SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4apb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DSC_C_DVAC8_0
(ACTINOMYCIN D)		 4apb FUMARATE HYDRATASE
CLASS II
(Mycobacterium
tuberculosis) 		3 / 3 THR A 145
THR A 147
PRO A 144
 None
 0.82A 1dscC-4apbA:
undetectable		 1dscC-4apbA:
4.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G60_A_SAMA500_0
(ADENINE-SPECIFIC
METHYLTRANSFERASE
MBOIIA)		 4apb FUMARATE HYDRATASE
CLASS II
(Mycobacterium
tuberculosis) 		5 / 12 ASN A 368
PHE A 100
GLY A 103
SER A 104
THR A 106
 None
 1.39A 1g60A-4apbA:
undetectable		 1g60A-4apbA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LHU_A_ESTA301_1
(SEX HORMONE-BINDING
GLOBULIN)		 4apb FUMARATE HYDRATASE
CLASS II
(Mycobacterium
tuberculosis) 		5 / 12 ASN A 134
LEU A  54
LYS A  58
ILE A  97
LEU A  46
 None
 1.26A 1lhuA-4apbA:
undetectable		 1lhuA-4apbA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SA1_B_PODB700_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 4apb FUMARATE HYDRATASE
CLASS II
(Mycobacterium
tuberculosis) 		5 / 12 VAL A 250
LEU A  54
ALA A  53
LEU A  57
ALA A 151
 None
 1.18A 1sa1A-4apbA:
undetectable
1sa1B-4apbA:
undetectable		 1sa1A-4apbA:
23.58
1sa1B-4apbA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SA1_D_PODD701_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 4apb FUMARATE HYDRATASE
CLASS II
(Mycobacterium
tuberculosis) 		5 / 12 VAL A 250
LEU A  54
ALA A  53
LEU A  57
ALA A 151
 None
 1.20A 1sa1C-4apbA:
undetectable
1sa1D-4apbA:
undetectable		 1sa1C-4apbA:
23.58
1sa1D-4apbA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T9W_A_NFNA6001_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 4apb FUMARATE HYDRATASE
CLASS II
(Mycobacterium
tuberculosis) 		3 / 3 SER A 300
GLY A 299
ARG A 185
 None
 0.63A 1t9wA-4apbA:
undetectable		 1t9wA-4apbA:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_W_DVAW8_0
(7-AMINO-ACTINOMYCIN
D)		 4apb FUMARATE HYDRATASE
CLASS II
(Mycobacterium
tuberculosis) 		3 / 3 THR A 145
THR A 147
PRO A 144
 None
 0.84A 1unjW-4apbA:
undetectable		 1unjW-4apbA:
4.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_X_DVAX8_0
(7-AMINO-ACTINOMYCIN
D)		 4apb FUMARATE HYDRATASE
CLASS II
(Mycobacterium
tuberculosis) 		3 / 3 THR A 145
THR A 147
PRO A 144
 None
 0.86A 1unjX-4apbA:
undetectable		 1unjX-4apbA:
4.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNM_E_DVAE2_0
(7-AMINOACTINOMYCIN D)		 4apb FUMARATE HYDRATASE
CLASS II
(Mycobacterium
tuberculosis) 		3 / 3 THR A 147
PRO A 144
THR A 145
 None
 0.86A 1unmE-4apbA:
undetectable		 1unmE-4apbA:
4.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNM_E_DVAE8_0
(7-AMINOACTINOMYCIN D)		 4apb FUMARATE HYDRATASE
CLASS II
(Mycobacterium
tuberculosis) 		3 / 3 THR A 145
THR A 147
PRO A 144
 None
 0.85A 1unmE-4apbA:
undetectable		 1unmE-4apbA:
4.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XVA_A_ACTA294_0
(GLYCINE
N-METHYLTRANSFERASE)		 4apb FUMARATE HYDRATASE
CLASS II
(Mycobacterium
tuberculosis) 		4 / 5 ILE A 149
LEU A 370
ALA A 154
GLU A 153
 None
 1.29A 1xvaA-4apbA:
undetectable
1xvaB-4apbA:
undetectable		 1xvaA-4apbA:
22.37
1xvaB-4apbA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOU_B_CQAB401_0
(HISTAMINE
N-METHYLTRANSFERASE)		 4apb FUMARATE HYDRATASE
CLASS II
(Mycobacterium
tuberculosis) 		4 / 7 GLY A 227
PHE A 241
PRO A 238
ASP A 240
 None
 0.88A 2aouB-4apbA:
undetectable		 2aouB-4apbA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HKK_A_ALEA300_1
(CARBONIC ANHYDRASE 2)		 4apb FUMARATE HYDRATASE
CLASS II
(Mycobacterium
tuberculosis) 		4 / 6 ASN A 134
ASN A 113
ILE A  86
THR A 142
 None
 1.17A 2hkkA-4apbA:
undetectable		 2hkkA-4apbA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HS1_B_017B203_1
(HIV-1 PROTEASE)		 4apb FUMARATE HYDRATASE
CLASS II
(Mycobacterium
tuberculosis) 		4 / 7 GLU A 212
PRO A 161
ARG A 215
GLY A 210
 None
 1.28A 2hs1B-4apbA:
undetectable		 2hs1B-4apbA:
15.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEO_A_SAMA328_0
(MODIFICATION
METHYLASE HHAI)		 4apb FUMARATE HYDRATASE
CLASS II
(Mycobacterium
tuberculosis) 		5 / 12 GLY A 184
ASP A 459
ILE A 435
PRO A 411
LEU A 412
 None
 1.04A 3eeoA-4apbA:
undetectable		 3eeoA-4apbA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZV_B_ECNB411_1
(FLAVOHEMOGLOBIN)		 4apb FUMARATE HYDRATASE
CLASS II
(Mycobacterium
tuberculosis) 		5 / 9 ILE A 149
ALA A 261
LEU A 224
LEU A  57
ALA A  53
 None
 0.97A 3ozvB-4apbA:
undetectable		 3ozvB-4apbA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R75_A_BEZA701_0
(ANTHRANILATE/PARA-AM
INOBENZOATE
SYNTHASES COMPONENT
I)		 4apb FUMARATE HYDRATASE
CLASS II
(Mycobacterium
tuberculosis) 		5 / 12 ILE A 362
SER A 104
GLY A 103
SER A 107
THR A 106
 None
 1.14A 3r75A-4apbA:
undetectable		 3r75A-4apbA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R75_B_BEZB701_0
(ANTHRANILATE/PARA-AM
INOBENZOATE
SYNTHASES COMPONENT
I)		 4apb FUMARATE HYDRATASE
CLASS II
(Mycobacterium
tuberculosis) 		5 / 12 ILE A 362
SER A 104
GLY A 103
SER A 107
THR A 106
 None
 1.16A 3r75B-4apbA:
undetectable		 3r75B-4apbA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V8V_B_SAMB802_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE L)		 4apb FUMARATE HYDRATASE
CLASS II
(Mycobacterium
tuberculosis) 		5 / 12 PHE A 241
SER A 264
SER A 138
CYH A  61
PRO A 238
 None
 1.42A 3v8vB-4apbA:
undetectable		 3v8vB-4apbA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IIL_A_RBFA401_1
(MEMBRANE LIPOPROTEIN
TPN38(B))		 4apb FUMARATE HYDRATASE
CLASS II
(Mycobacterium
tuberculosis) 		5 / 12 ALA A 384
ASP A 168
GLN A 164
ILE A 211
GLY A 202
 None
 1.37A 4iilA-4apbA:
undetectable		 4iilA-4apbA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KJJ_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4apb FUMARATE HYDRATASE
CLASS II
(Mycobacterium
tuberculosis) 		5 / 12 ILE A 291
ALA A 171
ILE A 309
LEU A 391
ILE A 295
 None
 0.92A 4kjjA-4apbA:
undetectable		 4kjjA-4apbA:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L8F_B_MTXB301_1
(GAMMA-GLUTAMYL
HYDROLASE)		 4apb FUMARATE HYDRATASE
CLASS II
(Mycobacterium
tuberculosis) 		5 / 11 GLY A 232
GLY A 228
GLY A 227
ALA A 230
GLN A 137
 None
 1.18A 4l8fB-4apbA:
undetectable		 4l8fB-4apbA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_A_STRA601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4apb FUMARATE HYDRATASE
CLASS II
(Mycobacterium
tuberculosis) 		4 / 6 LEU A 376
ASP A 344
GLU A 371
ALA A 151
 None
 0.98A 4nkxA-4apbA:
2.5		 4nkxA-4apbA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PSS_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4apb FUMARATE HYDRATASE
CLASS II
(Mycobacterium
tuberculosis) 		5 / 12 ILE A 291
ALA A 171
ILE A 309
LEU A 391
ILE A 295
 None
 0.94A 4pssA-4apbA:
undetectable		 4pssA-4apbA:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QCK_A_ASDA404_1
(3-KETOSTEROID-9-ALPH
A-MONOOXYGENASE
OXYGENASE SUBUNIT)		 4apb FUMARATE HYDRATASE
CLASS II
(Mycobacterium
tuberculosis) 		5 / 12 ASN A 134
VAL A 133
LEU A 249
ALA A  62
GLY A 227
 None
 1.27A 4qckA-4apbA:
undetectable		 4qckA-4apbA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVQ_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 4apb FUMARATE HYDRATASE
CLASS II
(Mycobacterium
tuberculosis) 		5 / 9 THR A 112
THR A 142
ILE A  51
GLY A  55
ALA A  53
 None
 1.00A 4qvqK-4apbA:
undetectable
4qvqL-4apbA:
undetectable		 4qvqK-4apbA:
18.38
4qvqL-4apbA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVQ_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 4apb FUMARATE HYDRATASE
CLASS II
(Mycobacterium
tuberculosis) 		5 / 9 THR A 112
THR A 142
ILE A  51
GLY A  55
ALA A  53
 None
 1.00A 4qvqY-4apbA:
undetectable
4qvqZ-4apbA:
undetectable		 4qvqY-4apbA:
18.38
4qvqZ-4apbA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_A_NOVA2000_1
(DNA GYRASE SUBUNIT B)		 4apb FUMARATE HYDRATASE
CLASS II
(Mycobacterium
tuberculosis) 		5 / 12 ASN A 111
SER A 108
ILE A  51
ASP A  88
GLN A  90
 None
 1.36A 4uroA-4apbA:
undetectable		 4uroA-4apbA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_B_NOVB2000_1
(DNA GYRASE SUBUNIT B)		 4apb FUMARATE HYDRATASE
CLASS II
(Mycobacterium
tuberculosis) 		5 / 12 ASN A 111
SER A 108
ILE A  51
ASP A  88
GLN A  90
 None
 1.36A 4uroB-4apbA:
undetectable		 4uroB-4apbA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGY_A_ERYA403_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 4apb FUMARATE HYDRATASE
CLASS II
(Mycobacterium
tuberculosis) 		5 / 12 HIS A 148
ASN A 359
ALA A 352
SER A 372
PHE A 373
 None
 1.24A 5igyA-4apbA:
undetectable		 5igyA-4apbA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MM4_B_TA1B501_1
(TUBULIN BETA CHAIN)		 4apb FUMARATE HYDRATASE
CLASS II
(Mycobacterium
tuberculosis) 		5 / 10 GLU A 266
LEU A  54
ALA A 225
THR A 106
LEU A 358
 None
 1.34A 5mm4B-4apbA:
undetectable		 5mm4B-4apbA:
11.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U63_B_ACTB405_0
(THIOREDOXIN
REDUCTASE)		 4apb FUMARATE HYDRATASE
CLASS II
(Mycobacterium
tuberculosis) 		3 / 3 GLY A 222
LEU A 221
HIS A 148
 None
 0.70A 5u63B-4apbA:
undetectable		 5u63B-4apbA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y9A_A_AR3A201_1
(PEPTIDYL-TRNA
HYDROLASE)		 4apb FUMARATE HYDRATASE
CLASS II
(Mycobacterium
tuberculosis) 		4 / 6 ALA A 251
GLN A 252
GLN A  63
ASP A  67
 None
 1.36A 5y9aA-4apbA:
undetectable		 5y9aA-4apbA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBP_C_DAHC123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 4apb FUMARATE HYDRATASE
CLASS II
(Mycobacterium
tuberculosis) 		5 / 10 LEU A 166
GLY A 210
ILE A 284
PHE A 383
ILE A 291
 None
 1.17A 6ebpC-4apbA:
undetectable		 6ebpC-4apbA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_A_TKTA508_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 4apb FUMARATE HYDRATASE
CLASS II
(Mycobacterium
tuberculosis) 		4 / 8 ASP A  92
ILE A  86
ARG A  48
ASN A 113
 None
 1.08A 6hisA-4apbA:
2.0
6hisB-4apbA:
2.0		 6hisA-4apbA:
11.14
6hisB-4apbA:
11.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_B_TKTB508_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 4apb FUMARATE HYDRATASE
CLASS II
(Mycobacterium
tuberculosis) 		4 / 8 ASP A  92
ILE A  86
ARG A  48
ASN A 113
 None
 1.09A 6hisB-4apbA:
2.0
6hisC-4apbA:
2.0		 6hisB-4apbA:
11.14
6hisC-4apbA:
11.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_C_TKTC508_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 4apb FUMARATE HYDRATASE
CLASS II
(Mycobacterium
tuberculosis) 		4 / 8 ASP A  92
ILE A  86
ARG A  48
ASN A 113
 None
 1.09A 6hisC-4apbA:
undetectable
6hisD-4apbA:
undetectable		 6hisC-4apbA:
11.14
6hisD-4apbA:
11.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_D_TKTD501_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 4apb FUMARATE HYDRATASE
CLASS II
(Mycobacterium
tuberculosis) 		4 / 8 ASP A  92
ILE A  86
ARG A  48
ASN A 113
 None
 1.07A 6hisD-4apbA:
2.0
6hisE-4apbA:
2.0		 6hisD-4apbA:
11.14
6hisE-4apbA:
11.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_E_TKTE501_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 4apb FUMARATE HYDRATASE
CLASS II
(Mycobacterium
tuberculosis) 		4 / 8 ASN A 113
ASP A  92
ILE A  86
ARG A  48
 None
 1.10A 6hisA-4apbA:
undetectable
6hisE-4apbA:
undetectable		 6hisA-4apbA:
11.14
6hisE-4apbA:
11.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6IFT_A_SAMA301_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE A)		 4apb FUMARATE HYDRATASE
CLASS II
(Mycobacterium
tuberculosis) 		5 / 12 ILE A 226
GLY A 227
GLY A 234
ASP A 239
VAL A 245
 None
 0.85A 6iftA-4apbA:
undetectable		 6iftA-4apbA:
22.46