SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4aoa'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A29_A_TFPA154_1
(CALMODULIN)		 4aoa BETA-PHENYLALANINE
AMINOTRANSFERASE
(Variovorax
paradoxus) 		5 / 10 GLU A 241
ALA A 248
LEU A 357
GLU A 207
MET A 209
 None
None
None
IK2  A1435 (-4.0A)
None
 1.41A 1a29A-4aoaA:
undetectable		 1a29A-4aoaA:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DFO_A_FFOA1002_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4aoa BETA-PHENYLALANINE
AMINOTRANSFERASE
(Variovorax
paradoxus) 		4 / 5 TYR A 394
TYR A  69
PHE A 385
PRO A 397
 None
 1.35A 1dfoB-4aoaA:
21.9		 1dfoB-4aoaA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DFO_B_FFOB2002_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4aoa BETA-PHENYLALANINE
AMINOTRANSFERASE
(Variovorax
paradoxus) 		4 / 5 TYR A 394
TYR A  69
PHE A 385
PRO A 397
 None
 1.34A 1dfoA-4aoaA:
21.1		 1dfoA-4aoaA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DFO_C_FFOC3002_2
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4aoa BETA-PHENYLALANINE
AMINOTRANSFERASE
(Variovorax
paradoxus) 		4 / 5 TYR A 394
TYR A  69
PHE A 385
PRO A 397
 None
 1.34A 1dfoD-4aoaA:
21.1		 1dfoD-4aoaA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DFO_D_FFOD4002_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4aoa BETA-PHENYLALANINE
AMINOTRANSFERASE
(Variovorax
paradoxus) 		4 / 5 TYR A 394
TYR A  69
PHE A 385
PRO A 397
 None
 1.34A 1dfoC-4aoaA:
22.1		 1dfoC-4aoaA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_B_SAMB1293_0
(GLYCINE
N-METHYLTRANSFERASE)		 4aoa BETA-PHENYLALANINE
AMINOTRANSFERASE
(Variovorax
paradoxus) 		5 / 12 ILE A 116
GLY A 279
ALA A 142
GLY A 276
HIS A 297
 None
 1.23A 1kiaB-4aoaA:
2.6		 1kiaB-4aoaA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MMT_A_H4BA1426_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 4aoa BETA-PHENYLALANINE
AMINOTRANSFERASE
(Variovorax
paradoxus) 		5 / 11 LEU A 262
PHE A 278
LEU A 126
THR A 141
HIS A 297
 None
 1.31A 1mmtA-4aoaA:
undetectable		 1mmtA-4aoaA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYU_B_SAMB201_0
(PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2)		 4aoa BETA-PHENYLALANINE
AMINOTRANSFERASE
(Variovorax
paradoxus) 		5 / 12 SER A 370
ALA A 212
GLY A 214
THR A 264
LEU A 205
 None
 0.92A 2nyuB-4aoaA:
undetectable		 2nyuB-4aoaA:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VMY_A_FFOA505_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4aoa BETA-PHENYLALANINE
AMINOTRANSFERASE
(Variovorax
paradoxus) 		4 / 6 TYR A 394
TYR A  69
PHE A 385
PRO A 397
 None
 1.29A 2vmyA-4aoaA:
23.3		 2vmyA-4aoaA:
25.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZB7_A_NCAA901_0
(PROSTAGLANDIN
REDUCTASE 2)		 4aoa BETA-PHENYLALANINE
AMINOTRANSFERASE
(Variovorax
paradoxus) 		4 / 5 TYR A 415
ILE A 393
MET A 358
LEU A 407
 None
 1.05A 2zb7A-4aoaA:
3.1		 2zb7A-4aoaA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E23_A_SAMA221_0
(UNCHARACTERIZED
PROTEIN RPA2492)		 4aoa BETA-PHENYLALANINE
AMINOTRANSFERASE
(Variovorax
paradoxus) 		5 / 12 LEU A 403
GLY A 325
GLY A 331
SER A 356
LEU A 334
 None
 1.05A 3e23A-4aoaA:
undetectable		 3e23A-4aoaA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_C_CHDC150_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 4aoa BETA-PHENYLALANINE
AMINOTRANSFERASE
(Variovorax
paradoxus) 		5 / 12 THR A 174
VAL A 163
PHE A 166
VAL A 203
ILE A 152
 None
 1.46A 3elzC-4aoaA:
undetectable		 3elzC-4aoaA:
15.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_B_H3PB552_1
(GLUTAMATE
DEHYDROGENASE)		 4aoa BETA-PHENYLALANINE
AMINOTRANSFERASE
(Variovorax
paradoxus) 		3 / 3 TYR A  46
TYR A  76
ILE A  73
 None
IK2  A1435 (-4.6A)
None
 0.64A 3eteA-4aoaA:
undetectable
3eteB-4aoaA:
undetectable		 3eteA-4aoaA:
22.04
3eteB-4aoaA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K9W_A_ACTA170_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 4aoa BETA-PHENYLALANINE
AMINOTRANSFERASE
(Variovorax
paradoxus) 		3 / 3 SER A 131
GLY A 132
THR A 133
 IK2  A1435 (-3.8A)
IK2  A1435 (-3.4A)
IK2  A1435 (-3.6A)
 0.15A 3k9wA-4aoaA:
undetectable		 3k9wA-4aoaA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_E_TFPE201_1
(PROTEIN S100-A4)		 4aoa BETA-PHENYLALANINE
AMINOTRANSFERASE
(Variovorax
paradoxus) 		4 / 7 GLY A 158
PHE A 166
PHE A 177
PHE A 179
 None
 1.14A 3ko0D-4aoaA:
undetectable
3ko0E-4aoaA:
undetectable		 3ko0D-4aoaA:
10.53
3ko0E-4aoaA:
10.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MTE_A_SAMA220_0
(16S RRNA METHYLASE)		 4aoa BETA-PHENYLALANINE
AMINOTRANSFERASE
(Variovorax
paradoxus) 		5 / 12 GLY A  79
ALA A  60
ALA A  70
THR A 408
LEU A 407
 None
GOL  A1436 ( 3.7A)
GOL  A1436 (-3.8A)
GOL  A1436 ( 4.8A)
None
 0.98A 3mteA-4aoaA:
undetectable		 3mteA-4aoaA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MTE_B_SAMB220_0
(16S RRNA METHYLASE)		 4aoa BETA-PHENYLALANINE
AMINOTRANSFERASE
(Variovorax
paradoxus) 		5 / 12 GLY A  79
ALA A  60
ALA A  70
THR A 408
LEU A 407
 None
GOL  A1436 ( 3.7A)
GOL  A1436 (-3.8A)
GOL  A1436 ( 4.8A)
None
 1.06A 3mteB-4aoaA:
undetectable		 3mteB-4aoaA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_A_SAMA6735_0
(16S RRNA METHYLASE)		 4aoa BETA-PHENYLALANINE
AMINOTRANSFERASE
(Variovorax
paradoxus) 		5 / 12 GLY A  79
ALA A  60
ALA A  70
THR A 408
LEU A 407
 None
GOL  A1436 ( 3.7A)
GOL  A1436 (-3.8A)
GOL  A1436 ( 4.8A)
None
 1.07A 3p2kA-4aoaA:
undetectable		 3p2kA-4aoaA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PFG_A_SAMA264_1
(N-METHYLTRANSFERASE)		 4aoa BETA-PHENYLALANINE
AMINOTRANSFERASE
(Variovorax
paradoxus) 		3 / 3 TYR A 394
TYR A  46
GLU A  75
 None
 0.90A 3pfgA-4aoaA:
3.1		 3pfgA-4aoaA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VM4_A_IZPA1_1
(FATTY ACID
ALPHA-HYDROXYLASE)		 4aoa BETA-PHENYLALANINE
AMINOTRANSFERASE
(Variovorax
paradoxus) 		4 / 5 LEU A 315
PHE A 319
PRO A 321
ALA A 324
 None
 1.07A 3vm4A-4aoaA:
undetectable		 3vm4A-4aoaA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DM8_B_REAB1501_1
(RETINOIC ACID
RECEPTOR BETA)		 4aoa BETA-PHENYLALANINE
AMINOTRANSFERASE
(Variovorax
paradoxus) 		5 / 12 LEU A  10
ALA A   9
LEU A 429
PHE A 422
GLY A 424
 None
 0.83A 4dm8B-4aoaA:
undetectable		 4dm8B-4aoaA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PCL_B_SAMB301_0
(O-METHYLTRANSFERASE
FAMILY PROTEIN)		 4aoa BETA-PHENYLALANINE
AMINOTRANSFERASE
(Variovorax
paradoxus) 		5 / 12 GLY A 346
CYH A 342
PHE A 422
ALA A 433
ASN A 434
 None
 1.22A 4pclB-4aoaA:
3.3		 4pclB-4aoaA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVP_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 4aoa BETA-PHENYLALANINE
AMINOTRANSFERASE
(Variovorax
paradoxus) 		5 / 10 ALA A 139
THR A 174
GLY A 162
GLY A 161
ASP A 240
 None
None
None
IK2  A1435 (-3.6A)
IK2  A1435 (-2.8A)
 0.97A 4qvpK-4aoaA:
undetectable
4qvpL-4aoaA:
undetectable		 4qvpK-4aoaA:
17.19
4qvpL-4aoaA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVP_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 4aoa BETA-PHENYLALANINE
AMINOTRANSFERASE
(Variovorax
paradoxus) 		5 / 10 ALA A 139
THR A 174
GLY A 162
GLY A 161
ASP A 240
 None
None
None
IK2  A1435 (-3.6A)
IK2  A1435 (-2.8A)
 0.97A 4qvpY-4aoaA:
undetectable
4qvpZ-4aoaA:
undetectable		 4qvpY-4aoaA:
17.19
4qvpZ-4aoaA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R7I_A_STIA1001_2
(MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR)		 4aoa BETA-PHENYLALANINE
AMINOTRANSFERASE
(Variovorax
paradoxus) 		4 / 5 LEU A 164
VAL A 181
VAL A 204
ARG A 368
 None
 0.96A 4r7iA-4aoaA:
undetectable		 4r7iA-4aoaA:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_D_SORD1343_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 4aoa BETA-PHENYLALANINE
AMINOTRANSFERASE
(Variovorax
paradoxus) 		4 / 5 ALA A  78
ARG A  41
HIS A  83
ALA A  74
 None
IK2  A1435 (-4.0A)
None
None
 1.21A 5a06C-4aoaA:
2.6
5a06D-4aoaA:
3.1		 5a06C-4aoaA:
23.99
5a06D-4aoaA:
23.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G5G_B_ACTB1321_0
(PUTATIVE XANTHINE
DEHYDROGENASE YAGR
MOLYBDENUM-BINDING
SU SUBUNIT)		 4aoa BETA-PHENYLALANINE
AMINOTRANSFERASE
(Variovorax
paradoxus) 		3 / 3 THR A 408
ASP A 409
ALA A 410
 GOL  A1436 ( 4.8A)
None
None
 0.10A 5g5gB-4aoaA:
undetectable		 5g5gB-4aoaA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_B_P06B801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4aoa BETA-PHENYLALANINE
AMINOTRANSFERASE
(Variovorax
paradoxus) 		4 / 7 ILE A 269
GLY A 270
PHE A 288
CYH A 117
 None
 0.89A 5hieB-4aoaA:
undetectable		 5hieB-4aoaA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_C_P06C801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4aoa BETA-PHENYLALANINE
AMINOTRANSFERASE
(Variovorax
paradoxus) 		4 / 7 VAL A 401
ILE A 412
ASN A 344
PHE A 351
 None
 0.93A 5hieC-4aoaA:
undetectable		 5hieC-4aoaA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_D_P06D801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4aoa BETA-PHENYLALANINE
AMINOTRANSFERASE
(Variovorax
paradoxus) 		4 / 8 ILE A 269
GLY A 270
PHE A 288
CYH A 117
 None
 0.87A 5hieD-4aoaA:
undetectable		 5hieD-4aoaA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJE_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 1)		 4aoa BETA-PHENYLALANINE
AMINOTRANSFERASE
(Variovorax
paradoxus) 		5 / 12 LEU A  61
ALA A  60
PRO A 406
LEU A 318
SER A 404
 None
GOL  A1436 ( 3.7A)
None
None
None
 1.05A 5ljeA-4aoaA:
undetectable		 5ljeA-4aoaA:
13.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HCO_A_FY5A1003_0
(ATP-BINDING CASSETTE
SUB-FAMILY G MEMBER
2)		 4aoa BETA-PHENYLALANINE
AMINOTRANSFERASE
(Variovorax
paradoxus) 		5 / 11 PHE A 179
VAL A 175
THR A 141
ILE A 201
VAL A 203
 None
 1.37A 6hcoA-4aoaA:
undetectable
6hcoB-4aoaA:
undetectable		 6hcoA-4aoaA:
21.49
6hcoB-4aoaA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HWD_K_BO2K301_0
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 4aoa BETA-PHENYLALANINE
AMINOTRANSFERASE
(Variovorax
paradoxus) 		5 / 11 ALA A 135
ALA A 139
GLY A 162
GLY A 161
ASP A 240
 None
None
None
IK2  A1435 (-3.6A)
IK2  A1435 (-2.8A)
 0.92A 6hwdK-4aoaA:
undetectable
6hwdL-4aoaA:
undetectable		 6hwdK-4aoaA:
10.96
6hwdL-4aoaA:
11.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HWD_Y_BO2Y301_0
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 4aoa BETA-PHENYLALANINE
AMINOTRANSFERASE
(Variovorax
paradoxus) 		5 / 11 ALA A 135
ALA A 139
GLY A 162
GLY A 161
ASP A 240
 None
None
None
IK2  A1435 (-3.6A)
IK2  A1435 (-2.8A)
 0.93A 6hwdY-4aoaA:
undetectable
6hwdZ-4aoaA:
undetectable		 6hwdY-4aoaA:
10.96
6hwdZ-4aoaA:
11.71