SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4aqt'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GN0_A_DMOA551_1
(ARGINASE-1)		 4aqt LAMININ SUBUNIT
GAMMA-1
(Mus
musculus) 		5 / 9 HIS A 361
ASP A 323
GLY A 363
ASP A 341
THR A 359
 None
 1.35A 3gn0A-4aqtA:
undetectable		 3gn0A-4aqtA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GN0_B_DMOB552_1
(ARGINASE-1)		 4aqt LAMININ SUBUNIT
GAMMA-1
(Mus
musculus) 		5 / 9 HIS A 361
ASP A 323
GLY A 363
ASP A 341
THR A 359
 None
 1.37A 3gn0B-4aqtA:
undetectable		 3gn0B-4aqtA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_A_ACHA301_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 4aqt LAMININ SUBUNIT
GAMMA-1
(Mus
musculus) 		4 / 7 TYR A 161
TYR A 175
TYR A 184
ARG A 253
 NAG  A3001 ( 4.1A)
None
None
None
 1.28A 3wipA-4aqtA:
undetectable
3wipB-4aqtA:
undetectable		 3wipA-4aqtA:
20.00
3wipB-4aqtA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_C_ACHC301_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 4aqt LAMININ SUBUNIT
GAMMA-1
(Mus
musculus) 		4 / 8 TYR A 161
TYR A 175
TYR A 184
ARG A 253
 NAG  A3001 ( 4.1A)
None
None
None
 1.28A 3wipC-4aqtA:
undetectable
3wipD-4aqtA:
undetectable		 3wipC-4aqtA:
20.00
3wipD-4aqtA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_D_ACHD301_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 4aqt LAMININ SUBUNIT
GAMMA-1
(Mus
musculus) 		4 / 8 TYR A 161
TYR A 175
TYR A 184
ARG A 253
 NAG  A3001 ( 4.1A)
None
None
None
 1.25A 3wipD-4aqtA:
undetectable
3wipE-4aqtA:
undetectable		 3wipD-4aqtA:
20.00
3wipE-4aqtA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_F_ACHF301_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 4aqt LAMININ SUBUNIT
GAMMA-1
(Mus
musculus) 		4 / 7 TYR A 161
TYR A 175
TYR A 184
ARG A 253
 NAG  A3001 ( 4.1A)
None
None
None
 1.20A 3wipF-4aqtA:
undetectable
3wipG-4aqtA:
undetectable		 3wipF-4aqtA:
20.00
3wipG-4aqtA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_G_ACHG301_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 4aqt LAMININ SUBUNIT
GAMMA-1
(Mus
musculus) 		4 / 8 TYR A 161
TYR A 175
TYR A 184
ARG A 253
 NAG  A3001 ( 4.1A)
None
None
None
 1.23A 3wipG-4aqtA:
undetectable
3wipH-4aqtA:
undetectable		 3wipG-4aqtA:
20.00
3wipH-4aqtA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_J_ACHJ301_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 4aqt LAMININ SUBUNIT
GAMMA-1
(Mus
musculus) 		4 / 8 ARG A 253
TYR A 161
TYR A 175
TYR A 184
 None
NAG  A3001 ( 4.1A)
None
None
 1.24A 3wipF-4aqtA:
undetectable
3wipJ-4aqtA:
undetectable		 3wipF-4aqtA:
20.00
3wipJ-4aqtA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYS_A_ACTA402_0
(MCCC FAMILY PROTEIN)		 4aqt LAMININ SUBUNIT
GAMMA-1
(Mus
musculus) 		4 / 6 SER A 177
ASP A 205
SER A 208
ASP A 209
 None
 1.14A 4eysA-4aqtA:
undetectable		 4eysA-4aqtA:
19.90