SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4alz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AI9_X_SAMX501_0
(UPF0217 PROTEIN
MJ1640)		 4alz YOP PROTEINS
TRANSLOCATION
PROTEIN D
(Yersinia
enterocolitica) 		5 / 9 LEU A 202
ILE A 207
GLY A 206
LEU A 198
SER A 197
 None
 0.99A 3ai9X-4alzA:
undetectable		 3ai9X-4alzA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DCJ_B_THHB401_0
(PROBABLE
5'-PHOSPHORIBOSYLGLY
CINAMIDE
FORMYLTRANSFERASE
PURN)		 4alz YOP PROTEINS
TRANSLOCATION
PROTEIN D
(Yersinia
enterocolitica) 		4 / 8 LEU A 265
LEU A 272
ASN A 277
VAL A 275
 None
 0.72A 3dcjB-4alzA:
undetectable		 3dcjB-4alzA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_G_IPHG101_0
(INSULIN)		 4alz YOP PROTEINS
TRANSLOCATION
PROTEIN D
(Yersinia
enterocolitica) 		5 / 11 LEU A 246
VAL A 279
LEU A 265
LEU A 227
ALA A 223
 None
 1.11A 4p65B-4alzA:
undetectable
4p65D-4alzA:
undetectable
4p65G-4alzA:
undetectable
4p65H-4alzA:
undetectable		 4p65B-4alzA:
10.36
4p65D-4alzA:
10.36
4p65G-4alzA:
6.15
4p65H-4alzA:
10.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L6E_B_ACTB401_0
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT
N6-ADENOSINE-METHYLT
RANSFERASE SUBUNIT
METTL14)		 4alz YOP PROTEINS
TRANSLOCATION
PROTEIN D
(Yersinia
enterocolitica) 		4 / 6 GLU A 159
LEU A 163
ARG A 162
ARG A 161
 None
 1.21A 5l6eA-4alzA:
undetectable
5l6eB-4alzA:
undetectable		 5l6eA-4alzA:
24.21
5l6eB-4alzA:
24.15