SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4apl'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_B_CCSB381_0
(ESTROGEN RECEPTOR)		 4apl APICAL MEMBRANE
ANTIGEN 1
(Neospora
caninum) 		3 / 3 GLU A 327
ALA A 329
SER A 358
 None
 0.66A 1errB-4aplA:
undetectable		 1errB-4aplA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KNY_A_KANA558_1
(KANAMYCIN
NUCLEOTIDYLTRANSFERA
SE)		 4apl APICAL MEMBRANE
ANTIGEN 1
(Neospora
caninum) 		4 / 7 ASP A 409
GLU A 174
GLU A 184
GLU A 171
 None
 0.97A 1knyA-4aplA:
undetectable
1knyB-4aplA:
undetectable		 1knyA-4aplA:
19.77
1knyB-4aplA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KNY_B_KANB559_1
(KANAMYCIN
NUCLEOTIDYLTRANSFERA
SE)		 4apl APICAL MEMBRANE
ANTIGEN 1
(Neospora
caninum) 		4 / 8 GLU A 171
ASP A 409
GLU A 174
GLU A 184
 None
 0.97A 1knyA-4aplA:
undetectable
1knyB-4aplA:
undetectable		 1knyA-4aplA:
19.77
1knyB-4aplA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T9W_A_NFNA6001_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 4apl APICAL MEMBRANE
ANTIGEN 1
(Neospora
caninum) 		3 / 3 SER A  87
GLY A  88
ARG A 105
 None
 0.65A 1t9wA-4aplA:
undetectable		 1t9wA-4aplA:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VIF_A_FOLA1_0
(DIHYDROFOLATE
REDUCTASE)		 4apl APICAL MEMBRANE
ANTIGEN 1
(Neospora
caninum) 		3 / 3 GLN A 119
ILE A 118
TYR A 117
 None
 0.74A 1vifA-4aplA:
undetectable		 1vifA-4aplA:
10.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_F_9CRF1600_2
(RETINOIC ACID
RECEPTOR, BETA)		 4apl APICAL MEMBRANE
ANTIGEN 1
(Neospora
caninum) 		3 / 3 LEU A 223
PHE A 153
ARG A 105
 None
 0.80A 1xdkF-4aplA:
undetectable		 1xdkF-4aplA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HMY_B_SAMB328_0
(PROTEIN
(CYTOSINE-SPECIFIC
METHYLTRANSFERASE
HHAI))		 4apl APICAL MEMBRANE
ANTIGEN 1
(Neospora
caninum) 		5 / 12 PHE A 264
GLY A 115
GLY A 401
ILE A 118
LEU A 223
 None
 0.98A 2hmyB-4aplA:
undetectable		 2hmyB-4aplA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_A_SC2A1290_1
(FICOLIN-2)		 4apl APICAL MEMBRANE
ANTIGEN 1
(Neospora
caninum) 		4 / 5 ASP A 274
SER A 182
LEU A 185
GLY A 186
 None
 1.12A 2j2pA-4aplA:
undetectable
2j2pB-4aplA:
undetectable		 2j2pA-4aplA:
20.14
2j2pB-4aplA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O7G_B_ASCB304_0
(PROBABLE
TRANSMEMBRANE
ASCORBATE
FERRIREDUCTASE 2)		 4apl APICAL MEMBRANE
ANTIGEN 1
(Neospora
caninum) 		4 / 6 PHE A 434
TYR A 288
PHE A  67
ASN A  65
 None
 1.49A 4o7gB-4aplA:
undetectable		 4o7gB-4aplA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOP_A_HQEA503_1
(CATALASE)		 4apl APICAL MEMBRANE
ANTIGEN 1
(Neospora
caninum) 		5 / 9 PRO A 385
LEU A 285
TYR A 288
LEU A  76
PHE A  67
 None
 1.46A 4qopA-4aplA:
undetectable		 4qopA-4aplA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOP_B_HQEB503_1
(CATALASE)		 4apl APICAL MEMBRANE
ANTIGEN 1
(Neospora
caninum) 		5 / 9 PRO A 385
LEU A 285
TYR A 288
LEU A  76
PHE A  67
 None
 1.46A 4qopB-4aplA:
undetectable		 4qopB-4aplA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOP_D_HQED503_1
(CATALASE)		 4apl APICAL MEMBRANE
ANTIGEN 1
(Neospora
caninum) 		5 / 9 PRO A 385
LEU A 285
TYR A 288
LEU A  76
PHE A  67
 None
 1.46A 4qopD-4aplA:
0.0		 4qopD-4aplA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UDC_A_DEXA1778_2
(GLUCOCORTICOID
RECEPTOR)		 4apl APICAL MEMBRANE
ANTIGEN 1
(Neospora
caninum) 		3 / 3 MET A 227
GLN A 119
TYR A 117
 None
 1.01A 4udcA-4aplA:
undetectable		 4udcA-4aplA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YV5_A_SVRA205_2
(BASIC PHOSPHOLIPASE
A2 HOMOLOG 2)		 4apl APICAL MEMBRANE
ANTIGEN 1
(Neospora
caninum) 		4 / 6 PHE A 250
LEU A 149
ASN A 147
PRO A 148
 None
 1.33A 4yv5B-4aplA:
undetectable		 4yv5B-4aplA:
15.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YV5_B_SVRB207_1
(BASIC PHOSPHOLIPASE
A2 HOMOLOG 2)		 4apl APICAL MEMBRANE
ANTIGEN 1
(Neospora
caninum) 		4 / 6 PHE A 250
LEU A 149
ASN A 147
PRO A 148
 None
 1.32A 4yv5A-4aplA:
undetectable		 4yv5A-4aplA:
15.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEO_A_VDYA206_2
(CDL2.3A)		 4apl APICAL MEMBRANE
ANTIGEN 1
(Neospora
caninum) 		4 / 8 PRO A 210
ILE A 136
TYR A 221
LEU A 262
 None
 0.90A 5ieoA-4aplA:
undetectable		 5ieoA-4aplA:
14.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2T_A_6ZZA900_2
(CYCLIN-DEPENDENT
KINASE 6)		 4apl APICAL MEMBRANE
ANTIGEN 1
(Neospora
caninum) 		3 / 3 LYS A 254
GLN A 283
ASN A 282
 None
 1.02A 5l2tA-4aplA:
undetectable		 5l2tA-4aplA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_A_486A801_2
(GLUCOCORTICOID
RECEPTOR)		 4apl APICAL MEMBRANE
ANTIGEN 1
(Neospora
caninum) 		3 / 3 TRP A 347
MET A 155
ASN A 154
 None
 1.19A 5uc1B-4aplA:
undetectable		 5uc1B-4aplA:
10.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_B_486B801_1
(GLUCOCORTICOID
RECEPTOR)		 4apl APICAL MEMBRANE
ANTIGEN 1
(Neospora
caninum) 		3 / 3 TRP A 347
MET A 155
ASN A 154
 None
 1.14A 5uc1A-4aplA:
undetectable		 5uc1A-4aplA:
10.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YOD_D_BEZD201_0
(NS3 PROTEASE)		 4apl APICAL MEMBRANE
ANTIGEN 1
(Neospora
caninum) 		4 / 5 HIS A  85
ALA A 108
SER A  87
GLY A  88
 None
 1.21A 5yodD-4aplA:
undetectable		 5yodD-4aplA:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5Y_D_9CRD501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4apl APICAL MEMBRANE
ANTIGEN 1
(Neospora
caninum) 		3 / 3 ASN A 282
VAL A  89
HIS A  85
 None
 0.85A 6a5yD-4aplA:
undetectable		 6a5yD-4aplA:
11.11