SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4apm'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZZ_A_ACTA421_0
(ACLACINOMYCIN-10-HYD
ROXYLASE)		 4apm APICAL MEMBRANE
ANTIGEN 1
(Babesia
divergens) 		5 / 8 ASP A 119
GLY A 136
GLY A 121
GLY A 122
MET A 133
 None
 1.33A 1qzzA-4apmA:
undetectable		 1qzzA-4apmA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1USQ_E_CLME1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 4apm APICAL MEMBRANE
ANTIGEN 1
(Babesia
divergens) 		4 / 6 PRO A 134
GLY A 136
ILE A 116
GLY A 115
 None
 0.85A 1usqE-4apmA:
undetectable		 1usqE-4apmA:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OTH_A_NIMA300_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 4apm APICAL MEMBRANE
ANTIGEN 1
(Babesia
divergens) 		4 / 5 ALA A 312
ILE A 313
SER A 429
LYS A 491
 None
None
None
ACT  A1513 (-2.7A)
 1.11A 2othA-4apmA:
undetectable		 2othA-4apmA:
16.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZUL_A_SAMA376_1
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)		 4apm APICAL MEMBRANE
ANTIGEN 1
(Babesia
divergens) 		3 / 3 SER A 462
GLU A 330
ASP A 407
 None
 0.78A 2zulA-4apmA:
undetectable		 2zulA-4apmA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AVO_A_PAUA314_0
(PANTOTHENATE KINASE)		 4apm APICAL MEMBRANE
ANTIGEN 1
(Babesia
divergens) 		5 / 11 ASP A 350
LEU A 351
TYR A 117
PHE A 344
ILE A 145
 None
 1.15A 3avoA-4apmA:
undetectable		 3avoA-4apmA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DMH_A_SAMA384_1
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)		 4apm APICAL MEMBRANE
ANTIGEN 1
(Babesia
divergens) 		3 / 3 SER A 462
GLU A 330
ASP A 407
 None
 0.76A 3dmhA-4apmA:
undetectable		 3dmhA-4apmA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FPJ_A_SAMA301_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN)		 4apm APICAL MEMBRANE
ANTIGEN 1
(Babesia
divergens) 		5 / 12 PHE A 314
ILE A 313
ILE A 425
ILE A 450
ALA A 431
 None
 1.00A 3fpjA-4apmA:
undetectable		 3fpjA-4apmA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N3I_A_ROCA201_2
(PROTEASE)		 4apm APICAL MEMBRANE
ANTIGEN 1
(Babesia
divergens) 		4 / 6 ILE A 116
PRO A 438
ASP A 240
GLY A 142
 None
 0.97A 3n3iA-4apmA:
undetectable		 3n3iA-4apmA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZBF_A_VGHA3000_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ROS)		 4apm APICAL MEMBRANE
ANTIGEN 1
(Babesia
divergens) 		6 / 12 LEU A 167
MET A 278
GLY A 148
THR A 272
LEU A 147
GLY A 166
 None
None
None
None
GOL  A1520 (-4.5A)
None
 1.37A 3zbfA-4apmA:
undetectable		 3zbfA-4apmA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E47_A_SAMA401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 4apm APICAL MEMBRANE
ANTIGEN 1
(Babesia
divergens) 		5 / 11 ILE A 248
ALA A 220
GLY A 221
GLU A 218
GLY A 136
 None
None
MPD  A1521 (-4.0A)
None
None
 1.24A 4e47A-4apmA:
undetectable		 4e47A-4apmA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E47_B_SAMB800_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 4apm APICAL MEMBRANE
ANTIGEN 1
(Babesia
divergens) 		5 / 11 ILE A 248
ALA A 220
GLY A 221
GLU A 218
GLY A 136
 None
None
MPD  A1521 (-4.0A)
None
None
 1.24A 4e47B-4apmA:
undetectable		 4e47B-4apmA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E47_C_SAMC800_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 4apm APICAL MEMBRANE
ANTIGEN 1
(Babesia
divergens) 		5 / 11 ILE A 248
ALA A 220
GLY A 221
GLU A 218
GLY A 136
 None
None
MPD  A1521 (-4.0A)
None
None
 1.27A 4e47C-4apmA:
undetectable		 4e47C-4apmA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JDS_A_SAMA401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 4apm APICAL MEMBRANE
ANTIGEN 1
(Babesia
divergens) 		5 / 11 ILE A 248
ALA A 220
GLY A 221
GLU A 218
GLY A 136
 None
None
MPD  A1521 (-4.0A)
None
None
 1.25A 4jdsA-4apmA:
undetectable		 4jdsA-4apmA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JDS_B_SAMB401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 4apm APICAL MEMBRANE
ANTIGEN 1
(Babesia
divergens) 		5 / 11 ILE A 248
ALA A 220
GLY A 221
GLU A 218
GLY A 136
 None
None
MPD  A1521 (-4.0A)
None
None
 1.27A 4jdsB-4apmA:
undetectable		 4jdsB-4apmA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JDS_C_SAMC401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 4apm APICAL MEMBRANE
ANTIGEN 1
(Babesia
divergens) 		5 / 11 ILE A 248
ALA A 220
GLY A 221
GLU A 218
GLY A 136
 None
None
MPD  A1521 (-4.0A)
None
None
 1.26A 4jdsC-4apmA:
undetectable		 4jdsC-4apmA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM4_B_8PRB603_2
(TRANSPORTER)		 4apm APICAL MEMBRANE
ANTIGEN 1
(Babesia
divergens) 		3 / 3 SER A 340
MET A 343
ASP A 407
 None
 0.96A 4mm4B-4apmA:
undetectable		 4mm4B-4apmA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AYF_A_SAMA401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 4apm APICAL MEMBRANE
ANTIGEN 1
(Babesia
divergens) 		5 / 11 ILE A 248
ALA A 220
GLY A 221
GLU A 218
GLY A 136
 None
None
MPD  A1521 (-4.0A)
None
None
 1.29A 5ayfA-4apmA:
undetectable		 5ayfA-4apmA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WWS_A_SAMA501_0
(PUTATIVE
METHYLTRANSFERASE
NSUN6)		 4apm APICAL MEMBRANE
ANTIGEN 1
(Babesia
divergens) 		5 / 12 PRO A 438
LYS A 310
ASP A 311
GLY A 428
ASP A 335
 None
None
None
None
GOL  A1517 (-2.4A)
 1.08A 5wwsA-4apmA:
undetectable		 5wwsA-4apmA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WWS_B_SAMB501_0
(PUTATIVE
METHYLTRANSFERASE
NSUN6)		 4apm APICAL MEMBRANE
ANTIGEN 1
(Babesia
divergens) 		5 / 12 PRO A 438
LYS A 310
ASP A 311
GLY A 428
ASP A 335
 None
None
None
None
GOL  A1517 (-2.4A)
 1.10A 5wwsB-4apmA:
undetectable		 5wwsB-4apmA:
22.67