SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4amc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BU5_B_RBFB302_1
(PROTEIN (FLAVODOXIN))		 4amc GLUCANSUCRASE
(Lactobacillus
reuteri) 		4 / 8 THR A 834
TRP A 835
ASP A 837
GLY A 832
 None
 1.00A 1bu5B-4amcA:
undetectable		 1bu5B-4amcA:
9.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DED_A_QPSA1001_1
(CYCLODEXTRIN
GLUCANOTRANSFERASE)		 4amc GLUCANSUCRASE
(Lactobacillus
reuteri) 		5 / 12 TYR A1470
LEU A 980
ASP A1024
ALA A1025
HIS A1132
 None
 0.71A 1dedA-4amcA:
6.0		 1dedA-4amcA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DED_B_QPSB1501_1
(CYCLODEXTRIN
GLUCANOTRANSFERASE)		 4amc GLUCANSUCRASE
(Lactobacillus
reuteri) 		6 / 12 ARG A1022
ASP A1024
ALA A1025
GLU A1061
HIS A1132
ASP A1133
 None
 0.88A 1dedB-4amcA:
8.3		 1dedB-4amcA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DED_B_QPSB1501_1
(CYCLODEXTRIN
GLUCANOTRANSFERASE)		 4amc GLUCANSUCRASE
(Lactobacillus
reuteri) 		7 / 12 TYR A1470
LEU A 981
ARG A1022
ASP A1024
ALA A1025
GLU A1061
HIS A1132
 None
 0.91A 1dedB-4amcA:
8.3		 1dedB-4amcA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JG4_A_SAMA500_0
(PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE)		 4amc GLUCANSUCRASE
(Lactobacillus
reuteri) 		5 / 12 ASN A1543
GLY A1603
THR A1525
ALA A1524
VAL A1523
 None
 1.12A 1jg4A-4amcA:
undetectable		 1jg4A-4amcA:
13.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_A_NOVA400_2
(DNA GYRASE SUBUNIT B)		 4amc GLUCANSUCRASE
(Lactobacillus
reuteri) 		3 / 3 ASN A1668
PHE A1707
VAL A1696
 None
 0.82A 1kijA-4amcA:
undetectable		 1kijA-4amcA:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQE_A_DVAA6_0
(MINI-GRAMICIDIN A)		 4amc GLUCANSUCRASE
(Lactobacillus
reuteri) 		3 / 3 ALA A1025
VAL A1023
TRP A1510
 None
 0.78A 1kqeA-4amcA:
undetectable
1kqeE-4amcA:
undetectable		 1kqeA-4amcA:
3.86
1kqeE-4amcA:
3.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQE_B_DVAB6_0
(MINI-GRAMICIDIN A)		 4amc GLUCANSUCRASE
(Lactobacillus
reuteri) 		3 / 3 ALA A1025
VAL A1023
TRP A1510
 None
 0.78A 1kqeB-4amcA:
undetectable
1kqeD-4amcA:
undetectable		 1kqeB-4amcA:
3.86
1kqeD-4amcA:
3.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQE_D_DVAD6_0
(MINI-GRAMICIDIN A)		 4amc GLUCANSUCRASE
(Lactobacillus
reuteri) 		3 / 3 TRP A1510
ALA A1025
VAL A1023
 None
 0.77A 1kqeB-4amcA:
undetectable
1kqeD-4amcA:
undetectable		 1kqeB-4amcA:
3.86
1kqeD-4amcA:
3.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQE_E_DVAE6_0
(MINI-GRAMICIDIN A)		 4amc GLUCANSUCRASE
(Lactobacillus
reuteri) 		3 / 3 TRP A1510
ALA A1025
VAL A1023
 None
 0.77A 1kqeA-4amcA:
undetectable
1kqeE-4amcA:
undetectable		 1kqeA-4amcA:
3.86
1kqeE-4amcA:
3.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MIC_A_DVAA6_0
(GRAMICIDIN A)		 4amc GLUCANSUCRASE
(Lactobacillus
reuteri) 		3 / 3 ALA A1025
VAL A1023
TRP A1510
 None
 0.88A 1micA-4amcA:
undetectable
1micB-4amcA:
undetectable		 1micA-4amcA:
5.19
1micB-4amcA:
5.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRJ_A_ADNA300_1
(ALPHA-TRICHOSANTHIN)		 4amc GLUCANSUCRASE
(Lactobacillus
reuteri) 		4 / 8 GLY A1209
ILE A1140
SER A1136
ARG A1130
 None
 0.79A 1mrjA-4amcA:
undetectable		 1mrjA-4amcA:
13.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NW3_A_ACTA600_0
(HISTONE
METHYLTRANSFERASE
DOT1L)		 4amc GLUCANSUCRASE
(Lactobacillus
reuteri) 		4 / 5 LEU A 944
VAL A1548
TYR A1546
THR A1604
 None
 1.44A 1nw3A-4amcA:
2.8		 1nw3A-4amcA:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QKN_A_RALA600_2
(ESTROGEN RECEPTOR
BETA)		 4amc GLUCANSUCRASE
(Lactobacillus
reuteri) 		3 / 3 ASP A1750
LEU A1749
HIS A1692
 None
 0.63A 1qknA-4amcA:
undetectable		 1qknA-4amcA:
13.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_1
(DNA TOPOISOMERASE II)		 4amc GLUCANSUCRASE
(Lactobacillus
reuteri) 		4 / 7 HIS A1132
ASN A1484
TYR A1486
GLN A1452
 None
 1.09A 1qzrA-4amcA:
undetectable		 1qzrA-4amcA:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X70_B_715B801_2
(DIPEPTIDYL PEPTIDASE
IV)		 4amc GLUCANSUCRASE
(Lactobacillus
reuteri) 		3 / 3 PHE A1447
TYR A1212
TYR A1206
 None
 0.95A 1x70B-4amcA:
undetectable		 1x70B-4amcA:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_1
(CES1 PROTEIN)		 4amc GLUCANSUCRASE
(Lactobacillus
reuteri) 		5 / 12 GLY A1360
SER A1282
VAL A1295
LEU A1289
LEU A1341
 None
 1.24A 1ya4B-4amcA:
2.1		 1ya4B-4amcA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AJV_L_COCL501_1
(ANTIBODY 7A1 FAB')		 4amc GLUCANSUCRASE
(Lactobacillus
reuteri) 		4 / 7 ALA A1495
TYR A1206
TYR A1202
PHE A1447
 None
 1.05A 2ajvH-4amcA:
undetectable
2ajvL-4amcA:
undetectable		 2ajvH-4amcA:
11.62
2ajvL-4amcA:
11.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E5D_A_NCAA1501_0
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 4amc GLUCANSUCRASE
(Lactobacillus
reuteri) 		4 / 7 ARG A1130
ALA A1143
ASP A1208
TYR A1167
 None
 1.25A 2e5dA-4amcA:
2.6
2e5dB-4amcA:
undetectable		 2e5dA-4amcA:
18.70
2e5dB-4amcA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E5D_B_NCAB1502_0
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 4amc GLUCANSUCRASE
(Lactobacillus
reuteri) 		4 / 7 ASP A1208
TYR A1167
ARG A1130
ALA A1143
 None
 1.26A 2e5dA-4amcA:
2.9
2e5dB-4amcA:
undetectable		 2e5dA-4amcA:
18.70
2e5dB-4amcA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_H_TACH4888_1
(ELONGATION FACTOR
EF-TU)		 4amc GLUCANSUCRASE
(Lactobacillus
reuteri) 		4 / 7 VAL A1129
LEU A1102
SER A1127
ASP A1082
 None
 1.04A 2hdnF-4amcA:
undetectable
2hdnG-4amcA:
undetectable
2hdnH-4amcA:
undetectable		 2hdnF-4amcA:
14.74
2hdnG-4amcA:
3.42
2hdnH-4amcA:
14.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OWC_A_ACRA600_1
(4-ALPHA-GLUCANOTRANS
FERASE)		 4amc GLUCANSUCRASE
(Lactobacillus
reuteri) 		5 / 11 TYR A1470
ASP A1024
HIS A1132
ASP A1133
ASN A1416
 None
 1.36A 2owcA-4amcA:
undetectable		 2owcA-4amcA:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OWW_A_ACRA600_1
(4-ALPHA-GLUCANOTRANS
FERASE)		 4amc GLUCANSUCRASE
(Lactobacillus
reuteri) 		5 / 11 TYR A1470
ASP A1024
HIS A1132
ASP A1133
ASN A1416
 None
 1.37A 2owwA-4amcA:
undetectable		 2owwA-4amcA:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QAK_A_1UNA1001_4
(PROTEASE RETROPEPSIN)		 4amc GLUCANSUCRASE
(Lactobacillus
reuteri) 		3 / 3 ASP A1463
THR A1420
PRO A1421
 None
 0.72A 2qakB-4amcA:
undetectable		 2qakB-4amcA:
6.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD4_A_CHDA803_0
(FERROCHELATASE)		 4amc GLUCANSUCRASE
(Lactobacillus
reuteri) 		4 / 5 LEU A1633
PRO A1634
LEU A1637
ILE A 810
 None
 0.87A 2qd4A-4amcA:
undetectable		 2qd4A-4amcA:
16.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A27_A_SAMA250_1
(UNCHARACTERIZED
PROTEIN MJ1557)		 4amc GLUCANSUCRASE
(Lactobacillus
reuteri) 		3 / 3 MET A1081
GLU A1412
ASN A1416
 None
 1.03A 3a27A-4amcA:
undetectable		 3a27A-4amcA:
13.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A27_A_SAMA250_1
(UNCHARACTERIZED
PROTEIN MJ1557)		 4amc GLUCANSUCRASE
(Lactobacillus
reuteri) 		3 / 3 MET A1081
GLU A1412
ASN A1468
 None
 1.11A 3a27A-4amcA:
undetectable		 3a27A-4amcA:
13.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3AIC_A_ACRA5044_1
(GLUCOSYLTRANSFERASE-
SI)		 4amc GLUCANSUCRASE
(Lactobacillus
reuteri) 		10 / 12 LEU A 980
ARG A1022
ASP A1024
ALA A1025
ASN A1028
GLU A1061
HIS A1132
ASP A1133
ASP A1463
GLN A1514
 None
 0.49A 3aicA-4amcA:
61.9		 3aicA-4amcA:
44.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3AIC_A_ACRA5044_2
(GLUCOSYLTRANSFERASE-
SI)		 4amc GLUCANSUCRASE
(Lactobacillus
reuteri) 		3 / 3 LEU A 981
TRP A1063
TYR A1470
 None
 0.27A 3aicA-4amcA:
61.9		 3aicA-4amcA:
44.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3AIC_B_ACRB5044_1
(GLUCOSYLTRANSFERASE-
SI)		 4amc GLUCANSUCRASE
(Lactobacillus
reuteri) 		10 / 12 LEU A 980
ARG A1022
ASP A1024
ALA A1025
ASN A1028
GLU A1061
HIS A1132
ASP A1133
ASP A1463
GLN A1514
 None
 0.47A 3aicB-4amcA:
61.0		 3aicB-4amcA:
44.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3AIC_B_ACRB5044_2
(GLUCOSYLTRANSFERASE-
SI)		 4amc GLUCANSUCRASE
(Lactobacillus
reuteri) 		3 / 3 LEU A 981
TRP A1063
TYR A1470
 None
 0.27A 3aicB-4amcA:
61.0		 3aicB-4amcA:
44.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3AIC_C_ACRC5044_1
(GLUCOSYLTRANSFERASE-
SI)		 4amc GLUCANSUCRASE
(Lactobacillus
reuteri) 		10 / 12 ARG A1022
ASP A1024
ALA A1025
ASN A1028
GLU A1061
HIS A1132
ASP A1133
ASP A1463
TYR A1470
GLN A1514
 None
 0.43A 3aicC-4amcA:
61.4		 3aicC-4amcA:
44.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3AIC_D_ACRD5044_1
(GLUCOSYLTRANSFERASE-
SI)		 4amc GLUCANSUCRASE
(Lactobacillus
reuteri) 		10 / 12 LEU A 980
ARG A1022
ASP A1024
ALA A1025
ASN A1028
GLU A1061
HIS A1132
ASP A1133
ASP A1463
GLN A1514
 None
 0.52A 3aicD-4amcA:
61.6		 3aicD-4amcA:
44.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3AIC_E_ACRE5044_1
(GLUCOSYLTRANSFERASE-
SI)		 4amc GLUCANSUCRASE
(Lactobacillus
reuteri) 		10 / 12 LEU A 980
ARG A1022
ASP A1024
ALA A1025
ASN A1028
GLU A1061
HIS A1132
ASP A1133
ASP A1463
GLN A1514
 None
 0.51A 3aicE-4amcA:
61.6		 3aicE-4amcA:
44.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3AIC_E_ACRE5044_2
(GLUCOSYLTRANSFERASE-
SI)		 4amc GLUCANSUCRASE
(Lactobacillus
reuteri) 		3 / 3 LEU A 981
TRP A1063
TYR A1470
 None
 0.30A 3aicE-4amcA:
61.6		 3aicE-4amcA:
44.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3AIC_F_ACRF5044_1
(GLUCOSYLTRANSFERASE-
SI)		 4amc GLUCANSUCRASE
(Lactobacillus
reuteri) 		10 / 12 LEU A 980
ARG A1022
ASP A1024
ALA A1025
ASN A1028
GLU A1061
HIS A1132
ASP A1133
ASP A1463
GLN A1514
 None
 0.49A 3aicF-4amcA:
61.6		 3aicF-4amcA:
44.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3AIC_F_ACRF5044_2
(GLUCOSYLTRANSFERASE-
SI)		 4amc GLUCANSUCRASE
(Lactobacillus
reuteri) 		3 / 3 LEU A 981
TRP A1063
TYR A1470
 None
 0.38A 3aicF-4amcA:
61.6		 3aicF-4amcA:
44.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3AIC_G_ACRG5044_1
(GLUCOSYLTRANSFERASE-
SI)		 4amc GLUCANSUCRASE
(Lactobacillus
reuteri) 		10 / 12 LEU A 980
ARG A1022
ASP A1024
ALA A1025
ASN A1028
GLU A1061
HIS A1132
ASP A1133
ASP A1463
GLN A1514
 None
 0.48A 3aicG-4amcA:
61.8		 3aicG-4amcA:
44.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3AIC_G_ACRG5044_2
(GLUCOSYLTRANSFERASE-
SI)		 4amc GLUCANSUCRASE
(Lactobacillus
reuteri) 		3 / 3 LEU A 817
TRP A 851
TYR A 823
 None
 1.00A 3aicG-4amcA:
61.8		 3aicG-4amcA:
44.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3AIC_G_ACRG5044_2
(GLUCOSYLTRANSFERASE-
SI)		 4amc GLUCANSUCRASE
(Lactobacillus
reuteri) 		3 / 3 LEU A 981
TRP A1063
TYR A1470
 None
 0.26A 3aicG-4amcA:
61.8		 3aicG-4amcA:
44.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3AIC_H_ACRH5044_1
(GLUCOSYLTRANSFERASE-
SI)		 4amc GLUCANSUCRASE
(Lactobacillus
reuteri) 		10 / 12 LEU A 980
ARG A1022
ASP A1024
ALA A1025
ASN A1028
GLU A1061
HIS A1132
ASP A1133
ASP A1463
GLN A1514
 None
 0.48A 3aicH-4amcA:
61.5		 3aicH-4amcA:
44.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3AIC_H_ACRH5044_2
(GLUCOSYLTRANSFERASE-
SI)		 4amc GLUCANSUCRASE
(Lactobacillus
reuteri) 		3 / 3 LEU A 981
TRP A1063
TYR A1470
 None
 0.28A 3aicH-4amcA:
61.5		 3aicH-4amcA:
44.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HAM_B_LLLB500_1
(AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 4amc GLUCANSUCRASE
(Lactobacillus
reuteri) 		5 / 11 ASP A1024
ASP A1509
ASP A1027
ASP A1067
ARG A1199
 None
 1.40A 3hamB-4amcA:
0.9		 3hamB-4amcA:
14.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HAV_A_SRYA403_1
(AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 4amc GLUCANSUCRASE
(Lactobacillus
reuteri) 		4 / 8 ASP A1082
ASP A1083
ASP A1112
ASP A1103
 None
 1.18A 3havA-4amcA:
undetectable		 3havA-4amcA:
14.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MS9_B_STIB1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 4amc GLUCANSUCRASE
(Lactobacillus
reuteri) 		4 / 7 TYR A1516
VAL A1529
ILE A1606
ARG A 960
 None
 1.24A 3ms9B-4amcA:
undetectable		 3ms9B-4amcA:
13.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OND_A_ADNA506_2
(ADENOSYLHOMOCYSTEINA
SE)		 4amc GLUCANSUCRASE
(Lactobacillus
reuteri) 		3 / 3 GLN A1216
THR A1217
LEU A1227
 None
 0.69A 3ondA-4amcA:
undetectable		 3ondA-4amcA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OND_B_ADNB507_2
(ADENOSYLHOMOCYSTEINA
SE)		 4amc GLUCANSUCRASE
(Lactobacillus
reuteri) 		3 / 3 GLN A1216
THR A1217
LEU A1227
 None
 0.70A 3ondB-4amcA:
undetectable		 3ondB-4amcA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S8P_B_SAMB500_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 4amc GLUCANSUCRASE
(Lactobacillus
reuteri) 		3 / 3 HIS A1091
SER A1186
ASN A1135
 None
 0.71A 3s8pB-4amcA:
undetectable		 3s8pB-4amcA:
14.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3S_D_9PLD1_1
(CYTOCHROME P450 2A13)		 4amc GLUCANSUCRASE
(Lactobacillus
reuteri) 		4 / 8 PHE A1439
ALA A1413
PHE A1447
ALA A1428
 None
 0.90A 3t3sD-4amcA:
undetectable		 3t3sD-4amcA:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ7_A_SAMA301_1
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 4amc GLUCANSUCRASE
(Lactobacillus
reuteri) 		3 / 3 SER A1094
ASP A1170
ASP A1146
 None
 0.82A 3uj7A-4amcA:
undetectable		 3uj7A-4amcA:
14.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_A_ACTA505_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 4amc GLUCANSUCRASE
(Lactobacillus
reuteri) 		3 / 3 THR A1527
ASN A1542
GLU A 947
 None
 0.78A 3v4tA-4amcA:
undetectable
3v4tC-4amcA:
undetectable		 3v4tA-4amcA:
18.28
3v4tC-4amcA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_B_W9TB504_1
(HEMOLYTIC LECTIN
CEL-III)		 4amc GLUCANSUCRASE
(Lactobacillus
reuteri) 		4 / 5 ASP A1477
GLU A1482
GLY A1479
TYR A1556
 None
 1.18A 3w9tB-4amcA:
undetectable		 3w9tB-4amcA:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_D_W9TD506_1
(HEMOLYTIC LECTIN
CEL-III)		 4amc GLUCANSUCRASE
(Lactobacillus
reuteri) 		4 / 5 ASP A1477
GLU A1482
GLY A1479
TYR A1556
 None
 1.19A 3w9tD-4amcA:
undetectable		 3w9tD-4amcA:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_E_W9TE505_1
(HEMOLYTIC LECTIN
CEL-III)		 4amc GLUCANSUCRASE
(Lactobacillus
reuteri) 		4 / 5 ASP A1477
GLU A1482
GLY A1479
TYR A1556
 None
 1.12A 3w9tE-4amcA:
undetectable		 3w9tE-4amcA:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_F_W9TF512_1
(HEMOLYTIC LECTIN
CEL-III)		 4amc GLUCANSUCRASE
(Lactobacillus
reuteri) 		4 / 6 THR A1604
ASN A1605
GLY A 942
ILE A1541
 None
 1.04A 3w9tF-4amcA:
undetectable		 3w9tF-4amcA:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_G_W9TG505_1
(HEMOLYTIC LECTIN
CEL-III)		 4amc GLUCANSUCRASE
(Lactobacillus
reuteri) 		4 / 5 ASP A1477
GLU A1482
GLY A1479
TYR A1556
 None
 1.14A 3w9tG-4amcA:
undetectable		 3w9tG-4amcA:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_B_CHDB504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4amc GLUCANSUCRASE
(Lactobacillus
reuteri) 		4 / 4 LEU A1633
PRO A1634
LEU A1637
ILE A 810
 None
 0.94A 4f4dB-4amcA:
undetectable		 4f4dB-4amcA:
16.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F5Z_A_BEZA302_0
(HALOALKANE
DEHALOGENASE)		 4amc GLUCANSUCRASE
(Lactobacillus
reuteri) 		4 / 8 ASN A1017
ASP A1019
HIS A1056
TYR A1045
 None
 1.22A 4f5zA-4amcA:
undetectable		 4f5zA-4amcA:
14.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_A_SAMA401_0
(METHYLTRANSFERASE
NSUN4)		 4amc GLUCANSUCRASE
(Lactobacillus
reuteri) 		5 / 12 GLY A1236
LEU A1227
GLY A1443
ASP A1406
PRO A1198
 None
 1.04A 4fp9A-4amcA:
undetectable		 4fp9A-4amcA:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_C_SAMC401_0
(METHYLTRANSFERASE
NSUN4)		 4amc GLUCANSUCRASE
(Lactobacillus
reuteri) 		5 / 12 GLY A1236
LEU A1227
GLY A1443
ASP A1406
PRO A1198
 None
 1.04A 4fp9C-4amcA:
undetectable		 4fp9C-4amcA:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_F_SAMF401_0
(METHYLTRANSFERASE
NSUN4)		 4amc GLUCANSUCRASE
(Lactobacillus
reuteri) 		5 / 12 GLY A1236
LEU A1227
GLY A1443
ASP A1406
PRO A1198
 None
 1.04A 4fp9F-4amcA:
undetectable		 4fp9F-4amcA:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K36_A_SAMA504_0
(ANAEROBIC
SULFATASE-MATURATING
ENZYME)		 4amc GLUCANSUCRASE
(Lactobacillus
reuteri) 		5 / 12 GLN A 996
ASN A 989
LEU A1033
ILE A1029
LEU A 980
 None
None
None
CA  A2764 ( 4.7A)
None
 1.06A 4k36A-4amcA:
undetectable		 4k36A-4amcA:
16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_A_ACTA506_0
(RNA POLYMERASE
3D-POL)		 4amc GLUCANSUCRASE
(Lactobacillus
reuteri) 		3 / 3 VAL A1581
GLY A1584
LYS A1579
 None
 0.36A 4k50A-4amcA:
undetectable		 4k50A-4amcA:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_E_ACTE504_0
(RNA POLYMERASE
3D-POL)		 4amc GLUCANSUCRASE
(Lactobacillus
reuteri) 		3 / 3 VAL A1581
GLY A1584
LYS A1579
 None
 0.38A 4k50E-4amcA:
undetectable		 4k50E-4amcA:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_I_ACTI504_0
(RNA POLYMERASE
3D-POL)		 4amc GLUCANSUCRASE
(Lactobacillus
reuteri) 		3 / 3 VAL A1581
GLY A1584
LYS A1579
 None
 0.37A 4k50I-4amcA:
undetectable		 4k50I-4amcA:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_B_STRB601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4amc GLUCANSUCRASE
(Lactobacillus
reuteri) 		4 / 5 ILE A1123
LEU A1110
ASP A1062
GLU A1069
 None
 1.03A 4nkxB-4amcA:
undetectable		 4nkxB-4amcA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QCK_A_ASDA404_1
(3-KETOSTEROID-9-ALPH
A-MONOOXYGENASE
OXYGENASE SUBUNIT)		 4amc GLUCANSUCRASE
(Lactobacillus
reuteri) 		5 / 12 ASN A1549
VAL A1548
ALA A1598
ASN A 983
GLY A1553
 None
 1.16A 4qckA-4amcA:
undetectable		 4qckA-4amcA:
15.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVV_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 4amc GLUCANSUCRASE
(Lactobacillus
reuteri) 		4 / 8 THR A1242
GLY A1247
GLY A1246
VAL A1245
 None
 0.82A 4qvvK-4amcA:
undetectable
4qvvL-4amcA:
undetectable		 4qvvK-4amcA:
12.24
4qvvL-4amcA:
14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVV_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 4amc GLUCANSUCRASE
(Lactobacillus
reuteri) 		4 / 8 THR A1242
GLY A1247
GLY A1246
VAL A1245
 None
 0.82A 4qvvY-4amcA:
undetectable
4qvvZ-4amcA:
undetectable		 4qvvY-4amcA:
12.24
4qvvZ-4amcA:
14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UDA_A_DEXA1985_2
(MINERALOCORTICOID
RECEPTOR)		 4amc GLUCANSUCRASE
(Lactobacillus
reuteri) 		4 / 6 LEU A1287
LEU A1341
THR A1314
VAL A1366
 None
 1.05A 4udaA-4amcA:
undetectable		 4udaA-4amcA:
13.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WCX_C_SAMC503_0
(BIOTIN AND THIAMIN
SYNTHESIS ASSOCIATED)		 4amc GLUCANSUCRASE
(Lactobacillus
reuteri) 		5 / 12 TYR A1322
GLY A1327
LEU A1346
LEU A1341
ALA A1371
 None
 1.27A 4wcxC-4amcA:
4.4		 4wcxC-4amcA:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XJE_A_TOYA202_1
(AADB)		 4amc GLUCANSUCRASE
(Lactobacillus
reuteri) 		4 / 8 ASP A1027
ASP A1067
ASP A1062
ILE A1123
 None
 1.01A 4xjeA-4amcA:
undetectable		 4xjeA-4amcA:
10.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AYF_A_C7HA402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 4amc GLUCANSUCRASE
(Lactobacillus
reuteri) 		4 / 5 TYR A1001
TYR A1040
TYR A1045
GLY A1046
 None
 1.03A 5ayfA-4amcA:
undetectable		 5ayfA-4amcA:
13.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CPR_B_SAMB402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 4amc GLUCANSUCRASE
(Lactobacillus
reuteri) 		3 / 3 HIS A1091
SER A1186
ASN A1135
 None
 0.68A 5cprB-4amcA:
undetectable		 5cprB-4amcA:
13.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CVT_B_ACTB200_0
(N5-CARBOXYAMINOIMIDA
ZOLE RIBONUCLEOTIDE
MUTASE)		 4amc GLUCANSUCRASE
(Lactobacillus
reuteri) 		3 / 3 ASN A1225
ALA A1311
ARG A1309
 None
 0.67A 5cvtB-4amcA:
undetectable		 5cvtB-4amcA:
10.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K7U_A_SAMA601_1
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT)		 4amc GLUCANSUCRASE
(Lactobacillus
reuteri) 		3 / 3 ASP A1165
ASN A1179
GLN A1171
 None
 0.71A 5k7uA-4amcA:
undetectable		 5k7uA-4amcA:
11.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_A_RCXA601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4amc GLUCANSUCRASE
(Lactobacillus
reuteri) 		3 / 3 ARG A 960
ILE A 985
PHE A1601
 None
 0.72A 5kirA-4amcA:
undetectable		 5kirA-4amcA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_E_C2FE3001_1
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 4amc GLUCANSUCRASE
(Lactobacillus
reuteri) 		4 / 5 ASN A 989
ASP A 986
ASN A1602
ASN A 948
 None
 1.42A 5vooE-4amcA:
2.6		 5vooE-4amcA:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_A_ACRA610_0
(ALPHA-AMYLASE)		 4amc GLUCANSUCRASE
(Lactobacillus
reuteri) 		5 / 12 TYR A1470
LEU A 980
ASP A1024
HIS A1132
ASP A1133
 None
 0.79A 6ag0A-4amcA:
11.8		 6ag0A-4amcA:
7.22