SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ani'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IBG_H_OBNH1_2
(IGG2B-KAPPA 40-50
FAB (HEAVY CHAIN)
IGG2B-KAPPA 40-50
FAB (LIGHT CHAIN))		 4ani PROTEIN GRPE
(Geobacillus
kaustophilus) 		4 / 7 SER A 148
ARG A 147
TYR A 146
LEU A 149
 None
 1.05A 1ibgL-4aniA:
undetectable		 1ibgL-4aniA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3B_B_FOLB401_1
(DIHYDROFOLATE
REDUCTASE)		 4ani PROTEIN GRPE
(Geobacillus
kaustophilus) 		3 / 3 GLU A 191
GLN A 194
ARG A 124
 None
 0.97A 2w3bB-4aniA:
undetectable		 2w3bB-4aniA:
21.52