SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4am2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6K_A_ACTA860_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 4am2 BACTERIOFERRITIN
(Blastochloris
viridis) 		4 / 6 GLY A 112
VAL A   7
ALA A 108
SER A 110
 None
 0.98A 1p6kA-4am2A:
undetectable		 1p6kA-4am2A:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P7L_C_SAMC685_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 4am2 BACTERIOFERRITIN
(Blastochloris
viridis) 		4 / 8 ALA A  97
GLU A 127
ASP A 132
ILE A 131
 None
FE  A1161 ( 2.6A)
None
None
 0.86A 1p7lD-4am2A:
undetectable		 1p7lD-4am2A:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P7L_C_SAMC885_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 4am2 BACTERIOFERRITIN
(Blastochloris
viridis) 		4 / 8 ALA A  97
GLU A 127
ASP A 132
ILE A 131
 None
FE  A1161 ( 2.6A)
None
None
 0.88A 1p7lC-4am2A:
undetectable		 1p7lC-4am2A:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_A_SAMA385_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 4am2 BACTERIOFERRITIN
(Blastochloris
viridis) 		4 / 8 ALA A  97
GLU A 127
ASP A 132
ILE A 131
 None
FE  A1161 ( 2.6A)
None
None
 0.86A 1rg9B-4am2A:
undetectable		 1rg9B-4am2A:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_B_SAMB485_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 4am2 BACTERIOFERRITIN
(Blastochloris
viridis) 		4 / 8 ALA A  97
GLU A 127
ASP A 132
ILE A 131
 None
FE  A1161 ( 2.6A)
None
None
 0.86A 1rg9A-4am2A:
undetectable		 1rg9A-4am2A:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_C_SAMC585_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 4am2 BACTERIOFERRITIN
(Blastochloris
viridis) 		4 / 8 ALA A  97
GLU A 127
ASP A 132
ILE A 131
 None
FE  A1161 ( 2.6A)
None
None
 0.86A 1rg9D-4am2A:
undetectable		 1rg9D-4am2A:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_C_SAMC685_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 4am2 BACTERIOFERRITIN
(Blastochloris
viridis) 		4 / 8 ALA A  97
GLU A 127
ASP A 132
ILE A 131
 None
FE  A1161 ( 2.6A)
None
None
 0.87A 1rg9C-4am2A:
undetectable		 1rg9C-4am2A:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_B_TFPB202_1
(PROTEIN S100-A4)		 4am2 BACTERIOFERRITIN
(Blastochloris
viridis) 		3 / 3 GLU A 135
LEU A 138
ASP A 139
 None
 0.43A 3ko0A-4am2A:
undetectable		 3ko0A-4am2A:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_S_TFPS202_2
(PROTEIN S100-A4)		 4am2 BACTERIOFERRITIN
(Blastochloris
viridis) 		3 / 3 GLU A 135
LEU A 138
ASP A 139
 None
 0.29A 3ko0T-4am2A:
undetectable		 3ko0T-4am2A:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9T_C_BEZC264_0
(ECHA1_1)		 4am2 BACTERIOFERRITIN
(Blastochloris
viridis) 		4 / 5 ALA A  93
GLU A  51
GLU A 127
ALA A  21
 None
FE  A1161 ( 2.4A)
FE  A1161 ( 2.6A)
None
 1.38A 3r9tC-4am2A:
undetectable		 3r9tC-4am2A:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KTT_A_SAMA405_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 4am2 BACTERIOFERRITIN
(Blastochloris
viridis) 		4 / 8 ALA A  97
GLU A 127
ASP A 132
ILE A 131
 None
FE  A1161 ( 2.6A)
None
None
 0.85A 4kttB-4am2A:
undetectable		 4kttB-4am2A:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KTT_C_SAMC404_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 4am2 BACTERIOFERRITIN
(Blastochloris
viridis) 		4 / 8 ALA A  97
GLU A 127
ASP A 132
ILE A 131
 None
FE  A1161 ( 2.6A)
None
None
 0.89A 4kttD-4am2A:
undetectable		 4kttD-4am2A:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NDN_A_SAMA407_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 4am2 BACTERIOFERRITIN
(Blastochloris
viridis) 		4 / 8 ALA A  97
GLU A 127
ASP A 132
ILE A 131
 None
FE  A1161 ( 2.6A)
None
None
 0.85A 4ndnB-4am2A:
undetectable		 4ndnB-4am2A:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NDN_C_SAMC405_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 4am2 BACTERIOFERRITIN
(Blastochloris
viridis) 		4 / 8 ALA A  97
GLU A 127
ASP A 132
ILE A 131
 None
FE  A1161 ( 2.6A)
None
None
 0.85A 4ndnD-4am2A:
undetectable		 4ndnD-4am2A:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJO_A_ERYA1101_0
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 4am2 BACTERIOFERRITIN
(Blastochloris
viridis) 		5 / 12 SER A  17
GLU A  51
GLU A 127
GLU A  94
LEU A 134
 None
FE  A1161 ( 2.4A)
FE  A1161 ( 2.6A)
FE  A1162 (-2.0A)
None
 1.49A 4zjoA-4am2A:
1.8		 4zjoA-4am2A:
8.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T8S_B_SAMB402_0
(S-ADENOSYLMETHIONINE
SYNTHASE)		 4am2 BACTERIOFERRITIN
(Blastochloris
viridis) 		4 / 8 ALA A  97
GLU A 127
ASP A 132
ILE A 131
 None
FE  A1161 ( 2.6A)
None
None
 0.93A 5t8sA-4am2A:
undetectable		 5t8sA-4am2A:
16.71