SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4am3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BZF_A_TMQA170_1
(DIHYDROFOLATE
REDUCTASE)
4am3 POLYRIBONUCLEOTIDE
NUCLEOTIDYLTRANSFERA
SE

(Caulobacter
vibrioides)
5 / 12 LEU A 140
ALA A  30
LEU A  41
LEU A  16
ALA A 136
None
1.02A 1bzfA-4am3A:
undetectable
1bzfA-4am3A:
12.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G50_B_ESTB1600_1
(ESTROGEN RECEPTOR)
4am3 POLYRIBONUCLEOTIDE
NUCLEOTIDYLTRANSFERA
SE

(Caulobacter
vibrioides)
5 / 12 LEU A 504
GLU A 199
LEU A 525
ILE A 466
GLY A 531
None
1.25A 1g50B-4am3A:
undetectable
1g50B-4am3A:
15.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G50_C_ESTC2600_1
(ESTROGEN RECEPTOR)
4am3 POLYRIBONUCLEOTIDE
NUCLEOTIDYLTRANSFERA
SE

(Caulobacter
vibrioides)
5 / 11 LEU A 504
GLU A 199
LEU A 525
ILE A 466
GLY A 531
None
1.24A 1g50C-4am3A:
undetectable
1g50C-4am3A:
15.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NHZ_A_486A800_1
(GLUCOCORTICOID
RECEPTOR)
4am3 POLYRIBONUCLEOTIDE
NUCLEOTIDYLTRANSFERA
SE

(Caulobacter
vibrioides)
5 / 12 LEU A 202
GLY A 204
VAL A 154
LEU A 507
MET A 509
None
1.18A 1nhzA-4am3A:
undetectable
1nhzA-4am3A:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVD_A_SAMA501_0
(CATECHOL-O-METHYLTRA
NSFERASE)
4am3 POLYRIBONUCLEOTIDE
NUCLEOTIDYLTRANSFERA
SE

(Caulobacter
vibrioides)
5 / 12 GLY A  29
PHE A  46
VAL A 113
ALA A  42
ALA A 137
None
1.32A 2avdA-4am3A:
undetectable
2avdA-4am3A:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVD_B_SAMB601_0
(CATECHOL-O-METHYLTRA
NSFERASE)
4am3 POLYRIBONUCLEOTIDE
NUCLEOTIDYLTRANSFERA
SE

(Caulobacter
vibrioides)
5 / 12 GLY A  29
PHE A  46
VAL A 113
ALA A  42
ALA A 137
None
1.31A 2avdB-4am3A:
undetectable
2avdB-4am3A:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C12_C_SPMC1434_1
(NITROALKANE OXIDASE)
4am3 POLYRIBONUCLEOTIDE
NUCLEOTIDYLTRANSFERA
SE

(Caulobacter
vibrioides)
5 / 12 LEU A 413
ALA A 343
SER A 431
LEU A 429
VAL A 430
None
1.22A 2c12C-4am3A:
undetectable
2c12C-4am3A:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4P_A_TPVA300_2
(PROTEASE)
4am3 POLYRIBONUCLEOTIDE
NUCLEOTIDYLTRANSFERA
SE

(Caulobacter
vibrioides)
5 / 9 ALA A 610
VAL A 582
ILE A 562
VAL A 577
ILE A 581
None
1.03A 2o4pB-4am3A:
undetectable
2o4pB-4am3A:
10.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B6R_B_CRNB603_1
(CREATINE KINASE
B-TYPE)
4am3 POLYRIBONUCLEOTIDE
NUCLEOTIDYLTRANSFERA
SE

(Caulobacter
vibrioides)
4 / 6 THR A 325
VAL A 326
GLU A 530
SER A 481
None
1.22A 3b6rB-4am3A:
1.6
3b6rB-4am3A:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKV_A_478A200_2
(PROTEASE)
4am3 POLYRIBONUCLEOTIDE
NUCLEOTIDYLTRANSFERA
SE

(Caulobacter
vibrioides)
5 / 9 ALA A 610
VAL A 582
ILE A 562
VAL A 577
ILE A 581
None
1.04A 3ekvB-4am3A:
undetectable
3ekvB-4am3A:
8.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_B_TRPB1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)
4am3 POLYRIBONUCLEOTIDE
NUCLEOTIDYLTRANSFERA
SE

(Caulobacter
vibrioides)
4 / 8 GLY A 586
ILE A 581
VAL A 589
VAL A 599
None
0.80A 3fi0B-4am3A:
undetectable
3fi0B-4am3A:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCP_B_CHDB4_0
(FERROCHELATASE,
MITOCHONDRIAL)
4am3 POLYRIBONUCLEOTIDE
NUCLEOTIDYLTRANSFERA
SE

(Caulobacter
vibrioides)
3 / 3 GLY A 499
PRO A 462
LEU A 536
None
0.63A 3hcpB-4am3A:
undetectable
3hcpB-4am3A:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Z_A_FLPA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)
4am3 POLYRIBONUCLEOTIDE
NUCLEOTIDYLTRANSFERA
SE

(Caulobacter
vibrioides)
6 / 12 VAL A 111
LEU A  59
GLY A  29
ALA A  44
SER A 141
LEU A 138
None
1.36A 3n8zA-4am3A:
3.5
3n8zA-4am3A:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OF4_B_ACTB313_0
(NITROREDUCTASE)
4am3 POLYRIBONUCLEOTIDE
NUCLEOTIDYLTRANSFERA
SE

(Caulobacter
vibrioides)
3 / 3 ALA A 478
VAL A 479
GLN A 527
None
0.54A 3of4B-4am3A:
undetectable
3of4B-4am3A:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_A_FLRA700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)
4am3 POLYRIBONUCLEOTIDE
NUCLEOTIDYLTRANSFERA
SE

(Caulobacter
vibrioides)
6 / 12 VAL A 111
LEU A  59
GLY A  29
ALA A  44
SER A 141
LEU A 138
None
1.38A 3rr3A-4am3A:
undetectable
3rr3A-4am3A:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_B_FLRB700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)
4am3 POLYRIBONUCLEOTIDE
NUCLEOTIDYLTRANSFERA
SE

(Caulobacter
vibrioides)
6 / 12 VAL A 111
LEU A  59
GLY A  29
ALA A  44
SER A 141
LEU A 138
None
1.38A 3rr3B-4am3A:
undetectable
3rr3B-4am3A:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RUN_A_CCSA165_0
(LYSOZYME)
4am3 POLYRIBONUCLEOTIDE
NUCLEOTIDYLTRANSFERA
SE

(Caulobacter
vibrioides)
3 / 3 ASN A 109
ALA A  47
LYS A  48
None
0.96A 3runA-4am3A:
undetectable
3runA-4am3A:
13.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3N_A_MIYA2001_1
(TETX2 PROTEIN)
4am3 POLYRIBONUCLEOTIDE
NUCLEOTIDYLTRANSFERA
SE

(Caulobacter
vibrioides)
5 / 11 GLY A 438
SER A 436
PHE A 384
GLY A 406
ASN A 383
PO4  A1622 (-3.9A)
PO4  A1622 (-3.1A)
None
None
None
1.20A 3v3nA-4am3A:
undetectable
3v3nA-4am3A:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3N_D_MIYD2001_1
(TETX2 PROTEIN)
4am3 POLYRIBONUCLEOTIDE
NUCLEOTIDYLTRANSFERA
SE

(Caulobacter
vibrioides)
5 / 11 GLY A 438
SER A 436
PHE A 384
GLY A 406
ASN A 383
PO4  A1622 (-3.9A)
PO4  A1622 (-3.1A)
None
None
None
1.20A 3v3nD-4am3A:
undetectable
3v3nD-4am3A:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQC_A_017A101_1
(ASPARTYL PROTEASE)
4am3 POLYRIBONUCLEOTIDE
NUCLEOTIDYLTRANSFERA
SE

(Caulobacter
vibrioides)
5 / 10 ALA A 610
VAL A 582
ILE A 562
VAL A 577
ILE A 581
None
1.10A 4dqcA-4am3A:
undetectable
4dqcA-4am3A:
9.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2X_A_TMQA202_1
(DIHYDROFOLATE
REDUCTASE)
4am3 POLYRIBONUCLEOTIDE
NUCLEOTIDYLTRANSFERA
SE

(Caulobacter
vibrioides)
5 / 12 ILE A 216
ASP A 127
ILE A 128
ARG A 153
ILE A 149
None
1.02A 4m2xA-4am3A:
undetectable
4m2xA-4am3A:
12.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2X_E_TMQE202_1
(DIHYDROFOLATE
REDUCTASE)
4am3 POLYRIBONUCLEOTIDE
NUCLEOTIDYLTRANSFERA
SE

(Caulobacter
vibrioides)
5 / 12 ILE A 216
ASP A 127
ILE A 128
ARG A 153
ILE A 149
None
0.98A 4m2xE-4am3A:
undetectable
4m2xE-4am3A:
12.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NQA_A_9CRA501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)
4am3 POLYRIBONUCLEOTIDE
NUCLEOTIDYLTRANSFERA
SE

(Caulobacter
vibrioides)
5 / 11 ILE A 219
GLN A 213
ALA A 183
VAL A  31
LEU A  16
None
1.18A 4nqaA-4am3A:
undetectable
4nqaA-4am3A:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_I_HCYI900_1
(GLUCOCORTICOID
RECEPTOR)
4am3 POLYRIBONUCLEOTIDE
NUCLEOTIDYLTRANSFERA
SE

(Caulobacter
vibrioides)
5 / 12 LEU A 202
ASN A 206
GLY A 204
LEU A 507
MET A 509
None
1.04A 4p6xI-4am3A:
undetectable
4p6xI-4am3A:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QTU_D_SAMD301_1
(PUTATIVE
METHYLTRANSFERASE
BUD23)
4am3 POLYRIBONUCLEOTIDE
NUCLEOTIDYLTRANSFERA
SE

(Caulobacter
vibrioides)
4 / 5 GLN A 508
LEU A 507
SER A 506
ASP A 125
None
1.30A 4qtuD-4am3A:
undetectable
4qtuD-4am3A:
15.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QTU_D_SAMD301_1
(PUTATIVE
METHYLTRANSFERASE
BUD23)
4am3 POLYRIBONUCLEOTIDE
NUCLEOTIDYLTRANSFERA
SE

(Caulobacter
vibrioides)
4 / 5 GLN A 508
LEU A 507
SER A 506
ASP A 176
None
1.09A 4qtuD-4am3A:
undetectable
4qtuD-4am3A:
15.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4I_A_IPHA903_0
(PROTEIN ARGONAUTE-2)
4am3 POLYRIBONUCLEOTIDE
NUCLEOTIDYLTRANSFERA
SE

(Caulobacter
vibrioides)
3 / 3 VAL A 162
ALA A 160
PHE A 207
None
0.87A 4z4iA-4am3A:
undetectable
4z4iA-4am3A:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_G_SAMG301_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)
4am3 POLYRIBONUCLEOTIDE
NUCLEOTIDYLTRANSFERA
SE

(Caulobacter
vibrioides)
5 / 12 GLY A 465
GLY A 537
LEU A 536
ALA A 467
LYS A 496
None
None
None
None
PO4  A1621 (-3.2A)
0.96A 5c0oG-4am3A:
undetectable
5c0oG-4am3A:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EAJ_B_FOLB201_1
(DIHYDROFOLATE
REDUCTASE)
4am3 POLYRIBONUCLEOTIDE
NUCLEOTIDYLTRANSFERA
SE

(Caulobacter
vibrioides)
3 / 3 ASP A 494
ARG A 327
ARG A 317
None
0.91A 5eajB-4am3A:
undetectable
5eajB-4am3A:
12.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGJ_A_CTYA402_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)
4am3 POLYRIBONUCLEOTIDE
NUCLEOTIDYLTRANSFERA
SE

(Caulobacter
vibrioides)
5 / 12 ILE A 193
VAL A 463
GLU A 530
MET A 442
VAL A 445
None
1.00A 5igjA-4am3A:
undetectable
5igjA-4am3A:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JI0_A_9CRA501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)
4am3 POLYRIBONUCLEOTIDE
NUCLEOTIDYLTRANSFERA
SE

(Caulobacter
vibrioides)
5 / 11 ILE A 219
GLN A 213
ALA A 183
VAL A  31
LEU A  16
None
1.14A 5ji0A-4am3A:
undetectable
5ji0A-4am3A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JS1_A_IPHA902_0
(PROTEIN ARGONAUTE-2)
4am3 POLYRIBONUCLEOTIDE
NUCLEOTIDYLTRANSFERA
SE

(Caulobacter
vibrioides)
3 / 3 VAL A 162
ALA A 160
PHE A 207
None
0.90A 5js1A-4am3A:
undetectable
5js1A-4am3A:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JVZ_B_FLPB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)
4am3 POLYRIBONUCLEOTIDE
NUCLEOTIDYLTRANSFERA
SE

(Caulobacter
vibrioides)
6 / 12 VAL A 111
LEU A  59
GLY A  29
ALA A  44
SER A 141
LEU A 138
None
1.41A 5jvzB-4am3A:
undetectable
5jvzB-4am3A:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5Z_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA
TYPE-5,PROTEASOME
SUBUNIT BETA TYPE-5
PROTEASOME SUBUNIT
BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA TYPE-6)
4am3 POLYRIBONUCLEOTIDE
NUCLEOTIDYLTRANSFERA
SE

(Caulobacter
vibrioides)
5 / 9 THR A 116
ALA A  42
THR A  43
ALA A  44
ALA A 137
None
1.07A 5l5zK-4am3A:
undetectable
5l5zL-4am3A:
undetectable
5l5zK-4am3A:
16.47
5l5zL-4am3A:
15.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5Z_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA
TYPE-5,PROTEASOME
SUBUNIT BETA TYPE-5
PROTEASOME SUBUNIT
BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA TYPE-6)
4am3 POLYRIBONUCLEOTIDE
NUCLEOTIDYLTRANSFERA
SE

(Caulobacter
vibrioides)
5 / 9 THR A 116
ALA A  42
THR A  43
ALA A  44
ALA A 137
None
1.07A 5l5zY-4am3A:
undetectable
5l5zZ-4am3A:
undetectable
5l5zY-4am3A:
16.47
5l5zZ-4am3A:
15.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MQT_C_STIC302_1
(DEOXYCYTIDINE KINASE)
4am3 POLYRIBONUCLEOTIDE
NUCLEOTIDYLTRANSFERA
SE

(Caulobacter
vibrioides)
5 / 12 GLU A 192
PRO A 126
ARG A 414
LEU A 167
GLU A  86
None
1.41A 5mqtC-4am3A:
undetectable
5mqtC-4am3A:
15.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_C_CVIC301_1
(REGULATORY PROTEIN
TETR)
4am3 POLYRIBONUCLEOTIDE
NUCLEOTIDYLTRANSFERA
SE

(Caulobacter
vibrioides)
4 / 7 GLN A 213
GLY A 150
ILE A 219
TRP A  11
None
1.16A 5vlmC-4am3A:
2.9
5vlmC-4am3A:
13.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_E_CHDE401_0
(BILE SALT HYDROLASE)
4am3 POLYRIBONUCLEOTIDE
NUCLEOTIDYLTRANSFERA
SE

(Caulobacter
vibrioides)
4 / 8 PHE A 345
LEU A 344
LEU A 450
ALA A 451
None
0.83A 5y7pE-4am3A:
undetectable
5y7pE-4am3A:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_C_EU7C101_0
(MATRIX PROTEIN 2)
4am3 POLYRIBONUCLEOTIDE
NUCLEOTIDYLTRANSFERA
SE

(Caulobacter
vibrioides)
5 / 9 ALA A 134
SER A 135
ALA A  44
SER A 141
GLY A  29
None
1.19A 6bklA-4am3A:
undetectable
6bklB-4am3A:
undetectable
6bklC-4am3A:
undetectable
6bklD-4am3A:
undetectable
6bklA-4am3A:
3.25
6bklB-4am3A:
3.25
6bklC-4am3A:
3.25
6bklD-4am3A:
3.25