SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4amg'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IT4_A_PPFA500_1
(CARBONIC ANHYDRASE 1)		 4amg SNOGD
(Streptomyces
nogalater) 		4 / 8 ALA A  15
VAL A  43
LEU A  32
THR A  29
 None
 0.82A 2it4A-4amgA:
undetectable		 2it4A-4amgA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CWK_A_REAA300_1
(CELLULAR RETINOIC
ACID-BINDING PROTEIN
2)		 4amg SNOGD
(Streptomyces
nogalater) 		5 / 12 ALA A 106
ALA A 130
PRO A 132
VAL A 122
THR A 134
 None
 1.22A 3cwkA-4amgA:
undetectable		 3cwkA-4amgA:
15.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E22_B_LOCB700_2
(TUBULIN BETA-2B
CHAIN)		 4amg SNOGD
(Streptomyces
nogalater) 		5 / 11 LEU A 217
LEU A 291
ALA A 290
ASN A 212
VAL A 283
 None
 1.20A 3e22B-4amgA:
4.8		 3e22B-4amgA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E22_D_LOCD700_2
(TUBULIN BETA-2B
CHAIN)		 4amg SNOGD
(Streptomyces
nogalater) 		5 / 11 LEU A 217
LEU A 291
ALA A 290
ASN A 212
VAL A 283
 None
 1.18A 3e22D-4amgA:
4.9		 3e22D-4amgA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LOQ_A_ACTA278_0
(UNIVERSAL STRESS
PROTEIN)		 4amg SNOGD
(Streptomyces
nogalater) 		3 / 3 SER A 103
GLY A 129
SER A  20
 None
 0.58A 3loqA-4amgA:
4.1		 3loqA-4amgA:
27.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_B_DXCB1473_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 4amg SNOGD
(Streptomyces
nogalater) 		5 / 9 GLY A 109
VAL A 122
THR A 134
GLN A 128
GLY A 131
 None
 1.42A 4acaB-4amgA:
6.7
4acaC-4amgA:
2.5		 4acaB-4amgA:
22.66
4acaC-4amgA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9K_A_CAMA424_0
(CYTOCHROME P450)		 4amg SNOGD
(Streptomyces
nogalater) 		5 / 9 THR A 264
LEU A 291
LEU A 292
GLY A 289
THR A 309
 None
 1.33A 4c9kA-4amgA:
undetectable		 4c9kA-4amgA:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K17_B_OHBB701_0
(LEUCINE-RICH
REPEAT-CONTAINING
PROTEIN 16A)		 4amg SNOGD
(Streptomyces
nogalater) 		4 / 5 GLU A 176
ARG A 161
PRO A 177
SER A 180
 None
 1.41A 4k17B-4amgA:
undetectable		 4k17B-4amgA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXA_A_ADNA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 4amg SNOGD
(Streptomyces
nogalater) 		4 / 5 GLU A 144
THR A 125
HIS A  41
LEU A 121
 None
 1.18A 5axaA-4amgA:
4.8		 5axaA-4amgA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXA_C_ADNC502_2
(ADENOSYLHOMOCYSTEINA
SE)		 4amg SNOGD
(Streptomyces
nogalater) 		4 / 5 GLU A 144
THR A 125
HIS A  41
LEU A 121
 None
 1.20A 5axaC-4amgA:
4.7		 5axaC-4amgA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JNC_D_ACTD305_0
(CARBONIC ANHYDRASE 4)		 4amg SNOGD
(Streptomyces
nogalater) 		4 / 5 ALA A 100
ALA A 163
ILE A 160
LEU A 156
 None
 0.81A 5jncD-4amgA:
undetectable		 5jncD-4amgA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_N_6V8N305_0
(PROTEASOME SUBUNIT
BETA TYPE-6
PROTEASOME SUBUNIT
BETA TYPE-7)		 4amg SNOGD
(Streptomyces
nogalater) 		5 / 12 TYR A  45
THR A  29
ALA A  33
GLY A 213
ALA A  57
 None
 1.19A 5lf7H-4amgA:
undetectable
5lf7N-4amgA:
undetectable		 5lf7H-4amgA:
20.62
5lf7N-4amgA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TT3_A_EZLA303_1
(ALPHA-CARBONIC
ANHYDRASE)		 4amg SNOGD
(Streptomyces
nogalater) 		5 / 10 VAL A 143
VAL A 181
ALA A 382
PRO A 378
TRP A 204
 None
None
None
None
MLY  A 384 ( 3.7A)
 1.08A 5tt3A-4amgA:
undetectable		 5tt3A-4amgA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TT3_C_EZLC303_1
(ALPHA-CARBONIC
ANHYDRASE)		 4amg SNOGD
(Streptomyces
nogalater) 		5 / 10 VAL A 143
VAL A 181
ALA A 382
PRO A 378
TRP A 204
 None
None
None
None
MLY  A 384 ( 3.7A)
 1.03A 5tt3C-4amgA:
undetectable		 5tt3C-4amgA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V02_R_657R201_0
(CALMODULIN-1
SMALL CONDUCTANCE
CALCIUM-ACTIVATED
POTASSIUM CHANNEL
PROTEIN 2)		 4amg SNOGD
(Streptomyces
nogalater) 		5 / 10 ALA A 382
LEU A 385
VAL A 386
VAL A  43
MET A  13
 None
MLY  A 384 ( 4.3A)
None
None
None
 1.13A 5v02B-4amgA:
undetectable
5v02R-4amgA:
undetectable		 5v02B-4amgA:
12.25
5v02R-4amgA:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YOD_D_BEZD201_0
(NS3 PROTEASE)		 4amg SNOGD
(Streptomyces
nogalater) 		4 / 5 HIS A 301
ALA A 344
SER A 241
GLY A 242
 None
 1.18A 5yodD-4amgA:
undetectable		 5yodD-4amgA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_A_ACRA608_0
(ALPHA-AMYLASE)		 4amg SNOGD
(Streptomyces
nogalater) 		4 / 6 GLY A  49
THR A  47
GLN A 128
TYR A  70
 None
 1.15A 6ag0A-4amgA:
undetectable		 6ag0A-4amgA:
11.03