SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ar9'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J36_A_LPRA801_1
(ANGIOTENSIN
CONVERTING ENZYME)		 4ar9 COLLAGENASE COLT
(Clostridium
tetani) 		5 / 12 HIS A 465
GLU A 466
HIS A 469
GLU A 499
TYR A 548
 ZN  A1731 (-3.3A)
ZN  A1731 (-3.9A)
ZN  A1731 (-3.2A)
ZN  A1731 (-2.6A)
None
 0.67A 1j36A-4ar9A:
3.6		 1j36A-4ar9A:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J36_B_LPRB802_1
(ANGIOTENSIN
CONVERTING ENZYME)		 4ar9 COLLAGENASE COLT
(Clostridium
tetani) 		5 / 12 HIS A 465
GLU A 466
HIS A 469
GLU A 499
TYR A 548
 ZN  A1731 (-3.3A)
ZN  A1731 (-3.9A)
ZN  A1731 (-3.2A)
ZN  A1731 (-2.6A)
None
 0.68A 1j36B-4ar9A:
3.6		 1j36B-4ar9A:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J37_A_X8ZA801_1
(ANGIOTENSIN
CONVERTING ENZYME)		 4ar9 COLLAGENASE COLT
(Clostridium
tetani) 		5 / 11 HIS A 465
GLU A 466
HIS A 469
GLU A 499
TYR A 548
 ZN  A1731 (-3.3A)
ZN  A1731 (-3.9A)
ZN  A1731 (-3.2A)
ZN  A1731 (-2.6A)
None
 0.65A 1j37A-4ar9A:
3.4		 1j37A-4ar9A:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J37_B_X8ZB802_1
(ANGIOTENSIN
CONVERTING ENZYME)		 4ar9 COLLAGENASE COLT
(Clostridium
tetani) 		5 / 11 HIS A 465
GLU A 466
HIS A 469
GLU A 499
TYR A 548
 ZN  A1731 (-3.3A)
ZN  A1731 (-3.9A)
ZN  A1731 (-3.2A)
ZN  A1731 (-2.6A)
None
 0.66A 1j37B-4ar9A:
2.8		 1j37B-4ar9A:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_D_SAMD3293_1
(GLYCINE
N-METHYLTRANSFERASE)		 4ar9 COLLAGENASE COLT
(Clostridium
tetani) 		4 / 5 ILE A 614
ARG A 464
ASP A 556
ASN A 561
 None
 1.36A 1kiaD-4ar9A:
0.9		 1kiaD-4ar9A:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1O86_A_LPRA702_1
(ANGIOTENSIN
CONVERTING ENZYME)		 4ar9 COLLAGENASE COLT
(Clostridium
tetani) 		5 / 12 HIS A 465
GLU A 466
HIS A 469
GLU A 499
TYR A 548
 ZN  A1731 (-3.3A)
ZN  A1731 (-3.9A)
ZN  A1731 (-3.2A)
ZN  A1731 (-2.6A)
None
 0.65A 1o86A-4ar9A:
undetectable		 1o86A-4ar9A:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_F_TFPF209_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 4ar9 COLLAGENASE COLT
(Clostridium
tetani) 		5 / 10 GLU A 503
LEU A 476
GLN A 472
GLU A 466
SER A 508
 None
None
None
ZN  A1731 (-3.9A)
None
 1.32A 1wrlE-4ar9A:
undetectable
1wrlF-4ar9A:
undetectable		 1wrlE-4ar9A:
13.48
1wrlF-4ar9A:
13.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C6N_A_LPRA705_1
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)		 4ar9 COLLAGENASE COLT
(Clostridium
tetani) 		5 / 12 HIS A 465
GLU A 466
HIS A 469
GLU A 499
TYR A 548
 ZN  A1731 (-3.3A)
ZN  A1731 (-3.9A)
ZN  A1731 (-3.2A)
ZN  A1731 (-2.6A)
None
 0.59A 2c6nA-4ar9A:
4.4		 2c6nA-4ar9A:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C6N_B_LPRB705_1
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)		 4ar9 COLLAGENASE COLT
(Clostridium
tetani) 		5 / 12 HIS A 465
GLU A 466
HIS A 469
GLU A 499
TYR A 548
 ZN  A1731 (-3.3A)
ZN  A1731 (-3.9A)
ZN  A1731 (-3.2A)
ZN  A1731 (-2.6A)
None
 0.66A 2c6nB-4ar9A:
4.2		 2c6nB-4ar9A:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O5Y_H_STRH249_1
(CHIMERIC ANTIBODY
FAB 1E9-DB3)		 4ar9 COLLAGENASE COLT
(Clostridium
tetani) 		4 / 7 ASN A 490
GLY A 492
THR A 495
TRP A 496
 None
 1.25A 2o5yH-4ar9A:
2.8
2o5yL-4ar9A:
2.8		 2o5yH-4ar9A:
20.30
2o5yL-4ar9A:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X8Z_A_X8ZA1615_1
(ANGIOTENSIN
CONVERTING ENZYME)		 4ar9 COLLAGENASE COLT
(Clostridium
tetani) 		5 / 11 HIS A 465
GLU A 466
HIS A 469
GLU A 499
TYR A 548
 ZN  A1731 (-3.3A)
ZN  A1731 (-3.9A)
ZN  A1731 (-3.2A)
ZN  A1731 (-2.6A)
None
 0.60A 2x8zA-4ar9A:
5.3		 2x8zA-4ar9A:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X91_A_LPRA1615_1
(ANGIOTENSIN
CONVERTING ENZYME)		 4ar9 COLLAGENASE COLT
(Clostridium
tetani) 		5 / 12 HIS A 465
GLU A 466
HIS A 469
GLU A 499
TYR A 548
 ZN  A1731 (-3.3A)
ZN  A1731 (-3.9A)
ZN  A1731 (-3.2A)
ZN  A1731 (-2.6A)
None
 0.63A 2x91A-4ar9A:
3.4		 2x91A-4ar9A:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CKZ_A_ZMRA469_1
(NEURAMINIDASE)		 4ar9 COLLAGENASE COLT
(Clostridium
tetani) 		5 / 12 GLU A 503
TYR A 487
GLU A 498
GLU A 499
TYR A 548
 None
None
None
ZN  A1731 (-2.6A)
None
 1.48A 3ckzA-4ar9A:
undetectable		 3ckzA-4ar9A:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_B_CHDB153_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 4ar9 COLLAGENASE COLT
(Clostridium
tetani) 		4 / 6 ILE A 494
THR A 468
PHE A 505
PHE A 566
 None
 1.11A 3elzB-4ar9A:
undetectable		 3elzB-4ar9A:
15.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_A_CHDA153_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 4ar9 COLLAGENASE COLT
(Clostridium
tetani) 		4 / 5 ILE A 494
THR A 468
PHE A 505
PHE A 566
 None
 1.34A 3em0A-4ar9A:
undetectable		 3em0A-4ar9A:
15.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_A_THHA642_1
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 4ar9 COLLAGENASE COLT
(Clostridium
tetani) 		3 / 3 ASN A 660
ASP A 360
ARG A 464
 None
 0.87A 3k13A-4ar9A:
undetectable		 3k13A-4ar9A:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KMO_B_EAAB213_1
(GLUTATHIONE
S-TRANSFERASE P)		 4ar9 COLLAGENASE COLT
(Clostridium
tetani) 		4 / 7 TYR A 381
PHE A 359
ASN A 361
GLY A 362
 None
 1.13A 3kmoB-4ar9A:
undetectable		 3kmoB-4ar9A:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C2P_A_X8ZA709_1
(ANGIOTENSIN-CONVERTI
NG ENZYME)		 4ar9 COLLAGENASE COLT
(Clostridium
tetani) 		5 / 11 HIS A 465
GLU A 466
HIS A 469
GLU A 499
TYR A 548
 ZN  A1731 (-3.3A)
ZN  A1731 (-3.9A)
ZN  A1731 (-3.2A)
ZN  A1731 (-2.6A)
None
 0.62A 4c2pA-4ar9A:
4.2		 4c2pA-4ar9A:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DPR_A_X8ZA702_1
(LEUKOTRIENE A-4
HYDROLASE)		 4ar9 COLLAGENASE COLT
(Clostridium
tetani) 		5 / 9 HIS A 465
GLU A 466
GLU A 499
TYR A 541
TYR A 548
 ZN  A1731 (-3.3A)
ZN  A1731 (-3.9A)
ZN  A1731 (-2.6A)
None
None
 1.45A 4dprA-4ar9A:
7.7		 4dprA-4ar9A:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIX_A_NIMA201_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 4ar9 COLLAGENASE COLT
(Clostridium
tetani) 		4 / 4 LEU A 480
ALA A 406
ILE A 442
LYS A 483
 None
 1.44A 4eixA-4ar9A:
undetectable		 4eixA-4ar9A:
16.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWX_A_ZMRA513_1
(NEURAMINIDASE)		 4ar9 COLLAGENASE COLT
(Clostridium
tetani) 		5 / 12 GLU A 503
ARG A 516
GLU A 498
GLU A 499
TYR A 548
 None
None
None
ZN  A1731 (-2.6A)
None
 1.45A 4mwxA-4ar9A:
undetectable		 4mwxA-4ar9A:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O8Z_A_BBIA402_1
(NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-3,
MITOCHONDRIAL)		 4ar9 COLLAGENASE COLT
(Clostridium
tetani) 		4 / 5 HIS A 601
PHE A 554
LEU A 605
PRO A 515
 None
 1.12A 4o8zA-4ar9A:
undetectable		 4o8zA-4ar9A:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R7L_A_SHHA709_1
(LEUKOTRIENE A-4
HYDROLASE)		 4ar9 COLLAGENASE COLT
(Clostridium
tetani) 		5 / 12 HIS A 465
GLU A 466
HIS A 469
GLU A 499
TYR A 548
 ZN  A1731 (-3.3A)
ZN  A1731 (-3.9A)
ZN  A1731 (-3.2A)
ZN  A1731 (-2.6A)
None
 0.53A 4r7lA-4ar9A:
6.6		 4r7lA-4ar9A:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_B_377B401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 4ar9 COLLAGENASE COLT
(Clostridium
tetani) 		4 / 5 TYR A 541
GLU A 499
GLU A 498
TYR A 487
 None
ZN  A1731 (-2.6A)
None
None
 1.42A 4twdA-4ar9A:
0.0
4twdB-4ar9A:
0.0		 4twdA-4ar9A:
22.06
4twdB-4ar9A:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJL_A_ERYA1101_0
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 4ar9 COLLAGENASE COLT
(Clostridium
tetani) 		5 / 12 SER A 653
PHE A 467
GLU A 651
THR A 658
GLY A 725
 None
 1.38A 4zjlA-4ar9A:
3.4		 4zjlA-4ar9A:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJO_A_ERYA1101_0
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 4ar9 COLLAGENASE COLT
(Clostridium
tetani) 		5 / 12 SER A 539
ALA A 533
GLU A 587
LEU A 565
THR A 572
 None
 1.32A 4zjoA-4ar9A:
3.3		 4zjoA-4ar9A:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZ8_A_GCSA208_1
(GLUCANASE/CHITOSANAS
E)		 4ar9 COLLAGENASE COLT
(Clostridium
tetani) 		4 / 7 GLU A 386
ARG A 464
TYR A 621
GLU A 460
 None
 1.16A 4zz8A-4ar9A:
undetectable		 4zz8A-4ar9A:
14.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GSN_C_MMZC503_1
(FLAVIN-CONTAINING
MONOOXYGENASE)		 4ar9 COLLAGENASE COLT
(Clostridium
tetani) 		4 / 4 TYR A 665
ASN A 676
SER A 669
SER A 668
 None
 1.48A 5gsnC-4ar9A:
0.8		 5gsnC-4ar9A:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D8P_B_ACTB804_0
(UNCHARACTERIZED
PROTEIN)		 4ar9 COLLAGENASE COLT
(Clostridium
tetani) 		4 / 4 HIS A 601
VAL A 520
LEU A 605
ALA A 553
 None
 1.41A 6d8pB-4ar9A:
3.1		 6d8pB-4ar9A:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBP_C_DAHC123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 4ar9 COLLAGENASE COLT
(Clostridium
tetani) 		5 / 10 PHE A 554
LEU A 536
SER A 589
ILE A 594
ILE A 585
 None
 1.24A 6ebpC-4ar9A:
undetectable		 6ebpC-4ar9A:
11.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MDQ_A_TESA605_0
(SERUM ALBUMIN)		 4ar9 COLLAGENASE COLT
(Clostridium
tetani) 		4 / 8 HIS A 351
GLY A 348
LEU A 427
GLU A 420
 None
 0.88A 6mdqA-4ar9A:
undetectable		 6mdqA-4ar9A:
13.44