SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ap3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DYR_A_TOPA407_1
(DIHYDROFOLATE
REDUCTASE)		 4ap3 STEROID
MONOOXYGENASE
(Rhodococcus
rhodochrous) 		5 / 11 ALA A 224
ILE A 318
ILE A 228
PRO A 229
ILE A 338
 None
 0.97A 1dyrA-4ap3A:
undetectable		 1dyrA-4ap3A:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FOH_A_IPHA802_0
(PHENOL HYDROXYLASE)		 4ap3 STEROID
MONOOXYGENASE
(Rhodococcus
rhodochrous) 		5 / 10 GLY A 198
VAL A 196
ILE A 207
TYR A 349
GLY A 200
 None
None
None
None
NAP  A1553 (-3.5A)
 0.95A 1fohA-4ap3A:
8.5		 1fohA-4ap3A:
24.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FOH_B_IPHB802_0
(PHENOL HYDROXYLASE)		 4ap3 STEROID
MONOOXYGENASE
(Rhodococcus
rhodochrous) 		5 / 10 GLY A 198
VAL A 196
ILE A 207
TYR A 349
GLY A 200
 None
None
None
None
NAP  A1553 (-3.5A)
 0.96A 1fohB-4ap3A:
8.5		 1fohB-4ap3A:
24.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FOH_D_IPHD802_0
(PHENOL HYDROXYLASE)		 4ap3 STEROID
MONOOXYGENASE
(Rhodococcus
rhodochrous) 		5 / 10 GLY A 198
VAL A 196
ILE A 207
TYR A 349
GLY A 200
 None
None
None
None
NAP  A1553 (-3.5A)
 0.95A 1fohD-4ap3A:
9.5		 1fohD-4ap3A:
24.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IWI_A_CAMA418_0
(CYTOCHROME P450-CAM)		 4ap3 STEROID
MONOOXYGENASE
(Rhodococcus
rhodochrous) 		4 / 8 VAL A  27
VAL A 146
ASP A 144
VAL A 138
 None
 0.79A 1iwiA-4ap3A:
undetectable		 1iwiA-4ap3A:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQE_A_DVAA6_0
(MINI-GRAMICIDIN A)		 4ap3 STEROID
MONOOXYGENASE
(Rhodococcus
rhodochrous) 		3 / 3 ALA A 467
VAL A 462
TRP A 461
 None
 0.86A 1kqeA-4ap3A:
undetectable
1kqeE-4ap3A:
undetectable		 1kqeA-4ap3A:
11.11
1kqeE-4ap3A:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQE_B_DVAB6_0
(MINI-GRAMICIDIN A)		 4ap3 STEROID
MONOOXYGENASE
(Rhodococcus
rhodochrous) 		3 / 3 ALA A 467
VAL A 462
TRP A 461
 None
 0.84A 1kqeB-4ap3A:
undetectable
1kqeD-4ap3A:
undetectable		 1kqeB-4ap3A:
11.11
1kqeD-4ap3A:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQE_D_DVAD6_0
(MINI-GRAMICIDIN A)		 4ap3 STEROID
MONOOXYGENASE
(Rhodococcus
rhodochrous) 		3 / 3 TRP A 461
ALA A 467
VAL A 462
 None
 0.85A 1kqeB-4ap3A:
undetectable
1kqeD-4ap3A:
undetectable		 1kqeB-4ap3A:
11.11
1kqeD-4ap3A:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQE_E_DVAE6_0
(MINI-GRAMICIDIN A)		 4ap3 STEROID
MONOOXYGENASE
(Rhodococcus
rhodochrous) 		3 / 3 TRP A 461
ALA A 467
VAL A 462
 None
 0.83A 1kqeA-4ap3A:
undetectable
1kqeE-4ap3A:
undetectable		 1kqeA-4ap3A:
11.11
1kqeE-4ap3A:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MEH_A_MOAA600_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 4ap3 STEROID
MONOOXYGENASE
(Rhodococcus
rhodochrous) 		5 / 10 ILE A  37
GLY A  33
GLU A 106
GLY A  55
GLU A  51
 None
None
None
None
FAD  A1552 (-2.5A)
 1.01A 1mehA-4ap3A:
undetectable		 1mehA-4ap3A:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PN0_A_IPHA6012_0
(PHENOL
2-MONOOXYGENASE)		 4ap3 STEROID
MONOOXYGENASE
(Rhodococcus
rhodochrous) 		5 / 10 GLY A 198
VAL A 196
ILE A 207
TYR A 349
GLY A 200
 None
None
None
None
NAP  A1553 (-3.5A)
 0.95A 1pn0A-4ap3A:
9.3		 1pn0A-4ap3A:
24.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PN0_B_IPHB6022_0
(PHENOL
2-MONOOXYGENASE)		 4ap3 STEROID
MONOOXYGENASE
(Rhodococcus
rhodochrous) 		5 / 10 GLY A 198
VAL A 196
ILE A 207
TYR A 349
GLY A 200
 None
None
None
None
NAP  A1553 (-3.5A)
 0.95A 1pn0B-4ap3A:
10.5		 1pn0B-4ap3A:
24.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XF1_A_ACTA1107_0
(C5A PEPTIDASE)		 4ap3 STEROID
MONOOXYGENASE
(Rhodococcus
rhodochrous) 		4 / 5 LEU A 469
GLY A 476
ILE A 546
PHE A 544
 None
 0.82A 1xf1A-4ap3A:
undetectable		 1xf1A-4ap3A:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XF1_B_ACTB1108_0
(C5A PEPTIDASE)		 4ap3 STEROID
MONOOXYGENASE
(Rhodococcus
rhodochrous) 		4 / 6 LEU A 469
GLY A 476
ILE A 546
PHE A 544
 None
 0.83A 1xf1B-4ap3A:
undetectable		 1xf1B-4ap3A:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DU8_A_BEZA352_0
(D-AMINO-ACID OXIDASE)		 4ap3 STEROID
MONOOXYGENASE
(Rhodococcus
rhodochrous) 		4 / 6 LEU A 105
TYR A  79
TYR A 104
ILE A 101
 None
 0.93A 2du8A-4ap3A:
7.0		 2du8A-4ap3A:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DU8_B_BEZB1352_0
(D-AMINO-ACID OXIDASE)		 4ap3 STEROID
MONOOXYGENASE
(Rhodococcus
rhodochrous) 		4 / 6 LEU A 105
TYR A  79
TYR A 104
ILE A 101
 None
 0.94A 2du8B-4ap3A:
7.0		 2du8B-4ap3A:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_D_CLMD1142_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 4ap3 STEROID
MONOOXYGENASE
(Rhodococcus
rhodochrous) 		4 / 5 PRO A  99
PRO A  66
ILE A 209
GLY A  67
 None
 1.10A 2jkjD-4ap3A:
undetectable		 2jkjD-4ap3A:
13.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_F_CLMF1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 4ap3 STEROID
MONOOXYGENASE
(Rhodococcus
rhodochrous) 		4 / 5 PRO A  99
PRO A  66
ILE A 209
GLY A  67
 None
 1.11A 2jkjF-4ap3A:
undetectable		 2jkjF-4ap3A:
13.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD3_A_CHDA502_0
(FERROCHELATASE)		 4ap3 STEROID
MONOOXYGENASE
(Rhodococcus
rhodochrous) 		4 / 8 ARG A 123
SER A 455
VAL A  27
GLY A  28
 FAD  A1552 (-4.0A)
FAD  A1552 ( 4.5A)
None
FAD  A1552 (-3.1A)
 1.03A 2qd3A-4ap3A:
2.8		 2qd3A-4ap3A:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9G_A_TOPA1159_1
(DIHYDROFOLATE
REDUCTASE)		 4ap3 STEROID
MONOOXYGENASE
(Rhodococcus
rhodochrous) 		5 / 10 LEU A  85
LEU A 105
VAL A 108
SER A 455
PHE A  81
 None
None
None
FAD  A1552 ( 4.5A)
None
 1.14A 2w9gA-4ap3A:
undetectable		 2w9gA-4ap3A:
13.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCP_B_CHDB4_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4ap3 STEROID
MONOOXYGENASE
(Rhodococcus
rhodochrous) 		3 / 3 GLY A 524
PRO A 521
LEU A 448
 None
 0.58A 3hcpB-4ap3A:
2.7		 3hcpB-4ap3A:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_C_MTXC164_2
(DIHYDROFOLATE
REDUCTASE)		 4ap3 STEROID
MONOOXYGENASE
(Rhodococcus
rhodochrous) 		4 / 4 ILE A 207
ARG A 193
ILE A 210
THR A 199
 None
 0.96A 3ia4C-4ap3A:
undetectable		 3ia4C-4ap3A:
14.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OWX_B_XRAB233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4ap3 STEROID
MONOOXYGENASE
(Rhodococcus
rhodochrous) 		5 / 11 VAL A 153
PHE A 120
GLY A  58
GLY A  57
ILE A  31
 None
None
FAD  A1552 (-3.1A)
None
FAD  A1552 (-3.9A)
 1.30A 3owxA-4ap3A:
undetectable
3owxB-4ap3A:
4.1		 3owxA-4ap3A:
18.13
3owxB-4ap3A:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCJ_A_AZMA229_2
(CARBONIC ANHYDRASE)		 4ap3 STEROID
MONOOXYGENASE
(Rhodococcus
rhodochrous) 		3 / 3 GLN A 300
PHE A 293
TYR A 282
 None
 0.87A 3ucjB-4ap3A:
undetectable		 3ucjB-4ap3A:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCJ_B_AZMB229_1
(CARBONIC ANHYDRASE)		 4ap3 STEROID
MONOOXYGENASE
(Rhodococcus
rhodochrous) 		3 / 3 GLN A 300
PHE A 293
TYR A 282
 None
 0.90A 3ucjA-4ap3A:
undetectable		 3ucjA-4ap3A:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6D_A_SAMA1350_0
(HYDROXYINDOLE
O-METHYLTRANSFERASE)		 4ap3 STEROID
MONOOXYGENASE
(Rhodococcus
rhodochrous) 		5 / 12 TRP A  62
GLY A  28
GLY A  30
ILE A  37
ALA A  52
 FAD  A1552 (-4.0A)
FAD  A1552 (-3.1A)
FAD  A1552 (-3.5A)
None
FAD  A1552 (-3.7A)
 1.06A 4a6dA-4ap3A:
undetectable		 4a6dA-4ap3A:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DUB_B_LDPB501_1
(CYTOCHROME P450 BM3
VARIANT 9D7)		 4ap3 STEROID
MONOOXYGENASE
(Rhodococcus
rhodochrous) 		4 / 6 PHE A 436
GLY A 441
PRO A 442
LEU A 401
 None
 0.93A 4dubB-4ap3A:
undetectable		 4dubB-4ap3A:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8Y_B_VK3B202_1
(NADPH QUINONE
OXIDOREDUCTASE)		 4ap3 STEROID
MONOOXYGENASE
(Rhodococcus
rhodochrous) 		4 / 6 ASN A 225
TYR A 353
TYR A 349
LEU A 331
 NAP  A1553 ( 4.2A)
None
None
None
 1.21A 4f8yA-4ap3A:
1.7
4f8yB-4ap3A:
2.7		 4f8yA-4ap3A:
13.22
4f8yB-4ap3A:
13.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JX1_B_CAMB502_0
(CAMPHOR
5-MONOOXYGENASE)		 4ap3 STEROID
MONOOXYGENASE
(Rhodococcus
rhodochrous) 		5 / 10 PHE A 220
TYR A 383
GLY A 380
ILE A 368
VAL A 369
 None
 1.22A 4jx1B-4ap3A:
undetectable		 4jx1B-4ap3A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L4B_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 4ap3 STEROID
MONOOXYGENASE
(Rhodococcus
rhodochrous) 		4 / 8 VAL A  27
VAL A 146
ASP A 144
VAL A 138
 None
 0.81A 4l4bA-4ap3A:
undetectable		 4l4bA-4ap3A:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_A_SAMA602_0
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 4ap3 STEROID
MONOOXYGENASE
(Rhodococcus
rhodochrous) 		5 / 12 ASN A  63
GLY A 203
SER A 201
ILE A 197
GLY A 195
 FAD  A1552 (-4.4A)
None
NAP  A1553 (-2.9A)
None
None
 1.01A 4obwA-4ap3A:
2.1		 4obwA-4ap3A:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_C_SAMC601_0
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 4ap3 STEROID
MONOOXYGENASE
(Rhodococcus
rhodochrous) 		5 / 12 ASN A  63
GLY A 203
SER A 201
ILE A 197
GLY A 195
 FAD  A1552 (-4.4A)
None
NAP  A1553 (-2.9A)
None
None
 1.04A 4obwC-4ap3A:
undetectable		 4obwC-4ap3A:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JLC_A_1YNA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4ap3 STEROID
MONOOXYGENASE
(Rhodococcus
rhodochrous) 		4 / 5 GLY A 375
THR A 374
GLY A  67
LEU A 217
 None
 0.89A 5jlcA-4ap3A:
undetectable		 5jlcA-4ap3A:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JQ7_B_T0RB705_2
(ENVELOPE
GLYCOPROTEIN 2)		 4ap3 STEROID
MONOOXYGENASE
(Rhodococcus
rhodochrous) 		4 / 7 LEU A 385
TYR A 383
THR A 378
THR A 379
 None
 1.07A 5jq7B-4ap3A:
undetectable		 5jq7B-4ap3A:
14.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0X_B_SAMB501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 4ap3 STEROID
MONOOXYGENASE
(Rhodococcus
rhodochrous) 		3 / 3 SER A 269
ALA A 270
THR A 309
 None
 0.60A 5n0xB-4ap3A:
undetectable		 5n0xB-4ap3A:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CP4_A_CAMA422_0
(CYTOCHROME P450CAM)		 4ap3 STEROID
MONOOXYGENASE
(Rhodococcus
rhodochrous) 		4 / 8 VAL A  27
VAL A 146
ASP A 144
VAL A 138
 None
 0.84A 6cp4A-4ap3A:
undetectable		 6cp4A-4ap3A:
20.18