SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4apf'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T9W_A_NFNA6002_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 4apf CULLIN 3
(Homo
sapiens) 		4 / 7 MET B 212
PHE B 209
ARG B 180
GLU B 243
 None
 1.27A 1t9wA-4apfB:
3.2		 1t9wA-4apfB:
15.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIM_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 4apf CULLIN 3
(Homo
sapiens) 		4 / 5 TYR B  58
ARG B  59
THR B  63
LEU B  66
 None
 1.20A 2eimW-4apfB:
undetectable		 2eimW-4apfB:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB2_A_SAMA1101_0
(STRUCTURAL PROTEIN
VP3)		 4apf CULLIN 3
(Homo
sapiens) 		5 / 12 GLU B 265
ARG B 240
VAL B 248
ILE B 245
ASN B 242
 None
 1.47A 3jb2A-4apfB:
2.6		 3jb2A-4apfB:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UMW_B_RBFB201_1
(GLYOXALASE/BLEOMYCIN
RESISANCE
PROTEIN/DIOXYGENASE)		 4apf CULLIN 3
(Homo
sapiens) 		4 / 7 VAL B 263
ARG B 247
GLU B 244
LEU B 166
 None
 1.11A 5umwB-4apfB:
undetectable
5umwE-4apfB:
undetectable		 5umwB-4apfB:
11.51
5umwE-4apfB:
11.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W97_J_CHDJ101_1
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4apf CULLIN 3
(Homo
sapiens) 		4 / 5 TYR B  58
ARG B  59
THR B  63
LEU B  66
 None
 1.06A 5w97J-4apfB:
undetectable		 5w97J-4apfB:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WAU_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4apf CULLIN 3
(Homo
sapiens) 		4 / 4 TYR B  58
ARG B  59
THR B  63
LEU B  66
 None
 1.18A 5wauj-4apfB:
0.0		 5wauj-4apfB:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1F_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4apf CULLIN 3
(Homo
sapiens) 		4 / 5 TYR B  58
ARG B  59
THR B  63
LEU B  66
 None
 1.14A 5x1fW-4apfB:
undetectable		 5x1fW-4apfB:
11.76