SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4akx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_A_RALA600_1
(ESTROGEN RECEPTOR)		 4akx EXOU
(Pseudomonas
aeruginosa) 		5 / 12 THR B 231
ALA B 234
LEU B 236
MET B 138
LEU B 269
 None
 1.14A 1errA-4akxB:
undetectable		 1errA-4akxB:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G50_B_ESTB1600_1
(ESTROGEN RECEPTOR)		 4akx EXOU
(Pseudomonas
aeruginosa) 		5 / 12 LEU B 328
GLU B 291
ILE B 202
GLY B 203
LEU B 208
 None
 1.15A 1g50B-4akxB:
undetectable		 1g50B-4akxB:
17.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G50_C_ESTC2600_1
(ESTROGEN RECEPTOR)		 4akx EXOU
(Pseudomonas
aeruginosa) 		5 / 11 LEU B 328
GLU B 291
ILE B 202
GLY B 203
LEU B 208
 None
 1.15A 1g50C-4akxB:
undetectable		 1g50C-4akxB:
17.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H7X_A_URFA1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)		 4akx EXOU
(Pseudomonas
aeruginosa) 		4 / 6 ASN B 360
ASN B 371
SER B 106
ASN B 369
 None
 1.16A 1h7xA-4akxB:
2.3		 1h7xA-4akxB:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H7X_B_URFB1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)		 4akx EXOU
(Pseudomonas
aeruginosa) 		4 / 6 ASN B 360
ASN B 371
SER B 106
ASN B 369
 None
 1.16A 1h7xB-4akxB:
undetectable		 1h7xB-4akxB:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H7X_C_URFC1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)		 4akx EXOU
(Pseudomonas
aeruginosa) 		4 / 6 ASN B 360
ASN B 371
SER B 106
ASN B 369
 None
 1.15A 1h7xC-4akxB:
undetectable		 1h7xC-4akxB:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H7X_D_URFD1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)		 4akx EXOU
(Pseudomonas
aeruginosa) 		4 / 6 ASN B 360
ASN B 371
SER B 106
ASN B 369
 None
 1.15A 1h7xD-4akxB:
2.2		 1h7xD-4akxB:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IT4_A_PPFA500_1
(CARBONIC ANHYDRASE 1)		 4akx EXOU
(Pseudomonas
aeruginosa) 		4 / 8 HIS B 242
ALA B 246
VAL B 245
LEU B 272
 None
 0.86A 2it4A-4akxB:
undetectable		 2it4A-4akxB:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KUG_A_HLTA149_1
(CALMODULIN)		 4akx EXOU
(Pseudomonas
aeruginosa) 		4 / 5 MET B 123
LEU B 126
MET B 138
LYS B 280
 None
 1.40A 2kugA-4akxB:
undetectable		 2kugA-4akxB:
7.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A35_B_RBFB191_1
(LUMAZINE PROTEIN)		 4akx EXOU
(Pseudomonas
aeruginosa) 		5 / 12 SER B 206
LEU B 209
GLN B 295
ALA B 288
THR B 287
 None
 1.21A 3a35B-4akxB:
undetectable		 3a35B-4akxB:
15.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_C_DHIC8_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 4akx SPCU
EXOU
(Pseudomonas
aeruginosa;
Pseudomonas
aeruginosa) 		3 / 3 SER A  15
GLY B  69
GLY B  71
 None
 0.56A 3bogA-4akxA:
undetectable
3bogC-4akxA:
undetectable		 3bogA-4akxA:
undetectable
3bogC-4akxA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ERD_A_DESA600_1
(ESTROGEN RECEPTOR
ALPHA)		 4akx EXOU
(Pseudomonas
aeruginosa) 		5 / 12 ALA B 122
LEU B 109
LEU B 374
LEU B 151
MET B 155
 None
 0.99A 3erdA-4akxB:
undetectable		 3erdA-4akxB:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ERD_B_DESB800_1
(ESTROGEN RECEPTOR
ALPHA)		 4akx EXOU
(Pseudomonas
aeruginosa) 		5 / 10 ALA B 122
LEU B 109
LEU B 374
LEU B 151
MET B 155
 None
 1.01A 3erdB-4akxB:
undetectable		 3erdB-4akxB:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OT2_A_NPSA602_1
(SERUM ALBUMIN)		 4akx EXOU
(Pseudomonas
aeruginosa) 		4 / 6 ARG B 515
ALA B 514
ASP B 490
LEU B 561
 None
 0.98A 4ot2A-4akxB:
2.7		 4ot2A-4akxB:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PBH_A_BEZA401_0
(TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT, PUTATIVE)		 4akx EXOU
(Pseudomonas
aeruginosa) 		5 / 12 ILE B 503
THR B 504
THR B  77
LEU B 485
LEU B 493
 None
 1.24A 4pbhA-4akxB:
undetectable		 4pbhA-4akxB:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_C_29SC601_2
(ESTROGEN RECEPTOR)		 4akx EXOU
(Pseudomonas
aeruginosa) 		4 / 6 LEU B 269
ASP B 306
GLU B 308
ILE B 239
 None
 1.07A 4xi3C-4akxB:
undetectable		 4xi3C-4akxB:
16.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_D_29SD601_1
(ESTROGEN RECEPTOR)		 4akx EXOU
(Pseudomonas
aeruginosa) 		5 / 12 THR B 231
ALA B 234
LEU B 236
MET B 138
LEU B 269
 None
 1.14A 4xi3D-4akxB:
undetectable		 4xi3D-4akxB:
16.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZN7_B_DESB600_1
(ESTROGEN RECEPTOR)		 4akx EXOU
(Pseudomonas
aeruginosa) 		5 / 11 ALA B 122
LEU B 109
LEU B 374
LEU B 151
MET B 155
 None
 1.02A 4zn7B-4akxB:
undetectable		 4zn7B-4akxB:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NFP_A_8W5A804_2
(GLUCOCORTICOID
RECEPTOR)		 4akx EXOU
(Pseudomonas
aeruginosa) 		4 / 4 LEU B 372
MET B 123
ILE B 357
LEU B 109
 None
 1.39A 5nfpA-4akxB:
undetectable		 5nfpA-4akxB:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUI_B_CTCB405_0
(TETRACYCLINE
DESTRUCTASE TET(50))		 4akx EXOU
(Pseudomonas
aeruginosa) 		5 / 12 GLY B 321
GLY B 113
GLY B 286
PHE B 299
ILE B 315
 None
 1.01A 5tuiB-4akxB:
undetectable		 5tuiB-4akxB:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F88_A_STRA502_1
(CYTOCHROME P450
CYP260A1)		 4akx SPCU
(Pseudomonas
aeruginosa) 		4 / 6 PHE A  42
LEU A 100
ALA A  90
ASN A  17
 None
 1.01A 6f88A-4akxA:
undetectable		 6f88A-4akxA:
23.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_G_ZOLG401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 4akx SPCU
(Pseudomonas
aeruginosa) 		4 / 7 ASP A  98
ASP A  96
ARG A 102
GLN A   8
 None
 1.42A 6g31G-4akxA:
undetectable		 6g31G-4akxA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_L_ZOLL401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 4akx SPCU
(Pseudomonas
aeruginosa) 		4 / 6 ASP A  98
ASP A  96
ARG A 102
GLN A   8
 None
 1.48A 6g31L-4akxA:
undetectable		 6g31L-4akxA:
20.69