SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4amt'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DG5_A_TOPA201_1
(DIHYDROFOLATE
REDUCTASE)		 4amt RENIN
(Homo
sapiens) 		5 / 11 ALA A 266
PHE A 313
SER A 281
LEU A 285
ILE A 275
 None
 1.07A 1dg5A-4amtA:
undetectable		 1dg5A-4amtA:
16.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HXW_B_RITB301_2
(HIV-1 PROTEASE)		 4amt RENIN
(Homo
sapiens) 		5 / 11 LEU A 267
ASP A 269
GLY A 271
ALA A 272
PRO A 349
 None
None
None
SO4  A1387 (-3.4A)
None
 0.82A 1hxwB-4amtA:
7.9		 1hxwB-4amtA:
12.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RL8_A_RITA9001_2
(PROTEASE RETROPEPSIN)		 4amt RENIN
(Homo
sapiens) 		5 / 12 LEU A 267
ASP A 269
GLY A 271
ALA A 272
PRO A 349
 None
None
None
SO4  A1387 (-3.4A)
None
 0.86A 1rl8B-4amtA:
7.6		 1rl8B-4amtA:
12.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T7I_A_017A200_1
(POL POLYPROTEIN)		 4amt RENIN
(Homo
sapiens) 		5 / 10 LEU A 267
ASP A 269
GLY A 271
ALA A 272
THR A 355
 None
None
None
SO4  A1387 (-3.4A)
None
 0.95A 1t7iA-4amtA:
7.2		 1t7iA-4amtA:
13.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O01_A_PQNA5001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 4amt RENIN
(Homo
sapiens) 		4 / 8 PHE A 313
TRP A 356
ALA A 357
LEU A 358
 None
 0.99A 2o01A-4amtA:
undetectable		 2o01A-4amtA:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RKG_B_AB1B501_1
(PROTEASE RETROPEPSIN)		 4amt RENIN
(Homo
sapiens) 		5 / 12 LEU A 267
ASP A 269
GLY A 271
ALA A 272
PRO A 349
 None
None
None
SO4  A1387 (-3.4A)
None
 0.80A 2rkgA-4amtA:
8.2		 2rkgA-4amtA:
12.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2V0Z_C_C41C1328_1
(RENIN)		 4amt RENIN
(Homo
sapiens) 		5 / 12 ASP A 269
GLY A 271
PRO A 349
ASP A  81
GLY A  83
 None
 0.87A 2v0zC-4amtA:
44.2		 2v0zC-4amtA:
88.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2V0Z_C_C41C1328_1
(RENIN)		 4amt RENIN
(Homo
sapiens) 		6 / 12 GLN A 178
ASP A 269
GLY A 271
ASP A  81
GLY A  83
SER A  85
 None
 1.00A 2v0zC-4amtA:
44.2		 2v0zC-4amtA:
88.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2V0Z_C_C41C1328_1
(RENIN)		 4amt RENIN
(Homo
sapiens) 		8 / 12 VAL A  79
ASP A  81
GLY A  83
SER A  84
PHE A 167
VAL A 170
ASP A 269
GLY A 271
 None
 0.62A 2v0zC-4amtA:
44.2		 2v0zC-4amtA:
88.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2V0Z_C_C41C1328_1
(RENIN)		 4amt RENIN
(Homo
sapiens) 		8 / 12 VAL A  79
ASP A  81
GLY A  83
SER A  84
VAL A 170
ASP A 269
GLY A 271
SER A 273
 None
None
None
None
None
None
None
SO4  A1387 (-3.8A)
 0.58A 2v0zC-4amtA:
44.2		 2v0zC-4amtA:
88.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2V0Z_C_C41C1328_1
(RENIN)		 4amt RENIN
(Homo
sapiens) 		6 / 12 VAL A  79
ASP A  81
SER A  84
PRO A 161
PHE A 167
VAL A 170
 None
 0.66A 2v0zC-4amtA:
44.2		 2v0zC-4amtA:
88.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2V0Z_O_C41O1327_1
(RENIN)		 4amt RENIN
(Homo
sapiens) 		6 / 12 GLN A 178
ASP A 269
GLY A 271
ASP A  81
GLY A  83
SER A  85
 None
 1.00A 2v0zO-4amtA:
44.0		 2v0zO-4amtA:
88.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2V0Z_O_C41O1327_1
(RENIN)		 4amt RENIN
(Homo
sapiens) 		6 / 12 VAL A  79
ASP A  81
ALA A 165
PHE A 167
VAL A 170
GLN A 178
 None
 0.71A 2v0zO-4amtA:
44.0		 2v0zO-4amtA:
88.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2V0Z_O_C41O1327_1
(RENIN)		 4amt RENIN
(Homo
sapiens) 		8 / 12 VAL A  79
ASP A  81
GLY A  83
PHE A 167
VAL A 170
GLN A 178
ASP A 269
GLY A 271
 None
 0.66A 2v0zO-4amtA:
44.0		 2v0zO-4amtA:
88.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2V0Z_O_C41O1327_1
(RENIN)		 4amt RENIN
(Homo
sapiens) 		9 / 12 VAL A  79
ASP A  81
GLY A  83
VAL A 170
GLN A 178
ASP A 269
GLY A 271
SER A 273
ILE A 348
 None
None
None
None
None
None
None
SO4  A1387 (-3.8A)
None
 0.70A 2v0zO-4amtA:
44.0		 2v0zO-4amtA:
88.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2V0Z_O_C41O1327_2
(RENIN)		 4amt RENIN
(Homo
sapiens) 		4 / 8 TYR A 126
SER A 127
THR A 128
PRO A 161
 None
 0.89A 2v0zO-4amtA:
44.0		 2v0zO-4amtA:
88.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3V_A_TOPA1169_1
(DIHYDROFOLATE
REDUCTASE)		 4amt RENIN
(Homo
sapiens) 		5 / 12 ALA A 266
PHE A 313
SER A 281
LEU A 285
ILE A 275
 None
 1.13A 2w3vA-4amtA:
undetectable		 2w3vA-4amtA:
16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_A_P1ZA1353_1
(PROSTAGLANDIN
REDUCTASE 2)		 4amt RENIN
(Homo
sapiens) 		5 / 9 GLU A 156
VAL A 131
GLY A 152
PHE A 134
GLU A 121
 None
 1.39A 2w98A-4amtA:
undetectable		 2w98A-4amtA:
23.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3D91_A_REMA350_1
(RENIN)		 4amt RENIN
(Homo
sapiens) 		7 / 12 ASP A  81
GLY A  83
LEU A 267
ASP A 269
SER A 273
SER A 276
ALA A 357
 None
None
None
None
SO4  A1387 (-3.8A)
None
None
 0.42A 3d91A-4amtA:
44.5		 3d91A-4amtA:
88.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3D91_A_REMA350_1
(RENIN)		 4amt RENIN
(Homo
sapiens) 		7 / 12 ASP A  81
GLY A  83
PHE A 167
LEU A 267
ASP A 269
SER A 276
ALA A 357
 None
 0.70A 3d91A-4amtA:
44.5		 3d91A-4amtA:
88.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3D91_A_REMA350_1
(RENIN)		 4amt RENIN
(Homo
sapiens) 		6 / 12 GLN A  62
ASP A  81
GLY A  83
LEU A 267
ASP A 269
SER A 273
 None
None
None
None
None
SO4  A1387 (-3.8A)
 1.32A 3d91A-4amtA:
44.5		 3d91A-4amtA:
88.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3D91_B_REMB350_1
(RENIN)		 4amt RENIN
(Homo
sapiens) 		8 / 12 ASP A  81
GLY A  83
VAL A 170
LEU A 267
ASP A 269
ALA A 272
SER A 273
SER A 276
 None
None
None
None
None
SO4  A1387 (-3.4A)
SO4  A1387 (-3.8A)
None
 0.57A 3d91B-4amtA:
44.2		 3d91B-4amtA:
88.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3D91_B_REMB350_1
(RENIN)		 4amt RENIN
(Homo
sapiens) 		8 / 12 GLN A  62
ASP A  81
GLY A  83
LEU A 267
ASP A 269
ALA A 272
SER A 273
SER A 276
 None
None
None
None
None
SO4  A1387 (-3.4A)
SO4  A1387 (-3.8A)
None
 1.35A 3d91B-4amtA:
44.2		 3d91B-4amtA:
88.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3D91_B_REMB350_1
(RENIN)		 4amt RENIN
(Homo
sapiens) 		8 / 12 GLN A  62
ASP A  81
GLY A  83
VAL A  79
LEU A 267
ASP A 269
ALA A 272
SER A 276
 None
None
None
None
None
None
SO4  A1387 (-3.4A)
None
 1.33A 3d91B-4amtA:
44.2		 3d91B-4amtA:
88.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDT_A_ROCA101_3
(PROTEASE)		 4amt RENIN
(Homo
sapiens) 		5 / 12 LEU A 267
ASP A 269
GLY A 271
ALA A 272
PRO A 349
 None
None
None
SO4  A1387 (-3.4A)
None
 0.75A 3ndtB-4amtA:
8.1		 3ndtB-4amtA:
14.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QOW_A_SAMA417_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE)		 4amt RENIN
(Homo
sapiens) 		5 / 12 TYR A  64
GLY A  65
GLU A  66
GLY A 169
ALA A 165
 None
 1.33A 3qowA-4amtA:
undetectable		 3qowA-4amtA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RV5_A_DXCA91_0
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 4amt RENIN
(Homo
sapiens) 		3 / 3 PHE A 151
GLN A 193
PHE A 107
 None
 0.83A 3rv5A-4amtA:
undetectable		 3rv5A-4amtA:
15.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAQ_B_ADNB401_2
(PUTATIVE ADENOSINE
KINASE)		 4amt RENIN
(Homo
sapiens) 		4 / 4 LEU A  33
GLY A  34
MET A  59
PHE A 296
 None
 1.40A 3vaqB-4amtA:
undetectable		 3vaqB-4amtA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AFG_B_QMRB1214_1
(CAPITELLA TELETA
ACHBP)		 4amt RENIN
(Homo
sapiens) 		5 / 9 ILE A 180
PHE A 162
PHE A 167
TRP A  88
TYR A  58
 None
 1.48A 4afgA-4amtA:
undetectable
4afgE-4amtA:
undetectable		 4afgA-4amtA:
19.13
4afgE-4amtA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9W_A_VGHA1158_1
(7,8-DIHYDRO-8-OXOGUA
NINE TRIPHOSPHATASE)		 4amt RENIN
(Homo
sapiens) 		5 / 12 LEU A 124
PHE A 162
MET A 157
VAL A 131
PHE A 167
 None
 1.37A 4c9wA-4amtA:
undetectable		 4c9wA-4amtA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJT_B_017B101_2
(PROTEASE)		 4amt RENIN
(Homo
sapiens) 		5 / 10 LEU A 267
ASP A 269
GLY A 271
ALA A 272
THR A 355
 None
None
None
SO4  A1387 (-3.4A)
None
 0.90A 4njtB-4amtA:
8.0		 4njtB-4amtA:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJT_D_017D101_2
(PROTEASE)		 4amt RENIN
(Homo
sapiens) 		5 / 9 LEU A 267
ASP A 269
GLY A 271
ALA A 272
THR A 355
 None
None
None
SO4  A1387 (-3.4A)
None
 0.92A 4njtD-4amtA:
8.0		 4njtD-4amtA:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q5M_A_ROCA1101_3
(PROTEASE)		 4amt RENIN
(Homo
sapiens) 		3 / 3 ASP A 269
ASP A  81
ASN A  86
 None
 0.59A 4q5mA-4amtA:
6.6		 4q5mA-4amtA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E5J_A_017A201_2
(PROTEASE)		 4amt RENIN
(Homo
sapiens) 		5 / 12 LEU A 267
ASP A 269
GLY A 271
ALA A 272
ILE A 348
 None
None
None
SO4  A1387 (-3.4A)
None
 0.68A 5e5jB-4amtA:
8.1		 5e5jB-4amtA:
14.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T7B_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 4amt RENIN
(Homo
sapiens) 		4 / 7 LEU A 289
PRO A 309
LEU A 341
TYR A 327
 None
 0.94A 5t7bA-4amtA:
undetectable		 5t7bA-4amtA:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YN6_A_SAMA401_0
(NSP16 PROTEIN)		 4amt RENIN
(Homo
sapiens) 		5 / 12 TYR A  58
GLY A 172
ASP A  81
MET A 173
PHE A 201
 None
 1.12A 5yn6A-4amtA:
undetectable		 5yn6A-4amtA:
21.07