SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4apw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NH8_A_HISA289_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 4apw ALP12
(Clostridium
tetani) 		4 / 5 ASP A 219
LEU A 225
ALA A 216
LEU A 217
 None
 1.06A 1nh8A-4apwA:
undetectable		 1nh8A-4apwA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWH_A_BAXA1723_2
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 4apw ALP12
(Clostridium
tetani) 		4 / 6 ILE A 283
VAL A 176
VAL A 116
ILE A 154
 None
 0.75A 1uwhA-4apwA:
undetectable		 1uwhA-4apwA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_A_STIA600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4apw ALP12
(Clostridium
tetani) 		4 / 6 LEU A 117
VAL A 106
VAL A 321
ILE A 152
 None
 0.97A 2hyyA-4apwA:
undetectable		 2hyyA-4apwA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q83_A_ADNA1_1
(YTAA PROTEIN)		 4apw ALP12
(Clostridium
tetani) 		4 / 7 ILE A 136
ILE A 130
LEU A 108
ILE A 149
 None
 0.67A 2q83A-4apwA:
undetectable		 2q83A-4apwA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_C_KLNC1499_1
(CYTOCHROME P450 3A4)		 4apw ALP12
(Clostridium
tetani) 		4 / 7 PHE A 169
SER A 281
ILE A 305
GLY A 158
 None
 1.00A 2v0mC-4apwA:
undetectable		 2v0mC-4apwA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_A_CHDA153_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 4apw ALP12
(Clostridium
tetani) 		4 / 5 ILE A 305
THR A 289
PHE A 179
PHE A 186
 None
 1.31A 3em0A-4apwA:
1.4		 3em0A-4apwA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWX_A_ZMRA513_2
(NEURAMINIDASE)		 4apw ALP12
(Clostridium
tetani) 		3 / 3 ARG A  35
TRP A 312
ILE A  22
 None
 0.98A 4mwxA-4apwA:
undetectable		 4mwxA-4apwA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_F_SAMF301_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 4apw ALP12
(Clostridium
tetani) 		6 / 12 THR A 313
GLY A 158
GLY A 160
GLY A 317
LEU A 164
ALA A 175
 None
 1.37A 5c0oF-4apwA:
undetectable		 5c0oF-4apwA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V1S_B_SAMB604_0
(RADICAL SAM)		 4apw ALP12
(Clostridium
tetani) 		5 / 9 CYH A 315
GLU A 316
THR A 307
TYR A 189
SER A 187
 None
 1.47A 5v1sB-4apwA:
1.2		 5v1sB-4apwA:
23.74