SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4akz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DVX_B_DIFB125_2
(TRANSTHYRETIN)		 4akz TYPE IV SECRETION
SYSTEM PROTEIN VIRB8
(Brucella
suis) 		4 / 7 ALA A 181
SER A 162
THR A 164
VAL A 166
 None
 0.93A 1dvxB-4akzA:
undetectable		 1dvxB-4akzA:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T03_P_TFOP822_1
(POL POLYPROTEIN
SYNTHETIC
OLIGONUCLEOTIDE
PRIMER)		 4akz TYPE IV SECRETION
SYSTEM PROTEIN VIRB8
(Brucella
suis) 		4 / 7 TYR A  98
MET A 102
ASP A 103
ASP A  99
 None
 1.11A 1t03A-4akzA:
undetectable		 1t03A-4akzA:
13.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AJV_L_COCL501_1
(ANTIBODY 7A1 FAB')		 4akz TYPE IV SECRETION
SYSTEM PROTEIN VIRB8
(Brucella
suis) 		4 / 7 ALA A 113
TYR A 110
ARG A 114
TYR A 126
 None
 1.01A 2ajvH-4akzA:
undetectable
2ajvL-4akzA:
undetectable		 2ajvH-4akzA:
21.82
2ajvL-4akzA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D2T_B_1FLB500_1
(TRANSTHYRETIN)		 4akz TYPE IV SECRETION
SYSTEM PROTEIN VIRB8
(Brucella
suis) 		4 / 6 ALA A 181
SER A 162
THR A 164
VAL A 166
 None
 0.97A 3d2tB-4akzA:
undetectable		 3d2tB-4akzA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZK_B_T44B128_1
(TRANSTHYRETIN)		 4akz TYPE IV SECRETION
SYSTEM PROTEIN VIRB8
(Brucella
suis) 		4 / 7 ALA A 181
SER A 162
THR A 164
VAL A 166
 None
 0.74A 3ozkB-4akzA:
undetectable		 3ozkB-4akzA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QXY_A_SAMA6734_0
(N-LYSINE
METHYLTRANSFERASE
SETD6)		 4akz TYPE IV SECRETION
SYSTEM PROTEIN VIRB8
(Brucella
suis) 		5 / 12 VAL A 163
TYR A 117
TYR A 141
TYR A 229
TYR A 110
 None
 1.13A 3qxyA-4akzA:
undetectable		 3qxyA-4akzA:
14.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QXY_B_SAMB6735_0
(N-LYSINE
METHYLTRANSFERASE
SETD6
TRANSCRIPTION FACTOR
P65)		 4akz TYPE IV SECRETION
SYSTEM PROTEIN VIRB8
(Brucella
suis) 		5 / 11 VAL A 163
TYR A 117
TYR A 141
TYR A 229
TYR A 110
 None
 1.12A 3qxyB-4akzA:
undetectable
3qxyQ-4akzA:
undetectable		 3qxyB-4akzA:
14.80
3qxyQ-4akzA:
8.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RC0_A_SAMA484_0
(N-LYSINE
METHYLTRANSFERASE
SETD6)		 4akz TYPE IV SECRETION
SYSTEM PROTEIN VIRB8
(Brucella
suis) 		5 / 11 VAL A 163
TYR A 117
TYR A 141
TYR A 229
TYR A 110
 None
 1.16A 3rc0A-4akzA:
undetectable		 3rc0A-4akzA:
14.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RC0_B_SAMB480_0
(N-LYSINE
METHYLTRANSFERASE
SETD6)		 4akz TYPE IV SECRETION
SYSTEM PROTEIN VIRB8
(Brucella
suis) 		5 / 12 VAL A 163
TYR A 117
TYR A 141
TYR A 229
TYR A 110
 None
 1.15A 3rc0B-4akzA:
undetectable		 3rc0B-4akzA:
14.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VT7_A_VDXA500_2
(VITAMIN D3 RECEPTOR)		 4akz TYPE IV SECRETION
SYSTEM PROTEIN VIRB8
(Brucella
suis) 		4 / 4 LEU A 132
ILE A 165
TYR A 229
TYR A 105
 None
 1.10A 3vt7A-4akzA:
undetectable		 3vt7A-4akzA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HXY_B_ACAB502_1
(PLM1)		 4akz TYPE IV SECRETION
SYSTEM PROTEIN VIRB8
(Brucella
suis) 		4 / 7 GLN A 144
TYR A 141
LEU A 122
ASP A 152
 None
 1.00A 4hxyB-4akzA:
undetectable		 4hxyB-4akzA:
12.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IK7_B_IMNB201_1
(TRANSTHYRETIN)		 4akz TYPE IV SECRETION
SYSTEM PROTEIN VIRB8
(Brucella
suis) 		4 / 8 ALA A 181
SER A 162
THR A 164
VAL A 166
 None
 0.82A 4ik7B-4akzA:
undetectable		 4ik7B-4akzA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B2S_A_ACTA107_0
(CRISPR-ASSOCIATED
ENDONUCLEASE CAS9
GUIDE RNA)		 4akz TYPE IV SECRETION
SYSTEM PROTEIN VIRB8
(Brucella
suis) 		3 / 3 VAL A 159
THR A 184
ARG A 186
 None
 0.75A 5b2sB-4akzA:
undetectable		 5b2sB-4akzA:
8.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B2T_A_ACTA108_0
(CRISPR-ASSOCIATED
ENDONUCLEASE CAS9
GUIDE RNA)		 4akz TYPE IV SECRETION
SYSTEM PROTEIN VIRB8
(Brucella
suis) 		3 / 3 VAL A 159
THR A 184
ARG A 186
 None
 0.76A 5b2tB-4akzA:
undetectable		 5b2tB-4akzA:
8.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BZO_C_FI8C1201_0
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 4akz TYPE IV SECRETION
SYSTEM PROTEIN VIRB8
(Brucella
suis) 		5 / 12 ILE A 165
THR A 164
THR A 161
VAL A 159
GLU A 234
 None
 1.30A 6bzoC-4akzA:
1.9		 6bzoC-4akzA:
8.12