SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4aov'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DF7_A_MTXA501_2
(DIHYDROFOLATE
REDUCTASE)		 4aov ISOCITRATE
DEHYDROGENASE [NADP]
(Desulfotalea
psychrophila) 		3 / 3 TRP A 332
ARG A 396
THR A 333
 None
 0.99A 1df7A-4aovA:
2.4		 1df7A-4aovA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EI6_D_PPFD412_1
(PHOSPHONOACETATE
HYDROLASE)		 4aov ISOCITRATE
DEHYDROGENASE [NADP]
(Desulfotalea
psychrophila) 		4 / 8 ASP A 103
ILE A 186
HIS A 188
HIS A 132
 None
 1.01A 1ei6D-4aovA:
undetectable		 1ei6D-4aovA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y4L_B_SVRB301_1
(PHOSPHOLIPASE A2
HOMOLOG 2)		 4aov ISOCITRATE
DEHYDROGENASE [NADP]
(Desulfotalea
psychrophila) 		5 / 12 LEU A 328
GLY A 306
LEU A  43
GLY A  44
PRO A  23
 None
NAP  A1403 (-3.0A)
None
None
None
 0.99A 1y4lA-4aovA:
undetectable		 1y4lA-4aovA:
15.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G70_A_SAMA2001_1
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 4aov ISOCITRATE
DEHYDROGENASE [NADP]
(Desulfotalea
psychrophila) 		4 / 7 GLY A  14
TYR A  85
ASP A  13
ASN A  72
 None
 1.06A 2g70A-4aovA:
undetectable		 2g70A-4aovA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G70_B_SAMB2002_1
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 4aov ISOCITRATE
DEHYDROGENASE [NADP]
(Desulfotalea
psychrophila) 		4 / 7 GLY A  14
TYR A  85
ASP A  13
ASN A  72
 None
 1.09A 2g70B-4aovA:
undetectable		 2g70B-4aovA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G72_A_SAMA2001_1
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 4aov ISOCITRATE
DEHYDROGENASE [NADP]
(Desulfotalea
psychrophila) 		4 / 6 GLY A  14
TYR A  85
ASP A  13
ASN A  72
 None
 1.07A 2g72A-4aovA:
undetectable		 2g72A-4aovA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G72_A_SAMA2001_1
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 4aov ISOCITRATE
DEHYDROGENASE [NADP]
(Desulfotalea
psychrophila) 		4 / 6 TYR A 312
GLY A  14
ASP A  13
ASN A  72
 None
 1.17A 2g72A-4aovA:
undetectable		 2g72A-4aovA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G72_B_SAMB2002_1
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 4aov ISOCITRATE
DEHYDROGENASE [NADP]
(Desulfotalea
psychrophila) 		4 / 7 GLY A  14
TYR A  85
ASP A  13
ASN A  72
 None
 1.11A 2g72B-4aovA:
undetectable		 2g72B-4aovA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_A_SNLA1001_1
(MINERALOCORTICOID
RECEPTOR)		 4aov ISOCITRATE
DEHYDROGENASE [NADP]
(Desulfotalea
psychrophila) 		5 / 12 LEU A 328
LEU A  30
LEU A   9
LEU A  12
THR A  18
 None
 1.40A 2oaxA-4aovA:
undetectable		 2oaxA-4aovA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZTH_A_SAMA305_1
(CATECHOL
O-METHYLTRANSFERASE)		 4aov ISOCITRATE
DEHYDROGENASE [NADP]
(Desulfotalea
psychrophila) 		3 / 3 SER A 275
GLU A 302
ASP A 272
 None
ICT  A1404 ( 4.3A)
MG  A1405 ( 2.8A)
 0.68A 2zthA-4aovA:
2.3		 2zthA-4aovA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWM_A_SAMA301_1
(CATECHOL
O-METHYLTRANSFERASE)		 4aov ISOCITRATE
DEHYDROGENASE [NADP]
(Desulfotalea
psychrophila) 		3 / 3 SER A 275
GLU A 302
ASP A 272
 None
ICT  A1404 ( 4.3A)
MG  A1405 ( 2.8A)
 0.75A 3bwmA-4aovA:
undetectable		 3bwmA-4aovA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWY_A_SAMA301_1
(COMT PROTEIN)		 4aov ISOCITRATE
DEHYDROGENASE [NADP]
(Desulfotalea
psychrophila) 		3 / 3 SER A 275
GLU A 302
ASP A 272
 None
ICT  A1404 ( 4.3A)
MG  A1405 ( 2.8A)
 0.70A 3bwyA-4aovA:
undetectable		 3bwyA-4aovA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OI8_A_ADNA2_1
(UNCHARACTERIZED
PROTEIN)		 4aov ISOCITRATE
DEHYDROGENASE [NADP]
(Desulfotalea
psychrophila) 		4 / 6 ILE A 387
PRO A  23
LEU A  24
ASP A 391
 None
 1.19A 3oi8A-4aovA:
undetectable		 3oi8A-4aovA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VQR_A_ACTA1002_0
(PUTATIVE
OXIDOREDUCTASE)		 4aov ISOCITRATE
DEHYDROGENASE [NADP]
(Desulfotalea
psychrophila) 		4 / 6 ASP A  13
GLY A  44
ASP A  15
THR A  74
 None
None
None
NAP  A1403 (-4.4A)
 0.85A 3vqrA-4aovA:
undetectable		 3vqrA-4aovA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VQR_B_ACTB1002_0
(PUTATIVE
OXIDOREDUCTASE)		 4aov ISOCITRATE
DEHYDROGENASE [NADP]
(Desulfotalea
psychrophila) 		4 / 5 ASP A  13
GLY A  44
ASP A  15
THR A  74
 None
None
None
NAP  A1403 (-4.4A)
 0.87A 3vqrB-4aovA:
undetectable		 3vqrB-4aovA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1478_0
(MJ0495-LIKE PROTEIN)		 4aov ISOCITRATE
DEHYDROGENASE [NADP]
(Desulfotalea
psychrophila) 		4 / 7 SER A 354
ASP A 353
THR A 359
PHE A 351
 None
 1.04A 4ac9C-4aovA:
2.1		 4ac9C-4aovA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_C_DXCC1478_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 4aov ISOCITRATE
DEHYDROGENASE [NADP]
(Desulfotalea
psychrophila) 		4 / 6 SER A 354
ASP A 353
THR A 359
PHE A 351
 None
 0.94A 4acbC-4aovA:
3.2		 4acbC-4aovA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_C_DXCC1478_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 4aov ISOCITRATE
DEHYDROGENASE [NADP]
(Desulfotalea
psychrophila) 		4 / 6 SER A 354
THR A 359
ILE A 358
PHE A 351
 None
 0.89A 4acbC-4aovA:
3.2		 4acbC-4aovA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGH_A_SAMA401_0
(CAFFEIC ACID
O-METHYLTRANSFERASE)		 4aov ISOCITRATE
DEHYDROGENASE [NADP]
(Desulfotalea
psychrophila) 		5 / 11 GLY A  44
GLY A  14
THR A  18
ASP A  42
ILE A  45
 None
 1.13A 4pghA-4aovA:
undetectable		 4pghA-4aovA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUD_A_SAMA303_0
(CATECHOL
O-METHYLTRANSFERASE)		 4aov ISOCITRATE
DEHYDROGENASE [NADP]
(Desulfotalea
psychrophila) 		5 / 12 MET A 255
GLU A 242
ILE A 241
ILE A 202
SER A 197
 None
 1.31A 4xudA-4aovA:
undetectable		 4xudA-4aovA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUD_A_SAMA303_1
(CATECHOL
O-METHYLTRANSFERASE)		 4aov ISOCITRATE
DEHYDROGENASE [NADP]
(Desulfotalea
psychrophila) 		3 / 3 SER A 275
GLU A 302
ASP A 272
 None
ICT  A1404 ( 4.3A)
MG  A1405 ( 2.8A)
 0.75A 4xudA-4aovA:
undetectable		 4xudA-4aovA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_D_SORD1341_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 4aov ISOCITRATE
DEHYDROGENASE [NADP]
(Desulfotalea
psychrophila) 		4 / 6 GLU A  46
GLY A  44
GLY A  14
ASP A  15
 None
 0.94A 5a06D-4aovA:
undetectable		 5a06D-4aovA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KLA_A_ACTA1505_0
(MATERNAL PROTEIN
PUMILIO)		 4aov ISOCITRATE
DEHYDROGENASE [NADP]
(Desulfotalea
psychrophila) 		3 / 3 HIS A 132
LYS A 267
PHE A 220
 None
 1.25A 5klaA-4aovA:
undetectable		 5klaA-4aovA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MTH_B_ACTB302_0
(ANTIBODY FAB HEAVY
CHAIN
ANTIBODY FAB LIGHT
CHAIN)		 4aov ISOCITRATE
DEHYDROGENASE [NADP]
(Desulfotalea
psychrophila) 		4 / 5 GLU A  16
TYR A 312
TYR A  85
ARG A  81
 None
None
None
NAP  A1403 (-3.8A)
 1.41A 5mthA-4aovA:
0.4
5mthB-4aovA:
0.0		 5mthA-4aovA:
19.25
5mthB-4aovA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MTH_H_ACTH304_0
(ANTIBODY FAB HEAVY
CHAIN
ANTIBODY FAB LIGHT
CHAIN)		 4aov ISOCITRATE
DEHYDROGENASE [NADP]
(Desulfotalea
psychrophila) 		4 / 5 GLU A  16
TYR A 312
TYR A  85
ARG A  81
 None
None
None
NAP  A1403 (-3.8A)
 1.38A 5mthH-4aovA:
0.3
5mthL-4aovA:
0.0		 5mthH-4aovA:
19.25
5mthL-4aovA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DYO_A_LDPA901_0
(EBONY)		 4aov ISOCITRATE
DEHYDROGENASE [NADP]
(Desulfotalea
psychrophila) 		4 / 5 VAL A  20
LEU A  21
HIS A 305
THR A 321
 None
None
NAP  A1403 (-3.7A)
None
 1.13A 6dyoA-4aovA:
undetectable		 6dyoA-4aovA:
11.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGC_A_ACTA810_0
(GEPHYRIN)		 4aov ISOCITRATE
DEHYDROGENASE [NADP]
(Desulfotalea
psychrophila) 		3 / 3 LEU A 384
SER A 386
PHE A 389
 None
 0.56A 6fgcA-4aovA:
5.5		 6fgcA-4aovA:
23.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GH9_A_MIXA1003_0
(UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 15)		 4aov ISOCITRATE
DEHYDROGENASE [NADP]
(Desulfotalea
psychrophila) 		4 / 5 ASN A 181
GLY A 130
HIS A 132
ASP A 103
 None
 1.26A 6gh9A-4aovA:
undetectable		 6gh9A-4aovA:
10.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GTQ_B_ACTB207_0
(DUF1778
DOMAIN-CONTAINING
PROTEIN
N-ACETYLTRANSFERASE)		 4aov ISOCITRATE
DEHYDROGENASE [NADP]
(Desulfotalea
psychrophila) 		4 / 6 LEU A 348
THR A 345
CYH A 349
GLY A 344
 None
 1.30A 6gtqB-4aovA:
undetectable
6gtqD-4aovA:
undetectable		 6gtqB-4aovA:
18.66
6gtqD-4aovA:
8.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6J21_A_GBQA1201_0
(SUBSTANCE-P
RECEPTOR,ENDOLYSIN)		 4aov ISOCITRATE
DEHYDROGENASE [NADP]
(Desulfotalea
psychrophila) 		5 / 12 PRO A 110
ILE A 111
ILE A 116
VAL A 326
HIS A 305
 None
None
None
None
NAP  A1403 (-3.7A)
 1.09A 6j21A-4aovA:
undetectable		 6j21A-4aovA:
20.97