SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ao7'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C6Y_B_MK1B524_1
(PROTEIN (PROTEASE))		 4ao7 ESTERASE
(unidentified) 		5 / 11 ALA A 125
VAL A  31
ILE A 119
PRO A  82
ILE A  79
 None
 0.83A 1c6yA-4ao7A:
undetectable		 1c6yA-4ao7A:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C6Z_B_ROCB505_2
(PROTEIN (PROTEASE))		 4ao7 ESTERASE
(unidentified) 		5 / 12 ALA A 125
VAL A  31
ILE A 119
PRO A  82
ILE A  79
 None
 0.83A 1c6zB-4ao7A:
undetectable		 1c6zB-4ao7A:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GMK_A_DVAA8_0
(GRAMICIDIN A)		 4ao7 ESTERASE
(unidentified) 		3 / 4 VAL A  70
TRP A 141
TRP A  36
 None
 1.31A 1gmkA-4ao7A:
undetectable
1gmkB-4ao7A:
undetectable		 1gmkA-4ao7A:
9.45
1gmkB-4ao7A:
9.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GMK_D_DVAD8_0
(GRAMICIDIN A)		 4ao7 ESTERASE
(unidentified) 		3 / 3 TRP A 141
VAL A 162
TRP A 140
 None
 1.32A 1gmkC-4ao7A:
undetectable
1gmkD-4ao7A:
undetectable		 1gmkC-4ao7A:
9.45
1gmkD-4ao7A:
9.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GMK_D_DVAD8_0
(GRAMICIDIN A)		 4ao7 ESTERASE
(unidentified) 		3 / 3 TRP A 141
VAL A 189
TRP A 140
 None
 1.37A 1gmkC-4ao7A:
undetectable
1gmkD-4ao7A:
undetectable		 1gmkC-4ao7A:
9.45
1gmkD-4ao7A:
9.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HPV_B_478B200_2
(HIV-1 PROTEASE)		 4ao7 ESTERASE
(unidentified) 		5 / 9 ALA A 125
VAL A  31
ILE A 119
PRO A  82
ILE A  79
 None
 0.82A 1hpvB-4ao7A:
undetectable		 1hpvB-4ao7A:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HSH_A_MK1A401_1
(HIV-II PROTEASE)		 4ao7 ESTERASE
(unidentified) 		5 / 12 ALA A 125
VAL A  26
ILE A 119
PRO A  82
ILE A  79
 None
 0.87A 1hshA-4ao7A:
undetectable		 1hshA-4ao7A:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HSH_A_MK1A401_2
(HIV-II PROTEASE)		 4ao7 ESTERASE
(unidentified) 		5 / 9 ALA A 125
VAL A  26
ILE A 119
PRO A  82
ILE A  79
 None
 0.96A 1hshB-4ao7A:
undetectable		 1hshB-4ao7A:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MUI_B_AB1B100_1
(PROTEASE)		 4ao7 ESTERASE
(unidentified) 		5 / 10 ALA A 125
VAL A  31
ILE A 119
PRO A  82
ILE A  79
 None
 0.75A 1muiA-4ao7A:
undetectable		 1muiA-4ao7A:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RL8_A_RITA9001_1
(PROTEASE RETROPEPSIN)		 4ao7 ESTERASE
(unidentified) 		5 / 12 ALA A 125
VAL A  31
ILE A 119
PRO A  82
ILE A  79
 None
 0.80A 1rl8A-4ao7A:
undetectable		 1rl8A-4ao7A:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T3R_A_017A1200_2
(PROTEASE RETROPEPSIN)		 4ao7 ESTERASE
(unidentified) 		5 / 11 ALA A 125
VAL A  31
ILE A 119
PRO A  82
ILE A  79
 None
 0.91A 1t3rB-4ao7A:
undetectable		 1t3rB-4ao7A:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA4_B_ACTB601_0
(ACETYLCHOLINESTERASE)		 4ao7 ESTERASE
(unidentified) 		4 / 7 GLY A 114
GLY A 113
ALA A 116
ALA A 117
 None
 0.63A 2ha4B-4ao7A:
12.5		 2ha4B-4ao7A:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IDW_B_017B401_1
(PROTEASE)		 4ao7 ESTERASE
(unidentified) 		5 / 11 ALA A 125
VAL A  31
ILE A 119
PRO A  82
ILE A  79
 None
 0.99A 2idwA-4ao7A:
undetectable		 2idwA-4ao7A:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYU_B_SAMB201_0
(PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2)		 4ao7 ESTERASE
(unidentified) 		5 / 12 ALA A  78
GLY A  33
LEU A  49
VAL A 153
THR A 154
 None
 0.89A 2nyuB-4ao7A:
3.6		 2nyuB-4ao7A:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PYM_A_1UNA1001_2
(PROTEASE RETROPEPSIN)		 4ao7 ESTERASE
(unidentified) 		5 / 12 ALA A 125
VAL A  31
ILE A 119
PRO A  82
ILE A  79
 None
 0.91A 2pymB-4ao7A:
undetectable		 2pymB-4ao7A:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PYN_A_1UNA1001_1
(PROTEASE RETROPEPSIN)		 4ao7 ESTERASE
(unidentified) 		5 / 12 ALA A 125
VAL A  31
ILE A 119
PRO A  82
ILE A  79
 None
 0.85A 2pynA-4ao7A:
undetectable		 2pynA-4ao7A:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q5K_A_AB1A201_1
(PROTEASE)		 4ao7 ESTERASE
(unidentified) 		5 / 9 ALA A 125
VAL A  31
ILE A 119
PRO A  82
ILE A  79
 None
 0.98A 2q5kA-4ao7A:
undetectable		 2q5kA-4ao7A:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q63_A_1UNA1001_3
(PROTEASE RETROPEPSIN)		 4ao7 ESTERASE
(unidentified) 		5 / 12 ALA A 125
VAL A  31
ILE A 119
PRO A  82
ILE A  79
 None
 0.84A 2q63B-4ao7A:
undetectable		 2q63B-4ao7A:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q64_B_1UNB1001_1
(PROTEASE RETROPEPSIN)		 4ao7 ESTERASE
(unidentified) 		5 / 12 ALA A 125
VAL A  31
ILE A 119
PRO A  82
ILE A  79
 None
 0.79A 2q64A-4ao7A:
undetectable		 2q64A-4ao7A:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QAK_A_1UNA1001_1
(PROTEASE RETROPEPSIN)		 4ao7 ESTERASE
(unidentified) 		5 / 12 ALA A 125
VAL A  31
ILE A 119
PRO A  82
ILE A  79
 None
 0.87A 2qakA-4ao7A:
undetectable		 2qakA-4ao7A:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHC_B_AB1B9001_1
(PROTEASE RETROPEPSIN)		 4ao7 ESTERASE
(unidentified) 		5 / 11 ALA A 125
VAL A  31
ILE A 119
PRO A  82
ILE A  79
 None
 0.86A 2qhcA-4ao7A:
undetectable		 2qhcA-4ao7A:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X1L_A_ADNA601_1
(METHIONYL-TRNA
SYNTHETASE)		 4ao7 ESTERASE
(unidentified) 		5 / 11 ALA A  78
ALA A  76
GLY A 139
GLY A  50
ILE A  62
 None
 1.09A 2x1lA-4ao7A:
undetectable		 2x1lA-4ao7A:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGN_A_PCFA1179_0
(WNT INHIBITORY
FACTOR 1)		 4ao7 ESTERASE
(unidentified) 		5 / 12 LEU A 192
LEU A 126
ILE A 160
ILE A 129
VAL A  65
 None
 1.10A 2ygnA-4ao7A:
undetectable		 2ygnA-4ao7A:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z54_A_AB1A200_1
(HIV-1 PROTEASE)		 4ao7 ESTERASE
(unidentified) 		5 / 12 ALA A 125
VAL A  31
ILE A 119
PRO A  82
ILE A  79
 None
 0.81A 2z54A-4ao7A:
undetectable		 2z54A-4ao7A:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z54_A_AB1A200_2
(HIV-1 PROTEASE)		 4ao7 ESTERASE
(unidentified) 		5 / 12 ALA A 125
VAL A  31
ILE A 119
PRO A  82
ILE A  79
 None
 0.84A 2z54B-4ao7A:
undetectable		 2z54B-4ao7A:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C6G_B_VD3B700_1
(CYTOCHROME P450 2R1)		 4ao7 ESTERASE
(unidentified) 		5 / 12 LEU A 208
ALA A 155
ALA A 163
GLY A 166
THR A 115
 None
 1.14A 3c6gB-4ao7A:
undetectable		 3c6gB-4ao7A:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D1Z_B_017B201_1
(HIV-1 PROTEASE)		 4ao7 ESTERASE
(unidentified) 		5 / 12 ALA A 125
VAL A  31
ILE A 119
PRO A  82
ILE A  79
 None
 0.78A 3d1zA-4ao7A:
undetectable		 3d1zA-4ao7A:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKP_B_478B200_2
(PROTEASE)		 4ao7 ESTERASE
(unidentified) 		5 / 10 ALA A 125
VAL A  31
ILE A 119
PRO A  82
ILE A  79
 None
 0.94A 3ekpB-4ao7A:
undetectable		 3ekpB-4ao7A:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKV_A_478A200_2
(PROTEASE)		 4ao7 ESTERASE
(unidentified) 		5 / 9 ALA A 125
VAL A  31
ILE A 119
PRO A  82
ILE A  79
 None
 0.93A 3ekvB-4ao7A:
undetectable		 3ekvB-4ao7A:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKX_B_1UNB201_1
(PROTEASE)		 4ao7 ESTERASE
(unidentified) 		5 / 11 ALA A 125
VAL A  31
ILE A 119
PRO A  82
ILE A  79
 None
 0.87A 3ekxA-4ao7A:
undetectable		 3ekxA-4ao7A:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKX_B_1UNB201_2
(PROTEASE)		 4ao7 ESTERASE
(unidentified) 		5 / 11 ALA A 125
VAL A  31
ILE A 119
PRO A  82
ILE A  79
 None
 0.89A 3ekxB-4ao7A:
undetectable		 3ekxB-4ao7A:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JVY_B_017B401_1
(GAG-POL POLYPROTEIN)		 4ao7 ESTERASE
(unidentified) 		5 / 12 ALA A 125
VAL A  31
ILE A 119
PRO A  82
ILE A  79
 None
 0.95A 3jvyA-4ao7A:
undetectable		 3jvyA-4ao7A:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_D_ROCD201_1
(HIV-1 PROTEASE)		 4ao7 ESTERASE
(unidentified) 		5 / 12 ALA A 125
VAL A  31
ILE A 119
PRO A  82
ILE A  79
 None
 0.84A 3k4vC-4ao7A:
undetectable		 3k4vC-4ao7A:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LZV_A_017A200_2
(HIV-1 PROTEASE)		 4ao7 ESTERASE
(unidentified) 		5 / 11 ALA A 125
VAL A  31
ILE A 119
PRO A  82
ILE A  79
 None
 0.94A 3lzvB-4ao7A:
undetectable		 3lzvB-4ao7A:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDW_A_RITA100_1
(PROTEASE)		 4ao7 ESTERASE
(unidentified) 		5 / 12 ALA A 125
VAL A  31
ILE A 119
PRO A  82
ILE A  79
 None
 0.74A 3ndwA-4ao7A:
undetectable		 3ndwA-4ao7A:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU6_B_478B401_1
(PROTEASE)		 4ao7 ESTERASE
(unidentified) 		5 / 10 ALA A 125
VAL A  31
ILE A 119
PRO A  82
ILE A  79
 None
 0.78A 3nu6A-4ao7A:
undetectable		 3nu6A-4ao7A:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NUJ_B_478B401_1
(PROTEASE)		 4ao7 ESTERASE
(unidentified) 		5 / 10 ALA A 125
VAL A  31
ILE A 119
PRO A  82
ILE A  79
 None
 0.89A 3nujA-4ao7A:
undetectable		 3nujA-4ao7A:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXC_A_ROCA401_1
(PROTEASE)		 4ao7 ESTERASE
(unidentified) 		5 / 12 ALA A 125
VAL A  31
ILE A 119
PRO A  82
ILE A  79
 None
 0.82A 3oxcA-4ao7A:
undetectable		 3oxcA-4ao7A:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OY4_B_017B200_1
(HIV-1 PROTEASE)		 4ao7 ESTERASE
(unidentified) 		5 / 11 ALA A 125
VAL A  31
ILE A 119
PRO A  82
ILE A  79
 None
 0.85A 3oy4A-4ao7A:
undetectable		 3oy4A-4ao7A:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_C_RTZC2_1
(CYTOCHROME P450 2D6)		 4ao7 ESTERASE
(unidentified) 		5 / 10 LEU A 212
THR A 214
VAL A 189
VAL A 153
THR A 154
 None
 1.42A 3tbgC-4ao7A:
undetectable		 3tbgC-4ao7A:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQC_A_017A101_1
(ASPARTYL PROTEASE)		 4ao7 ESTERASE
(unidentified) 		5 / 10 ALA A 125
VAL A  31
ILE A 119
PRO A  82
ILE A  79
 None
 0.90A 4dqcA-4ao7A:
undetectable		 4dqcA-4ao7A:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQE_B_017B101_1
(ASPARTYL PROTEASE)		 4ao7 ESTERASE
(unidentified) 		5 / 11 ALA A 125
VAL A  31
ILE A 119
PRO A  82
ILE A  79
 None
 0.91A 4dqeA-4ao7A:
undetectable		 4dqeA-4ao7A:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQH_B_017B101_1
(WILD-TYPE HIV-1
PROTEASE DIMER)		 4ao7 ESTERASE
(unidentified) 		5 / 11 ALA A 125
VAL A  31
ILE A 119
PRO A  82
ILE A  79
 None
 0.93A 4dqhA-4ao7A:
undetectable		 4dqhA-4ao7A:
16.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JEC_B_478B401_2
(HIV-1 PROTEASE)		 4ao7 ESTERASE
(unidentified) 		5 / 12 ALA A 125
VAL A  31
ILE A 119
PRO A  82
ILE A  79
 None
 0.81A 4jecB-4ao7A:
undetectable		 4jecB-4ao7A:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJT_B_017B101_1
(PROTEASE)		 4ao7 ESTERASE
(unidentified) 		5 / 11 ALA A 125
VAL A  31
ILE A 119
PRO A  82
ILE A  79
 None
 0.97A 4njtA-4ao7A:
undetectable		 4njtA-4ao7A:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJV_A_RITA500_1
(PROTEASE)		 4ao7 ESTERASE
(unidentified) 		5 / 12 ALA A 125
VAL A  31
ILE A 119
PRO A  82
ILE A  79
 None
 0.73A 4njvA-4ao7A:
undetectable		 4njvA-4ao7A:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJV_D_RITD500_2
(PROTEASE)		 4ao7 ESTERASE
(unidentified) 		5 / 12 ALA A 125
VAL A  31
ILE A 119
PRO A  82
ILE A  79
 None
 0.87A 4njvD-4ao7A:
undetectable		 4njvD-4ao7A:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q1W_A_017A104_2
(ASPARTYL PROTEASE)		 4ao7 ESTERASE
(unidentified) 		5 / 10 ALA A 125
VAL A  31
ILE A 119
PRO A  82
ILE A  79
 None
 0.94A 4q1wB-4ao7A:
undetectable		 4q1wB-4ao7A:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QGI_A_ROCA101_2
(PROTEASE)		 4ao7 ESTERASE
(unidentified) 		5 / 11 ALA A 125
VAL A  31
ILE A 119
PRO A  82
ILE A  79
 None
 0.93A 4qgiB-4ao7A:
undetectable		 4qgiB-4ao7A:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RVJ_B_478B101_1
(HIV-1 PROTEASE)		 4ao7 ESTERASE
(unidentified) 		5 / 11 ALA A 125
VAL A  31
ILE A 119
PRO A  82
ILE A  79
 None
 0.93A 4rvjA-4ao7A:
undetectable		 4rvjA-4ao7A:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RVJ_D_478D101_1
(HIV-1 PROTEASE)		 4ao7 ESTERASE
(unidentified) 		5 / 11 ALA A 125
VAL A  31
ILE A 119
PRO A  82
ILE A  79
 None
 0.90A 4rvjC-4ao7A:
undetectable		 4rvjC-4ao7A:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_A_HISA302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 4ao7 ESTERASE
(unidentified) 		5 / 10 GLY A 101
VAL A 100
VAL A  99
HIS A 226
SER A 144
 None
 1.16A 4yb6A-4ao7A:
undetectable
4yb6E-4ao7A:
undetectable		 4yb6A-4ao7A:
21.74
4yb6E-4ao7A:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_B_HISB302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 4ao7 ESTERASE
(unidentified) 		5 / 10 GLY A 101
VAL A 100
VAL A  99
HIS A 226
SER A 144
 None
 1.16A 4yb6B-4ao7A:
undetectable
4yb6C-4ao7A:
undetectable		 4yb6B-4ao7A:
21.74
4yb6C-4ao7A:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_C_HISC302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 4ao7 ESTERASE
(unidentified) 		5 / 10 GLY A 101
VAL A 100
VAL A  99
HIS A 226
SER A 144
 None
 1.20A 4yb6C-4ao7A:
undetectable
4yb6F-4ao7A:
undetectable		 4yb6C-4ao7A:
21.74
4yb6F-4ao7A:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_D_HISD302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 4ao7 ESTERASE
(unidentified) 		5 / 10 HIS A 226
SER A 144
GLY A 101
VAL A 100
VAL A  99
 None
 1.21A 4yb6A-4ao7A:
undetectable
4yb6D-4ao7A:
undetectable		 4yb6A-4ao7A:
21.74
4yb6D-4ao7A:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_E_HISE302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 4ao7 ESTERASE
(unidentified) 		5 / 10 HIS A 226
SER A 144
GLY A 101
VAL A 100
VAL A  99
 None
 1.20A 4yb6D-4ao7A:
undetectable
4yb6E-4ao7A:
undetectable		 4yb6D-4ao7A:
21.74
4yb6E-4ao7A:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_F_HISF302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 4ao7 ESTERASE
(unidentified) 		5 / 10 HIS A 226
SER A 144
GLY A 101
VAL A 100
VAL A  99
 None
 1.16A 4yb6B-4ao7A:
undetectable
4yb6F-4ao7A:
undetectable		 4yb6B-4ao7A:
21.74
4yb6F-4ao7A:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E26_C_PAUC602_0
(PANTOTHENATE KINASE
2, MITOCHONDRIAL)		 4ao7 ESTERASE
(unidentified) 		5 / 7 GLY A  41
SER A  43
GLY A  73
TYR A  35
ALA A  39
 None
 1.29A 5e26C-4ao7A:
undetectable
5e26D-4ao7A:
undetectable		 5e26C-4ao7A:
21.18
5e26D-4ao7A:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HG0_A_SAMA301_0
(PANTOTHENATE
SYNTHETASE)		 4ao7 ESTERASE
(unidentified) 		5 / 12 HIS A 226
LEU A 143
VAL A 118
GLY A 166
GLN A 194
 None
 1.22A 5hg0A-4ao7A:
2.4		 5hg0A-4ao7A:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I71_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 4ao7 ESTERASE
(unidentified) 		5 / 12 ILE A  62
TYR A  61
GLY A 150
LEU A  69
GLY A  52
 None
 1.32A 5i71A-4ao7A:
undetectable		 5i71A-4ao7A:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KQY_B_017B101_1
(PROTEASE E35D-DRV)		 4ao7 ESTERASE
(unidentified) 		5 / 12 ALA A 125
VAL A  31
ILE A 119
PRO A  82
ILE A  79
 None
 0.93A 5kqyA-4ao7A:
undetectable		 5kqyA-4ao7A:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B0C_D_TA1D502_1
(TUBULIN BETA CHAIN)		 4ao7 ESTERASE
(unidentified) 		5 / 12 VAL A  26
LEU A 126
ALA A 125
LEU A  48
GLY A  81
 None
 1.00A 6b0cD-4ao7A:
4.1		 6b0cD-4ao7A:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJ2_B_AB1B201_0
(HIV-1 PROTEASE)		 4ao7 ESTERASE
(unidentified) 		5 / 10 ALA A 125
VAL A  31
ILE A 119
PRO A  82
ILE A  79
 None
 0.90A 6dj2A-4ao7A:
undetectable		 6dj2A-4ao7A:
18.27