SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4amq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BLA_A_CP6A302_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4amq L544
(Acanthamoeba
polyphaga
mimivirus) 		5 / 11 ILE A  80
PHE A 180
SER A 280
ILE A 281
ILE A 267
 None
 1.27A 2blaA-4amqA:
undetectable		 2blaA-4amqA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZSE_A_PAUA600_0
(PANTOTHENATE KINASE)		 4amq L544
(Acanthamoeba
polyphaga
mimivirus) 		4 / 7 ARG A  63
PHE A  71
ILE A 192
ASN A  49
 None
 1.03A 2zseA-4amqA:
undetectable		 2zseA-4amqA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O1X_A_ADNA1450_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 1)		 4amq L544
(Acanthamoeba
polyphaga
mimivirus) 		5 / 10 ILE A 330
ASP A 288
ILE A 285
SER A 284
LEU A 253
 None
 0.94A 3o1xA-4amqA:
undetectable		 3o1xA-4amqA:
13.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QGZ_A_ADNA127_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 1)		 4amq L544
(Acanthamoeba
polyphaga
mimivirus) 		5 / 10 ILE A 330
ASP A 288
ILE A 285
SER A 284
LEU A 253
 None
 0.98A 3qgzA-4amqA:
undetectable		 3qgzA-4amqA:
13.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UM5_A_CP6A609_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4amq L544
(Acanthamoeba
polyphaga
mimivirus) 		5 / 10 ILE A  80
THR A 277
SER A 280
ILE A 281
ILE A 267
 None
 1.16A 3um5A-4amqA:
undetectable		 3um5A-4amqA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UM5_B_CP6B709_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4amq L544
(Acanthamoeba
polyphaga
mimivirus) 		5 / 10 ILE A  80
PHE A 180
THR A 277
SER A 280
ILE A 281
 None
 1.34A 3um5B-4amqA:
undetectable		 3um5B-4amqA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UM5_B_CP6B709_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4amq L544
(Acanthamoeba
polyphaga
mimivirus) 		5 / 10 ILE A  80
THR A 277
SER A 280
ILE A 281
ILE A 267
 None
 1.17A 3um5B-4amqA:
undetectable		 3um5B-4amqA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KM0_B_CP6B201_1
(DIHYDROFOLATE
REDUCTASE)		 4amq L544
(Acanthamoeba
polyphaga
mimivirus) 		5 / 12 ILE A  20
ILE A  31
PHE A 190
LEU A   8
ILE A  16
 None
 0.92A 4km0B-4amqA:
undetectable		 4km0B-4amqA:
15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KM2_A_TOPA202_1
(DIHYDROFOLATE
REDUCTASE)		 4amq L544
(Acanthamoeba
polyphaga
mimivirus) 		5 / 12 ILE A  20
ILE A  31
PHE A 190
LEU A   8
ILE A  16
 None
 0.93A 4km2A-4amqA:
undetectable		 4km2A-4amqA:
15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNW_A_T3A501_2
(THYROID HORMONE
RECEPTOR ALPHA)		 4amq L544
(Acanthamoeba
polyphaga
mimivirus) 		3 / 3 ILE A 289
MET A   1
ARG A   0
 None
 0.82A 4lnwA-4amqA:
undetectable		 4lnwA-4amqA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNX_A_T3A502_2
(THYROID HORMONE
RECEPTOR ALPHA)		 4amq L544
(Acanthamoeba
polyphaga
mimivirus) 		3 / 3 ILE A 289
MET A   1
ARG A   0
 None
 0.80A 4lnxA-4amqA:
undetectable		 4lnxA-4amqA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O7G_A_ASCA303_0
(PROBABLE
TRANSMEMBRANE
ASCORBATE
FERRIREDUCTASE 2)		 4amq L544
(Acanthamoeba
polyphaga
mimivirus) 		4 / 7 PHE A  35
ILE A  31
TYR A  29
ARG A  26
 None
 1.43A 4o7gA-4amqA:
2.5
4o7gB-4amqA:
2.5		 4o7gA-4amqA:
19.42
4o7gB-4amqA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RVG_A_SAMA503_0
(D-MYCAROSE
3-C-METHYLTRANSFERAS
E)		 4amq L544
(Acanthamoeba
polyphaga
mimivirus) 		5 / 12 TYR A 186
THR A 266
ILE A  45
GLY A 189
ILE A  42
 None
 0.85A 4rvgA-4amqA:
undetectable		 4rvgA-4amqA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVN_D_PFLD410_1
(PROTON-GATED ION
CHANNEL)		 4amq L544
(Acanthamoeba
polyphaga
mimivirus) 		5 / 10 TYR A  11
ILE A  16
ILE A  12
VAL A 181
ILE A  42
 None
 1.47A 5mvnD-4amqA:
2.8		 5mvnD-4amqA:
11.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		 4amq L544
(Acanthamoeba
polyphaga
mimivirus) 		3 / 3 LYS A 182
LEU A 273
ASP A 276
 None
 0.69A 5zv2A-4amqA:
2.6		 5zv2A-4amqA:
12.78