LEU B  16
 None
 0.94A 3ogpA-4akrB:
undetectable		 3ogpA-4akrB:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P73_A_ACTA275_0
(MHC RFP-Y CLASS I
ALPHA CHAIN)		 4akr F-ACTIN-CAPPING
PROTEIN SUBUNIT
ALPHA
(Dictyostelium
discoideum) 		3 / 3 ILE A  74
VAL A  87
ARG A 101
 None
 0.74A 3p73A-4akrA:
undetectable		 3p73A-4akrA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAS_B_ADNB401_2
(PUTATIVE ADENOSINE
KINASE)		 4akr F-ACTIN-CAPPING
PROTEIN SUBUNIT
ALPHA
(Dictyostelium
discoideum) 		4 / 5 LEU A  16
ALA A  18
THR A  47
PHE A  23
 None
 1.32A 3vasB-4akrA:
undetectable		 3vasB-4akrA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4akr F-ACTIN-CAPPING
PROTEIN SUBUNIT
ALPHA
(Dictyostelium
discoideum) 		3 / 3 LEU A  34
PRO A  35
LEU A  39
 None
 0.46A 3w1wB-4akrA:
undetectable		 3w1wB-4akrA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1479_0
(MJ0495-LIKE PROTEIN)		 4akr F-ACTIN-CAPPING
PROTEIN SUBUNIT
ALPHA
(Dictyostelium
discoideum) 		4 / 5 THR A 140
ILE A 111
GLU A 112
PHE A 175
 None
 1.31A 4ac9C-4akrA:
undetectable		 4ac9C-4akrA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DTZ_A_LDPA501_1
(CYTOCHROME P450 BM3
VARIANT 8C8)		 4akr F-ACTIN-CAPPING
PROTEIN SUBUNIT
ALPHA
(Dictyostelium
discoideum) 		4 / 6 ALA A  11
ALA A  44
LEU A  15
THR A  47
 None
 1.02A 4dtzA-4akrA:
undetectable		 4dtzA-4akrA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AOX_C_ACTC1001_0
(ALU JO CONSENSUS RNA
SIGNAL RECOGNITION
PARTICLE 14 KDA
PROTEIN)		 4akr F-ACTIN-CAPPING
PROTEIN SUBUNIT
ALPHA
(Dictyostelium
discoideum) 		3 / 3 TYR A 138
THR A 140
THR A 149
 None
 0.73A 5aoxB-4akrA:
1.7		 5aoxB-4akrA:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AOX_F_ACTF1001_0
(ALU JO CONSENSUS RNA
SIGNAL RECOGNITION
PARTICLE 14 KDA
PROTEIN)		 4akr F-ACTIN-CAPPING
PROTEIN SUBUNIT
ALPHA
(Dictyostelium
discoideum) 		3 / 3 TYR A 138
THR A 140
THR A 149
 None
 0.81A 5aoxE-4akrA:
1.7		 5aoxE-4akrA:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CZY_A_SAMA603_0
(LEGIONELLA EFFECTOR
LEGAS4)		 4akr F-ACTIN-CAPPING
PROTEIN SUBUNIT BETA
(Dictyostelium
discoideum) 		5 / 12 GLY B 114
SER B 153
PHE B 104
GLU B 223
TYR B 107
 None
 0.95A 5czyA-4akrB:
undetectable		 5czyA-4akrB:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CZY_A_SAMA603_0
(LEGIONELLA EFFECTOR
LEGAS4)		 4akr F-ACTIN-CAPPING
PROTEIN SUBUNIT BETA
(Dictyostelium
discoideum) 		5 / 12 GLY B 115
SER B 153
PHE B 104
GLU B 223
TYR B 107
 None
 1.07A 5czyA-4akrB:
undetectable		 5czyA-4akrB:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ENT_C_MIYC901_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT
ACRB,MULTIDRUG
EFFLUX PUMP SUBUNIT
ACRB)		 4akr F-ACTIN-CAPPING
PROTEIN SUBUNIT
ALPHA
F-ACTIN-CAPPING
PROTEIN SUBUNIT BETA
(Dictyostelium
discoideum) 		5 / 9 PHE A 251
GLY A 247
SER A 244
ASN A 242
ILE B 179
 None
 1.42A 5entC-4akrA:
undetectable		 5entC-4akrA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5PBE_A_TYLA2001_1
(BROMODOMAIN ADJACENT
TO ZINC FINGER
DOMAIN PROTEIN 2B)		 4akr F-ACTIN-CAPPING
PROTEIN SUBUNIT BETA
(Dictyostelium
discoideum) 		4 / 6 VAL B 159
VAL B 157
TYR B 169
ILE B  96
 None
 0.94A 5pbeA-4akrB:
undetectable		 5pbeA-4akrB:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V0V_A_8QPA612_1
(SERUM ALBUMIN)		 4akr F-ACTIN-CAPPING
PROTEIN SUBUNIT
ALPHA
F-ACTIN-CAPPING
PROTEIN SUBUNIT BETA
(Dictyostelium
discoideum) 		5 / 12 LEU B  16
LEU B  12
LEU B  28
ILE A  10
ALA A  11
 None
 0.99A 5v0vA-4akrB:
undetectable		 5v0vA-4akrB:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JNH_A_ASCA202_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 4akr F-ACTIN-CAPPING
PROTEIN SUBUNIT
ALPHA
F-ACTIN-CAPPING
PROTEIN SUBUNIT BETA
(Dictyostelium
discoideum;
Dictyostelium
discoideum) 		3 / 3 ASN A 199
PRO B  18
GLN B  20
 None
 0.91A 6jnhA-4akrA:
undetectable		 6jnhA-4akrA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JOG_A_ASCA202_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 4akr F-ACTIN-CAPPING
PROTEIN SUBUNIT
ALPHA
F-ACTIN-CAPPING
PROTEIN SUBUNIT BETA
(Dictyostelium
discoideum;
Dictyostelium
discoideum) 		3 / 3 ASN A 199
PRO B  18
GLN B  20
 None
 0.93A 6jogA-4akrA:
undetectable		 6jogA-4akrA:
19.79