SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4akv'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XRH_A_NIOA200_1
(PROTEIN HP0721)		 4akv SORTING NEXIN-33
(Homo
sapiens) 		4 / 7 GLY A 524
ILE A 364
GLN A 369
MET A 216
 None
 0.79A 2xrhA-4akvA:
undetectable		 2xrhA-4akvA:
14.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZV_B_ECNB411_1
(FLAVOHEMOGLOBIN)		 4akv SORTING NEXIN-33
(Homo
sapiens) 		5 / 9 ILE A 486
ILE A 485
PHE A 482
ALA A 526
LEU A 527
 None
 0.89A 3ozvB-4akvA:
undetectable		 3ozvB-4akvA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G0U_B_ASWB1301_1
(DNA TOPOISOMERASE
2-BETA)		 4akv SORTING NEXIN-33
(Homo
sapiens) 		4 / 7 ILE A 364
PRO A 365
GLY A 217
GLN A 536
 None
 0.97A 4g0uB-4akvA:
undetectable		 4g0uB-4akvA:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G0U_B_ASWB1301_1
(DNA TOPOISOMERASE
2-BETA)		 4akv SORTING NEXIN-33
(Homo
sapiens) 		4 / 7 ILE A 364
PRO A 365
GLY A 220
GLN A 536
 None
 0.94A 4g0uB-4akvA:
undetectable		 4g0uB-4akvA:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QTU_D_SAMD301_1
(PUTATIVE
METHYLTRANSFERASE
BUD23)		 4akv SORTING NEXIN-33
(Homo
sapiens) 		4 / 5 GLN A 476
LEU A 479
SER A 480
ASP A 271
 None
 1.25A 4qtuD-4akvA:
undetectable		 4qtuD-4akvA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YV5_B_SVRB207_2
(BASIC PHOSPHOLIPASE
A2 HOMOLOG 2)		 4akv SORTING NEXIN-33
(Homo
sapiens) 		4 / 7 LYS A 280
TYR A 274
LEU A 273
PHE A 332
 None
 1.22A 4yv5B-4akvA:
undetectable		 4yv5B-4akvA:
15.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KLA_A_ACTA1505_0
(MATERNAL PROTEIN
PUMILIO)		 4akv SORTING NEXIN-33
(Homo
sapiens) 		3 / 3 HIS A 406
LYS A 405
PHE A 410
 None
 0.61A 5klaA-4akvA:
undetectable		 5klaA-4akvA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYJ_A_NIZA810_1
(CATALASE-PEROXIDASE)		 4akv SORTING NEXIN-33
(Homo
sapiens) 		4 / 6 ARG A 537
HIS A 533
LEU A 323
PRO A 287
 None
 1.31A 5syjA-4akvA:
undetectable		 5syjA-4akvA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYJ_B_NIZB810_1
(CATALASE-PEROXIDASE)		 4akv SORTING NEXIN-33
(Homo
sapiens) 		4 / 6 ARG A 537
HIS A 533
LEU A 323
PRO A 287
 None
 1.31A 5syjB-4akvA:
undetectable		 5syjB-4akvA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC3_A_486A801_2
(GLUCOCORTICOID
RECEPTOR)		 4akv SORTING NEXIN-33
(Homo
sapiens) 		4 / 5 LEU A 469
LEU A 465
MET A 545
GLN A 476
 None
 1.40A 5uc3A-4akvA:
undetectable		 5uc3A-4akvA:
12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXC_A_ZITA306_1
(PREDICTED
AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 4akv SORTING NEXIN-33
(Homo
sapiens) 		4 / 7 THR A 380
ARG A 377
LEU A 527
SER A 285
 None
 1.07A 5uxcA-4akvA:
4.3		 5uxcA-4akvA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_B_AQ4B602_1
(CYTOCHROME P450 1A1)		 4akv SORTING NEXIN-33
(Homo
sapiens) 		4 / 7 ASN A 481
GLY A 355
ALA A 356
LEU A 488
 None
 0.80A 6dwnB-4akvA:
undetectable		 6dwnB-4akvA:
12.57