SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4am6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A28_A_STRA1_1
(PROGESTERONE
RECEPTOR)		 4am6 ACTIN-LIKE PROTEIN
ARP8
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 536
LEU A 539
GLN A 543
LEU A 609
MET A 330
 None
 1.25A 1a28A-4am6A:
undetectable		 1a28A-4am6A:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A28_B_STRB2_1
(PROGESTERONE
RECEPTOR)		 4am6 ACTIN-LIKE PROTEIN
ARP8
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 536
LEU A 539
GLN A 543
LEU A 609
MET A 330
 None
 1.26A 1a28B-4am6A:
undetectable		 1a28B-4am6A:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EII_A_RTLA135_0
(CELLULAR
RETINOL-BINDING
PROTEIN II)		 4am6 ACTIN-LIKE PROTEIN
ARP8
(Saccharomyces
cerevisiae) 		5 / 12 THR A 717
ALA A 714
ILE A 503
THR A 508
LEU A 526
 None
 1.34A 1eiiA-4am6A:
undetectable		 1eiiA-4am6A:
10.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J3J_A_CP6A609_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4am6 ACTIN-LIKE PROTEIN
ARP8
(Saccharomyces
cerevisiae) 		5 / 10 ILE A 750
SER A 652
ILE A 524
ILE A 707
TYR A 727
 None
 1.22A 1j3jA-4am6A:
undetectable		 1j3jA-4am6A:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R30_B_SAMB501_0
(BIOTIN SYNTHASE)		 4am6 ACTIN-LIKE PROTEIN
ARP8
(Saccharomyces
cerevisiae) 		5 / 12 GLY A 386
HIS A 431
ILE A 271
LEU A 452
VAL A 453
 None
 1.18A 1r30B-4am6A:
undetectable		 1r30B-4am6A:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZU_A_MTLA870_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 4am6 ACTIN-LIKE PROTEIN
ARP8
(Saccharomyces
cerevisiae) 		4 / 8 SER A 307
ASN A 627
ASN A 306
ASP A 303
 None
 1.34A 1zzuA-4am6A:
undetectable		 1zzuA-4am6A:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BL9_A_CP6A1240_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4am6 ACTIN-LIKE PROTEIN
ARP8
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 750
SER A 652
ILE A 524
ILE A 707
TYR A 727
 None
 1.17A 2bl9A-4am6A:
undetectable		 2bl9A-4am6A:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BLA_A_CP6A302_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4am6 ACTIN-LIKE PROTEIN
ARP8
(Saccharomyces
cerevisiae) 		5 / 11 ILE A 750
SER A 652
ILE A 524
ILE A 707
TYR A 727
 None
 1.24A 2blaA-4am6A:
undetectable		 2blaA-4am6A:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2MJI_A_KTRA201_1
(FATTY ACID-BINDING
PROTEIN, INTESTINAL)		 4am6 ACTIN-LIKE PROTEIN
ARP8
(Saccharomyces
cerevisiae) 		5 / 12 MET A 723
TYR A 767
PHE A 763
LEU A 758
TYR A 662
 None
 1.43A 2mjiA-4am6A:
undetectable		 2mjiA-4am6A:
11.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V57_A_PRLA1188_0
(TETR FAMILY
TRANSCRIPTIONAL
REPRESSOR LFRR)		 4am6 ACTIN-LIKE PROTEIN
ARP8
(Saccharomyces
cerevisiae) 		4 / 8 SER A 736
ILE A 533
ASP A 532
ARG A 621
 None
 1.00A 2v57A-4am6A:
undetectable		 2v57A-4am6A:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V57_C_PRLC1187_0
(TETR FAMILY
TRANSCRIPTIONAL
REPRESSOR LFRR)		 4am6 ACTIN-LIKE PROTEIN
ARP8
(Saccharomyces
cerevisiae) 		4 / 8 SER A 736
ILE A 533
ASP A 532
ARG A 621
 None
 1.00A 2v57C-4am6A:
undetectable		 2v57C-4am6A:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_B_DIFB1376_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 4am6 ACTIN-LIKE PROTEIN
ARP8
(Saccharomyces
cerevisiae) 		4 / 7 GLY A 734
ALA A 839
LEU A 840
SER A 737
 None
SO4  A1883 (-3.5A)
None
None
 0.89A 2wekB-4am6A:
undetectable		 2wekB-4am6A:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D90_B_NOGB2001_1
(PROGESTERONE
RECEPTOR)		 4am6 ACTIN-LIKE PROTEIN
ARP8
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 536
LEU A 539
GLN A 543
LEU A 609
MET A 330
 None
 1.21A 3d90B-4am6A:
undetectable		 3d90B-4am6A:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GCL_A_AINA609_1
(LACTOPEROXIDASE)		 4am6 ACTIN-LIKE PROTEIN
ARP8
(Saccharomyces
cerevisiae) 		4 / 6 ARG A 722
PHE A 825
GLN A 765
PRO A 764
 None
 1.35A 3gclA-4am6A:
undetectable		 3gclA-4am6A:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HEG_A_BAXA1_2
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 4am6 ACTIN-LIKE PROTEIN
ARP8
(Saccharomyces
cerevisiae) 		4 / 6 VAL A 501
ILE A 750
ILE A 732
LEU A 731
 None
 0.78A 3hegA-4am6A:
undetectable		 3hegA-4am6A:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJX_B_HCZB800_1
(GLUTAMATE RECEPTOR 2)		 4am6 ACTIN-LIKE PROTEIN
ARP8
(Saccharomyces
cerevisiae) 		5 / 10 SER A 407
LEU A 428
ILE A 278
PRO A 273
GLY A 274
 None
None
None
None
SO4  A1882 (-3.1A)
 1.27A 3ijxB-4am6A:
undetectable
3ijxD-4am6A:
undetectable		 3ijxB-4am6A:
17.25
3ijxD-4am6A:
17.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK6_B_HCZB262_1
(GLUTAMATE RECEPTOR 2)		 4am6 ACTIN-LIKE PROTEIN
ARP8
(Saccharomyces
cerevisiae) 		5 / 10 ILE A 278
PRO A 273
GLY A 274
SER A 407
LEU A 428
 None
None
SO4  A1882 (-3.1A)
None
None
 1.21A 3ik6B-4am6A:
undetectable
3ik6E-4am6A:
undetectable		 3ik6B-4am6A:
17.25
3ik6E-4am6A:
17.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILU_B_HFZB800_1
(GLUTAMATE RECEPTOR 2)		 4am6 ACTIN-LIKE PROTEIN
ARP8
(Saccharomyces
cerevisiae) 		5 / 10 SER A 407
LEU A 428
ILE A 278
PRO A 273
GLY A 274
 None
None
None
None
SO4  A1882 (-3.1A)
 1.27A 3iluB-4am6A:
undetectable
3iluE-4am6A:
undetectable		 3iluB-4am6A:
17.25
3iluE-4am6A:
17.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILU_E_HFZE800_1
(GLUTAMATE RECEPTOR 2)		 4am6 ACTIN-LIKE PROTEIN
ARP8
(Saccharomyces
cerevisiae) 		5 / 11 ILE A 278
PRO A 273
GLY A 274
SER A 407
LEU A 428
 None
None
SO4  A1882 (-3.1A)
None
None
 1.27A 3iluB-4am6A:
undetectable
3iluE-4am6A:
undetectable		 3iluB-4am6A:
17.25
3iluE-4am6A:
17.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_B_SALB3003_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 4am6 ACTIN-LIKE PROTEIN
ARP8
(Saccharomyces
cerevisiae) 		4 / 6 ILE A 422
VAL A 425
LEU A 429
LEU A 470
 None
 0.51A 3kp6A-4am6A:
3.0
3kp6B-4am6A:
undetectable		 3kp6A-4am6A:
13.00
3kp6B-4am6A:
13.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L35_H_DHIH3_0
(GP41 N-PEPTIDE
HIV ENTRY INHIBITOR
PIE12)		 4am6 ACTIN-LIKE PROTEIN
ARP8
(Saccharomyces
cerevisiae) 		3 / 3 LEU A 840
TRP A 843
GLY A 281
 None
 0.65A 3l35A-4am6A:
undetectable
3l35H-4am6A:
undetectable		 3l35A-4am6A:
5.25
3l35H-4am6A:
2.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L35_K_DHIK3_0
(GP41 N-PEPTIDE
HIV ENTRY INHIBITOR
PIE12)		 4am6 ACTIN-LIKE PROTEIN
ARP8
(Saccharomyces
cerevisiae) 		3 / 3 LEU A 840
TRP A 843
GLY A 281
 None
 0.56A 3l35B-4am6A:
undetectable
3l35K-4am6A:
undetectable		 3l35B-4am6A:
5.25
3l35K-4am6A:
2.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXV_B_478B200_2
(HIV-1 PROTEASE)		 4am6 ACTIN-LIKE PROTEIN
ARP8
(Saccharomyces
cerevisiae) 		5 / 10 VAL A 453
ILE A 842
GLY A 491
VAL A 451
ILE A 482
 None
 1.05A 3oxvB-4am6A:
undetectable		 3oxvB-4am6A:
9.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QGT_A_CP6A609_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4am6 ACTIN-LIKE PROTEIN
ARP8
(Saccharomyces
cerevisiae) 		5 / 10 ILE A 750
SER A 652
ILE A 524
ILE A 707
TYR A 727
 None
 1.19A 3qgtA-4am6A:
undetectable		 3qgtA-4am6A:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QGT_B_CP6B609_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4am6 ACTIN-LIKE PROTEIN
ARP8
(Saccharomyces
cerevisiae) 		5 / 10 ILE A 750
SER A 652
ILE A 524
ILE A 707
TYR A 727
 None
 1.14A 3qgtB-4am6A:
undetectable		 3qgtB-4am6A:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UM5_A_CP6A609_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4am6 ACTIN-LIKE PROTEIN
ARP8
(Saccharomyces
cerevisiae) 		5 / 10 ILE A 750
SER A 652
ILE A 524
ILE A 707
TYR A 727
 None
 1.19A 3um5A-4am6A:
undetectable		 3um5A-4am6A:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UM5_B_CP6B709_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4am6 ACTIN-LIKE PROTEIN
ARP8
(Saccharomyces
cerevisiae) 		5 / 10 ILE A 750
SER A 652
ILE A 524
ILE A 707
TYR A 727
 None
 1.20A 3um5B-4am6A:
undetectable		 3um5B-4am6A:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P68_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 4am6 ACTIN-LIKE PROTEIN
ARP8
(Saccharomyces
cerevisiae) 		5 / 11 ILE A 750
SER A 652
ILE A 524
ILE A 707
TYR A 727
 None
 1.11A 4p68A-4am6A:
undetectable		 4p68A-4am6A:
12.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNV_B_QI9B602_0
(CYTOCHROME P450 2D6)		 4am6 ACTIN-LIKE PROTEIN
ARP8
(Saccharomyces
cerevisiae) 		5 / 9 PHE A 403
LEU A 634
SER A 407
VAL A 469
VAL A 425
 None
 1.28A 4wnvB-4am6A:
undetectable		 4wnvB-4am6A:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E26_B_PAUB601_0
(PANTOTHENATE KINASE
2, MITOCHONDRIAL)		 4am6 ACTIN-LIKE PROTEIN
ARP8
(Saccharomyces
cerevisiae) 		4 / 7 ALA A 506
GLU A 563
GLY A 529
SER A 736
 None
 0.87A 5e26A-4am6A:
undetectable
5e26B-4am6A:
9.6		 5e26A-4am6A:
19.60
5e26B-4am6A:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E26_C_PAUC602_0
(PANTOTHENATE KINASE
2, MITOCHONDRIAL)		 4am6 ACTIN-LIKE PROTEIN
ARP8
(Saccharomyces
cerevisiae) 		4 / 7 GLU A 563
GLY A 529
SER A 736
ALA A 506
 None
 0.88A 5e26C-4am6A:
undetectable
5e26D-4am6A:
4.0		 5e26C-4am6A:
19.60
5e26D-4am6A:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIK_A_SAMA301_0
(GLYCINE SARCOSINE
N-METHYLTRANSFERASE)		 4am6 ACTIN-LIKE PROTEIN
ARP8
(Saccharomyces
cerevisiae) 		5 / 12 ARG A 509
GLY A 735
ASP A 370
GLY A 274
SER A 277
 SO4  A1882 (-3.6A)
SO4  A1883 ( 3.9A)
None
SO4  A1882 (-3.1A)
SO4  A1883 (-2.5A)
 1.21A 5hikA-4am6A:
undetectable		 5hikA-4am6A:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_E_FK5E201_1
(FK506-BINDING
PROTEIN 1)		 4am6 ACTIN-LIKE PROTEIN
ARP8
(Saccharomyces
cerevisiae) 		5 / 11 VAL A 453
ILE A 454
ILE A 467
ILE A 860
PHE A 879
 None
 1.24A 5hw8E-4am6A:
undetectable		 5hw8E-4am6A:
10.37