SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4aoe'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RK3_A_VDXA500_2
(VITAMIN D3 RECEPTOR)		 4aoe ACETYLCHOLINE-BINDIN
G PROTEIN TYPE 2
(Biomphalaria
glabrata) 		4 / 4 LEU A 155
ILE A  23
ARG A  63
TYR A 148
 None
 1.35A 1rk3A-4aoeA:
undetectable		 1rk3A-4aoeA:
24.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WNC_A_TKTA300_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 4aoe ACETYLCHOLINE-BINDIN
G PROTEIN TYPE 2
(Biomphalaria
glabrata) 		5 / 10 TYR A  92
TRP A 146
TYR A 186
CSS A 188
CSS A 189
 None
 0.71A 2wncA-4aoeA:
26.9
2wncE-4aoeA:
21.2		 2wncA-4aoeA:
29.82
2wncE-4aoeA:
29.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZLC_A_VDXA500_2
(VITAMIN D3 RECEPTOR)		 4aoe ACETYLCHOLINE-BINDIN
G PROTEIN TYPE 2
(Biomphalaria
glabrata) 		4 / 5 LEU A 155
ILE A  23
ARG A  63
TYR A 148
 None
 1.39A 2zlcA-4aoeA:
undetectable		 2zlcA-4aoeA:
23.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3WIP_A_ACHA301_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 4aoe ACETYLCHOLINE-BINDIN
G PROTEIN TYPE 2
(Biomphalaria
glabrata) 		4 / 7 TYR A  92
TRP A 146
THR A 147
TYR A 186
 None
 0.80A 3wipA-4aoeA:
24.5
3wipB-4aoeA:
24.2		 3wipA-4aoeA:
33.76
3wipB-4aoeA:
33.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3WIP_F_ACHF301_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 4aoe ACETYLCHOLINE-BINDIN
G PROTEIN TYPE 2
(Biomphalaria
glabrata) 		4 / 7 TYR A  92
TRP A 146
THR A 147
TYR A 186
 None
 0.81A 3wipF-4aoeA:
24.5
3wipG-4aoeA:
25.1		 3wipF-4aoeA:
33.76
3wipG-4aoeA:
33.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3WIP_J_ACHJ301_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 4aoe ACETYLCHOLINE-BINDIN
G PROTEIN TYPE 2
(Biomphalaria
glabrata) 		4 / 8 TYR A  92
TRP A 146
THR A 147
TYR A 186
 None
 0.80A 3wipF-4aoeA:
24.5
3wipJ-4aoeA:
24.8		 3wipF-4aoeA:
33.76
3wipJ-4aoeA:
33.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AMJ_B_CVDB1360_1
(BETA-1 ADRENERGIC
RECEPTOR)		 4aoe ACETYLCHOLINE-BINDIN
G PROTEIN TYPE 2
(Biomphalaria
glabrata) 		5 / 12 LEU A 155
VAL A 200
PHE A 124
ASN A  93
TYR A  35
 None
 1.32A 4amjB-4aoeA:
undetectable		 4amjB-4aoeA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWT_D_BEZD202_0
(PR 10 PROTEIN)		 4aoe ACETYLCHOLINE-BINDIN
G PROTEIN TYPE 2
(Biomphalaria
glabrata) 		3 / 3 PHE A 193
ASP A 195
LYS A 184
 None
 0.80A 6awtD-4aoeA:
undetectable		 6awtD-4aoeA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CNK_B_NCTB402_1
(NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
ALPHA-4
NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
BETA-2)		 4aoe ACETYLCHOLINE-BINDIN
G PROTEIN TYPE 2
(Biomphalaria
glabrata) 		4 / 7 TYR A  92
TRP A 146
CSS A 188
CSS A 189
 None
 0.58A 6cnkB-4aoeA:
15.1
6cnkC-4aoeA:
20.7		 6cnkB-4aoeA:
15.31
6cnkC-4aoeA:
15.31