SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ap8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SOA_A_DB8A445_1
(CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II
SUBUNIT ALPHA WITH A
BETA 7 LINKER)		 4ap8 MOLYBDOPTERIN
SYNTHASE CATALYTIC
SUBUNIT
(Homo
sapiens) 		4 / 6 LEU A 158
VAL A 162
PHE A  49
VAL A 121
 None
 1.13A 3soaA-4ap8A:
undetectable		 3soaA-4ap8A:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NPT_A_017A401_1
(PROTEASE)		 4ap8 MOLYBDOPTERIN
SYNTHASE CATALYTIC
SUBUNIT
(Homo
sapiens) 		5 / 9 ALA A 120
ILE A 110
ILE A 155
ILE A  71
VAL A  63
 None
 0.96A 4nptA-4ap8A:
undetectable		 4nptA-4ap8A:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GWY_E_010E6_0
(N-[(5-METHYLISOXAZOL
-3-YL)CARBONYL]ALANY
L-L-VALYL-N~1~-((1R,
2Z)-4-(BENZYLOXY)-4-
OXO-1-{[(3R)-2-OXOPY
RROLIDIN-3-YL]METHYL
}BUT-2-ENYL)-L-LEUCI
NAMIDE
MAIN PROTEASE)		 4ap8 MOLYBDOPTERIN
SYNTHASE CATALYTIC
SUBUNIT
(Homo
sapiens) 		4 / 4 THR A  50
LEU A 125
HIS A 123
GLY A 126
 None
 0.95A 5gwyA-4ap8A:
undetectable		 5gwyA-4ap8A:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KKZ_E_ASCE1004_0
(CYTOCHROME B
UBIQUINOL-CYTOCHROME
C REDUCTASE
IRON-SULFUR SUBUNIT)		 4ap8 MOLYBDOPTERIN
SYNTHASE CATALYTIC
SUBUNIT
(Homo
sapiens) 		4 / 7 HIS A 118
ILE A 119
VAL A  46
ARG A 104
 None
 1.30A 5kkzC-4ap8A:
undetectable
5kkzE-4ap8A:
undetectable		 5kkzC-4ap8A:
22.11
5kkzE-4ap8A:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KKZ_O_ASCO1004_0
(CYTOCHROME B
UBIQUINOL-CYTOCHROME
C REDUCTASE
IRON-SULFUR SUBUNIT)		 4ap8 MOLYBDOPTERIN
SYNTHASE CATALYTIC
SUBUNIT
(Homo
sapiens) 		4 / 7 HIS A 118
ILE A 119
VAL A  46
ARG A 104
 None
 1.30A 5kkzM-4ap8A:
undetectable
5kkzO-4ap8A:
undetectable		 5kkzM-4ap8A:
22.11
5kkzO-4ap8A:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BRD_C_RFPC502_1
(RIFAMPIN
MONOOXYGENASE)		 4ap8 MOLYBDOPTERIN
SYNTHASE CATALYTIC
SUBUNIT
(Homo
sapiens) 		5 / 12 VAL A 103
VAL A 162
GLY A 126
THR A  77
GLY A  76
 None
 1.18A 6brdC-4ap8A:
1.0		 6brdC-4ap8A:
23.97