SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4aqb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_C_SAMC2293_0
(GLYCINE
N-METHYLTRANSFERASE)		 4aqb MANNAN-BINDING
LECTIN SERINE
PROTEASE 1
(Homo
sapiens) 		5 / 12 THR A 215
ALA A 296
GLY A 252
SER A 272
HIS A 273
 None
 1.31A 1nbiC-4aqbA:
undetectable		 1nbiC-4aqbA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FJ1_A_CTCA222_0
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		 4aqb MANNAN-BINDING
LECTIN SERINE
PROTEASE 1
(Homo
sapiens) 		5 / 12 PRO A 360
THR A 344
VAL A 327
LEU A 304
SER A 356
 None
 1.46A 2fj1A-4aqbA:
undetectable		 2fj1A-4aqbA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q8H_A_TF4A438_1
([PYRUVATE
DEHYDROGENASE
[LIPOAMIDE]] KINASE
ISOZYME 1)		 4aqb MANNAN-BINDING
LECTIN SERINE
PROTEASE 1
(Homo
sapiens) 		4 / 6 LEU A 304
TYR A 319
ILE A 347
ILE A 312
 None
 0.78A 2q8hA-4aqbA:
undetectable		 2q8hA-4aqbA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FPJ_A_SAMA301_1
(PUTATIVE
UNCHARACTERIZED
PROTEIN)		 4aqb MANNAN-BINDING
LECTIN SERINE
PROTEASE 1
(Homo
sapiens) 		4 / 6 TYR A  40
GLY A  92
THR A 129
GLU A  99
 None
 1.08A 3fpjA-4aqbA:
undetectable		 3fpjA-4aqbA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TOP_B_ACRB1_2
(MALTASE-GLUCOAMYLASE
, INTESTINAL)		 4aqb MANNAN-BINDING
LECTIN SERINE
PROTEASE 1
(Homo
sapiens) 		4 / 5 PRO A 265
ILE A 216
TRP A 290
PHE A 259
 None
 1.47A 3topB-4aqbA:
undetectable		 3topB-4aqbA:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJG_C_NCTC501_1
(CYTOCHROME P450 2A13)		 4aqb MANNAN-BINDING
LECTIN SERINE
PROTEASE 1
(Homo
sapiens) 		4 / 7 PHE A  65
PHE A  62
ALA A  88
LEU A  60
 None
None
CA  A 707 ( 4.9A)
None
 0.74A 4ejgC-4aqbA:
undetectable		 4ejgC-4aqbA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJG_C_NCTC501_1
(CYTOCHROME P450 2A13)		 4aqb MANNAN-BINDING
LECTIN SERINE
PROTEASE 1
(Homo
sapiens) 		4 / 7 PHE A 131
PHE A  65
PHE A  62
LEU A  60
 None
 0.79A 4ejgC-4aqbA:
undetectable		 4ejgC-4aqbA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q1X_A_017A101_2
(ASPARTYL PROTEASE)		 4aqb MANNAN-BINDING
LECTIN SERINE
PROTEASE 1
(Homo
sapiens) 		5 / 12 LEU A 256
ILE A 277
ILE A 197
VAL A 251
ILE A 249
 None
 0.86A 4q1xB-4aqbA:
undetectable		 4q1xB-4aqbA:
15.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V30_B_LVYB151_1
(CEREBLON ISOFORM 4)		 4aqb MANNAN-BINDING
LECTIN SERINE
PROTEASE 1
(Homo
sapiens) 		4 / 8 PRO A 265
PHE A 259
TRP A 290
TYR A 206
 None
 1.44A 4v30B-4aqbA:
undetectable		 4v30B-4aqbA:
15.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA309_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 4aqb MANNAN-BINDING
LECTIN SERINE
PROTEASE 1
(Homo
sapiens) 		4 / 4 LEU A  67
GLY A  92
SER A  69
SER A  70
 None
 1.08A 5uunA-4aqbA:
undetectable		 5uunA-4aqbA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_B_ACTB306_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 4aqb MANNAN-BINDING
LECTIN SERINE
PROTEASE 1
(Homo
sapiens) 		4 / 4 LEU A  67
GLY A  92
SER A  69
SER A  70
 None
 1.07A 5uunB-4aqbA:
undetectable		 5uunB-4aqbA:
21.17