SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4apq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3K9F_F_LFXF0_1 (DNA TOPOISOMERASE 4 SUBUNIT A DNA TOPOISOMERASE 4 SUBUNIT B)	4apq	MOUSE NKT TCR AUTOREACTIVE-VBETA6, HUMAN NKT TCR AUTOREACTIVE-VBETA6 (Mus musculus)	4 / 5	SER D 54 ARG D 68 GLY D 94 GLU D 105	None	0.90A	3k9fA-4apqD: undetectable 3k9fB-4apqD: undetectable 3k9fC-4apqD: undetectable	3k9fA-4apqD: 19.32 3k9fB-4apqD: 19.32 3k9fC-4apqD: 21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3K9F_H_LFXH0_1 (DNA TOPOISOMERASE 4 SUBUNIT A DNA TOPOISOMERASE 4 SUBUNIT B)	4apq	MOUSE NKT TCR AUTOREACTIVE-VBETA6, HUMAN NKT TCR AUTOREACTIVE-VBETA6 (Mus musculus)	4 / 6	ARG D 68 SER D 54 GLY D 94 GLU D 105	None	0.90A	3k9fA-4apqD: undetectable 3k9fB-4apqD: undetectable 3k9fD-4apqD: undetectable	3k9fA-4apqD: 19.32 3k9fB-4apqD: 19.32 3k9fD-4apqD: 21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3OU6_C_SAMC300_1 (SAM-DEPENDENT METHYLTRANSFERASE)	4apq	MOUSE NKT TCR AUTOREACTIVE-VBETA6, HUMAN NKT TCR AUTOREACTIVE-VBETA6 (Mus musculus)	3 / 3	TYR D 48 GLY D 58 ASP D 59	None	0.44A	3ou6C-4apqD: undetectable	3ou6C-4apqD: 24.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4HXY_B_ACAB502_1 (PLM1)	4apq	MOUSE NKT TCR AUTOREACTIVE-VBETA6, HUMAN NKT TCR AUTOREACTIVE-VBETA6 (Mus musculus)	4 / 7	VAL D 117 GLN D 14 LEU D 220 ASP D 224	None	1.06A	4hxyB-4apqD: undetectable	4hxyB-4apqD: 17.61

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["3K9F_F_LFXF0_1","DNA TOPOISOMERASE 4 SUBUNIT A;DNA TOPOISOMERASE 4 SUBUNIT A;DNA TOPOISOMERASE 4 SUBUNIT B","4apq","MOUSE NKT TCR AUTOREACTIVE-VBETA6, HUMAN NKT TCR AUTOREACTIVE-VBETA6","Mus musculus",4,"SER D  54;ARG D  68;GLY D  94;GLU D 105","None","0.90A","3k9fA-4apqD:undetectable;3k9fB-4apqD:undetectable;3k9fC-4apqD:undetectable","3k9fA-4apqD:19.32;3k9fB-4apqD:19.32;3k9fC-4apqD:21.02"],["3K9F_H_LFXH0_1","DNA TOPOISOMERASE 4 SUBUNIT A;DNA TOPOISOMERASE 4 SUBUNIT A;DNA TOPOISOMERASE 4 SUBUNIT B","4apq","MOUSE NKT TCR AUTOREACTIVE-VBETA6, HUMAN NKT TCR AUTOREACTIVE-VBETA6","Mus musculus",4,"ARG D  68;SER D  54;GLY D  94;GLU D 105","None","0.90A","3k9fA-4apqD:undetectable;3k9fB-4apqD:undetectable;3k9fD-4apqD:undetectable","3k9fA-4apqD:19.32;3k9fB-4apqD:19.32;3k9fD-4apqD:21.02"],["3OU6_C_SAMC300_1","SAM-DEPENDENT METHYLTRANSFERASE","4apq","MOUSE NKT TCR AUTOREACTIVE-VBETA6, HUMAN NKT TCR AUTOREACTIVE-VBETA6","Mus musculus",3,"TYR D  48;GLY D  58;ASP D  59","None","0.44A","3ou6C-4apqD:undetectable","3ou6C-4apqD:24.32"],["4HXY_B_ACAB502_1","PLM1","4apq","MOUSE NKT TCR AUTOREACTIVE-VBETA6, HUMAN NKT TCR AUTOREACTIVE-VBETA6","Mus musculus",4,"VAL D 117;GLN D  14;LEU D 220;ASP D 224","None","1.06A","4hxyB-4apqD:undetectable","4hxyB-4apqD:17.61"]]