SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4aqs'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NW5_A_SAMA401_1
(MODIFICATION
METHYLASE RSRI)		 4aqs LAMININ SUBUNIT
BETA-1
(Mus
musculus) 		3 / 3 ASP A 363
HIS A 317
ASP A 314
 None
 0.88A 1nw5A-4aqsA:
undetectable		 1nw5A-4aqsA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK7_C_ADNC1247_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 4aqs LAMININ SUBUNIT
BETA-1
(Mus
musculus) 		5 / 10 GLY A 360
VAL A 361
GLU A 375
SER A 358
ASP A 318
 None
 1.41A 1pk7C-4aqsA:
undetectable		 1pk7C-4aqsA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QAB_F_RTLF2_0
(PROTEIN (RETINOL
BINDING PROTEIN))		 4aqs LAMININ SUBUNIT
BETA-1
(Mus
musculus) 		5 / 12 ALA A 277
LEU A 210
GLY A 275
TYR A 274
GLN A 225
 None
 1.24A 1qabF-4aqsA:
undetectable		 1qabF-4aqsA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TKQ_A_DVAA6_0
(MINI-GRAMICIDIN A)		 4aqs LAMININ SUBUNIT
BETA-1
(Mus
musculus) 		3 / 3 ALA A  47
VAL A  99
TRP A 112
 None
 0.93A 1tkqA-4aqsA:
undetectable		 1tkqA-4aqsA:
4.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWJ_A_BAXA1723_2
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 4aqs LAMININ SUBUNIT
BETA-1
(Mus
musculus) 		4 / 7 ILE A 177
LEU A 227
ILE A 216
ASP A 211
 None
 0.76A 1uwjA-4aqsA:
undetectable		 1uwjA-4aqsA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C8A_C_NCAC1252_0
(MONO-ADP-RIBOSYLTRAN
SFERASE C3)		 4aqs LAMININ SUBUNIT
BETA-1
(Mus
musculus) 		4 / 6 ARG A 193
SER A 195
PHE A 166
ARG A 164
 None
 1.44A 2c8aC-4aqsA:
undetectable		 2c8aC-4aqsA:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F6D_A_ACRA996_1
(GLUCOAMYLASE GLU1)		 4aqs LAMININ SUBUNIT
BETA-1
(Mus
musculus) 		4 / 7 ASP A 491
THR A 476
GLY A 477
TYR A 478
 None
 0.58A 2f6dA-4aqsA:
undetectable		 2f6dA-4aqsA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WEL_A_ACRA1001_2
(ALPHA-GLUCOSIDASE)		 4aqs LAMININ SUBUNIT
BETA-1
(Mus
musculus) 		4 / 6 ILE A 206
TRP A 112
ILE A  96
MET A 265
 None
 1.46A 3welA-4aqsA:
undetectable		 3welA-4aqsA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NC3_A_ERMA1202_1
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 4aqs LAMININ SUBUNIT
BETA-1
(Mus
musculus) 		5 / 12 LEU A 136
PHE A 166
MET A 148
PHE A 140
VAL A 262
 None
 1.27A 4nc3A-4aqsA:
undetectable		 4nc3A-4aqsA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RP9_A_ASCA501_0
(ASCORBATE-SPECIFIC
PERMEASE IIC
COMPONENT ULAA)		 4aqs LAMININ SUBUNIT
BETA-1
(Mus
musculus) 		5 / 12 HIS A  94
GLN A 113
ASP A  92
ILE A  66
PHE A  77
 None
 1.07A 4rp9A-4aqsA:
undetectable		 4rp9A-4aqsA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_A_SAMA902_1
(MRNA CAPPING ENZYME
P5)		 4aqs LAMININ SUBUNIT
BETA-1
(Mus
musculus) 		3 / 3 TYR A 414
ASP A 412
ASP A 416
 None
 0.79A 5x6yA-4aqsA:
undetectable		 5x6yA-4aqsA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AJI_A_AY6A1001_0
(DRUG EXPORTERS OF
THE RND
SUPERFAMILY-LIKE
PROTEIN,ENDOLYSIN)		 4aqs LAMININ SUBUNIT
BETA-1
(Mus
musculus) 		5 / 12 LEU A 125
ILE A 235
ILE A  96
VAL A  99
LEU A 136
 None
 1.09A 6ajiA-4aqsA:
undetectable		 6ajiA-4aqsA:
18.47