SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4aq9'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WSV_A_THHA3001_0
(AMINOMETHYLTRANSFERA
SE)		 4aq9 ACETYLCHOLINE
RECEPTOR GAMMA
SUBUNIT
(Torpedo
marmorata) 		5 / 12 THR E  50
LEU E  49
VAL E  95
ASN E  93
LEU E 212
 None
 1.33A 1wsvA-4aq9E:
undetectable		 1wsvA-4aq9E:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WSV_B_THHB4001_0
(AMINOMETHYLTRANSFERA
SE)		 4aq9 ACETYLCHOLINE
RECEPTOR GAMMA
SUBUNIT
(Torpedo
marmorata) 		5 / 12 THR E  50
LEU E  49
VAL E  95
ASN E  93
LEU E 212
 None
 1.33A 1wsvB-4aq9E:
undetectable		 1wsvB-4aq9E:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA1_1
(CES1 PROTEIN)		 4aq9 ACETYLCHOLINE
RECEPTOR GAMMA
SUBUNIT
(Torpedo
marmorata) 		5 / 12 PHE E  99
SER E 125
LEU E  39
LEU E  34
LEU E 212
 None
 1.04A 1ya4A-4aq9E:
undetectable		 1ya4A-4aq9E:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L2V_A_RLTA397_1
(INTEGRASE)		 4aq9 ACETYLCHOLINE
RECEPTOR GAMMA
SUBUNIT
(Torpedo
marmorata) 		4 / 7 ASP E 202
ASP E 204
GLN E 206
GLN E 197
 None
 1.19A 3l2vA-4aq9E:
undetectable		 3l2vA-4aq9E:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U5J_A_08HA1_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 4aq9 ACETYLCHOLINE
RECEPTOR GAMMA
SUBUNIT
(Torpedo
marmorata) 		4 / 7 TRP E  85
PRO E  87
LEU E 157
ILE E  57
 None
 1.00A 3u5jA-4aq9E:
undetectable		 3u5jA-4aq9E:
13.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VRJ_A_1KXA301_1
(HLA CLASS I
HISTOCOMPATIBILITY
ANTIGEN, B-57 ALPHA
CHAIN
10-MER PEPTIDE)		 4aq9 ACETYLCHOLINE
RECEPTOR GAMMA
SUBUNIT
(Torpedo
marmorata) 		5 / 12 ILE E 296
VAL E 292
ILE E 268
THR E 468
ILE E 232
 None
 1.17A 3vrjA-4aq9E:
2.2
3vrjC-4aq9E:
undetectable		 3vrjA-4aq9E:
18.38
3vrjC-4aq9E:
4.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PWJ_A_30ZA201_1
(TRANSTHYRETIN)		 4aq9 ACETYLCHOLINE
RECEPTOR GAMMA
SUBUNIT
(Torpedo
marmorata) 		4 / 6 THR E 468
ALA E 464
LEU E 460
SER E 459
 None
 0.89A 4pwjA-4aq9E:
undetectable		 4pwjA-4aq9E:
14.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PWJ_B_30ZB201_1
(TRANSTHYRETIN)		 4aq9 ACETYLCHOLINE
RECEPTOR GAMMA
SUBUNIT
(Torpedo
marmorata) 		4 / 7 THR E 468
ALA E 464
LEU E 460
SER E 459
 None
 0.85A 4pwjB-4aq9E:
undetectable		 4pwjB-4aq9E:
14.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RMJ_A_NCAA402_0
(NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-2)		 4aq9 ACETYLCHOLINE
RECEPTOR GAMMA
SUBUNIT
(Torpedo
marmorata) 		4 / 7 ILE E 172
LEU E  36
LEU E 212
ILE E 214
 None
 0.70A 4rmjA-4aq9E:
undetectable		 4rmjA-4aq9E:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BOJ_B_4TXB201_1
(TRANSTHYRETIN)		 4aq9 ACETYLCHOLINE
RECEPTOR GAMMA
SUBUNIT
(Torpedo
marmorata) 		4 / 7 THR E 468
ALA E 464
LEU E 460
SER E 459
 None
 0.92A 5bojB-4aq9E:
undetectable		 5bojB-4aq9E:
13.40