SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4amf'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DBB_H_STRH229_1
(IGG1-KAPPA DB3 FAB
(HEAVY CHAIN)
IGG1-KAPPA DB3 FAB
(LIGHT CHAIN))
4amf PHOX
(Pseudomonas
fluorescens)
4 / 8 GLY A 174
GLY A 145
HIS A  43
VAL A 121
None
0.69A 1dbbH-4amfA:
undetectable
1dbbL-4amfA:
undetectable
1dbbH-4amfA:
15.95
1dbbL-4amfA:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DBB_H_STRH229_1
(IGG1-KAPPA DB3 FAB
(HEAVY CHAIN)
IGG1-KAPPA DB3 FAB
(LIGHT CHAIN))
4amf PHOX
(Pseudomonas
fluorescens)
4 / 8 GLY A 464
GLY A 465
TYR A 426
VAL A 415
None
0.89A 1dbbH-4amfA:
undetectable
1dbbL-4amfA:
undetectable
1dbbH-4amfA:
15.95
1dbbL-4amfA:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GM7_B_PNNB1577_0
(PENICILLIN G ACYLASE
ALPHA SUBUNIT
PENICILLIN G ACYLASE
BETA SUBUNIT)
4amf PHOX
(Pseudomonas
fluorescens)
4 / 8 SER A 120
ALA A  86
PHE A  74
ILE A  87
None
1.01A 1gm7A-4amfA:
undetectable
1gm7B-4amfA:
undetectable
1gm7A-4amfA:
16.58
1gm7B-4amfA:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_A_BEZA502_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)
4amf PHOX
(Pseudomonas
fluorescens)
4 / 6 ASN A  67
ASN A  68
ILE A 549
GLY A 548
None
1.01A 1oniA-4amfA:
undetectable
1oniB-4amfA:
undetectable
1oniA-4amfA:
14.38
1oniB-4amfA:
14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_D_BEZD508_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)
4amf PHOX
(Pseudomonas
fluorescens)
4 / 6 ASN A  67
ASN A  68
ILE A 549
GLY A 548
None
0.98A 1oniD-4amfA:
undetectable
1oniF-4amfA:
undetectable
1oniD-4amfA:
14.38
1oniF-4amfA:
14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_I_BEZI518_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)
4amf PHOX
(Pseudomonas
fluorescens)
5 / 7 ILE A 549
GLY A 548
PRO A 561
ASN A  67
ASN A  68
None
1.28A 1oniG-4amfA:
undetectable
1oniI-4amfA:
undetectable
1oniG-4amfA:
14.38
1oniI-4amfA:
14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_A_SAMA801_1
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)
4amf PHOX
(Pseudomonas
fluorescens)
4 / 6 ARG A 385
ASP A  69
ASP A  66
ASN A  93
ACP  A1589 (-2.8A)
CA  A1592 ( 4.5A)
EDO  A1598 ( 3.7A)
EDO  A1598 (-3.4A)
1.30A 1rjdA-4amfA:
undetectable
1rjdA-4amfA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_B_SAMB802_1
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)
4amf PHOX
(Pseudomonas
fluorescens)
4 / 6 ARG A 385
ASP A  69
ASP A  66
ASN A  93
ACP  A1589 (-2.8A)
CA  A1592 ( 4.5A)
EDO  A1598 ( 3.7A)
EDO  A1598 (-3.4A)
1.29A 1rjdB-4amfA:
undetectable
1rjdB-4amfA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_C_SAMC803_1
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)
4amf PHOX
(Pseudomonas
fluorescens)
4 / 6 ARG A 385
ASP A  69
ASP A  66
ASN A  93
ACP  A1589 (-2.8A)
CA  A1592 ( 4.5A)
EDO  A1598 ( 3.7A)
EDO  A1598 (-3.4A)
1.32A 1rjdC-4amfA:
undetectable
1rjdC-4amfA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T69_A_SHHA379_1
(HISTONE DEACETYLASE
8)
4amf PHOX
(Pseudomonas
fluorescens)
5 / 12 ASP A 515
HIS A 338
GLY A 519
ASP A 447
TYR A 399
None
None
EDO  A1602 ( 4.1A)
None
None
0.97A 1t69A-4amfA:
undetectable
1t69A-4amfA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WG8_A_SAMA3142_0
(PREDICTED
S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)
4amf PHOX
(Pseudomonas
fluorescens)
5 / 12 GLY A 465
GLY A 464
ASP A 337
PHE A 449
SER A 467
None
None
EDO  A1602 ( 3.3A)
None
EDO  A1602 (-4.0A)
1.24A 1wg8A-4amfA:
undetectable
1wg8A-4amfA:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P2F_A_ACTA653_0
(ACETYL-COENZYME A
SYNTHETASE)
4amf PHOX
(Pseudomonas
fluorescens)
4 / 5 VAL A 250
THR A 191
VAL A 119
GLY A 118
None
1.10A 2p2fA-4amfA:
undetectable
2p2fA-4amfA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P2F_B_ACTB653_0
(ACETYL-COENZYME A
SYNTHETASE)
4amf PHOX
(Pseudomonas
fluorescens)
4 / 4 VAL A 250
THR A 191
VAL A 119
GLY A 118
None
1.09A 2p2fB-4amfA:
undetectable
2p2fB-4amfA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E23_A_SAMA221_1
(UNCHARACTERIZED
PROTEIN RPA2492)
4amf PHOX
(Pseudomonas
fluorescens)
3 / 3 TYR A  30
ASP A 580
HIS A 587
None
0.88A 3e23A-4amfA:
undetectable
3e23A-4amfA:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H9U_B_ADNB438_1
(ADENOSYLHOMOCYSTEINA
SE)
4amf PHOX
(Pseudomonas
fluorescens)
5 / 10 THR A  92
ASN A 146
LEU A 114
GLY A 145
HIS A 144
None
1.41A 3h9uB-4amfA:
undetectable
3h9uB-4amfA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JW3_B_TOPB208_1
(DIHYDROFOLATE
REDUCTASE)
4amf PHOX
(Pseudomonas
fluorescens)
5 / 9 ALA A 278
VAL A 398
ILE A 298
LEU A 430
ILE A 389
None
1.32A 3jw3B-4amfA:
undetectable
3jw3B-4amfA:
12.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JZ0_B_CLYB900_1
(LINCOSAMIDE
NUCLEOTIDYLTRANSFERA
SE)
4amf PHOX
(Pseudomonas
fluorescens)
4 / 8 GLU A 273
TYR A  91
GLU A 194
ILE A 536
FEO  A1595 ( 2.4A)
None
FEO  A1595 ( 2.5A)
None
0.94A 3jz0B-4amfA:
undetectable
3jz0B-4amfA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_B_SAMB300_1
(SAM-DEPENDENT
METHYLTRANSFERASE)
4amf PHOX
(Pseudomonas
fluorescens)
3 / 3 TYR A 399
ASP A 447
ASP A 337
None
None
EDO  A1602 ( 3.3A)
0.86A 3ou6B-4amfA:
undetectable
3ou6B-4amfA:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3N_A_MIYA2001_1
(TETX2 PROTEIN)
4amf PHOX
(Pseudomonas
fluorescens)
5 / 11 MET A 474
GLY A 427
SER A 477
GLY A 501
ASN A 499
EDO  A1601 (-4.6A)
None
None
None
None
1.48A 3v3nA-4amfA:
undetectable
3v3nA-4amfA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_F_W9TF512_1
(HEMOLYTIC LECTIN
CEL-III)
4amf PHOX
(Pseudomonas
fluorescens)
4 / 6 THR A 493
ASN A 509
GLY A 527
ILE A  16
None
0.81A 3w9tF-4amfA:
undetectable
3w9tF-4amfA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEU_D_KAND301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)
4amf PHOX
(Pseudomonas
fluorescens)
4 / 8 ASP A 494
ASP A  66
ASN A 195
GLU A 273
CA  A1594 (-2.6A)
EDO  A1598 ( 3.7A)
ACP  A1589 (-3.4A)
FEO  A1595 ( 2.4A)
1.01A 4feuD-4amfA:
undetectable
4feuD-4amfA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KR3_A_GLYA701_0
(GLYCINE--TRNA LIGASE)
4amf PHOX
(Pseudomonas
fluorescens)
4 / 6 GLU A 194
GLU A 273
ARG A 385
GLU A 387
FEO  A1595 ( 2.5A)
FEO  A1595 ( 2.4A)
ACP  A1589 (-2.8A)
CA  A1593 ( 2.3A)
1.37A 4kr3A-4amfA:
undetectable
4kr3A-4amfA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LXZ_A_SHHA407_1
(HISTONE DEACETYLASE
2)
4amf PHOX
(Pseudomonas
fluorescens)
5 / 12 ASP A 515
HIS A 338
GLY A 519
ASP A 447
TYR A 399
None
None
EDO  A1602 ( 4.1A)
None
None
0.99A 4lxzA-4amfA:
undetectable
4lxzA-4amfA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LXZ_C_SHHC406_1
(HISTONE DEACETYLASE
2)
4amf PHOX
(Pseudomonas
fluorescens)
5 / 12 ASP A 515
HIS A 338
GLY A 519
ASP A 447
TYR A 399
None
None
EDO  A1602 ( 4.1A)
None
None
0.96A 4lxzC-4amfA:
undetectable
4lxzC-4amfA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MI4_A_SPMA201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)
4amf PHOX
(Pseudomonas
fluorescens)
4 / 6 ASN A  68
GLU A  90
TYR A  91
GLU A 532
None
FEO  A1595 ( 2.6A)
None
CA  A1594 (-2.3A)
1.27A 4mi4A-4amfA:
undetectable
4mi4A-4amfA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MI4_C_SPMC201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)
4amf PHOX
(Pseudomonas
fluorescens)
4 / 7 ASN A  68
GLU A  90
TYR A  91
GLU A 532
None
FEO  A1595 ( 2.6A)
None
CA  A1594 (-2.3A)
1.29A 4mi4A-4amfA:
undetectable
4mi4C-4amfA:
undetectable
4mi4A-4amfA:
16.49
4mi4C-4amfA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJ8_C_SPMC201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)
4amf PHOX
(Pseudomonas
fluorescens)
4 / 7 ASN A  68
GLU A  90
TYR A  91
GLU A 532
None
FEO  A1595 ( 2.6A)
None
CA  A1594 (-2.3A)
1.28A 4mj8C-4amfA:
undetectable
4mj8C-4amfA:
14.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NTX_A_AMRA509_1
(ACID-SENSING ION
CHANNEL 1
BASIC PHOSPHOLIPASE
A2 HOMOLOG TX-BETA)
4amf PHOX
(Pseudomonas
fluorescens)
4 / 6 GLU A 554
ASP A 479
ASN A 404
ARG A 385
None
CA  A1592 (-2.1A)
ACP  A1589 ( 4.7A)
ACP  A1589 (-2.8A)
1.03A 4ntxA-4amfA:
undetectable
4ntxC-4amfA:
undetectable
4ntxA-4amfA:
19.90
4ntxC-4amfA:
11.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PEV_B_ADNB501_1
(MEMBRANE LIPOPROTEIN
FAMILY PROTEIN)
4amf PHOX
(Pseudomonas
fluorescens)
5 / 12 VAL A 390
ASN A 274
GLY A 480
ASP A 479
ASP A 292
EDO  A1597 (-3.8A)
None
None
CA  A1592 (-2.1A)
FEO  A1595 ( 3.1A)
1.35A 4pevB-4amfA:
undetectable
4pevB-4amfA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QB9_D_PARD500_1
(ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN)
4amf PHOX
(Pseudomonas
fluorescens)
4 / 8 PHE A 475
THR A 403
GLU A 194
ASP A 292
None
CA  A1593 ( 4.5A)
FEO  A1595 ( 2.5A)
FEO  A1595 ( 3.1A)
1.13A 4qb9D-4amfA:
undetectable
4qb9D-4amfA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R87_I_SPMI202_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)
4amf PHOX
(Pseudomonas
fluorescens)
4 / 7 ASN A  68
GLU A  90
TYR A  91
GLU A 532
None
FEO  A1595 ( 2.6A)
None
CA  A1594 (-2.3A)
1.30A 4r87I-4amfA:
undetectable
4r87I-4amfA:
14.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XDQ_A_BEZA306_0
(GLYCOSIDE HYDROLASE
FAMILY PROTEIN)
4amf PHOX
(Pseudomonas
fluorescens)
3 / 3 ARG A 488
ASP A 484
TRP A 490
None
1.10A 4xdqA-4amfA:
undetectable
4xdqA-4amfA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XDT_A_ACTA407_0
(FAD:PROTEIN FMN
TRANSFERASE)
4amf PHOX
(Pseudomonas
fluorescens)
3 / 3 ASP A 333
GLY A 341
ASP A 330
None
0.60A 4xdtA-4amfA:
undetectable
4xdtA-4amfA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJO_A_ERYA1101_0
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)
4amf PHOX
(Pseudomonas
fluorescens)
5 / 12 ASN A 195
ASP A 479
GLU A 194
GLU A 273
THR A 534
ACP  A1589 (-3.4A)
CA  A1592 (-2.1A)
FEO  A1595 ( 2.5A)
FEO  A1595 ( 2.4A)
None
1.45A 4zjoA-4amfA:
undetectable
4zjoA-4amfA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJO_A_ERYA1101_0
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)
4amf PHOX
(Pseudomonas
fluorescens)
5 / 12 ASN A 195
ASP A 479
GLU A 273
GLU A 194
GLU A 387
ACP  A1589 (-3.4A)
CA  A1592 (-2.1A)
FEO  A1595 ( 2.4A)
FEO  A1595 ( 2.5A)
CA  A1593 ( 2.3A)
1.48A 4zjoA-4amfA:
undetectable
4zjoA-4amfA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HES_B_032B401_2
(MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT)
4amf PHOX
(Pseudomonas
fluorescens)
4 / 4 CYH A 513
PHE A 524
ILE A 583
GLY A  12
None
1.46A 5hesB-4amfA:
undetectable
5hesB-4amfA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_A_RCXA601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)
4amf PHOX
(Pseudomonas
fluorescens)
3 / 3 ARG A 523
ILE A 491
PHE A 475
None
0.76A 5kirA-4amfA:
undetectable
5kirA-4amfA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYJ_B_NIZB810_1
(CATALASE-PEROXIDASE)
4amf PHOX
(Pseudomonas
fluorescens)
4 / 6 TRP A 490
LEU A  10
PRO A 516
SER A 392
None
1.42A 5syjB-4amfA:
undetectable
5syjB-4amfA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BPL_B_PA1B605_1
(LIPID A EXPORT
ATP-BINDING/PERMEASE
PROTEIN MSBA)
4amf PHOX
(Pseudomonas
fluorescens)
3 / 3 ARG A 223
ARG A 372
ARG A 294
ACP  A1589 (-3.5A)
None
ACP  A1589 (-3.2A)
0.97A 6bplA-4amfA:
undetectable
6bplB-4amfA:
undetectable
6bplA-4amfA:
9.79
6bplB-4amfA:
9.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_A_GMJA301_1
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)
4amf PHOX
(Pseudomonas
fluorescens)
4 / 6 SER A 477
ASP A 292
GLU A 273
THR A 534
None
FEO  A1595 ( 3.1A)
FEO  A1595 ( 2.4A)
None
1.31A 6djzA-4amfA:
undetectable
6djzA-4amfA:
16.91