SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ala'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1USQ_A_CLMA1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 4ala FAB 2H12 HEAVY CHAIN
(Mus
musculus) 		4 / 7 GLY H  54
PRO H  53
ILE H  51
GLY H  56
 None
 0.78A 1usqA-4alaH:
undetectable		 1usqA-4alaH:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1USQ_B_CLMB1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 4ala FAB 2H12 HEAVY CHAIN
(Mus
musculus) 		4 / 6 GLY H  54
PRO H  53
ILE H  51
GLY H  56
 None
 0.79A 1usqB-4alaH:
undetectable		 1usqB-4alaH:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1USQ_C_CLMC1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 4ala FAB 2H12 HEAVY CHAIN
(Mus
musculus) 		4 / 6 GLY H  54
PRO H  53
ILE H  51
GLY H  56
 None
 0.79A 1usqC-4alaH:
undetectable		 1usqC-4alaH:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1USQ_D_CLMD1142_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 4ala FAB 2H12 HEAVY CHAIN
(Mus
musculus) 		4 / 6 GLY H  54
PRO H  53
ILE H  51
GLY H  56
 None
 0.79A 1usqD-4alaH:
2.3		 1usqD-4alaH:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1USQ_E_CLME1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 4ala FAB 2H12 HEAVY CHAIN
(Mus
musculus) 		4 / 6 GLY H  54
PRO H  53
ILE H  51
GLY H  56
 None
 0.81A 1usqE-4alaH:
undetectable		 1usqE-4alaH:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1USQ_F_CLMF1144_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 4ala FAB 2H12 HEAVY CHAIN
(Mus
musculus) 		4 / 7 GLY H  54
PRO H  53
ILE H  51
GLY H  56
 None
 0.78A 1usqF-4alaH:
2.3		 1usqF-4alaH:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IEO_A_017A402_2
(PROTEASE)		 4ala FAB 2H12 HEAVY CHAIN
(Mus
musculus) 		5 / 12 LEU H 142
VAL H 167
GLY H 161
VAL H 187
VAL H 185
 None
 0.93A 2ieoB-4alaH:
undetectable		 2ieoB-4alaH:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_A_CLMA1141_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 4ala FAB 2H12 HEAVY CHAIN
(Mus
musculus) 		4 / 6 GLY H  54
PRO H  53
ILE H  51
GLY H  56
 None
 0.85A 2jkjA-4alaH:
2.3		 2jkjA-4alaH:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_B_CLMB1141_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 4ala FAB 2H12 HEAVY CHAIN
(Mus
musculus) 		4 / 6 GLY H  54
PRO H  53
ILE H  51
GLY H  56
 None
 0.85A 2jkjB-4alaH:
2.3		 2jkjB-4alaH:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_C_CLMC1141_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 4ala FAB 2H12 HEAVY CHAIN
(Mus
musculus) 		4 / 6 GLY H  54
PRO H  53
ILE H  51
GLY H  56
 None
 0.85A 2jkjC-4alaH:
2.2		 2jkjC-4alaH:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_E_CLME1141_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 4ala FAB 2H12 HEAVY CHAIN
(Mus
musculus) 		4 / 7 GLY H  54
PRO H  53
ILE H  51
GLY H  56
 None
 0.85A 2jkjE-4alaH:
2.1		 2jkjE-4alaH:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKL_A_CLMA1144_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 4ala FAB 2H12 HEAVY CHAIN
(Mus
musculus) 		4 / 7 GLY H  54
PRO H  53
ILE H  51
GLY H  56
 None
 0.81A 2jklA-4alaH:
2.3		 2jklA-4alaH:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKL_B_CLMB1144_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 4ala FAB 2H12 HEAVY CHAIN
(Mus
musculus) 		4 / 6 GLY H  54
PRO H  53
ILE H  51
GLY H  56
 None
 0.82A 2jklB-4alaH:
2.3		 2jklB-4alaH:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKL_C_CLMC1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 4ala FAB 2H12 HEAVY CHAIN
(Mus
musculus) 		4 / 7 GLY H  54
PRO H  53
ILE H  51
GLY H  56
 None
 0.81A 2jklC-4alaH:
2.2		 2jklC-4alaH:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKL_D_CLMD1145_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 4ala FAB 2H12 HEAVY CHAIN
(Mus
musculus) 		4 / 7 GLY H  54
PRO H  53
ILE H  51
GLY H  56
 None
 0.82A 2jklD-4alaH:
2.3		 2jklD-4alaH:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKL_E_CLME1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 4ala FAB 2H12 HEAVY CHAIN
(Mus
musculus) 		4 / 7 GLY H  54
PRO H  53
ILE H  51
GLY H  56
 None
 0.83A 2jklE-4alaH:
2.2		 2jklE-4alaH:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKL_F_CLMF1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 4ala FAB 2H12 HEAVY CHAIN
(Mus
musculus) 		4 / 7 GLY H  54
PRO H  53
ILE H  51
GLY H  56
 None
 0.83A 2jklF-4alaH:
2.3		 2jklF-4alaH:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNP_A_ROCA401_2
(PROTEASE)		 4ala FAB 2H12 HEAVY CHAIN
(Mus
musculus) 		5 / 11 LEU H 142
VAL H 167
GLY H 161
VAL H 187
VAL H 185
 None
 1.04A 2nnpB-4alaH:
undetectable		 2nnpB-4alaH:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z71_C_PNVC904_1
(PENICILLIN ACYLASE)		 4ala FAB 2H12 HEAVY CHAIN
(Mus
musculus) 		5 / 10 GLY H 100
THR H  97
ASN H  35
GLU H  37
ASP H 105
 None
 1.49A 2z71A-4alaH:
0.0
2z71C-4alaH:
0.0		 2z71A-4alaH:
22.02
2z71C-4alaH:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU9_A_478A401_2
(PROTEASE)		 4ala FAB 2H12 HEAVY CHAIN
(Mus
musculus) 		5 / 10 LEU H 142
VAL H 167
GLY H 161
VAL H 187
VAL H 185
 None
 1.14A 3nu9B-4alaH:
undetectable		 3nu9B-4alaH:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SNF_A_ACTA110_0
(PROTEIN P-30)		 4ala FAB 2H12 HEAVY CHAIN
(Mus
musculus) 		4 / 5 ILE H  72
THR H  74
SER H  76
PHE H  29
 None
 1.16A 3snfA-4alaH:
undetectable		 3snfA-4alaH:
19.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4M7K_H_ACTH302_0
(10H10 HEAVY CHAIN)		 4ala FAB 2H12 HEAVY CHAIN
(Mus
musculus) 		4 / 5 VAL H   2
TYR H  27
ARG H  98
TYR H 106
 None
 0.28A 4m7kH-4alaH:
24.9		 4m7kH-4alaH:
66.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJ8_A_SPMA201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 4ala FAB 2H12 HEAVY CHAIN
(Mus
musculus) 		4 / 8 MET H  20
GLU H   6
GLU H  37
TYR H  32
 None
 1.05A 4mj8A-4alaH:
undetectable
4mj8C-4alaH:
undetectable		 4mj8A-4alaH:
19.56
4mj8C-4alaH:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UMD_A_YMZA3801_1
(60S RIBOSOMAL
PROTEIN L28
28S RIBOSOMAL RNA
60S RIBOSOMAL
PROTEIN L4)		 4ala FAB 2H12 HEAVY CHAIN
(Mus
musculus) 		4 / 6 ASN H  77
ALA H  24
PRO H  53
TYR H  27
 None
 1.04A 5umd2-4alaH:
undetectable
5umdF-4alaH:
undetectable		 5umd2-4alaH:
20.65
5umdF-4alaH:
16.49