SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ap5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSE_A_EAAA224_1
(GLUTATHIONE
TRANSFERASE)		 4ap5 GDP-FUCOSE PROTEIN
O-FUCOSYLTRANSFERASE
2
(Homo
sapiens) 		5 / 12 GLY A 290
LEU A 289
LEU A 319
MET A 349
PHE A 411
 None
 1.24A 1gseA-4ap5A:
undetectable		 1gseA-4ap5A:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_C_ACTC2294_0
(GLYCINE
N-METHYLTRANSFERASE)		 4ap5 GDP-FUCOSE PROTEIN
O-FUCOSYLTRANSFERASE
2
(Homo
sapiens) 		4 / 7 TRP A 234
TYR A 228
ARG A 392
TYR A 233
 None
 1.50A 1kiaC-4ap5A:
undetectable		 1kiaC-4ap5A:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_D_ACTD3294_0
(GLYCINE
N-METHYLTRANSFERASE)		 4ap5 GDP-FUCOSE PROTEIN
O-FUCOSYLTRANSFERASE
2
(Homo
sapiens) 		4 / 7 TRP A 234
TYR A 228
ARG A 392
TYR A 233
 None
 1.50A 1kiaD-4ap5A:
undetectable		 1kiaD-4ap5A:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_G_SAMG199_0
(METHIONINE REPRESSOR)		 4ap5 GDP-FUCOSE PROTEIN
O-FUCOSYLTRANSFERASE
2
(Homo
sapiens) 		5 / 10 GLU A 395
ARG A 237
GLU A 396
ALA A 376
GLY A 383
 None
 1.18A 1mjqG-4ap5A:
undetectable
1mjqH-4ap5A:
undetectable		 1mjqG-4ap5A:
12.50
1mjqH-4ap5A:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRJ_A_ADNA300_1
(ALPHA-TRICHOSANTHIN)		 4ap5 GDP-FUCOSE PROTEIN
O-FUCOSYLTRANSFERASE
2
(Homo
sapiens) 		4 / 8 ILE A 427
GLY A 230
TYR A 228
GLU A 395
 None
 0.85A 1mrjA-4ap5A:
undetectable		 1mrjA-4ap5A:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK9_C_2FAC308_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 4ap5 GDP-FUCOSE PROTEIN
O-FUCOSYLTRANSFERASE
2
(Homo
sapiens) 		5 / 11 ARG A 303
SER A 387
GLY A 383
SER A 390
ILE A 382
 None
 1.24A 1pk9C-4ap5A:
undetectable		 1pk9C-4ap5A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PW7_A_RABA645_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 4ap5 GDP-FUCOSE PROTEIN
O-FUCOSYLTRANSFERASE
2
(Homo
sapiens) 		5 / 10 ARG A 303
SER A 387
GLY A 383
SER A 390
ILE A 382
 None
 1.22A 1pw7A-4ap5A:
undetectable		 1pw7A-4ap5A:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AQJ_A_TRPA650_0
(TRYPTOPHAN
HALOGENASE, PRNA)		 4ap5 GDP-FUCOSE PROTEIN
O-FUCOSYLTRANSFERASE
2
(Homo
sapiens) 		5 / 11 ILE A 267
PRO A 268
ILE A 399
GLU A 396
TRP A 373
 None
 1.38A 2aqjA-4ap5A:
0.0		 2aqjA-4ap5A:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H21_A_SAMA801_0
(RIBULOSE-1,5
BISPHOSPHATE
CARBOXYLASE/OXYGENAS
E)		 4ap5 GDP-FUCOSE PROTEIN
O-FUCOSYLTRANSFERASE
2
(Homo
sapiens) 		5 / 10 GLY A 290
LEU A 289
SER A 260
HIS A 257
PHE A 253
 None
 1.41A 2h21A-4ap5A:
undetectable		 2h21A-4ap5A:
24.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H21_B_SAMB802_0
(RIBULOSE-1,5
BISPHOSPHATE
CARBOXYLASE/OXYGENAS
E)		 4ap5 GDP-FUCOSE PROTEIN
O-FUCOSYLTRANSFERASE
2
(Homo
sapiens) 		5 / 11 GLY A 290
LEU A 289
SER A 260
HIS A 257
PHE A 253
 None
 1.45A 2h21B-4ap5A:
undetectable		 2h21B-4ap5A:
24.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H21_C_SAMC803_0
(RIBULOSE-1,5
BISPHOSPHATE
CARBOXYLASE/OXYGENAS
E)		 4ap5 GDP-FUCOSE PROTEIN
O-FUCOSYLTRANSFERASE
2
(Homo
sapiens) 		5 / 11 GLY A 290
LEU A 289
SER A 260
HIS A 257
PHE A 253
 None
 1.45A 2h21C-4ap5A:
undetectable		 2h21C-4ap5A:
24.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OA1_A_TRPA2002_0
(TRYPTOPHAN
HALOGENASE)		 4ap5 GDP-FUCOSE PROTEIN
O-FUCOSYLTRANSFERASE
2
(Homo
sapiens) 		5 / 12 ILE A 267
PRO A 268
ILE A 399
GLU A 396
TRP A 373
 None
 1.37A 2oa1A-4ap5A:
0.8		 2oa1A-4ap5A:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OA1_A_TRPA2003_0
(TRYPTOPHAN
HALOGENASE)		 4ap5 GDP-FUCOSE PROTEIN
O-FUCOSYLTRANSFERASE
2
(Homo
sapiens) 		5 / 12 ILE A 267
PRO A 268
ILE A 399
GLU A 396
TRP A 373
 None
 1.37A 2oa1B-4ap5A:
1.0		 2oa1B-4ap5A:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QR2_B_VK3B235_1
(PROTEIN (QUINONE
REDUCTASE TYPE 2))		 4ap5 GDP-FUCOSE PROTEIN
O-FUCOSYLTRANSFERASE
2
(Homo
sapiens) 		4 / 6 PHE A 108
TRP A 104
GLY A 365
GLY A 366
 None
None
CL  A1432 (-4.2A)
None
 0.95A 2qr2A-4ap5A:
undetectable
2qr2B-4ap5A:
undetectable		 2qr2A-4ap5A:
20.19
2qr2B-4ap5A:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QR2_B_VK3B236_1
(PROTEIN (QUINONE
REDUCTASE TYPE 2))		 4ap5 GDP-FUCOSE PROTEIN
O-FUCOSYLTRANSFERASE
2
(Homo
sapiens) 		4 / 5 TRP A 104
GLY A 365
GLY A 366
PHE A 108
 None
CL  A1432 (-4.2A)
None
None
 0.91A 2qr2A-4ap5A:
undetectable
2qr2B-4ap5A:
undetectable		 2qr2A-4ap5A:
20.19
2qr2B-4ap5A:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QX4_A_ML1A233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4ap5 GDP-FUCOSE PROTEIN
O-FUCOSYLTRANSFERASE
2
(Homo
sapiens) 		4 / 8 PHE A 108
TRP A 104
GLY A 365
GLY A 366
 None
None
CL  A1432 (-4.2A)
None
 0.91A 2qx4A-4ap5A:
2.7
2qx4B-4ap5A:
2.7		 2qx4A-4ap5A:
20.19
2qx4B-4ap5A:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WLJ_A_SPMA1303_1
(POTASSIUM CHANNEL)		 4ap5 GDP-FUCOSE PROTEIN
O-FUCOSYLTRANSFERASE
2
(Homo
sapiens) 		3 / 3 ARG A 295
ARG A 303
PRO A 307
 None
 1.06A 2wljA-4ap5A:
undetectable		 2wljA-4ap5A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8W_A_FLPA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 4ap5 GDP-FUCOSE PROTEIN
O-FUCOSYLTRANSFERASE
2
(Homo
sapiens) 		5 / 12 VAL A 291
LEU A 345
GLY A 311
ALA A 312
LEU A 293
 None
 1.03A 3n8wA-4ap5A:
undetectable		 3n8wA-4ap5A:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D9H_A_ADNA301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 4ap5 GDP-FUCOSE PROTEIN
O-FUCOSYLTRANSFERASE
2
(Homo
sapiens) 		5 / 11 ARG A 303
SER A 387
GLY A 383
SER A 390
VAL A 291
 None
 1.32A 4d9hA-4ap5A:
undetectable		 4d9hA-4ap5A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DAN_B_2FAB301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 4ap5 GDP-FUCOSE PROTEIN
O-FUCOSYLTRANSFERASE
2
(Homo
sapiens) 		5 / 12 ARG A 303
SER A 387
GLY A 383
SER A 390
VAL A 291
 None
 1.29A 4danA-4ap5A:
undetectable
4danB-4ap5A:
undetectable		 4danA-4ap5A:
20.58
4danB-4ap5A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GC9_A_SAMA401_1
(DIMETHYLADENOSINE
TRANSFERASE 1,
MITOCHONDRIAL)		 4ap5 GDP-FUCOSE PROTEIN
O-FUCOSYLTRANSFERASE
2
(Homo
sapiens) 		3 / 3 GLU A 416
ASP A 305
ASP A 414
 None
 0.64A 4gc9A-4ap5A:
undetectable		 4gc9A-4ap5A:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QKN_A_JMSA602_1
(ALPHA-KETOGLUTARATE-
DEPENDENT
DIOXYGENASE FTO)		 4ap5 GDP-FUCOSE PROTEIN
O-FUCOSYLTRANSFERASE
2
(Homo
sapiens) 		4 / 8 LEU A  89
PRO A  53
ARG A 219
LEU A 166
 None
 1.14A 4qknA-4ap5A:
undetectable		 4qknA-4ap5A:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVN_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4ap5 GDP-FUCOSE PROTEIN
O-FUCOSYLTRANSFERASE
2
(Homo
sapiens) 		5 / 12 THR A 406
THR A 407
ARG A 266
GLY A 285
ALA A 283
 None
 1.26A 4qvnV-4ap5A:
undetectable
4qvnb-4ap5A:
undetectable		 4qvnV-4ap5A:
21.39
4qvnb-4ap5A:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVQ_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4ap5 GDP-FUCOSE PROTEIN
O-FUCOSYLTRANSFERASE
2
(Homo
sapiens) 		5 / 11 THR A 406
THR A 407
ARG A 266
GLY A 285
ALA A 283
 None
 1.25A 4qvqV-4ap5A:
undetectable
4qvqb-4ap5A:
undetectable		 4qvqV-4ap5A:
21.39
4qvqb-4ap5A:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVQ_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4ap5 GDP-FUCOSE PROTEIN
O-FUCOSYLTRANSFERASE
2
(Homo
sapiens) 		5 / 11 THR A 406
THR A 407
ARG A 266
GLY A 285
ALA A 283
 None
 1.26A 4qvqH-4ap5A:
undetectable
4qvqN-4ap5A:
undetectable		 4qvqH-4ap5A:
21.39
4qvqN-4ap5A:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW0_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4ap5 GDP-FUCOSE PROTEIN
O-FUCOSYLTRANSFERASE
2
(Homo
sapiens) 		5 / 11 THR A 406
THR A 407
ARG A 266
GLY A 285
ALA A 283
 None
 1.28A 4qw0V-4ap5A:
undetectable
4qw0b-4ap5A:
undetectable		 4qw0V-4ap5A:
21.39
4qw0b-4ap5A:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW0_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4ap5 GDP-FUCOSE PROTEIN
O-FUCOSYLTRANSFERASE
2
(Homo
sapiens) 		5 / 11 THR A 406
THR A 407
ARG A 266
GLY A 285
ALA A 283
 None
 1.28A 4qw0H-4ap5A:
undetectable
4qw0N-4ap5A:
undetectable		 4qw0H-4ap5A:
21.39
4qw0N-4ap5A:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW3_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4ap5 GDP-FUCOSE PROTEIN
O-FUCOSYLTRANSFERASE
2
(Homo
sapiens) 		5 / 11 THR A 406
THR A 407
ARG A 266
GLY A 285
ALA A 283
 None
 1.28A 4qw3V-4ap5A:
undetectable
4qw3b-4ap5A:
undetectable		 4qw3V-4ap5A:
21.39
4qw3b-4ap5A:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CZ7_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4ap5 GDP-FUCOSE PROTEIN
O-FUCOSYLTRANSFERASE
2
(Homo
sapiens) 		5 / 11 THR A 406
THR A 407
ARG A 266
GLY A 285
ALA A 283
 None
 1.26A 5cz7H-4ap5A:
undetectable
5cz7N-4ap5A:
undetectable		 5cz7H-4ap5A:
21.39
5cz7N-4ap5A:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0X_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4ap5 GDP-FUCOSE PROTEIN
O-FUCOSYLTRANSFERASE
2
(Homo
sapiens) 		5 / 11 THR A 406
THR A 407
ARG A 266
GLY A 285
ALA A 283
 None
 1.29A 5d0xV-4ap5A:
undetectable
5d0xb-4ap5A:
undetectable		 5d0xV-4ap5A:
21.39
5d0xb-4ap5A:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0X_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4ap5 GDP-FUCOSE PROTEIN
O-FUCOSYLTRANSFERASE
2
(Homo
sapiens) 		5 / 11 THR A 406
THR A 407
ARG A 266
GLY A 285
ALA A 283
 None
 1.29A 5d0xH-4ap5A:
undetectable
5d0xN-4ap5A:
undetectable		 5d0xH-4ap5A:
21.39
5d0xN-4ap5A:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DV4_A_NMYA601_2
(CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT
6-LIKE)		 4ap5 GDP-FUCOSE PROTEIN
O-FUCOSYLTRANSFERASE
2
(Homo
sapiens) 		3 / 3 GLU A 232
TRP A 234
ASN A 116
 None
 1.05A 5dv4A-4ap5A:
undetectable		 5dv4A-4ap5A:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5Z_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4ap5 GDP-FUCOSE PROTEIN
O-FUCOSYLTRANSFERASE
2
(Homo
sapiens) 		5 / 12 THR A 406
THR A 407
ARG A 266
GLY A 285
ALA A 283
 None
 1.28A 5l5zV-4ap5A:
undetectable
5l5zb-4ap5A:
undetectable		 5l5zV-4ap5A:
21.39
5l5zb-4ap5A:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5Z_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4ap5 GDP-FUCOSE PROTEIN
O-FUCOSYLTRANSFERASE
2
(Homo
sapiens) 		5 / 12 THR A 406
THR A 407
ARG A 266
GLY A 285
ALA A 283
 None
 1.28A 5l5zH-4ap5A:
undetectable
5l5zN-4ap5A:
undetectable		 5l5zH-4ap5A:
21.39
5l5zN-4ap5A:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_E_CVIE301_1
(REGULATORY PROTEIN
TETR)		 4ap5 GDP-FUCOSE PROTEIN
O-FUCOSYLTRANSFERASE
2
(Homo
sapiens) 		4 / 7 GLN A  99
GLY A 365
TYR A  48
TRP A  86
 CL  A1432 (-4.0A)
CL  A1432 (-4.2A)
None
None
 1.14A 5vlmE-4ap5A:
undetectable		 5vlmE-4ap5A:
21.01